[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"paralytic-lagophthalmos\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:paralytic-lagophthalmos":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100584941","early-phase-1-suture-lid-spring-for-lid-closure-in-patients-with-facial-nerve-palsy-100584941",false,"NCT06895902","Suture Lid Spring for Lid Closure in Patients With Facial Nerve Palsy","Suture Eyelid Spring for Eyelid Closure in Patients With Facial Nerve Palsy","SESPL","Inclusion Criteria:\n\n* Adults 18 years of age or older with facial nerve transection or paralytic lagophthalmos that has not improved after 6 weeks.\n\nExclusion Criteria:\n\n* Patients unable to tolerate awake eyelid surgery under local anesthetic.","ALL","18 Years",{"count":20,"type":21},10,"ESTIMATED","INTERVENTIONAL",[24],"EARLY_PHASE1","The eyelids protect the cornea and eyelid closure is essential to ocular health and clear vision.\n\nPatients with permanent Bells palsy or facial nerve palsy from other reasons such as tumours or trauma may be unable to blink and protect their cornea.\n\nIrreversible visual loss can occur if the cornea is not kept lubricated.\n\nCurrent treatment options for patients whose eyelid blink does not recover include lubricating the eye every hour or two with drops and lubricating ointment at night, patching the eye closed, sewing parts of the eyelid together (tarsorrpahy), upper lid gold weight or a dental wire spring.\n\nIt is inconvenient to lubricate the cornea constantly, and the lubricating drops and ointment usually cost more than $80.00 per month. Lubrication often blurs vision, because the patient must look through a film.\n\nPatching the eye closed and tarsorraphy deprives the patient of peripheral vision, can impede social interaction, and is objectionable cosmetically.\n\nUpper-lid gold weights can be placed underneath the eyelid skin and work by gravity. A gold weight will only work when the patient initiates a forced blink. Gold weights may not work when the patient is lying down because there is no gravity to assist lid closure. The eyelid skin is the thinnest skin in the body and can extrude through the skin over time.\n\nEyelid springs made of metal dental wire exist but are not frequently used because they often extrude through the thin eyelid skin. Also, dental wire springs require attachment to the bone near the side of the eye. It is not uncommon that dental wire springs have to be removed or replaced.\n\nThe investigators propose a new spring to close the eyelid made out of the surgical stitches (sutures) commonly used in medicine and eyelid surgery. The stitch will be made into a custom shape and attached underneath the skin near the centre of the lid, without attachment to the bone.\n\nUpper lid gold weights, dental wire springs, and our proposed suture spring are all foreign bodies and can all become infected or extrude through the skin. Because the suture spring is thinner than a gold weight and because it does not have sharp edges like a metal spring, there should be less risk of extrusion. The suture spring will lose its elasticity over time and will require replacement.",[27,28,29],"Facial Nerve Palsy","Corneal Exposure","Paralytic Lagophthalmos",[31],"Paralytic lagophthalmos","RECRUITING","2026-05-29",{"date":35,"type":36},"2026-06-02","ACTUAL",{"date":38,"type":36},"2025-04-28",{"date":40,"type":21},"2028-07-31",{"name":42,"class":43},"University of Alberta","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":66},"100538513","self-adhering-magnetic-device-to-treat-corneal-exposure-100538513","NCT06291818","Self-Adhering Magnetic Device to Treat Corneal Exposure","Inclusion Criteria:\n\n* Males and females ages 18-80 years old.\n* Patients with recent corneal abrasion and no signs of infection in the examination\n* Patients with lagophthalmos\n* Normal Controls\n\nExclusion Criteria:\n\n* Individuals with adhesive or tape allergies.\n* Individuals with a history of metal pieces\u002Fshavings embedded in the eye (such as from welding or metalworking)\n* Individuals with eye infections","80 Years",{"count":52,"type":21},25,[54],"NA","Paralytic lagophthalmos can be difficult to treat and manage. It has a host of causes and effects, one of which (for the latter) is exposure keratopathy. Untreated, this can lead to corneal ulceration, inflammation, and potentially blindness. Despite a variety of attempts at treating this complex condition, none have satisfactorily reduced complications ranging from ease of use to aesthetics. With improvement in magnetic technology, however, that may change. Barmettler et al (2014) have demonstrated preliminary success of externally affixed magnets in closing both model and patient eyelids. As such, we hypothesize that magnetic devices can be used to treat corneal exposure by controlling eyelid position.",[29,28],"2026-05-18",{"date":59,"type":36},"2026-05-22",{"date":61,"type":36},"2024-04-17",{"date":63,"type":21},"2027-09-01",{"name":65,"class":43},"University of Illinois at Chicago",1]