[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"patient-controlled-analgesia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:patient-controlled-analgesia":97},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,51,76,114,132,163,191],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100611543","external-oblique-intercostal-block-eoicb-for-laparoscopic-cholecystectomy-100611543",false,"NCT07241949","External Oblique Intercostal Block (EOICB) for Laparoscopic Cholecystectomy","Paravertebral Block or External Oblique Intercostal Block? A Comparative Analysis of Pain and Opioid Consumption After Laparoscopic Cholecystectomy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* Scheduled for elective laparoscopic cholecystectomy under general anesthesia\n* ASA physical status I-III\n* Able to understand the study procedure and provide informed consent\n\nExclusion Criteria:\n\nPatient refusal or inability to provide informed consent\n\nAllergy or contraindication to local anesthetics, tramadol, or study medications\n\nCoagulopathy or current anticoagulant therapy\n\nLocal infection at the planned block injection site\n\nSevere hepatic or renal impairment\n\nChronic opioid use or opioid dependence\n\nNeurological or psychiatric disorders affecting pain perception or communication\n\nPregnancy or breastfeeding\n\nBody mass index (BMI) \\> 35 kg\u002Fm²\n\nConversion to open cholecystectomy during surgery","ALL","18 Years","65 Years",{"count":20,"type":21},147,"ESTIMATED","INTERVENTIONAL",[24],"NA","This single-center, prospective, randomized controlled trial aims to compare the effects of paravertebral block (PVB), external oblique intercostal (EOI) block, and intravenous patient-controlled analgesia (PCA) with tramadol on postoperative pain and opioid consumption in patients undergoing elective laparoscopic cholecystectomy. The primary endpoint is total tramadol consumption within 24 hours postoperatively. Secondary outcomes include pain scores, additional analgesic use, incidence of nausea\u002Fvomiting, mobilization time, and length of hospital stay.",[27,28,29,30,31],"Postoperative Pain","Laparoscopic Cholecystectomy","Paravertebral Block","External Oblique Intercostal Plane Block","Patient Controlled Analgesia",[33,34,35,36,37],"Cholecystectomy","Pain","Analgesia","Tramadol","Nerve Block","RECRUITING","2026-06-30",{"date":41,"type":42},"2026-07-02","ACTUAL",{"date":44,"type":42},"2025-12-01",{"date":46,"type":21},"2026-12-05",{"name":48,"class":49},"Cukurova University","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":50},"100620761","comparison-of-cumulative-opioid-consumption-between-variable-rate-feedback-infusion-and-fixed-rate-basal-infusion-modes-of-intravenous-pca-following-mixed-surgery-100620761","NCT07361822","Comparison of Cumulative Opioid Consumption Between Variable-Rate Feedback Infusion and Fixed-Rate Basal Infusion Modes of Intravenous PCA Following Mixed Surgery","Prospective Randomized Controlled Study of Individualized PCA Model Based on Multi-dimensional Strategies (Cumulative Opioid Consumption Between Variable-Rate Feedback Infusion and Fixed-Rate Basal Infusion Modes)","Inclusion Criteria:\n\n* aged between 18 to 65 years;\n* American Society of Anesthesiologists physical status Ⅰ - Ⅲ;\n* Patients scheduled for elective mixed surgery were enrolled. Mixed surgeries included thoracic, abdominal, spinal, orthopaedic, and cranial procedures performed using either minimally invasive or open approaches.\n\nExclusion Criteria:\n\n* Allergy to PCA medications;\n* Presence of chronic pain syndromes;\n* Presence of psychiatric disorders, or severe cardiovascular, cerebrovascular, renal, or hepatic dysfunction.",{"count":59,"type":21},1170,[24],"Perioperative pain management affects patient recovery. However, the rate of moderate to severe postoperative pain is as high as 73.8%, which hinders recovery and increases the risk of complications. Although opioids are the first-line analgesics, excessive use leads to adverse reactions. The traditional fixed-rate PCA mode is difficult to match the changes in postoperative pain. This study will compare different PCA mode optimization strategies, assuming that they can reduce opioid dosage, improve analgesic effect, and reduce