[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"parathyroid-adenoma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:parathyroid-adenoma":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,42,74,108],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100507775","phase-2-99mtc-sestamibi-spectct-vs-18f-fluorocholine-petct-100507775",false,"NCT05891769","99mTc Sestamibi SPECT\u002FCT vs 18F Fluorocholine PET\u002FCT","Evaluation of Patients With Suspected Parathyroid Adenoma and Negative or Equivocal 99mTc Sestamibi SPECT\u002FCT Using 18F Fluorocholine PET\u002FCT","18FCH","Inclusion Criteria:\n\n1. Suspected parathyroid adenoma (elevated serum calcium and inappropriately normal or high levels of parathyroid hormone)\n2. Negative or equivocal 99mTc Sestamibi SPECT\u002FCT\n3. Able to provide written consent\n4. Total bilirubin ≤ 1.5 x upper limit of normal (ULN)\n5. Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) ≤ 5 xULN\n6. Karnofsky performance status of \\>50 (or ECOG\u002FWHO equivalent)\n7. Women must not be pregnant per the Department of Radiology Policy on Imaging in Potentially Pregnant and Pregnant Women.\n\nExclusion Criteria:\n\n1. Less than 18 years old at the time of radiotracer administration\n2. Creatinine clearance (calculated using Cockcroft-Gault formula, or measured) \\\u003C 60 mL\u002Fmin or serum creatinine \\>1.5 x ULN\n3. QTcF \\>470 msec on electrocardiogram (ECG) or congenital long QT syndrome","ALL","18 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24,25],"PHASE2","PHASE3","This study proposes the use of a well-established PET isotope, Fluorine-18 (18F), bound to Choline, for a prospective single-center, single-arm study for participants with suspected parathyroid adenoma and negative or equivocal standard of care 99mTc Sestamibi SPECT\u002FCT",[28],"Parathyroid Adenoma","RECRUITING","2026-06-19",{"date":32,"type":33},"2026-06-24","ACTUAL",{"date":35,"type":33},"2023-09-27",{"date":37,"type":21},"2028-07-01",{"name":39,"class":40},"Andrei Iagaru","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":4},"100598444","new-intraoperative-nerve-monitoring-device-100598444","NCT07071571","New Intraoperative Nerve Monitoring Device","Evaluation of the Usability and Safety of the Newly Developed Piezoelectric Sensor Intraoperative Nerve Monitoring Device in Thyroid and Parathyroid Surgery: A Pilot Study","IONM","Inclusion Criteria:\n\n* Age 18-70, diagnosis of benign\u002Fmalignant thyroid disease, informed consent\n\nExclusion Criteria:\n\n* History of previous nerve injury, concomitant neurological disorder","70 Years",{"count":52,"type":21},40,[54],"NA","This study is testing a new device developed to protect the recurrent laryngeal nerve, which is at risk of damage during thyroid and parathyroid surgeries.",[57,58],"Thryoid Cancer","parathyrıoid Adenoma",[60,61,62,63],"neuromonitorization","introperative","recurrent nerve","new device","NOT_YET_RECRUITING","2025-07-16",{"date":67,"type":33},"2025-07-17",{"date":69,"type":21},"2025-08-01",{"date":71,"type":21},"2026-12-01",{"name":73,"class":40},"SB Istanbul Education and Research Hospital",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":85,"briefSummary":86,"conditions":87,"keywords":91,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":41},"100596250","white-cap-intra-operative-parathyroid-tissue-sensor-pts-guided-assessment-of-parathyroid-viability-and-surgical-decision-making-100596250","NCT07043010","WHITE CAP: Intra-operative Parathyroid Tissue Sensor (PTS)-Guided Assessment of Parathyroid Viability and Surgical Decision-Making","WHITE CAP Trial: Optical Parathyroid Tissue Sensor-Guided Assessment of Parathyroid Viability and Its Impact on Clinical Decision-Making","WHITE CAP-PTS","Inclusion Criteria:\n\n* Age 18 to 75 years, able to give informed consent.\n* Biochemically proven primary hyperparathyroidism (elevated serum calcium and inappropriately high PTH).\n* Pre-operative imaging (sestamibi scan, 4-phase CT, or ultrasound) concordant with a single parathyroid adenoma.