[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"patellar-tendinopathy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:patellar-tendinopathy":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,47,75,107,130,156],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100572143","transcranial-direct-current-stimulation-on-functionality-and-pain-in-individuals-with-patellar-tendinopathy-100572143",false,"NCT06729437","Transcranial Direct Current Stimulation on Functionality and Pain in Individuals With Patellar Tendinopathy","Effectiveness of Transcranial Direct Current Stimulation on Functionality and Pain in Individuals With Patellar Tendinopathy: Randomized Clinical Trial","Inclusion Criteria:\n\n* Age between 18 and 50 years.\n* Diagnosis of patellar tendinopathy (VISA-P score of 80 or lower).\n* Pain lasting more than 3 months.\n\nExclusion Criteria:\n\n* Previous knee surgery.\n* Corticosteroid injection in the previous 6 weeks.\n* Systemic inflammatory, autoimmune, or rheumatic diseases.\n* Cognitive or behavioural issues that hinder comprehension and adherence to the intervention.\n* Any neurological disease.\n* Neoplastic disease.\n* Subjects presenting contraindications for tDCS (Thair et al., 2017), including: personal and family history of epilepsy, metallic implants in the head, implanted medication pump, pacemaker, recurrent headaches, skin conditions (psoriasis, eczema), or major head surgeries, pregnancy, heart diseases, and various medications (psychotropic or antihistamines).\n* Subjects must not have undergone pharmacological treatment or knee physical rehabilitation programs for a period of 1 year.",true,"ALL","18 Years","50 Years",{"count":21,"type":22},42,"ESTIMATED","INTERVENTIONAL",[25],"NA","The aim of the present study is to investigate the effectiveness of transcranial direct current stimulation (tDCS) prior to a therapeutic eccentric exercise program on parameters related to pain and functionality in individuals with patellar tendinopathy. For this purpose, participants will be randomly divided into two groups: i) experimental group, receiving tDCS prior to a therapeutic exercise program; and ii) control group, receiving sham tDCS and a therapeutic exercise program. The interventions will last for 8 weeks. Additionally, four assessments will be conducted (baseline, week 4, week 8 and week 12). The variables studied are related to pain, functionality, muscle activity and strength, proprioception, and quality of life.",[28],"Patellar Tendinopathy",[30,31,32,33],"patellar tendinopathy","transcranial direct current stimulation","therapeutic exercise","eccentric exercise","RECRUITING","2026-06-22",{"date":37,"type":38},"2026-06-25","ACTUAL",{"date":40,"type":38},"2024-07-01",{"date":42,"type":22},"2027-07-01",{"name":44,"class":45},"University of Valencia","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100635890","evaluation-of-platelet-rich-plasma-prp-treatment-in-tendinopathies-100635890","NCT07558564","Evaluation of Platelet-Rich Plasma (PRP) Treatment in Tendinopathies","Multicenter Real-World Evidence (RWE) Study: Evaluation of Platelet-Rich Plasma (PRP) Treatment in Tendinopathies","RWE-TDP-PRP","Inclusion Criteria:\n\n* Clinical and\u002For ultrasound diagnosis of chronic tendinopathy (duration \\>6 weeks)\n* Age \\>18 years\n* Provision of written informed consent\n* Willingness and ability to complete follow-up assessments for 12 months\n\nExclusion Criteria:\n\n* Surgical treatment of the affected tendon within the previous 6 months\n* Corticosteroid injection within the last month\n* Systemic inflammatory disease (e.g., rheumatoid arthritis)\n* Coagulopathies or ongoing anticoagulant therapy\n* Complete blood count showing a platelet concentration \\\u003C100 × 10⁹\u002FL (to exclude patients with potential thrombocytopenia)\n* Pregnancy or breastfeeding",{"count":56,"type":22},2000,"OBSERVATIONAL","This multicenter, prospective, observational study, based on real-world evidence (RWE), aims to evaluate the efficacy and safety of Platelet-Rich Plasma (PRP) treatment across four types of tendinopathies: patellar, Achilles, epicondylar, and plantar fasciosis. Data collection and analysis will be conducted using the BioSmartData® platform, including hematology analyzers for PRP characterization, clinical variables, treatment protocols, and longitudinal assessment of therapeutic response.",[28,60,61,62],"Achilles Tendinopathy (AT)","Epicondylitis, Lateral","Plantar Fasciitis, Chronic",[64],"tendinopathy, Real World Evidence (RWE), platelet-rich plasma, plantar fasciosis, epicondylitis, patellar tendon, Achilles tendon","2026-04-23",{"date":67,"type":38},"2026-04-30",{"date":69,"type":22},"2026-04",{"date":71,"type":22},"2028-03",{"name":73,"class":45},"ReSport