adverse reactions, providing high-quality evidence-based basis for postoperative analgesia and promoting individualized and intelligent management.",[63,64,65,66],"Surgery","Pain Management","Opioid Consumption","Patient-controlled Analgesia","2026-06-11",{"date":69,"type":42},"2026-06-12",{"date":71,"type":42},"2025-12-30",{"date":73,"type":21},"2027-12-30",{"name":75,"class":49},"Beijing Tiantan Hospital",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":22,"phases":86,"briefSummary":87,"conditions":88,"keywords":92,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":50},"100643654","comparison-of-iv-analgesia-protocols-after-the-regional-blocks-effect-diminishes-in-thoracic-surgery-100643654","NCT07610408","Comparison of IV Analgesia Protocols After the Regional Block's Effect Diminishes in Thoracic Surgery","Comparison of the Effectiveness of Intravenous Analgesia Protocols Used After the Duration of Block Action for Postoperative Pain Control in Thoracic Surgery","Inclusion Criteria:\n\n1. \\- Patients aged 18 to 80 years.\n2. \\- ASA (American Society of Anesthesiologists) Physical Status Score of I-III.\n3. \\- Body Mass Index (BMI) between 18 and 35 kg\u002Fm².\n4. \\- Undergoing elective thoracic surgery via Video-Assisted Thoracoscopic Surgery (VATS).\n5. \\- Voluntary participation confirmed by signing the written Informed Consent Form.\n\nExclusion Criteria:\n\n1. \\- Age below 18 or above 80 years.\n2. \\- Advanced organ failure (e.g., severe hepatic or renal impairment).\n3. \\- ASA physical status \\> III.\n4. \\- History of chronic pain treatment or long-term opioid use.\n5. \\- BMI \\\u003C 18 kg\u002Fm² or \\> 35 kg\u002Fm².\n6. \\- Pregnancy or breastfeeding.\n7. \\- Limited cooperation due to dementia or uncontrolled psychiatric disorders.\n8. \\- Communication barriers (inability to communicate in the native language).\n9. \\- History of substance or drug abuse.\n10. \\- Known allergy or contraindication to the study drugs (Fentanyl, Tramadol, or Ibuprofen).\n11. \\- Contraindication to regional block placement (e.g., infection at the injection site).","80 Years",{"count":85,"type":21},135,[24],"The purpose of this study is to compare the effectiveness of three different intravenous (IV) patient-controlled analgesia (PCA) regimens-Fentanyl, Tramadol, and Ibuprofen-in managing postoperative pain and respiratory performance in patients undergoing Video-Assisted Thoracoscopic Surgery (VATS). While regional blocks like Erector Spinae Plane (ESP) block provide effective early analgesia, their effect typically diminishes after 8-12 hours, leading to potential 'rebound pain.' This study specifically investigates the period following the duration of the regional block's action. The primary goal is to evaluate which IV PCA protocol better controls pain (Visual Analog Scale scores) and supports better respiratory performance (measured by incentive spirometry) during the first 72 hours post-surgery",[89,27,90,31,91],"Postoperative Pain After Thoracic Surgery","Thoracic Surgery, Video Assisted","Acute Pain",[93,94,95,96,97,98,99,100,101,102,103],"Video-Assisted Thoracoscopic Surgery","VATS","Erector Spinae Plane Block","ESP","Patient-Controlled Analgesia","PCA","IV analgesia","Incentive spirometry","Opioid-sparing","Postoperative pain after thoracic surgery","Rebound Pain","2026-06-06",{"date":106,"type":42},"2026-06-09",{"date":108,"type":42},"2026-06-02",{"date":110,"type":21},"2026-10-15",{"name":112,"class":113},"Ankara Etlik City Hospital","OTHER_GOV",{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":121,"targetDuration":4,"studyType":22,"phases":123,"briefSummary":61,"conditions":124,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":129,"leadSponsor":131,"locationsCount":50},"100621784","comparison-of-the-efficacy-and-safety-of-fixed-rate-basal-infusion-mode-and-time-programmed-decremental-background-infusion-mode-of-intravenous-pca-following-mixed-surgery-100621784","NCT07375121","Comparison of the Efficacy and Safety of Fixed-rate Basal Infusion Mode and Time-programmed Decremental Background Infusion Mode of Intravenous PCA Following Mixed Surgery","Prospective Randomized Controlled Study of Individualized PCA Model Based on Multi-dimensional Strategies (Fixed-rate Basal Infusion Mode and Time-programmed Decremental Background Infusion Mode)","Inclusion Criteria:\n\n* aged between 18 to 65 years;\n* American Society of Anesthesiologists physical status Ⅰ - Ⅲ;\n* Patients scheduled for elective mixed surgery were enrolled. Mixed surgeries included thoracoscopic surgery, laparoscopic surgery, hysteroscopy surgery, laparotomy, thoracotomy, open spinal surgery, craniotomy, and so on.