[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pathological-fracture\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pathological-fracture":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,40,70],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100455164","device-global-registry-for-the-illuminoss-bone-stabilization-system-100455164",false,"NCT05206981","Device Global Registry for the IlluminOss Bone Stabilization System","IlluminOss Device Global Registry - A Prospective, Post-Market, Multi-Center Evaluation of the Clinical Outcomes of the IlluminOss Device","Inclusion Criteria:\n\n1. Patient has been deemed a candidate for the IlluminOss device\n2. Patient is male or non-pregnant female\n3. Patient is willing and able to comply with the postoperative scheduled clinical and radiographic evaluations\n4. Patient is willing and able to give informed consent if required\n5. Traumatic patient is over the age of 50\n6. IlluminOss procedure is the initial procedure to treat the traumatic injury\n\nExclusion Criteria:\n\nUnited States (U.S.)\n\nThis product is contraindicated in U.S. patients who have:\n\n1. an active or incompletely treated infection that could involve the site where the device will be implanted;\n2. are allergic to any of the implant materials or to dental glue;\n3. have an intramedullary canal measuring smaller than the diameter of the delivery sheath provided at the site of the fracture;\n4. distant foci of infections which may spread to the implant site, have open fractures with severe contamination;\n5. or in patients for whom delivery sheath is unable to cross fracture site after proper fracture reduction and realignment.\n\nEuropean Union (EU)\n\nThis product is contraindicated in EU patients who have:\n\nFor all Bones:\n\n1. Patients who are considered skeletally immature.\n2. Presence of active or incompletely treated infections that could involve the site where the device will be implanted.\n3. Patients allergic to any of the implant materials, or to dental glue.\n4. Patients whose intramedullary canal at site of fracture measures smaller than the diameter of the sheath provided.\n5. Uncooperative patient or patient with neurologic disorder, incapable of following directions.\n6. Distant foci of infections which may spread to the implant site.\n7. Vascular insufficiency.\n8. Open fractures with severe contamination.\n9. Extremely comminuted fractures where insufficient holding power of the balloon on the intramedullary canal is probable.\n10. Delivery sheath is unable to cross fracture site after proper fracture reduction and realignment.\n\n    For acute Humerus fractures:\n11. Patients who are under the age of Fifty (50)\n\n    For all bones excluding pathologic Humerus:\n12. Metabolic disorders which may impair bone formation.\n13. Osteomalacia.\n14. Vascular insufficiency, muscular atrophy, or neuro-muscular disease.","ALL","50 Years",{"count":19,"type":20},300,"ESTIMATED","1 Year","OBSERVATIONAL","This is a multi-center, observational patient registry. The primary objective of the study is to collect safety and performance data on the IlluminOss Device when used to provide stabilization and alignment for the treatment of traumatic or impending and pathologic fractures.",[25,26],"Traumatic Fracture","Pathological Fracture","RECRUITING","2026-04-14",{"date":30,"type":31},"2026-04-17","ACTUAL",{"date":33,"type":31},"2021-06-11",{"date":35,"type":20},"2026-12",{"name":37,"class":38},"IlluminOss Medical, Inc.","INDUSTRY",16,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":51,"conditions":52,"keywords":55,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":69},"100567608","prospective-evaluation-of-therapeutic-combination-in-treating-vertebral-compression-fractures-100567608","NCT06670404","Prospective Evaluation of Therapeutic Combination in Treating Vertebral Compression Fractures","PROTECT - Prospective Evaluation of Therapeutic Combination in Treating Vertebral Compression Fractures","PROTECT","Inclusion Criteria:\n\n* Patients \\>18 years.\n* Patients requiring vertebroplasty for the fixation of symptomatic pathological fractures of the thoracic or lumbar vertebral body resulting from osteoporosis or tumor.\n* Symptomatic vertebral compression fracture(s) confirmed by MRI with bone marrow oedema on T2\u002FSTIR sequences.\n* Diagnosis of osteoporosis (clinically and confirmed on DXA with quantifiable BMD) or pathological fracture due to tumor\n* Patients with 1 or more vertebral compression fractures of the thoracic or lumbar spine Note: Patients with a current vertebral compression fracture who also have a previous history of vertebral compression fractures of the thoracic or lumbar spine may be included.