[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"patent-foramen-ovale-pfo\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:patent-foramen-ovale-pfo":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,49,83,107],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100632914","pulmonary-embolism-and-right-to-left-shunts-100632914",false,"NCT07519876","Pulmonary Embolism and Right-to-Left Shunts","PEaRLS","Inclusion Criteria:\n\n1. Age ≥18\n2. Acute pulmonary embolism (any grade\u002Fsize)\n3. Patient or legally authorized representative is able to provide consent to participate in the study\n\nExclusion Criteria:\n\n1. Patients who, in the opinion of the study investigators, are unable to participate in required study activities\n2. Patients unable to undergo MRI imaging","ALL","18 Years",{"count":19,"type":20},256,"ESTIMATED","OBSERVATIONAL","Every fetus has a small hole in their heart, called a foramen ovale when they are developing in the womb. For most people this hole closes shortly after birth, but it doesn't close completely in 1 out of every 4 people. This is called a \"patent\" foramen ovale, or PFO. In people with a PFO it is possible for a blood clot in a vein to enter the heart, pass through the opening, and then go into an artery - this is referred to as a paradoxical embolism which passes through a \"Right-to-Left Shunt,\" or RLS. If this occurs, the blood clot can cause a stroke. The most common RLS (more than 90%) is a PFO. Much rarer causes include other types of holes in the heart (like an atrial septal defect, or ASD), or a vascular communication in the lungs (like a pulmonary arteriovenous malformation, or AVM).\n\nWe are investigating whether people with a PE are at higher risk of stroke if they happen to have an RLS compared to PE patients who don't have an RLS. This study will simply observe and compare the differences in stroke-related outcomes between those 2 groups.\n\nParticipation in the study last roughly 90-days and includes the following activities:\n\n* The study team will review your medical records to collect general information such as your age, sex, race\u002Fethnicity, height, weight, medications, medical history, and other medical information\n* Magnetic Resonance Imaging (MRI) of your brain will be done as soon as possible following your enrollment in the study. For more information on MRI scans, please see the \"MRI scan\" section below.\n* A Transcranial Doppler (TCD) with bubble study will be performed to determine if an opening is present in your heart or lungs. TCD is performed using ultrasound. A contrast called agitated saline will be injected into your vein for this test.\n* You will be asked to return for a follow-up visit 90 days after your pulmonary embolism. At this visit, the following will occur:\n\n  1. A second MRI of your brain will be performed.\n  2. You will complete a questionnaire to evaluate whether you may have had a stroke since being discharged from the hospital\n  3. You will meet with a member of the study team who will collect information about your health status.",[24,25,26,27,28,29],"Pulmonary Embolism (PE)","Right-to-Left Shunt","Stroke","Atrial Septal Defects","Patent Foramen Ovale (PFO)","Pulmonary Arteriovenous Malformation",[31,32,25,33,34,26,27,35],"Pulmonary Embolism","PE","PFO","ASD","Patent Foramen Ovale","RECRUITING","2026-04-02",{"date":39,"type":40},"2026-04-09","ACTUAL",{"date":42,"type":40},"2026-01-30",{"date":44,"type":20},"2028-01",{"name":46,"class":47},"Tufts Medical Center","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":57,"enrollmentInfo":58,"targetDuration":60,"studyType":21,"phases":4,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":82},"100629782","senior-stroke-prevention-in-the-elderly-by-patent-foramen-ovale-closure-vs-anticoagulation-100629782","NCT07479147","SENIOR: Stroke Prevention in the Elderly by Patent Foramen Ovale closuRe vs Anticoagulation","Patent Foramen Ovale-Related Stroke Management and Outcome: Age-dependent Risk Prediction and Atrial Cardiopathy Study (SENIOR Study)","SENIOR","Inclusion Criteria:\n\n* Patient or his\u002Fher legal representative signs a written informed consent\n* Participants who have diagnosed as PFO related stroke\n* For patient aged 18-59: patient with high risk PFO feature or RoPE score ≥ 7\n* For patient aged 60-90: patient with high risk PFO feature or RoPE score ≥ 4, must include cortical infarct\n\nExclusion Criteria:\n\n* Follow-up less than 6 months\n* Extracardiac right-to-left shunt\n* Known stroke mechanism was diagnosed","90 Years",{"count":59,"type":20},400,"3 Years","Patent foramen ovale (PFO) is an important mechanism of embolic stroke of undetermined source (ESUS). Current guidelines recommend PFO closure for high-risk PFO in patients younger than 60 years, and a recent retrospective cohort study from Taichung Veterans General Hospital has shown that closure is effective and safe in older adults; however, the optimal treatment strategy for those \\>60 years and direct head-to-head comparisons of PFO closure versus direct oral anticoagulants (DOACs) remain insufficient. Robust evidence from a multicenter study combining prospective and retrospective cohorts is warranted.