[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"paresis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:paresis":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,45,76,109],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100537790","pupil-indexed-noninvasive-neuromodulation-100537790",false,"NCT06282406","Pupil-Indexed Noninvasive Neuromodulation","Transcutaneous Auricular Vagus Nerve Stimulation: Motor Learning & Mechanisms","Inclusion Criteria:\n\nALL PROSPECTIVE SUBJECTS:\n\n1. 18-75 years of age\n\n   PROSPECTIVE SUBJECTS DIAGNOSED WITH STROKE:\n2. Diagnosis of a single stroke resulting in hand impairment\n3. Diagnosis of stroke at least six months prior to the time of participation\n\nExclusion Criteria:\n\nALL PROSPECTIVE SUBJECTS:\n\n1. History of vestibular disorders or dizziness\n2. Difficulty maintaining alertness and\u002For remaining still\n3. Pregnant or expecting to become pregnant\n4. Diagnosis of neurological and\u002For musculoskeletal disorder(s) (other than stroke) that affect movement\n5. Ocular disease and\u002For impairment in more than one eye\n6. History of seizure and\u002For epilepsy\n7. Implants, devices, or foreign objects in the brain\u002Fbody that are incompatible with MRI\n8. Body size that is incompatible with MRI scanner dimensions\n9. Anyone already enrolled and actively participating in another greater than minimal risk study.\n\n   PROSPECTIVE SUBJECTS DIAGNOSED WITH STROKE:\n10. Other impairments secondary to stroke (e.g., attention, cognition, etc.) that would interfere with the ability to understand study goals or follow simple instructions, as judged by the investigators.",true,"ALL","18 Years","75 Years",{"count":21,"type":22},110,"ESTIMATED","INTERVENTIONAL",[25],"NA","Vagus nerve stimulation (VNS) is thought to activate neural pathways that release chemicals which promote plasticity and learning. Previous work has shown that the auricular branch of the vagus nerve innervates landmarks on the external ear. Work from the PI's laboratory has shown that electrical current applied to the external ear modulates physiological indexes of brain states implicated in the therapeutic effects of VNS. The broad objective of this project is to better understand physiological mechanisms modulated by auricular stimulation to support possible therapeutic effects in the form of motor learning.",[28],"Paresis",[30,31],"Learning","Neurological Rehabilitation","RECRUITING","2026-04-21",{"date":35,"type":36},"2026-04-24","ACTUAL",{"date":38,"type":36},"2024-06-03",{"date":40,"type":22},"2028-08-05",{"name":42,"class":43},"VA Office of Research and Development","FED",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":51,"targetDuration":4,"studyType":23,"phases":53,"briefSummary":55,"conditions":56,"keywords":62,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":44},"100420510","early-phase-1-chronic-transcutaneous-stimulation-to-promote-motor-function-and-recovery-in-individuals-with-paralysis-or-paresis-100420510","NCT04755699","Chronic Transcutaneous Stimulation to Promote Motor Function and Recovery in Individuals With Paralysis or Paresis","Healthy Volunteer Inclusion Criteria:\n\n* Individuals between 18 and 75 years of age\n* Individuals without physical disabilities or conditions\u002Fdiseases that may make them incapable of completing the physical study tasks or otherwise places them at a greater risk of harm\n* Individuals that are considered English Proficient due to the study requirements to follow verbal commands during sessions\n* Individuals that are able to comprehend the study goals and procedures, and are able to provide informed consent for participation\n* Individuals that are willing and able to visit the study center for study procedures, which may be up to 5 sessions a week for up to 1 year (at least 2 months) at up to 4 hours per session\n\nStroke and Spinal Cord Injury Participant Inclusion Criteria:\n\n* Individuals between 18 and 75 years of age\n* Individuals with a limited ability to use at least one hand due to a spinal cord injury or stroke\n* Individuals that are at least six months from their initial stroke or one year from their initial spinal cord injury\n* Individuals that are considered English Proficient due to the study requirements to follow verbal commands during testing sessions\n* Individuals that are able to comprehend the study goals and procedures, and are able to provide informed consent for participation\n* Individuals that are willing and able to visit the study center for study procedures, which may be up to 5 sessions a week for up to 1 year (at least 2 months) at up to 4 hours per session\n\nBrain or Nerve Injury Participant Inclusion Criteria:\n\n* Individuals between 18 and 75 years of age\n* Individuals with a limited ability or no ability to use at least one limb due to a brain or nerve injury such as a traumatic brain injury, brachial plexus injury, peripheral nerve damage, or Parkinson's Disease.