[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"paraplegia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:paraplegia":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,46,72,102],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100640039","effects-of-functional-electrical-stimulation-on-spasticity-quadriceps-muscle-strength-and-functional-mobility-in-individuals-with-paraplegia-100640039",false,"NCT07583576","Effects of Functional Electrical Stimulation on Spasticity, Quadriceps Muscle Strength and Functional Mobility in Individuals With Paraplegia","Effects of Functional Electrical Stimulation on Spasticity, Quadriceps Muscle Strength and Functional Mobility in Individuals With Paraplegia: A Randomized Controlled Trial","FES-PAR-RCT","Inclusion Criteria:\n\n* Participants will be included in the study if they meet all of the following criteria:\n* Aged between 18 and 65 years\n* Diagnosed with spinal cord injury resulting in paraplegia (traumatic or non-traumatic etiology)\n* Classified as ASIA Impairment Scale C or D\n* Medically stable condition\n* Presence of lower extremity spasticity (Modified Ashworth Scale ≥ 1)\n* Ability to understand and follow simple instructions\n* Willingness to participate and provide informed consent\n\nExclusion Criteria:\n\n* Participants will be excluded if they present any of the following conditions:\n* Presence of cardiac pacemaker or implanted electrical device\n* Severe cognitive impairment or communication difficulties preventing participation\n* Active infection or systemic inflammatory condition\n* Severe lower extremity contractures or deformities limiting movement\n* Dermatological conditions or open wounds preventing FES application\n* History of severe autonomic dysreflexia triggered by electrical stimulation\n* Uncontrolled medical conditions that may interfere with participation or safety","ALL","18 Years","65 Years",{"count":21,"type":22},40,"ESTIMATED","INTERVENTIONAL",[25],"NA","Spinal cord injury (SCI)-related paraplegia is a complex neurological condition characterized by motor impairment, increased spasticity, and significant functional limitations in daily activities. Spasticity is one of the most common secondary complications after upper motor neuron lesions and can negatively affect rehabilitation outcomes, gait ability, and functional independence.\n\nThis randomized controlled study aims to investigate the effects of Functional Electrical Stimulation (FES) applied to the quadriceps muscle in individuals with paraplegia. Participants will be randomly assigned to either a control group receiving conventional neurorehabilitation or an intervention group receiving additional FES treatment.\n\nThe primary outcomes include changes in spasticity level, quadriceps muscle strength, and functional mobility. Spasticity will be assessed using the Modified Ashworth Scale (MAS), muscle strength will be evaluated with Manual Muscle Testing (MMT), and functional mobility will be measured using the Spinal Cord Independence Measure (SCIM), Timed Up and Go Test (TUG), and 6-Minute Walk Test (6MWT).\n\nThe intervention period will last 8 weeks, with standardized rehabilitation programs applied to both groups. The FES group will additionally receive quadriceps stimulation with specific neuromuscular electrical stimulation parameters.\n\nThe findings of this study are expected to provide evidence regarding the effectiveness of FES as an adjunct to conventional rehabilitation in improving motor function and functional independence in individuals with paraplegia.",[28,29,30,31],"Spinal Cord Injury","Paraplegia","Spasticity","Neurorehabilitation",[28,33,31,30,29],"Paraplegia Rehabilitation","NOT_YET_RECRUITING","2026-05-15",{"date":37,"type":38},"2026-05-19","ACTUAL",{"date":40,"type":22},"2026-05-10",{"date":42,"type":22},"2026-07-10",{"name":44,"class":45},"Istanbul Medipol University Hospital","OTHER",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":55,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":71},"100538769","virtual-peer-coaching-in-manual-wheelchair-skills-100538769","NCT06295146","Virtual Peer Coaching in Manual Wheelchair Skills","Improving Manual Wheelchair Skills Through Remote Training","Inclusion Criteria:\n\nCoaches:\n\n* At least 18 years old\n* Non-progressive SCI\n* Able to speak and read English\n* Reside in the community\n* Independently use a manual wheelchair for at least 50% of mobility\n\nCoaches with paraplegia:\n\n\\- Able to complete all skills targeted by the intervention, except stair ascent, (WST-Q item scores 2) independently.\n\nCoaches with tetraplegia:\n\n\\- Able to complete all skills targeted by the intervention with or without assistance\n\nTrainees:\n\n* At least 18 years old\n* Non-progressive SCI\n* Able to speak and read English\n* Reside in the community\n* Independently use a manual wheelchair for 50% of mobility\n* Access to an Internet-ready device with video capabilities.