\n\nThe SENIOR study is a multicenter observational cohort registry with a combined retrospective and prospective design. The prospective period is from September 15, 2025 to December 31, 2031, and the retrospective period covers January 1, 2013 to September 1, 2025; target sample sizes are 400 (prospective) and 500 (retrospective). We will enroll adults with ESUS and PFO; the prospective arm will focus on patients aged \\>60 years with PFO related stroke. Treatments will be assigned as PFO closure, standard-dose DOAC, or antiplatelet agents (if DOAC intolerance) by local principal investigator. The primary outcome is recurrent ischemic stroke or transient ischemic attack. Secondary outcomes include 6-month functional outcome, all stroke, and serial comparison of atrial cardiopathy changes. Safety endpoints include peri-procedural adverse events (including newly-onset atrial fibrillation), hemorrhagic stroke, and all caused mortality. Clinical presentation, imaging, cardiac testing, biomarker, and genetic data will be collected for stratified and multivariable analyses.",[63,64,28,65],"Ischemic Stroke","Embolic Stroke of Undetermined Source","Elderly",[67,68,69,70,71,72],"patent foramen ovale","patent foramen ovale closure","embolic stroke of undetermined source","elderly","multi-center","anticoagulation","2026-03-18",{"date":75,"type":40},"2026-03-23",{"date":77,"type":40},"2025-12-16",{"date":79,"type":20},"2031-12-31",{"name":81,"class":47},"Taichung Veterans General Hospital",3,{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":91,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":93,"conditions":94,"keywords":95,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":48},"100625266","non-invasive-detection-of-right-to-left-cardiac-shunts-100625266","NCT07420400","Non-Invasive Detection of Right-to-Left Cardiac Shunts","Novel Approach for the Detection of Right-to-Left Cardiac Shunts","HEADBAND","Undergoing clinically indicated TEE with bubble study for the detection of a PFO",{"count":92,"type":20},75,"This study will test the sensitivity of a novel, battery-powered, non-invasive ultrasound device to detect a right-to-left shunt",[28],[33,96,97],"Cryptogenic stroke","shunt","2026-02-12",{"date":100,"type":40},"2026-02-19",{"date":102,"type":40},"2026-01-07",{"date":104,"type":20},"2027-03-01",{"name":106,"class":47},"Scripps Health",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":114,"enrollmentInfo":115,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":117,"conditions":118,"keywords":121,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":48},"100542777","cerebral-microembolization-associated-with-pfo-closure-100542777","NCT06347276","Cerebral Microembolization Associated With PFO Closure","De Novo Cerebral Microembolization Associated With Patent Foramen Ovale Closure","PFO group\n\nInclusion Criteria:\n\n1\\) age 18 to 65 years; 2) documented PFO with medium-to-large shunts (≥ 20 microbubbles by c-TCD at rest or during the Valsalva maneuver); 3) history of embolic stroke (based on brain magnetic resonance imaging within 24 hours after symptom onset) or TIA within 6 months without other identifiable causes; 4) history of migraine for more than one year without other identifiable causes; 5) asymptomatic group: incidental finding of PFO in asymptomatic individuals, and presence of high-risk activities and\u002For anatomical features related to PFO (high-risk activities were defined as those in which the Valsalva maneuver was performed frequently or those that increased the risk of venous gas formation; and high-risk anatomical features included atrial septal aneurysm and\u002For curtain pattern on c-TCD).\n\nExclusion Criteria:\n\n1\\) presence of any known vascular risk factor, including hypertension, hypercholesterolemia, diabetes mellitus, atrial fibrillation, smoking and obesity; 2) history of embolic stroke or TIA within the past one month; 3) history of deep vein thrombosis or pulmonary embolism; 4) presence of coronary artery disease and carotid artery lesions; 5) presence of coexistent cardiovascular structural malformations or diseases; 6) allergy to contrast medium; 7) refusal to participate.\n\nASD group\n\nInclusion Criteria:\n\n1\\) age 18 to 65 years; 2) secundum ASD size 10 to 20 mm, with sufficient surrounding rims, except the aortic rim; 3) right heart catheterization: resting SPAP \\\u003C 50 mm Hg, Qp\u002FQs ≥ 1.5 and PVR \\\u003C 5 WU.\n\nExclusion Criteria:\n\n1\\) presence of any known vascular risk factor, including hypertension, hypercholesterolemia, diabetes mellitus, atrial fibrillation, smoking and obesity; 2) associated with other cardiac abnormalities or diseases; 3) resting SPAP ≥50 mm Hg and resting PVR ≥5 Wood units;4) primum or sinus venosus type ASD; 5) presence of intracardiac thrombi, permanent contraindications to platelet therapy, and allergic reaction to nickel.","65 Years",{"count":116,"type":20},800,"This study aims to investigate (1) the de novo cerebral microembolization in patients who undergo transcatheter closure of PFO or ASD, and (2) evaluate the relationship between de novo cerebral microembolization and in situ thrombus within PFO.",[119,120,28],"Thrombosis Cardiac","Atrial Septal Defect",[122],"Patent foramen ovale; stroke; migraine; thrombus","2025-07-20",{"date":125,"type":40},"2025-07-24",{"date":127,"type":40},"2024-01-01",{"date":129,"type":20},"2026-12-31",{"name":131,"class":132},"China National Center for Cardiovascular Diseases","OTHER_GOV"]