[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"parenteral-nutrition\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:parenteral-nutrition":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,43,79,104],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100556488","weaning-is-winning-wewin-study-100556488",false,"NCT06525753","Weaning is Winning? (WeWin Study)","Weaning is Winning? (WeWin Study): Are Parenteral Nutrition (PN) Graduates Growing up Healthy?","Inclusion Criteria:\n\n* Parenteral Nutrition graduates for at least 1 year, with a history of intestinal failure.\n* Age \\\u003C18 years at time of inclusion.\n\nExclusion criteria:\n\n* No consent provided.","ALL","0 Years","18 Years",{"count":20,"type":21},120,"ESTIMATED","OBSERVATIONAL","We propose a multicenter prospective study on pediatric patients with intestinal failure (IF) who weaned off parenteral nutrition (PN).",[25,26],"Intestinal Failure","Parenteral Nutrition",[28,29],"Quality of Life","Pediatric","RECRUITING","2026-06-19",{"date":33,"type":34},"2026-06-24","ACTUAL",{"date":36,"type":34},"2024-06-01",{"date":38,"type":21},"2034-06-01",{"name":40,"class":41},"The Hospital for Sick Children","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100623143","age-accumulation-in-patients-on-long-term-parenteral-nutrition-100623143","NCT07392801","AGE Accumulation in Patients on Long-term Parenteral Nutrition","Study of Advanced Glycation End-products Accumulation in Patients Under Long-Term Parenteral Nutrition (NUPARAGE2)","NUPARAGE2","Inclusion Criteria:\n\n* Patients (adults and children, all ages) initiating long-term parenteral nutrition\n* Followed at CHU de Bordeaux or Robert Debré Hospital (APHP)\n* Covered by French Social Security system\n* Written informed consent obtained from patient (if adult) or legal guardian (if minor)\n\nExclusion Criteria:\n\n* Fitzpatrick skin type ≥ V (darker skin tones)\n* Forearm tattoos at the site of measurement\n* For patients included under 1 year of age: patients born prematurely (before 37 weeks of amenorrhea)\n* Pregnant or breastfeeding women.",{"count":52,"type":21},50,"INTERVENTIONAL",[55],"NA","This prospective and observational study aims to evaluate the accumulation of advanced glycation end-products (AGEs) in adult and pediatric patients starting long-term parenteral nutrition, by non-invasive skin AGE measurements over a 12-month follow-up.",[58,59,26],"Chronic Intestinal Insufficiency","Advanced Glycation and Products",[61,62,63,64,65,66,67],"parenteral nutrition","Advanced Glycation End Products","Oxidative Stress","Metabolic Diseases","Cardiovascular Diseases","Short Bowel Syndrome","chronic intestinal insufficiency","NOT_YET_RECRUITING","2026-04-30",{"date":71,"type":34},"2026-05-06",{"date":73,"type":21},"2026-05",{"date":75,"type":21},"2028-05",{"name":77,"class":41},"University Hospital, Bordeaux",3,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":16,"minAge":86,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":53,"phases":89,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":103},"100564190","phase-3-clinical-trial-to-evaluate-the-safety-and-efficacy-of-ntcb02-1-in-patients-who-require-parenteral-nutrition-100564190","NCT06625957","Clinical Trial to Evaluate the Safety and Efficacy of NTCB02-1 in Patients Who Require Parenteral Nutrition","A Randomized, Open-labeled, Multi-center, Active-controlled, Parallel-group Phase 3 Clinical Trial to Evaluate the Safety and Efficacy of NTCB02-1 Versus NTCB-C in Patients Who Require Parenteral Nutrition","Inclusion Criteria:\n\n* Those who are 19 years old or older at the screening visit\n* Patients are expected to require PN for more than 3 days\n* Patients who voluntarily signed the consent form\n\nExclusion Criteria:\n\n* Patients are expected difficult to survive more than 3 days\n* Patients BMI is over 30 kg\u002Fm2\n* Patients having hypersensitivity to any peanut-, fish-, soy-, egg protein, or investigational drug\n* Patients with difficult central venous line\n* Patients judged to be unsuitable for this trial by investigators","19 Years",{"count":88,"type":21},60,[90],"PHASE3","A Randomized, Open-labeled, Multi-center, Active-controlled, Parallel-group Phase 3 Clinical Trial to Evaluate the Safety and Efficacy of NTCB02-1 versus NTCB-C in patients who require parenteral nutrition",[26],"2025-01-05",{"date":95,"type":34},"2025-01-07",{"date":97,"type":34},"2024-12-04",{"date":99,"type":21},"2025-07-18",{"name":101,"class":102},"Yuhan Corporation","INDUSTRY",5,{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":111,"targetDuration":4,"studyType":53,"phases":113,"briefSummary":114,"conditions":115,"keywords":120,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":42},"100555304","achieving-nutritional-target-in-critically-ill-patients-with-impaired-gastrointestinal-dysfunction-100555304","NCT06510348","Achieving