[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"parp\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:parp":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":26,"conditions":27,"keywords":39,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":5},"100579047","phase-1-phase-iii-clinical-study-to-evaluate-vb15010-tablets-in-patients-with-advanced-solid-tumors-100579047",false,"NCT06819215","Phase I\u002FII Clinical Study to Evaluate VB15010 Tablets in Patients With Advanced Solid Tumors","Phase I\u002FII Clinical Study To Evaluate The Safety, Tolerability, Pharmacokinetics, Pharmacodynamics And Preliminary Efficacy of VB15010 Tablets In Patients With Advanced Solid Tumors","Inclusion Criteria:\n\n* Age ≥ 18 at the time of screening;\n* Histological or cytological confirmation of advanced malignancy ;\n* Progressive cancer at the time of study entry;\n* Adequate organ and marrow function as defined by the protocol;\n* Homologous recombination repair gene mutation.\n\nExclusion Criteria:\n\n* Major surgery within 4 weeks of the first dose of study treatment.\n* Spinal cord compression or brain metastases unless asymptomatic, treated and stable and not requiring continuous corticosteroids at a dose of \\>10mg prednisone\u002Fday or equivalent for at least 4 weeks prior to start of study treatment. Patients with leptomeningeal carcinomatosis are excluded.\n* Patients with myelodysplastic syndrome\u002Facute myeloid leukaemia or with features suggestive of myelodysplastic syndrome (MDS)\u002Facute myeloid leukaemia (AML).","ALL","18 Years","75 Years",{"count":20,"type":21},188,"ESTIMATED","INTERVENTIONAL",[24,25],"PHASE1","PHASE2","This research is designed to determine if experimental treatment with PARP1 inhibitor, VB15010 is safe, tolerable, and has anti-cancer activity in patients with advanced solid tumors.",[28,29,30,31,32,33,34,35,36,37,38],"Cancer","Neoplasms","Neoplasms, Breast","Tumor","PARP","Ovarian Neoplasms","Prostatic Cancer","Pancreatic Cancer","Breast Cancer","Biliary Cancer","Colorectal Cancer",[40,32,41,34,42,43,37],"VB15010","Ovarian cancer","Pancreatic cancer","Breast cancer","RECRUITING","2025-02-04",{"date":47,"type":48},"2025-02-11","ACTUAL",{"date":50,"type":48},"2024-10-30",{"date":52,"type":21},"2026-03-30",{"name":54,"class":55},"Zhejiang Yangli Pharmaceutical Technology Co., Ltd.","INDUSTRY"]