[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"parkinsons-disease-with-dementia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:parkinsons-disease-with-dementia":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,79],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100392395","oct-angiography-and-adaptive-optics-in-patients-with-memory-impairment-100392395",false,"NCT04389437","OCT-Angiography and Adaptive Optics in Patients With Memory Impairment","OCTAVO","Inclusion Criteria:\n\n* Patient presenting in memory consultation for memory complaint or person accompanying a patient in memory consultation for memory complaint\n\nExclusion Criteria:\n\n* pregnant or lactating women\n* history of known non-degenerative neurological pathology (tumor, stroke territorial, in particular multiple sclerosis)\n* history of retinal pathology\n* ametropia greater in absolute value than 3 diopters on the sphere, or\u002Fand 1.5 diopters on the cylinder.\n* history of taking ethambutol for more than 2 months\n* history of takingsynthetic antimalarial for more than 2 years\n* Mini Mental State Score (MMS) and \u002F or Montreal Cognitive Assessment (MoCA) \\\u003C10 for patients and 26 for accompanying persons\n* MRI contraindication (for patients only)",true,"ALL","18 Years",{"count":20,"type":21},450,"ESTIMATED","INTERVENTIONAL",[24],"NA","Studies suggest an association between retinal abnormalities and NCD (Neuro Cognitive Disorders) whether they are linked to proven or prodromal Alzheimer's disease (aMCI : amnestic mild cognitive impairment), or to other neurodegenerative diseases such as frontotemporal dementia or Lewy body diseases.\n\nThese retinal anomalies objectified by OCT-A (Optical coherence tomography angiography) and adaptive optics (AO) appear different depending on the pathologies and could therefore serve as markers in vivo of the pathophysiological processes underlying NCD.\n\nNo study to date has studied the retina and its vessels in NCD using adaptive optics. In this pilot study, we are proposing a combination of two new ophthalmological imaging techniques (OCT-A and AO), which allow rapid in vivo analysis in a completely non-invasive way of the morphology of small vessels as well as architecture of the retina to better specify the retinal anomalies associated with NCD. We will compare the parameters in OCT-A and AO between patients with NCD and controls without NCD (with memory complaint or without) and will seek to determine if there are different profiles according to the causes of NCD.",[27,28,29,30],"Amnesia","Alzheimer Disease","Lewy Body Disease","Parkinsons Disease With Dementia",[32,33],"OCT-A","adaptative optics","RECRUITING","2025-09-26",{"date":37,"type":38},"2025-09-29","ACTUAL",{"date":40,"type":38},"2020-06-26",{"date":42,"type":21},"2026-06",{"name":44,"class":45},"Fondation Ophtalmologique Adolphe de Rothschild","NETWORK",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":65,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":46},"100388301","enhancing-outcomes-in-cognitive-impairment-through-use-of-home-sleep-apnea-testing-100388301","NCT04335994","ENhancing Outcomes in Cognitive Impairment Through Use of Home Sleep ApNea Testing","ENhancing Outcomes in Cognitive Impairment Through Use of Home Sleep ApNea Testing: A Randomized Controlled Trial (ENCHANT Study)","ENCHANT","Inclusion Criteria:\n\n* Evidence of cognitive impairment by any one of: (i) Montreal Cognitive Assessment (MoCA) score of 13-28, or (ii) Mini Mental State Examination (MMSE) score of 18-30, or (iii) Toronto Cognitive Assessment (TorCA) score ≤281.\n* A diagnosis of: (i) Single-domain amnestic or multiple cognitive domain (with one feature being amnestic) Mild Cognitive Impairment due to Alzheimer's disease (AD); or (ii) Probable AD dementia; or (iii) Possible AD dementia due to limited concomitant cerebrovascular disease; or (iv) Probable Vascular dementia or Vascular Mild Cognitive Impairment, as per the 2011 American Heart Association Scientific Statement; or (v) Patients with a suspected neurodegenerative condition known to be associated with non-OSA sleep disorders (e.g. Parkinson's disease-related dementia and dementia with Lewy Bodies); and\u002For (vi) Mixed disease\n* Have the competency to provide informed consent, or the availability of a substitute decision maker\u002Fcaregiver who can provide consent (if needed).\n* The availability of a caregiver to assist in the completion of HSAT or iPSG, if needed.\n\nExclusion Criteria:\n\n* Prior diagnosis of OSA within the last 2 years\n* Patients already using CPAP or a dental appliance for previously diagnosed OSA.\n* A known contraindication for the use of the HSAT that will be used in this study: (a) Moderate to severe pulmonary disease or congestive heart failure that could compromise the validity of the HSAT results (in users of the ApneaLink); (b) Permanent pacemaker or history of sustained non-sinus cardiac arrhythmia (in users of the WatchPAT).