Clinic",5,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":23,"phases":86,"briefSummary":87,"conditions":88,"keywords":89,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":46},"100628804","effects-of-hmb-and-rehabilitation-program-in-athletes-with-patellar-tendinopathy-100628804","NCT07466407","Effects of HMB and Rehabilitation Program in Athletes With Patellar Tendinopathy","Effects of Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation in Athletes With Patellar Tendinopathy","HMB_TEN","Inclusion Criteria:\n\n* Age between 18 and 49 years\n* Clinical diagnosis of patellar tendinopathy confirmed by a physician and physiotherapist\n* Competitive athlete in sports involving repetitive knee loading (e.g., basketball, volleyball, handball, athletics)\n* Minimum training frequency of three sessions per week\n* No knee surgery within the previous 12 months\n* No nutritional supplementation within the previous 3 months\n* No injection therapy (analgesics or platelet-rich plasma) within the previous 12 months\n* Non-smoker\n* Signed informed consent\n\nExclusion Criteria:\n\n* Any musculoskeletal injury other than patellar tendinopathy affecting performance\n* Systemic disease affecting musculoskeletal function\n* Inability to comply with the rehabilitation or supplementation protocol","49 Years",{"count":85,"type":22},30,[25],"This randomized, double-blind, placebo-controlled clinical trial evaluates the effects of oral beta-hydroxy-beta-methylbutyrate (HMB) supplementation combined with an eccentric exercise and extracorporeal shockwave rehabilitation program on pain, tendon morphology, and neuromuscular performance in athletes with patellar tendinopathy.\n\nThirty athletes with a confirmed diagnosis of patellar tendinopathy are randomized to receive either HMB supplementation (3 g\u002Fday) or placebo during an 8-week rehabilitation program. Participants are evaluated at baseline, week 4, and week 8.\n\nThe primary outcome is pain and functional limitation assessed using the Victorian Institute of Sport Assessment-Patella (VISA-P) questionnaire. Secondary outcomes include patellar tendon thickness measured by ultrasound imaging, countermovement jump (CMJ) performance, and neuromuscular performance variables derived from an incremental squat test using a linear position transducer.\n\nThe aim of the study is to determine whether HMB supplementation enhances clinical recovery and neuromuscular performance when combined with a standardized rehabilitation program compared with placebo.",[28],[90,91,92,93,94,95,96],"Tendinopathy","HMB","Rehabilitation","Knee pain","Sports injury","Nutritional supplement","Beta-hydroxy-beta-methylbutyrate","NOT_YET_RECRUITING","2026-03-09",{"date":100,"type":38},"2026-03-12",{"date":102,"type":22},"2026-03-01",{"date":104,"type":22},"2026-07-01",{"name":106,"class":45},"Universidad Complutense de Madrid",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":114,"targetDuration":4,"studyType":23,"phases":116,"briefSummary":117,"conditions":118,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":46},"100575612","early-implementation-of-plyometric-exercises-in-the-rehabilitation-of-individuals-suffering-from-lower-extremity-tendinopathies-100575612","NCT06774547","Early Implementation of Plyometric Exercises in the Rehabilitation of Individuals Suffering From Lower-Extremity Tendinopathies","The Efficacy of Early Implementation of Plyometric Exercises in the Rehabilitation of Individuals Suffering From Lower-Extremity Tendinopathies: A Randomised Clinical Trial","Inclusion Criteria:\n\n1. participants are required to have performed either recreational running or participated in sports that include running or jumping activities (e.g., football, basketball, handball, volleyball) at least once per week for at least three months immediately prior to pain onset\n2. have had symptoms for at least three months\n3. have pain\u002Fsoreness with palpation of the tendon\u002Ffascia\n4. mean pain during the past week of at least 2 on a 0 to 10 Numerical Rating Scale\n5. pain during a pain provocation test (patellar tendinopathy: five single-legged decline squats, Achilles tendinopathy and plantar fasciopathy: ten single-legged heel raises)\n\nExclusion Criteria:\n\n1. previous lower-extremity surgery\n2. other lower-extremity musculoskeletal conditions that have required treatment by a healthcare professional during the past three months\n3. pregnancy\n4. diabetes\n5. history of inflammatory systemic diseases (e.g., rheumatoid arthritis or spondylarthritis)\n6. having received an injection with corticosteroid within the past six months.",{"count":115,"type":22},120,[25],"This clinical trial aims to compare the effectiveness of an early plyometric exercise approach with traditional heavy, slow resistance training in treating tendinopathies of the Achilles tendon, patellar tendon, and plantar fascia. These conditions, commonly seen in general and rheumatology practices, cause pain, reduced function, and stiffness, often leading to prolonged recovery and incomplete return to full physical activity. The study hypothesizes that introducing plyometric exercises early in rehabilitation will improve jump function after 12 weeks and reduce re-injury rates within 52 weeks compared to traditional methods.