[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"partial-epilepsy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:partial-epilepsy":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,69],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":4,"leadSponsor":40,"locationsCount":43},"100153739","surgery-as-a-treatment-for-medically-intractable-epilepsy-100153739",false,"NCT01273129","Surgery as a Treatment for Medically Intractable Epilepsy","* INCLUSION CRITERIA:\n\nTo be eligible for entry into the study, candidates must:\n\n1\\. Be 8 years of age or older with drug resistant epilepsy or tumor related epilepsy.\n\nEXCLUSION CRITERIA:\n\nCandidates will be excluded if they:\n\n1\\. Are unable or unwilling to give informed consent, or have a parent able to provide informed consent if a minor, to the research procedures.","ALL","8 Years","99 Years",{"count":19,"type":20},300,"ESTIMATED","OBSERVATIONAL","Background:\n\n\\- Drug resistant epilepsy is the term used to describe epilepsy that cannot be controlled by medication. Many people whose seizures do not respond to medication will respond to surgical treatment, relieving seizures completely or almost completely in one-half to two-thirds of patients who qualify for surgery. The tests and surgery performed as part of this treatment are not experimental, but researchers are interested in using the data collected as part of routine standard epilepsy care to better understand epilepsy and its treatment.\n\nObjectives:\n\n\\- To use surgery as a treatment for drug resistant epilepsy in children and adults.\n\nEligibility:\n\n\\- Children and adults at least 8 years of age who have simple or complex partial seizures (seizures that come from one area of the brain) that have not responded to medication, and who are willing to have brain surgery to treat their medically intractable epilepsy.\n\nDesign:\n\n* Participants will be screened with a medical history, physical examination, and neurological examination. Imaging studies, including magnetic resonance imaging and computer-assisted tomography (CT), may also be conducted as part of the screening. Participants who do not need surgery or whose epilepsy cannot be treated surgically will follow up with a primary care physician or neurologist and will not need to return to the National Institutes of Health for this study.\n* Prior to the surgery, participants will have the following procedures to provide information on the correct surgical approach.\n* Video electroencephalography monitoring to measure brain activity during normal activities within a 24-hour period. Three to four 15-minute breaks are allowed within this period.\n* Electrodes placed directly in the brain or on the surface of the brain to measure brain activities and determine the part of the brain that is responsible for the seizures (seizure focus).\n* Participants will have a surgical procedure at the site of their seizure focus. Brain lesions, abnormal blood vessels, tumors, infections, or other areas of brain abnormality will be either removed or treated in a way that will stop or help prevent the spread of seizures without affecting irreplaceable brain functions, such as the ability to speak, understand, move, feel, or see.\n* Participants will return for outpatient visits and brain imaging studies 2 months, 1 year, and 2 years after surgery.",[24,25,26],"Epilepsy","Epilepsy, Temporal Lobe","Partial Epilepsy",[28,29,24,30,31,32],"Neurosurgery","Childhood Epilepsy","Frontal Lobe Epilepsy","Temporal Lobe Epilepsy","Natural History","RECRUITING","2026-06-04",{"date":36,"type":37},"2026-06-05","ACTUAL",{"date":39,"type":37},"2011-03-21",{"name":41,"class":42},"National Institute of Neurological Disorders and Stroke (NINDS)","NIH",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":43},"100322511","investigating-epilepsy-screening-and-evaluation-100322511","NCT03478852","Investigating Epilepsy: Screening and Evaluation","* INCLUSION CRITERIA:\n* Age 8 years or older\n* Known or suspected diagnosis of epilepsy\n* Ability to give informed consent or have a legally authorized representative able to give consent (for adults without consent capacity) or parent\u002Fguardian able to provide informed consent (for a child)\n* If unable to give informed consent, ability to give verbal assent\n\nEXCLUSION CRITERIA:\n\n* Patients with unstable medical conditions that, in the opinion of the investigators, makes participation unsafe, or who, in the opinion of the investigators may be unable to comply with the protocol\n* Patients who are unable to travel to the NIH","110 Years",{"count":52,"type":20},1000,"Background:\n\nEpilepsy affects about 1 percent of the U.S. population. Most people with epilepsy respond well to medicine, but some do not. Researchers want people who have diagnosed or suspected epilepsy to participate in ongoing studies. They want to learn more about clinical care for epilepsy. They want fellows and residents to learn more about the care of people with epilepsy.