\n* Any medical device that would interfere with the placement of the HSAT\n* Significant physical impairment or language barrier that would restrict the ability to use the HSAT or complete the study assessments.",{"count":56,"type":21},200,[24],"Obstructive sleep apnea (OSA), which causes abnormal pauses in breathing during sleep, is common in patients with vascular cognitive impairment (VCI) and Alzheimer's disease (AD), and exacerbates the cognitive deficits seen in these conditions. OSA is typically treated with continuous positive airway pressure (CPAP), which has been shown to improve cognition in VCI and slow cognitive decline in AD. Despite the need to identify OSA in patients with VCI\u002FAD, these patients often do not undergo testing for OSA. One major barrier is that in-laboratory polysomnography (iPSG), the current standard for diagnosing OSA, is inconvenient for patients with VCI\u002FAD who may be reliant on others for care or require familiar sleep environments. A convenient and cheaper alternative to iPSG is home sleep apnea testing (HSAT), which has been validated against iPSG to diagnose OSA and has proven feasible for use in VCI\u002FAD. Our primary objective is to determine whether the use of HSAT is superior to iPSG in terms of the proportion of patients who complete sleep testing by 6 months post-randomization. We will also investigate cost-effectiveness, patient satisfaction, proportion of patients treated with CPAP, changes in cognition, mood, sleep-related and functional outcomes between HSAT and iPSG at 6 months.",[60,28,61,62,30,63,64],"Obstructive Sleep Apnea","Vascular Dementia","Mild Cognitive Impairment","Dementia With Lewy Bodies","Mixed Dementia",[60,66,67,68],"Cognitive Impairment","Home Sleep Apnea Test","Screening","2025-05-14",{"date":71,"type":38},"2025-05-18",{"date":73,"type":38},"2019-09-23",{"date":75,"type":21},"2027-06",{"name":77,"class":78},"Sunnybrook Health Sciences Centre","OTHER",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":16,"sex":17,"minAge":87,"maxAge":4,"enrollmentInfo":88,"targetDuration":4,"studyType":22,"phases":90,"briefSummary":91,"conditions":92,"keywords":96,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":5},"100569032","neuropsychological-profiles-and-musical-engagement-in-parkinsons-and-alzheimers-disease-100569032","NCT06688968","Neuropsychological Profiles and Musical Engagement in Parkinson's and Alzheimer's Disease","Observational Pilot Study of Neuropsychological Profiles and Musical Engagement in Parkinson's and Alzheimer's Disease. What Are the Effects of Mnestic or Hedonic Impairment on Emotion, Reminiscence and Musical Enjoyment","MUSENGAGE","Inclusion Criteria:\n\nGeneral inclusion criteria:\n\n* 60 years and older\n* French-speaking and volunteering for the study\n* Living at home with a relative\n\nAlzheimer's disease inclusion criteria:\n\n* Biological diagnosis of probable Alzheimer's disease according to NINCDS-ADRDA criteria (McKhann et al., 1984)\n* MMSE greater than or equal to 20\n\nInclusion criteria Parkinson's disease :\n\n* Diagnosis of Idiopathic Parkinson's disease\n* MMSE greater than or equal to 20\n\nExclusion Criteria:\n\n* No known neurological pathologies (epilepsy and other non-degenerative CNS diseases) or psychiatric disorders (chronic psychosis and psychotic episodes)\n* Autistic disorders\n* History of stroke or head trauma\n* Unstable medical condition (cancer)\n* Subject unable to read and\u002For write\n* Hearing impairment without hearing aids\n* Refusal of consent after information\n* Persons unable to give consent, research carried out in emergency situations, etc.)\n* Non-affiliation with a social security scheme\n* Person deprived of liberty (by judicial or administrative decision, or forced hospitalization)\n* Person under legal protection (guardianship, curatorship, legal protection)\n* Person participating in another research project with an exclusion period still in progress","60 Years",{"count":89,"type":21},120,[24],"The goal of this Multicenter observational pilot study is to Compare the specifics of musical engagement (behaviors related to music in everyday life) in subjects aged over 60 with Alzheimer s disease, Parkinson s disease and control subjects.\n\nThe main questions it aims to answer are:\n\n1. The description of different profiles of musical engagement in early-stage AD, in PD and in healthy elderly subjects.\n2. The extent of executive, mnestic and hedonic dysfunctions will impact differently on emotional engagement, autobiographical evocation and sensitivity to musical reward, and will therefore enable distinct profiles to be drawn up.\n\nParticipants will have an intervention consisting of an interview with a neuropsychologist lasting approximately 2 hours, including :\n\n* A semi-structured interview to check the participants eligibility and gather demographic data.\n* Neuropsychological tests and questionnaires will then be administered.\n* A relative of the study participant will help complete questionnaires.",[93,94,95],"Alzheimer Disease, Early Onset","Parkinsons Disease with Dementia","Non Pharmacological Intervention",[97,93,94,98],"Non Pharmacological intervention","Music Therapy","2025-03-14",{"date":101,"type":38},"2025-03-19",{"date":103,"type":38},"2025-02-04",{"date":105,"type":21},"2025-12-01",{"name":107,"class":78},"University Hospital, Montpellier"]