\n* Planned minimally invasive parathyroidectomy using near-infrared parathyroid tissue sensor (PTS) guidance.\n\nExclusion Criteria:\n\n* Multiple endocrine neoplasia (MEN 1 or 2) or suspicion of multi-gland disease (\\>1 enlarged gland on imaging).\n* Prior parathyroid or extensive neck surgery causing distorted anatomy.\n* Need for simultaneous total thyroidectomy or other major neck procedure.\n* Estimated glomerular filtration rate (eGFR) \\\u003C 30 mL\u002Fmin\u002F1.73 m².\n* Pregnancy or breastfeeding.\n* Inability to tolerate general anaesthesia or contraindication to intra-operative PTS imaging.","75 Years",{"count":84,"type":21},120,[54],"Primary hyperparathyroidism is usually cured by removing the single over-active parathyroid adenoma. During surgery, however, surgeons often see a thin rim of normal parathyroid tissue that still \"glows\" under a near-infrared parathyroid tissue sensor (PTS). It is unclear whether keeping this tissue in place helps preserve hormone function or whether it leaves behind cells that could become over-active again.\n\nThe WHITE CAP study will compare two common surgical choices:\n\nPreservation strategy - the surgeon removes only the adenoma and leaves the glowing rim of normal tissue untouched.\n\nEn-bloc strategy - the surgeon removes the adenoma together with the glowing rim; if too little parathyroid tissue remains, a small fragment is transplanted into the forearm muscle.\n\nAbout 120 adult patients who have a single parathyroid adenoma will be randomly assigned (like tossing a coin) to one of the two strategies. All operations will use the same FDA-cleared PTS camera that shows the glands in real time without dye or radiation.\n\nThe main question is whether preserving the normal rim lowers the rate of temporary low blood-calcium (numbness, tingling) during the first two days after surgery. The study will also check long-term results-blood calcium and parathyroid hormone (PTH) levels, symptoms, and any return of the disease-over two years.\n\nThe PTS imaging itself is painless and adds only a few minutes to the operation. Risks are the same as for standard parathyroid surgery, and participants can withdraw at any time without affecting their usual care.",[88,89,28,90],"Hyperparathyroidism, Primary","Parathyroid Neoplasms","Hypocalcemia",[92,93,94,95,96,97,98],"Near-Infrared Autofluorescence","Parathyroid Tissue Sensor","Parathyroid Viability","Peri-adenoma Rim Preservation","Intra-operative Imaging","Calcium Homeostasis","PTS Camera","2025-06-27",{"date":101,"type":33},"2025-06-29",{"date":103,"type":21},"2025-07-01",{"date":105,"type":21},"2029-12-31",{"name":107,"class":40},"Fujian Medical University",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":115,"targetDuration":4,"studyType":117,"phases":4,"briefSummary":118,"conditions":119,"keywords":120,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":41},"100586278","pteye-in-parathyroid-adenoma-100586278","NCT06913296","PTeye in Parathyroid Adenoma","Do PTeye Score Correlate With Biochemical Markers in Parathyroid Adenoma?","Inclusion Criteria:\n\n* Age \\>18 years old\n* primary hyperparathyroidism caused by adenoma\n* patient's informed consent acquired\n\nExclusion Criteria:\n\n* Secondary and tertiary hyperparathyroidism\n* Re-operation for adenoma\n* Previous neck surgery\n* Patient enrolled in another study that may affect the results of this study",{"count":116,"type":21},50,"OBSERVATIONAL","Identifying the parathyroids is compulsory for success of parathyroidectomy for parathyroid adenoma. Near-infrared autofluorescence devices have been proposed as useful intraoperative tools for the identification of parathyroid glands. The aim of the present study is to evaluate the correlation of PTeye autofluorescence device with biochemical data of parathyroid adenoma patients.",[28],[121,122],"parathyroid adenoma","near-infrared autofluorescence","2025-03-30",{"date":125,"type":33},"2025-04-06",{"date":127,"type":33},"2025-03-28",{"date":129,"type":21},"2025-05-30",{"name":131,"class":40},"Aristotle University Of Thessaloniki"]