\n\nExclusion Criteria:\n\n* Chronic pain syndromes;\n* Psychiatric disorders;\n* Severe cardiovascular or cerebrovascular disease, renal or hepatic functional dysfunction, or allergic to PCA medications.",{"count":122,"type":21},450,[24],[63,64,65,31],"2026-03-31",{"date":127,"type":42},"2026-04-06",{"date":71,"type":42},{"date":130,"type":21},"2026-12-30",{"name":75,"class":49},{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":138,"eligibilityCriteria":139,"healthyVolunteers":11,"sex":16,"minAge":140,"maxAge":17,"enrollmentInfo":141,"targetDuration":4,"studyType":22,"phases":143,"briefSummary":145,"conditions":146,"keywords":147,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":50},"100530389","phase-4-nausea-and-vomiting-in-postoperative-paediatric-patients-with-patient-controlled-analgesia-pca-morphine-vs-oxycodone-100530389","NCT06186141","Nausea and Vomiting in Postoperative Paediatric Patients With Patient-Controlled Analgesia (PCA): Morphine vs Oxycodone","A Comparison of Nausea and Vomiting in Postoperative Paediatric Patients With Patient-controlled Analgesia (PCA): Morphine vs Oxycodone (POPCORN)","POPCORN","Inclusion Criteria:\n\n* Postoperative patients who are appropriate for a PCA including those aged 6 and above and up to age 18 years.\n* Those deemed appropriate for either morphine or oxycodone by their treating anaesthetist.\n* American Society of Anaesthesiologists (ASA) score 1-3 inclusive\n* Those whose parents or legal guardians have provided informed consent on the patient's behalf.\n\nExclusion Criteria:\n\n* Any patients with an allergy, hypersensitivity, or contraindication to morphine or oxycodone.\n* Patients in the age group with significant intellectual disability or physical incapacity rendering them incapable of using the PCA device\n* ASA score 4 or above\n* Inability or unwillingness of parent or legal guardian to provide informed consent for the study.","6 Years",{"count":142,"type":21},690,[144],"PHASE4","POPCORN trial will compare the side effects and effectiveness of Morphine versus Oxycodone medication when prescribed for use as patient controlled analgesia (PCA) for pain relief for paediatric patients after-surgery. This trial is embedded into routine patient care using the hospital electronic medical record (EMR). Participants will be randomly assigned to either medication after they enrol in the study.\n\nThe main questions the POPCORN trial aims to answer are:\n\n* 1\\. Is there a difference in the usage of medication to treat nausea and vomiting for those who received oxycodone PCA versus morphine PCA for post-surgery pain relief?\n* 2\\. Is there a difference in side effects or pain relief needed between the two groups?\n\nStudy activities are as follows:\n\n* Participants enrolled to study during their pre-operative consultation\n* Participants are randomly assigned to morphine or oxycodone\n* No further study-specific activities expected from participant after enrolment and randomisation\n* Participant receives routine medical care as planned\n* Clinicians record assessments as per routine care in electronic medical record (EMR)\n* EMR data are extracted as trial data",[97],[148,149,150,151,152,153],"Post-operative Pain","Paediatric","Patient-controlled analgesia","Paediatric analgesia","Post-operative","Embedded clinical trials","2025-08-20",{"date":156,"type":42},"2025-08-27",{"date":158,"type":42},"2024-03-13",{"date":160,"type":21},"2027-03-19",{"name":162,"class":49},"Murdoch Childrens Research Institute",{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":168,"acronym":4,"eligibilityCriteria":169,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":170,"enrollmentInfo":171,"targetDuration":4,"studyType":22,"phases":173,"briefSummary":176,"conditions":177,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":50},"100477999","phase-2-perioperative-analgesia-modes-in-minimally-invasive-esophagectomy-100477999","NCT05504265","Perioperative Analgesia Modes in Minimally Invasive Esophagectomy","Comparison of Efficacy and Safety of Different Analgesic Modes in Minimally Invasive Esophagectomy for Esophageal Cancer","Inclusion Criteria:\n\n* 18-75 years;\n* Patients underwent laparoscopic and thoracoscopic or robotic-assisted minimally invasive esophagectomy ;\n* Informed consent.