\n\nThe study is a randomized clinical trial including 120 participants aged 18-50 with tendinopathy in one of the targeted areas. Participants must regularly engage in running or jumping sports, have symptoms for at least three months, and meet other inclusion criteria. Exclusion criteria include recent surgery or specific medical conditions. Both groups will perform exercises three times weekly for 12 weeks, tailored to their tendinopathy. The intervention group will add progressive plyometric exercises to the standard strength training performed by the control group. Plyometric training will consist of three levels, with patients self-assessing readiness to progress.\n\nThe primary outcome is the change in the plyometric quotient, a measure of functional ability, based on a jump test using a force platform at 0 and 12 weeks. Secondary outcomes include dynamic strength, jump height, patient-reported symptoms (via questionnaires), return to sport, training compliance, adverse events, pain thresholds, re-injury rates, and psychological readiness for sports. Assessments will occur at baseline, 12 weeks, and 52 weeks.",[119,28,120],"Achilles Tendinopathy","Plantar Fasciopathy","2026-03-02",{"date":123,"type":38},"2026-03-04",{"date":125,"type":38},"2025-09-18",{"date":127,"type":22},"2028-01",{"name":129,"class":45},"Aalborg University",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":134,"acronym":4,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":136,"enrollmentInfo":137,"targetDuration":4,"studyType":23,"phases":139,"briefSummary":140,"conditions":141,"keywords":143,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":46},"100570333","efficacy-of-the-extracorporeal-shock-wave-therapy-in-athletes-with-patellar-tendinopathy-100570333","NCT06705881","Efficacy of the Extracorporeal Shock Wave Therapy in Athletes With Patellar Tendinopathy","Inclusion Criteria:\n\n* Localized pain in the inferior pole of the patella during single-leg squatting due to load,\n* Pain or tenderness with palpation of the patellar tendon,\n* Complaints of pain in the patellar tendon due to training, competition or physical activity in the last 6 months,\n* Performing sports\u002Fphysical activities related to jumping and landing,\n* Professional and recreational athletes who perform at least 5 and above according to the Tegner Activity score,\n* VISA-P scale score \\\u003C80 out of 100.\n\nExclusion Criteria:\n\n* Presence of other knee pathologies,\n* Known presence of inflammatory joint diseases or familial hypercholesterolemia,\n* Daily use of drugs with presumed effects on the patellar tendon (e.g. fluoroquinolones) in the last 12 months,\n* Local injection therapy with corticosteroids in the last 12 months,\n* Previous patellar tendon rupture,\n* Any lower extremity surgery in the last 6 months.","65 Years",{"count":138,"type":22},32,[25],"The aim of this study is to investigate the effectiveness of extracorporeal shock wave therapy (ESWT) in addition to eccentric exercise on the clinical outcomes of PT in the treatment of athletes with patellar tendinopathy (PT). Participants will be randomly divided into two groups. The intervention group will receive focus ESWT 3 times a week in addition to 6 weeks of exercise. The control group will be given 6 weeks of exercise. Evaluations will be made at the 3rd and 6th weeks, and at the 3rd, 6th and 12th months. Patient evaluation will begin with obtaining sociodemographic information. Patients' pain level will be assessed using visual analog scale (VAS), tendon pain and function VISA-P, functional capacity; The patients will be assessed with the maximal vertical jump test (MDS), single leg jump distance test (SLHD), single leg squat test (STS) on the incline board, pain catastrophe with the pain catastrophe scale (PCS), kinesiophobia with the Tampa Kinesiophobia Scale (TKS), quality of life short form-12 (SF-12) and physical activity level with the Tegner Activity Scale (TAS).",[28,142],"Patellar Tendon Pain",[144,145,146,30],"exercise","Extracorporeal shock waves therapy","pain","2025-01-29",{"date":149,"type":38},"2025-01-31",{"date":151,"type":38},"2024-12-01",{"date":153,"type":22},"2025-09-01",{"name":155,"class":45},"Ahi Evran University Education and Research