nuTritional Target in criticAlly Ill patieNts With iMpairEd gastroiNtesTinal Dysfunction","ATTAINMENT","Inclusion Criteria:\n\n* All adults (\\> 18 years old)\n* Mechanical ventilation for more than four days,\n* Controlled shock state (hemodynamic and tissue perfusion goals are reached) - Impaired intestinal absorbtion, defiend by both ultrasound measurement of gastric residual volume and paracetamol absorbtion test\n\nExclusion Criteria:\n\n* patients on non-invasive mechanichal ventilation\n* contraindication for EN for \\> 48 h after admission\n* patients with gastrointestinal surgical intervention within 3 months,\n* history of malabsorption, inflammatory bowel disease\n* short bowel syndrom\n* anorexia nervosa\n* gastrointestinal bleeding\n* cirrhosis\n* traumatic brain injury\n* subarahnoidal hemorrhage\n* neoplasia\n* post cardiac arrest patients\n* patients on chronic therapy with corticosteroids\n* pregnant women.",{"count":112,"type":21},164,[55],"Clear study hypothesis \u002F research question\n\nIt has already been proven that a prolonged negative energy balance during intensive care stay is an independent risk factor for mortality. Although it was thought that achivieng optimal delivery of calories will prevent nutritional deficits in critically ill patients, published randomized controlled trials failed to confirm this hypothesis.\n\nCombinging enteral and parenteral support may be an efficent strategy to reach nutritional target in critically ill patients. According to the current guidelines the use of suplemental parenteral nutrition (SPN) should be considered when energy targets are not achieved by enteral (EN) route, however, no clear data regarding timing, amount and composition is specified. Moreover, based on recente published data overfeeding should also be avoided, considering the negative impact on outcome.\n\nNutritional support for critically ill patients was focused more on preventing caloric and protein deficits and no great emphasis was placed on the efficiency of intestinal absorption. Gastrointestinal dysfunction is a prevalent reported complication that may contribute to falling short of meeting nutritional goals. This encompasses a wide spectrum of symptoms, such as impaired gastric emptying, ileus or impaired intestinal absorbtion, exposing patients to feeding intolerance, malnutrition and worse outcomes. No standard definition and monitoring techniques are so far available for the diagnostic of feeding intolerance. Although increased gastric residual volume (GRV) is the most used parameter for highlighting feeding intolerance, a controversy regarding the adequate threshold of GRV persists. Acetaminophen absorption test has been previously proposed as a diagnostic tool to asses impaired gastric emptying and intestinal absorbtion.\n\nBesides intestinal absorbtion, efficient utilization of macronutients should also be assessed, considering that critically ill patients have varying metabolic conditions and may not be able to metabolically handle adminsitered substrates. As a result body composition analysis should be taken into account in order to obtain a dynamic quantification, especially, of the mucle mass compartiments.\n\nTherefore the following low-interventional study is designed to investigate the hypothesis regarding energy and protein intake achievement in critically ill patients with diagnosed impaired gastrointestinal dysfunction to whom tailored nutritional support is administered.\n\nTaking into account that we aim to identify patients with early-phase gastrointestinal dysfunction impaired gastric emptying and reduced intestinal absorbtion (diagnosed using ultrasound gastric residual volume and byacetaminiphen absorbtion test) will serve as defining factors. Patients will be randomized to receive nutritional support either according to the EN protocol or enteral trophic feed + SPN protocol.\n\nDifferences in rectus femoris thickness measured on admission, on day 10 and 15, variation of lean body mass measured by bioelectrical impedance on admission on day 10 and 15, and differences between groups in muscle function using handgrip dynamometer will also be evaluated in both groups.",[26,116,117,118,119],"Gastroparesis","Gastrointestinal Dysfunction","Protein Deficiency","Critical Illness",[121,122,61,123,124,125,126,127,128],"gastrointestinal dysfunction","supplemental parenteral nutrition","enteral nutrition","critically ill","protein intake","calorie intake","gastroparesis","malabsorption","2024-11-04",{"date":131,"type":34},"2024-11-06",{"date":133,"type":34},"2024-10-01",{"date":135,"type":21},"2026-12-31",{"name":137,"class":41},"Romanian Society for Enteral and Parenteral Nutrition"]