[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"parsonage-turner-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:parsonage-turner-syndrome":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":5},"100573006","neuromuscular-complications-of-mek-inhibitors-a-french-case-series-and-a-systematic-review-of-the-literature-100573006",false,"NCT06740656","Neuromuscular Complications of MEK Inhibitors: a French Case Series and a Systematic Review of the Literature","Inclusion Criteria:\n\n* Patients with neuromuscular complications of MEK inhibitors used alone or in combination\n* Age \\> 18 years\n\nExclusion Criteria:\n\n* Refusal of data collection","ALL","18 Years",{"count":18,"type":19},5,"ESTIMATED","OBSERVATIONAL","MEK inhibitors (trametinib, cobimetinib, selumetinib or binimetinib) have been used since 2016 to treat metastatic melanoma, by targeting the MAPK pathway Neuromuscular complications (neuropathy, myasthenia or myositis) have been reported in patients treated with MEK inhibitors.\n\nWith the growing use of these new oncology therapies, neurologists, oncologists and other clinicians are likely to be increasingly confronted with MEK inhibitor-induced neuropathy, myasthenia or myositis.\n\nYet, so far, these complications have only been documented in a few single case reports.\n\nOur aim was to characterize the neuromuscular complications associated with MEK inhibitors used either alone or in combination.",[23,24,25,26,27],"Myositis","Myasthaenia Gravis","Neuropathy","Guillain Barré Syndrome","Parsonage Turner Syndrome","NOT_YET_RECRUITING","2025-02-16",{"date":31,"type":32},"2025-02-18","ACTUAL",{"date":34,"type":19},"2025-03-01",{"date":36,"type":19},"2026-01-01",{"name":38,"class":39},"Central Hospital, Nancy, France","OTHER"]