\n\nObjectives:\n\nTo learn more about seizures and find ways to best treat people with drug-resistant epilepsy.\n\nEligibility:\n\nAdults and children ages 8 years and older with diagnosed or suspected epilepsy\n\nDesign:\n\nParticipants will be screened with:\n\nPhysical exam\n\nMedical history\n\nQuestionnaires\n\nParticipants will have many visits. They may be admitted to the hospital for several weeks. Their medication might be stopped or changed.\n\nParticipants will have many tests:\n\nBlood and urine tests\n\nEEG: Wires attached to the head with paste record brain waves. This may be videotaped.\n\nThinking and memory tests\n\nMRI: Participants lie on a table that slides in and out of a tube. They perform simple tasks in the tube.\n\nMEG: Participants lie on a table and place their head in a helmet to record brain waves.\n\nPET scan: Participants lie on a table that slides into a machine. A small amount of radioactive dye is injected into their arm with an IV. For the IV, a small tube is inserted into the arm with a needle.\n\nParticipants will stay enrolled in this study if they join other epilepsy-related studies. They may be contacted at intervals for follow-up. Their participation will end if they have not been seen clinically for their epilepsy for 3 years.",[55,24,25,26],"Seizures",[57,55,58,59,60],"Seizure Disorder","Antiepileptic Drug","Natural History Study","Screening Protocol","2026-06-02",{"date":63,"type":37},"2026-06-03",{"date":65,"type":37},"2018-03-28",{"date":67,"type":20},"2027-07-30",{"name":41,"class":42},{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":15,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":4,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":43},"100639370","phase-3-a-study-to-evaluate-the-safety-efficacy-and-pk-of-ono-2017-in-japanese-patients-with-pos-2-to-17-year-olds-100639370","NCT07594158","A Study to Evaluate the Safety, Efficacy, and PK of ONO-2017 in Japanese Patients With POS 2 to 17 Year Olds","A Multicenter, Open-label Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of ONO-2017 in Japanese Patients With Partial Onset Seizures Aged 2 to Under 18 Years.","Inclusion Criteria:\n\n* Japanese male or female patients aged 2 to under 18 years at the time of informed consent.\n* Patients diagnosed with epilepsy as having POS with uncontrolled seizures at least 6 months prior to informed consent, regardless of the presence or absence of secondarily generalized seizures.\n* Patients who have had POS at least once in 4 weeks before registration. Seizure information can be obtained from the participant's own retrospective patient epilepsy diary, etc.\n* Participants must have been treated with 1 to 3 ASMs at stable doses for at least 2 months before registration.\n\nExclusion Criteria:\n\n* Patients with a history of status epilepticus requiring hospitalization within 3 months before registration.\n* Patients with a history of non-epileptic psychogenic seizures.\n* Patients with simple partial seizures without motor symptoms or idiopathic generalized epilepsy.\n* Patients diagnosed with Lennox-Gastaut syndrome.\n* Patients with a history of serious drug-induced hypersensitivity reaction (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS, drug-induced hypersensitivity syndrome \\[DIHS\\]) or drug-induced rash requiring hospitalization.","2 Years","17 Years",{"count":79,"type":20},20,"INTERVENTIONAL",[82],"PHASE3","Primary objective: To evaluate the safety and tolerability of cenobamate in Japanese pediatric subjects 2-17 years of age with partial-onset (focal) seizures",[26],"2026-05-11",{"date":87,"type":37},"2026-05-18",{"date":89,"type":20},"2026-05-30",{"date":91,"type":20},"2029-12-31",{"name":93,"class":94},"Ono Pharmaceutical Co., Ltd.","INDUSTRY"]