[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pathogenesis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pathogenesis":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,50,77],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":30,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":5},"100504659","mechanisms-of-disease-progression-in-aortic-stenosis---the-modas-study-100504659",false,"NCT05851209","Mechanisms Of Disease Progression in Aortic Stenosis - the MODAS Study","Evaluation of Immunologic and Image Morphologic Parameters to Predict Disease Progression in Patients With Moderate Aortic Valve Stenosis","Inclusion Criteria:\n\n* The patient has an acquired (tricuspid) moderate aortic valve stenosis, which is the reason for regular outpatient cardiological care.\n* The subject has been informed verbally and in writing about the study and has given written consent to participate in this study.\n* Age \\> 18 years\n\nExclusion Criteria:\n\n* The subject has contraindications for the performance of a magnetic resonance imaging or computed tomography (e.g., severe arrhythmias , contrast agent intolerance, a pacemaker, or severe renal insufficiency or severe renal insufficiency or claustrophobia).\n* Presence of only mild or already high-grade acquired tricuspid Aortic valve stenosis\n* Patient with bicuspid aortic valve\n* Inability to follow the instructions of study personnel\n* Lack of written informed consent","ALL","18 Years",{"count":19,"type":20},938,"ESTIMATED","OBSERVATIONAL","Biomarkers and mechanisms in the progression of aortic valve stenosis are sometimes not sufficiently understood. The current project will take into account image morphological and immunological aspects that predict the development of hemodynamically relevant aortic valve stenosis in order to identify high-risk patients and to develop further therapeutic options.",[24,25,26,27,28,29],"Aortic Stenosis","Imaging","Pathogenesis","Disease Progression","Aortic Valve Calcification","Genetics",[31,32,33,34,35,36,37],"severe aortic stenosis","disease progression","pathogenesis of degenerative aortic stenosis","early detection","Cardiovascular magnet resonance","Transthoracal echocardiography","computertomography","RECRUITING","2026-06-26",{"date":41,"type":42},"2026-06-30","ACTUAL",{"date":44,"type":42},"2023-07-01",{"date":46,"type":20},"2031-07",{"name":48,"class":49},"Heinrich-Heine University, Duesseldorf","OTHER",{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":4,"leadSponsor":73,"locationsCount":76},"100165376","the-pathogenesis-and-natural-history-of-sjogrens-disease-100165376","NCT01425892","The Pathogenesis and Natural History of Sjogren's Disease","* INCLUSION CRITERIA:\n\n  1. Ability to sign informed consent form\n  2. Fulfilling one the definitions below:\n\n     1. Sjogren s defined by European-American (EA) classification criteria for primary or secondary Sjogren s Disease (SjD group)\n     2. Excluded from the EA criteria because of a comorbid condition but otherwise fulfilling the European-American classification criteria (EA excluded SjD group)\n     3. Incomplete SjD\n\n     i. at least 2 of the EA criteria with a common manifestation of SjD not included in these criteria (e.g., fatigue, vasculitis, arthritis, etc) or\n\n     ii. 2 or more common manifestations of SjD which are not included in the EA criteria (e.g.,: fatigue, vasculitis, arthritis, autonomic dysfunction, etc ) and are not explained by other conditions\n\n     EXCLUSION CRITERIA:\n\n  \u003C!-- -->\n\n  1. Age \\\u003C16 years\n  2. inability or unwillingness to comply with follow up requirements\n  3. Any medical or psychological\u002Fpsychiatric condition or treatment that, in the opinion of the Principal Investigator, would exclude the subjects from the research studies (e.g., alternative explanation for subjects signs and symptoms)\n  4. NIH employees who report directly to the principal investigator or who are a co-worker or relative of the principal investigator.","16 Years","100 Years",{"count":59,"type":20},300,"Background:\n\n-Sjogren s Disease (formerly: Sjogrens Syndrome, Sj(SqrRoot)(Delta)gren s syndrome) is a disease that affects about 1-4 million Americans. It is more common in women. It mainly affects the glands that produce saliva and tears, leading to dry eyes and dry mouth. The cause of Sjogren s Disease is unknown, but inflammation plays an important role. The purpose of this study is to learn more about Sjogren s Disease.\n\nObjectives:\n\n-To better understand how Sjogren s Disease begins and how it affects patients so that we can develop better ways to treat them.\n\nEligibility:\n\n* Participants must be 16 years of age or older.\n* They must have a diagnosis of Sjogren s Disease or have at least two symptoms of Sjogren s Disease.\n\nDesign:\n\n* People taking part in the study will come to the NIH Clinical Center for at least three visits.\n* During these visits, participants will have a medical history and physical exam. They will have oral and dental assessments, and saliva collection. Lab tests (blood and urine) and dry eye exams will be done. Participants will answer questionnaires and have salivary scintigraphy (adults only unless required for diagnosis).\n* Other optional tests may also be done. Participants may have to come in for additional visits if they have these optional tests or if their disease changes.\n* The only treatment provided as part of this study is for medical emergencies or complications that occur while you are at NIH for evaluation.",[62,63,26],"Sjogren's Syndrome","Salivary Gland",[62,63,26,65,66,67],"Natural History","Sj(SqrRoot)(Delta)gren s syndrome","Sjogrens Syndrome","2026-06-17",{"date":70,"type":42},"2026-06-18",{"date":72,"type":42},"2012-01-18",{"name":74,"class":75},"National Institute of Dental and Craniofacial Research (NIDCR)","NIH",1,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":84,"sex":16,"minAge":85,"maxAge":4,"enrollmentInfo":86,"targetDuration":88,"studyType":21,"phases":4,"briefSummary":89,"conditions":90,"keywords":95,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":76},"100617141","elderly-patients-undergoing-surgery-during-perioperative-period-100617141","NCT07314762","Elderly Patients Undergoing Surgery During Perioperative Period","Elderly Patients Undergoing Surgery During Perioperative Period: a Prospective Cohort Study","Inclusion Criteria:\n\n1\\) Surgical patients aged 65 or above or non-surgical subjects aged 65 or above. 2) Agree to participate in this study and sign the informed consent form.\n\nExclusion Criteria:\n\n1）Refused to participate in the study.",true,"65 Years",{"count":87,"type":20},1200,"1 Year","The elderly patients have poorer overall conditions and have lower tolerance to trauma, anesthesia, and surgery. Therefore, the incidence of postoperative complications is relatively higher. In non-cardiac surgeries, approximately 20% of elderly patients experience postoperative complications, and the incidence of postoperative delirium (POD) is 23.8%. This may lead to prolonged hospital stays, increased hospital costs, and affect prognosis and even mortality. The investigators plan to conduct a prospective cohort study by systematically collecting biological samples and clinical information of elderly patients during the perioperative period to explore the possible risk factors and pathogenesis of postoperative delirium and postoperative complications in elderly surgical patients, and to construct a risk prediction model for postoperative complications.",[91,92,93,94,26],"Postoperative Complications","Elderly","Postoperative Delirium (POD)","Risk Prediction Model",[96,97,98],"postoperative delirium","elderly","Cohort study","2026-03-26",{"date":101,"type":42},"2026-04-01",{"date":103,"type":42},"2023-12-30",{"date":105,"type":20},"2030-12-30",{"name":107,"class":49},"Second Affiliated Hospital of Wenzhou Medical University"]