[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"paracetamol\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:paracetamol":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100640453","paracetamol-and-cefazolin-pharmacokinetics-in-normal-weight-and-overweight-children-100640453",false,"NCT07585487","Paracetamol and Cefazolin Pharmacokinetics in Normal Weight and Overweight Children","TISSUE","Inclusion Criteria:\n\n* Patient admitted to the operating room for minor elective surgery\n* Patients undergoing general anesthesia for minor elective surgery\n* Patient age: children from 2 years to 15 years\n* Patients receiving cefazolin or paracetamol according to the standard procedure\n* Intra-arterial (preferred) or intravenous access available for blood sampling\n* BMI\n\nExclusion Criteria:\n\n* Personal or family history of excessive bleeding\n* Pre-existing coagulopathy and\u002For thrombocytopenia\n* No catheter available for blood sampling\n* Absence of parental consent\n* Known allergy to one of the components of the study\n* Pregnancy","ALL","2 Years","15 Years",{"count":20,"type":21},120,"ESTIMATED","OBSERVATIONAL","Pharmacokinetic evaluations will be conducted to characterize the cefazolin plasma concentration-time profile, cefazolin penetration into subcutaneous adipose tissue, and paracetamol metabolization as assessed through blood sampling. The study population consists of children aged 2 to 15 years with either normal weight or overweight. All participants are admitted for a minor elective surgical procedure and will receive paracetamol and\u002For cefazolin as part of standard perioperative care.\n\nDuring the procedure, multiple blood and tissue-fluid samples will be collected to quantify paracetamol and cefazolin concentrations in the bloodstream, as well as cefazolin concentrations in subcutaneous adipose tissue. The study aims to characterize drug concentration-time profiles in blood (paracetamol), plasma (cefazolin), and adipose tissue (cefazolin), and to compare these pharmacokinetic parameters between normal-weight and overweight children.\n\nThese data are essential to determine whether standard dosing regimens provide adequate drug exposure across different weight categories. Previous research indicates that achieving specific target concentrations in blood and tissue is necessary for optimal therapeutic effect, yet uncertainty remains regarding appropriate dosing in overweight children.",[25,26],"Paracetamol","Cefazolin",[25,26,28,29],"Overweight","children","RECRUITING","2026-05-08",{"date":33,"type":34},"2026-05-13","ACTUAL",{"date":36,"type":34},"2023-12-22",{"date":38,"type":21},"2027-01-30",{"name":40,"class":41},"University Hospital, Ghent","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":65,"leadSponsor":67,"locationsCount":42},"100628781","hemodynamic-effects-of-intravenous-paracetamol-in-patients-undergoing-emergency-laparotomy-100628781","NCT07466108","Hemodynamic Effects of Intravenous Paracetamol in Patients Undergoing Emergency Laparotomy","Hemodynamic Effects of Intravenous Paracetamol in Patients Undergoing Emergency Laparotomy: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Adult patients, ASA I-III undergoing emergency laparotomy\n\nExclusion Criteria:\n\n* Severe cardiac morbidities (impaired contractility with ejection fraction \\\u003C 40%, heart block, arrhythmias, tight valvular lesions)\n* Hemodynamically unstable patients (defined as patients with MAP \\\u003C 65 mmHg or need vasopressor to maintain MAP\\>65 mmHg).\n* Patients with high shock index (heart rate \u002F systolic blood pressure \\>1)\n* Pregnant or lactating women,\n* Allergy of any of the study drugs","21 Years","65 Years",{"count":53,"type":21},90,"INTERVENTIONAL",[56],"NA","Emergency laparotomy is a high-risk procedure often performed in patients with severe physiological derangements due to sepsis, making perioperative management challenging. Although multimodal analgesia is essential, options are often limited by factors such as hemodynamic instability, renal dysfunction, and coagulopathy. Intravenous paracetamol is commonly recommended for perioperative analgesia because of its opioid-sparing effect, but evidence suggests it may cause hypotension through peripheral vasodilation, particularly in critically ill patients. Most data on this effect come from observational studies, and evidence regarding its intraoperative hemodynamic impact remains limited.",[25,59,60],"Hypotension Drug-Induced","Emergency Surgery","2026-03-18",{"date":63,"type":34},"2026-03-20",{"date":61,"type":34},{"date":66,"type":21},"2026-09",{"name":68,"class":41},"Cairo University"]