\n\nStudy Specific Inclusion Criterion • Signed informed consent\n\nExclusion Criteria:\n\n* Infection\n* Vertebral body collapse to less than 1\u002F3 (33%) of original height\n* Vertebral plana (\\>90% vertebral body collapse)\n* Spinal stenosis (retro pulsed fragments).\n* Unstable spine warranting surgical stabilization\n* Prophylactic treatment of any vertebrae with vertebroplasty\n* Irreversible life threating bleeding disorders\n* End stage kidney disease\n* Drug dependence (IVDU)\n* Pregnancy\n\nStudy Specific Exclusion Criterion:\n\n• Unable or unwilling to follow the standard of care prescribed follow-up visits","18 Years",{"count":50,"type":20},130,"The purpose of this study is to collect clinical and radiographic outcomes in patients undergoing vertebroplasty procedures for the treatment of osteoporotic or pathological fractures of the vertebral body to understand the role of sagittal balance in patient outcomes. To support this objective, the sagittal balance measurement of sagittal vertical axis (SVA), NRS back pain, Quebec Back Pain Disability Scale (Quebec) score, and complications will be collected. The secondary purpose of the study is to review the role of sagittal balance and adjacent facet joint arthropathy treatment in patients with vertebral body fractures due to osteoporosis or tumor.",[53,26,54],"Vertebral Compression Fractures","Facet Joint Arthropathy",[56,57,58],"vertebroplasty","CONFIDENCE High Viscosity Spinal Cement","observational post-market study","2025-02-13",{"date":61,"type":31},"2025-02-17",{"date":63,"type":31},"2024-11-06",{"date":65,"type":20},"2026-12-31",{"name":67,"class":68},"Prof Nicolas Theumann","OTHER",1,{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":16,"minAge":77,"maxAge":4,"enrollmentInfo":78,"targetDuration":4,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":88,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":4},"100513745","short-versus-long-intramedullary-nails-in-the-treatment-of-proximal-femur-metastasis-100513745","NCT05969470","Short Versus Long Intramedullary Nails in the Treatment of Proximal Femur Metastasis.","Compare the Efficacy of Long-nailed and Short-nailed Fixation for Proximal Femur Metastasis - a Non-inferior Randomized Controlled Trial","Inclusion Criteria:\n\n* Femur (impending) pathological fracture that is suitable for intramedullary nail fixation as determined by the physician\n* Patient is willing to participate in this clinical trial and cooperate with follow-up\n\nExclusion Criteria:\n\n* The patient has a more appropriate treatment alternative to single intramedullary nail fixation as determined by the multidisciplinary decision, such as,\n\n  * The metastatic lesions involved the femur head\n  * The metastatic lesions involved the pelvis\n  * The metastatic lesions compromised the greater or lesser trochanter to a certain extent that arthroplasty was indicated\n  * The metastatic lesions involved\u002Foccurred more distal than the intertrochanteric line\n* There are justified, clinically significant rationales that either long or short intramedullary nails be a more appropriate treatment during pre-operative assessment\n* The patient has imaging-confirmed distant femoral metastases before treatment\n* Patient has renal cell carcinoma or sarcoma\n* Patient is unable to cooperate with follow-up or to understand the trial protocol\n* Patient is unable to communicate in Chinese","20 Years",{"count":79,"type":20},50,"INTERVENTIONAL",[82],"NA","The goal of this interventional randomized controlled trial is to compare the clinical outcomes in treating extremities pathological fractures (fractures of limbs caused by metastatic tumors) or impending pathological fractures with short or long intramedullary nails. The main questions it aims to answer are:\n\n1. What is the rate of developing new distant metastasis of the operated extremities?\n2. Does treating extremities (impending) pathological fractures with long intramedullary nails have lower or similar reoperation rate than the short nails?\n3. Are there any differences when comparing the surgical-related complication, functional outcomes and life quality assessment between treating extremities (impending) pathological fractures with long or short intramedullary nails.\n\nParticipants who meet surgical indication will be randomized into either the long or short intramedullary nail group after informed consent. The patient will receive bone fixation with the corresponding prosthesis.",[85,26,86,87],"Bone Metastases","Pathological Fracture, Left Femur","Pathological Fracture, Right Femur",[89,90,85,91],"Long Intramedullary Nails","Short Intramedullary Nails","Pathological Fracture of Femur","NOT_YET_RECRUITING","2023-08-15",{"date":95,"type":31},"2023-08-18",{"date":97,"type":20},"2023-08-31",{"date":99,"type":20},"2027-06",{"name":101,"class":68},"National Taiwan University Hospital"]