\n* Individuals that are considered English Proficient due to the study requirements to follow verbal commands during testing sessions\n* Individuals that are able to comprehend the study goals and procedures, and are able to provide informed consent for participation\n* Individuals that are willing and able to visit the study center for study procedures, which may be up to 5 sessions a week for up to 1 year (at least 2 months) at up to 4 hours per session\n\nExclusion Criteria for All Study Participants:\n\n* Individuals participating in another study that may affect the conduct or results of this study\n* Individuals having or exhibiting any of the following, as specified by self-report:\n\n  * Stage III-IV pressure ulcers that adversely interfere with study involvement (i.e., pressure ulcer on the extremity of interest or prohibits extended bouts of sitting)\n  * History of epilepsy\n  * Chronically-implanted electronic medical device (e.g. deep brain stimulator, epidural stimulator, cardiac pacemaker, vagus nerve stimulator, or other)\n  * Abnormalities of the arms\u002Fhands, legs\u002Ffeet, or spinal column that would prevent electrical stimulation\n  * Ventilator dependence\n  * History of serious mood or thought disorder\n  * Uncontrolled autonomic dysreflexia\n  * Severe spasticity in extremities of interest that are uncontrolled by pharmacological methods or prevents electrical stimulation\n  * Botulinum toxin injections to the extremity of interest within 3 months\n  * Presence of active cancer at or near the areas of transcutaneous stimulation\n  * History of heart or kidney disease\n  * History of additional neurologic diseases (e.g., multiple strokes, multiple sclerosis, etc.)\n  * Presence of other serious infections, diseases, or disorders that could affect ability to participate in this study (e.g., uncontrolled hypertension, uncontrolled diabetes, rheumatic disease, peripheral neuropathy, HIV or AIDS, etc.)\n* Individuals with a substance abuse (alcoholism or other) problem\n* Pregnant women\n* Prisoners",{"count":52,"type":22},64,[54],"EARLY_PHASE1","This is an early feasibility trial to determine whether transcutaneous neuromuscular electrical stimulation, with or without transcutaneous spinal cord stimulation, using an investigational neurostimulation device improves functional arm\u002Fhand movements in individuals with paralysis or paresis due to a spinal cord injury or stroke and improves functional arm\u002Fhand or leg\u002Ffoot movements in individuals with paralysis or paresis due to other brain or nerve injuries.\n\nIn this study, eligible individuals that agree to participate will be asked to attend up to 5 study sessions a week for 1 year (depending on participant availability), with each session lasting up to 4 hours. At the first study session, participants will have their demographic information collected, vital signs assessed, and have measurements performed of their limbs and torso, as appropriate. They will also undergo clinical evaluations and tests to assess their current functional movement and sensation capabilities.\n\nDuring subsequent study sessions, participants will undergo many tasks designed to improve functional movements in paralyzed limbs. Specifically, participants will receive neuromuscular electrical stimulation to the limb(s) and\u002For electrical stimulation to the spinal cord to evoke specified movements. The stimulation parameters and locations on the spinal column and\u002For limb(s) that evoke specific movements will be noted. The movements will be assessed with visual inspection, electromyography, and\u002For sensors.\n\nThe clinical evaluations and tests to assess functional movement and sensation capabilities will be repeated throughout the study and at the last study session to assess for functional improvements compared to the first study session. Upon completion of these study sessions, the individual's participation in the study is considered complete.",[57,58,59,60,28,61],"Healthy Volunteers","Spinal Cord Injury","Stroke","Paralysis","Neurological Injury",[63,64,65],"Neuromuscular Stimulation","Spinal Cord Stimulation","Physical Medicine and Rehabilitation","2026-03-09",{"date":68,"type":36},"2026-03-11",{"date":70,"type":36},"2020-12-02",{"date":72,"type":22},"2028-06-30",{"name":74,"class":75},"Northwell