\n* Access to a spotter for practicing wheelchair skills\n* Desire training for at least 5 of the 16 skills targeted by the training program\n\nExclusion Criteria:\n\n* none",{"count":54,"type":22},132,[25],"The objective of this study is to determine the effectiveness of remote manual wheelchair skills training program. First, peer coaches will be enrolled and trained. Then, trainees will be enrolled into one of three interventions: intervention with remote feedback (Group 1), and a wait list control group (Group 2).",[58,29,28,59,60],"Wheelchair","Tetraplegia\u002FTetraparesis","Spinal Cord Injuries (SCI)","RECRUITING","2026-04-08",{"date":64,"type":38},"2026-04-14",{"date":66,"type":38},"2024-06-25",{"date":68,"type":22},"2027-12-30",{"name":70,"class":45},"University of Pittsburgh",1,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":17,"minAge":79,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":23,"phases":82,"briefSummary":83,"conditions":84,"keywords":87,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":71},"100169050","a-neuroprosthesis-for-seated-posture-and-balance-100169050","NCT01474148","A Neuroprosthesis for Seated Posture and Balance","Trunk Protocol","Inclusion Criteria:\n\n* C4-T12\n* ASIA Scale A through C\n* Time post injury greater than 6 months\n* Innervated and excitable trunk and pelvis musculature\n* Absence of acute or chronic psychological problems or chemical dependency\n* Range of motion within normal limits\n* Controlled spasticity and absence of hip flexion and adduction spasm\n* Height and weight within normal limits\n* No history of balance problems or spontaneous falls\n* No history of spontaneous fracture or evidence low bone density\n* No acute orthopaedic problems\n* No acute medical complications\n* Adequate social support and stability\n* Able to speak and read English\n\nExclusion Criteria:\n\n* Pregnancy\n* Non-English speaking","21 Years",{"count":81,"type":22},10,[25],"The purpose of this study is to evaluate a surgically implanted functional electrical stimulation (FES) system to facilitate stability of the trunk and hips. FES involves applying small electric currents to the nerves, which cause the muscles to contract. This study evaluates how stabilizing and stiffening the trunk with FES can change the way spinal cord injured volunteers sit, breathe, reach, push a wheelchair, or roll in bed.",[28,85,86,29],"Paralysis","Tetraplegia",[88,89,90,91],"paraplegia","tetraplegia","Spinal cord injured","FES","2025-10-23",{"date":94,"type":38},"2025-10-27",{"date":96,"type":38},"2011-11-30",{"date":98,"type":22},"2027-01-31",{"name":100,"class":101},"VA Office of Research and Development","FED",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":17,"minAge":79,"maxAge":110,"enrollmentInfo":111,"targetDuration":4,"studyType":23,"phases":112,"briefSummary":113,"conditions":114,"keywords":117,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":130},"100104456","evaluation-of-an-advanced-lower-extremity-neuroprostheses-100104456","NCT00623389","Evaluation of an Advanced Lower Extremity Neuroprostheses","Evaluation of Advanced Lower Extremity Neuroprostheses","LE-IST","Phase I Inclusion Criteria\n\n1. Skeletal maturity and ability to sign informed consent (\\>18 years)\n2. Non-ventilator dependent paralysis resulting from injuries such as: mid cervical\u002Fthoracic (C4 or below) spinal cord injuries, poststroke hemiparesis, TBI, or MS, affecting the trunk and\u002For lower limbs\n3. Innervated and excitable lower extremity and trunk musculature\n4. Adequate social support and stability\n5. Willingness to comply with follow-up procedures\n\nPhase I Exclusion Criteria\n\n1. Non-English speaking\n2. Females who are pregnant\n3. Current pressure injuries that would be exacerbated by study activities\n4. Severe contractures or uncontrolled spasticity of any major joint of the upper or lower extremities that results in a fixed deformity that would interfere with study activities\n5. History of spontaneous fractures or other evidence of excessively low bone density\n6. History of vestibular dysfunction, balance problems, or spontaneous falls\n7. Acute and or\u002Funtreated orthopedic problems that would prevent a participant from weight bearing or exercising such as a dislocation or fracture.","75 Years",{"count":81,"type":22},[25],"The purpose of this study is to evaluate a surgically implanted functional electrical stimulation (FES) system to facilitate exercise, standing, stepping and\u002For balance in people with various degrees of paralysis.",[115,116,85,86,29],"Spinal Cord Injuries","Stroke",[118,119,120,116,29,86],"Neurologic disorders","Rare disease","Spinal cord injuries","2025-06-12",{"date":123,"type":38},"2025-06-15",{"date":125,"type":38},"2018-06-01",{"date":127,"type":22},"2027-12-31",{"name":129,"class":45},"Case Western Reserve University",2]