Hospital",{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":162,"eligibilityCriteria":163,"healthyVolunteers":16,"sex":17,"minAge":164,"maxAge":165,"enrollmentInfo":166,"targetDuration":4,"studyType":23,"phases":168,"briefSummary":169,"conditions":170,"keywords":171,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":46},"100470540","effect-of-collagenvitamin-c-in-jumpers-knee-a-rct-100470540","NCT05407194","Effect of Collagen\u002FVitamin C in Jumper's Knee; a RCT","Additional Effect of Collagen\u002FVitamin C in Exercise Treatment for Patellar Tendinopathy (Jumper's Knee); a Randomized Controlled Trial","Jumpfood","Inclusion Criteria:\n\n* Age 16 - 40 years old (the chosen age range will minimize chances of other conditions causing anterior knee pain such as osteoarthritis among patients above 40 years and osteochondrotic diseases like Sinding-Larsen-Johansson syndrome and Osgood-Schlatter disease among patients below the age of 16).\n* History of focal knee pain in patellar tendon or its patellar or tibial insertion in association with training and\u002For competition.\n* Current symptom duration of at least 12 weeks.\n* Sports participation at least once a week for at least one year.\n* Palpation tenderness to the corresponding painful area on the patellar tendon.\n* Focal patellar tendon pain during patellar tendon loading with a pain provocation test (single leg decline squat and\u002For single leg jump squat)\n* Victorian Institute of Sports Assessment (VISA-P) score \\\u003C 80 out of 100 points.\n* Willingness to take (non-vegetarian) nutritional supplements.\n\nExclusion Criteria:\n\n* Known presence of inflammatory joint diseases (e.g. spondylarthropathy, gout or rheumatoid arthritis) or familial hypercholesterolaemia.\n* Daily use of drugs with a putative effect on the patellar tendon in the preceding year (e.g. fluoroquinolones and statins)\n* Knee surgery without a full completion of the rehabilitation program in the history of the index knee\n* Previous patellar tendon rupture of the index knee\n* Local injection therapy with corticosteroids, other drugs, blood, platelet rich plasma or stem cells in the preceding 12 months\n* Acute knee injuries, including patellar tendon injuries with an acute onset\n* Inability to perform the PTLE program\n* Participation in other concomitant treatment programs\n* Signs or symptoms of other coexisting knee pathology on physical examination (such as patellofemoral pain syndrome, joint effusion and joint line tenderness) or additional diagnostics when found necessary by the sports physician (Chondral lesion of the patella or trochlea on MRI or prepatellar bursitis on US).\n* Already using collagen supplementation\n* Giving blood donation in a period of two months prior to each test day\n* Being pregnant or wish to become pregnant in the upcoming year\n* Abuse of hard drugs\n* An alcohol consumption \\>21 units\u002Fweek (men) or \\>14 units\u002Fweek (women)","16 Years","40 Years",{"count":167,"type":22},76,[25],"Patellar tendinopathy (PT) is a tendon overuse injury with high prevalence rates in elite and recreational athletes. PT sometimes results in a prolonged absence from sport participation, hampering individuals to achieve their desired performance levels and to benefit from the health related effects of sports participation. Many treatment options are used but management of PT remains challenging. Current treatment involves progressive education, load management and tendon loading exercises (PTLE). Recent studies have shown that nutrition can positively affect collagen synthesis in musculoskeletal tissues. A study showed that supplementing 15g of gelatine combined with 50mg of Vitamin C, 1 hour before loading exercises, resulted in an increase in whole body collagen synthesis and increased mechanics and collagen content of human engineered ligaments. However the effectiveness of oral supplementation of hydrolysed collagen in combination with vitamin C in athletes with PT has not been studied in a randomized controlled trial yet.\n\nObjective: The primary aim of this RCT is to evaluate whether the use of oral supplementation of hydrolysed collagen\u002Fvitamin C in addition to usual care (education, load management and PTLE) is superior to usual care and placebo on VISA-P score after 12, 24 and 52 weeks for athletes with PT. The secondary aim of this RCT is to evaluate whether the use of oral supplementation of hydrolysed collagen\u002Fvitamin C in addition to usual care (education, load management and PTLE) is superior to usual care and placebo on other clinical outcome parameters, functional tests and tendon structure after 12 and 24 weeks for athletes with PT.",[28],[172,173,174,175],"collagen","progressive tendon loading therapy","gelatin","RCT","2024-09-24",{"date":178,"type":38},"2024-09-26",{"date":180,"type":38},"2023-04-01",{"date":182,"type":22},"2026-05-01",{"name":184,"class":45},"Gelderse Vallei Hospital"]