Health","OTHER",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":82,"targetDuration":84,"studyType":85,"phases":4,"briefSummary":86,"conditions":87,"keywords":92,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":108},"100624720","investigation-of-preoperative-factors-influencing-the-outcome-of-motor-deficits-in-patients-undergoing-lumbar-microdiskectomy-100624720","NCT07413302","Investigation of Preoperative Factors Influencing the Outcome of Motor Deficits in Patients Undergoing Lumbar Microdiskectomy","Inclusion Criteria:\n\n* Patients suffering from lower limb paresis (motor deficit) caused by lumbar disk herniation undergoing a single-level microdiskectomy\n* Age (years) \\> 17\n\nExclusion Criteria:\n\n* Age (years) \\\u003C 18\n* Medical history of lumbar spine surgery\n* Absence of limb paresis\n* Motor deficit caused by other than disk herniation aetiologies\n* Reoperation within 6 months after microdiskectomy\n* Microdiskectomy at more than one level\n* Cauda equina syndrome\n* Peripheral neuropathy",{"count":83,"type":22},40,"6 Months","OBSERVATIONAL","Lumbar disc herniations may result in lower limb weakness. In such cases, there is a strong indication for surgical intervention through microdiscectomy. This clinical study aims to investigate preoperative factors that may influence the postoperative outcomes of patients undergoing this procedure.",[88,89,90,28,91],"Motor Deficits","Lumbar Discectomy","Muscle Weakness","Lumbar Disc Herniation",[93,94,95,96,97,98],"microdiscectomy","lumbar disc herniation","motor deficit","lower limb paresis","prognostic factors microdiscectomy","disc herniation outcome","2026-02-09",{"date":101,"type":36},"2026-02-17",{"date":103,"type":36},"2024-07-03",{"date":105,"type":22},"2026-12",{"name":107,"class":75},"Aristotle University Of Thessaloniki",3,{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":116,"targetDuration":4,"studyType":23,"phases":118,"briefSummary":119,"conditions":120,"keywords":124,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":44},"100615113","investigating-the-feasibility-of-combining-virtual-reality-and-bilateral-transcranial-direct-stimulation-to-improve-upper-limb-recovery-in-patients-with-stroke-100615113","NCT07288385","Investigating the Feasibility of Combining Virtual Reality and Bilateral Transcranial Direct Stimulation to Improve Upper Limb Recovery in Patients With Stroke","bi-tDCS+VR","Inclusion Criteria: 1- Adult participants (over 18 years of age) (Elsner et al., 2020).\n\n2- Patients with a unilateral cerebral infarction or haemorrhage who are at least three months post-stroke (Muller et al., 2021).\n\n3- Adequate mental status confirmed by an MMSE (Arabic version) should be ≥24 (Kim, 2021). ensuring the ability to comprehend and follow instructions.\n\n4- Modified Ashworth scale score \\\u003C 3 (Ögün et al., 2019). 5- Fugl-Meyer assessment (FMA) scores between 29 and 58, indicating moderate impairments (Woytowicz et al., 2017).\n\n\\-\n\nExclusion Criteria: - Visual impairment and severe hemisensory neglect or inattention (Stahl et al., 2019; Fluet1 et al., 2015).\n\n2- Individuals who have aphasia find it difficult to follow instructions (Fluet et al., 2015).\n\n3- Presence of any medical condition that contraindicates the use of non-invasive brain stimulation (Stahl et al., 2019; Learmonth et al., 2021).\n\n4- History of neurological disorders unrelated to stroke or participation in another study.\n\n\\-",{"count":117,"type":22},100,[25],"Following a stroke, the function of the distal upper limb, especially hand and finger movements, is often severely compromised, significantly restricting the ability to carry out daily activities. It is estimated that 55-75% of stroke survivors suffer from motor dysfunction, with upper limb impairments affecting up to 85% of them (Tang et al., 2024). Current rehabilitation approaches, while beneficial, often produce limited gains in hand function, particularly in patients with chronic stroke. Virtual reality (VR) training has emerged as a promising tool in neurorehabilitation, providing repetitive, task-specific, and engaging practice environments that can promote motor learning (Cameirão et al., 2012). tDCS has also shown potential to enhance motor recovery when combined with motor practice (Kang et al., 2016). To date, no studies have directly compared the effectiveness of Bi-tDCS with VR for improving upper limb function after stroke.",[121,122,123,59,28],"Brain Diseases","Central Nervous System Diseases","Nervous System Diseases",[125,126,127,128,129,130,131,132,133,59],"ischemic stroke","Hemorrhagic stroke","bi-tDCS","Hemiparesis","Neural activation","Primary motor cortex","NIBS","Non-invasive brain stimulation","Transcranial direct current stimulation","2025-12-29",{"date":136,"type":36},"2025-12-30",{"date":138,"type":36},"2025-12-28",{"date":140,"type":22},"2027-01-30",{"name":142,"class":75},"King Saud University"]