\n\nExclusion Criteria:\n\n* Has a history of cholecystitis or urolithiasis within 3 months;\n* Has a history of atherothrombosis (peripheral arterial disease), stroke, myocardial infarction;\n* With lung diseases, such as pneumonia, atelectasis, emphysema, pulmonary bullae, etc;\n* Preoperative cardiac function grade ≥ III or coronary artery stenosis;\n* Preoperative indwelling of a thoracic drainage tube;\n* Long-term heavy drinker(heavy drinking was defined as follows: for men, consuming more than 4 drinks on any day or more than 14 drinks per week; For women, consuming more than 3 drinks on any day or more than 7 drinks per week);\n* Opioid-tolerant patients(defined as those who have been taking, for a week or longer, at least 60 mg of morphine daily, or at least 30 mg of oral oxycodone daily, or at least 8 mg of oral hydromorphone daily or an equianalgesic dose of another opioid);\n* With painful skin complications, such as rashes and blisters;\n* Conversion to open surgery;\n* The postoperative ventilation function was limited, or the duration of endotracheal intubation was more than 24h.","75 Years",{"count":172,"type":21},102,[174,175],"PHASE2","PHASE3","This study was designed to compare analgesic efficacy and safety of different perioperative analgesic modes in minimally invasive esophagectomy for esophageal cancer.",[178,179,180,181,66],"Esophageal Cancer","Perioperative Analgesia","NSAIDs","Opioid","2025-03-17",{"date":184,"type":42},"2025-03-20",{"date":186,"type":42},"2022-10-10",{"date":188,"type":21},"2025-12-20",{"name":190,"class":49},"Cancer Institute and Hospital, Chinese Academy of Medical Sciences",{"id":192,"slug":193,"hasResults":11,"nctId":194,"briefTitle":195,"officialTitle":196,"acronym":4,"eligibilityCriteria":197,"healthyVolunteers":11,"sex":16,"minAge":198,"maxAge":4,"enrollmentInfo":199,"targetDuration":4,"studyType":22,"phases":201,"briefSummary":202,"conditions":203,"keywords":205,"overallStatus":207,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":211,"completionDateStruct":213,"leadSponsor":215,"locationsCount":50},"100572037","erector-spinae-plane-block-vs-patient-controlled-analgesia-in-correction-surgery-for-idiopathic-scoliosis-100572037","NCT06728046","Erector Spinae Plane Block v.s Patient Controlled Analgesia in Correction Surgery for Idiopathic Scoliosis","Analgesic Effects of Ultrasound-Guided Erector Spinae Plane Block v.s Patient Controlled Analgesia in Correction Surgery for Idiopathic Scoliosis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 14 years or older, regardless of gender.\n* Scheduled for scoliosis correction surgery.\n* Signed informed consent from the participant or their legal guardian.\n\nExclusion Criteria:\n\n* Allergy to local anesthetics such as ropivacaine.\n* Family history of malignant hyperthermia.\n* Severe systemic diseases affecting the heart, lungs, liver, or kidneys.\n* Neurological or psychiatric disorders.\n* Communication difficulties, such as hearing impairment or speech disorders.\n* Concurrent participation in other clinical studies.\n* Other conditions deemed unsuitable for participation by the investigators.","14 Years",{"count":200,"type":21},40,[24],"Scoliosis correction surgery involves extensive surgical wounds, intense intraoperative stimulation, and severe postoperative pain, often necessitating the use of potent opioids. However, there is a critical clinical need for effective pain management strategies that both ensure sufficient analgesia and minimize opioid-related adverse effects. The Erector Spinae Plane Block (ESPB) has shown promise as an effective analgesic technique, but its application in scoliosis correction surgery has not been reported.We hypothesize that ESPB provides superior postoperative analgesia compared to patient-controlled intravenous analgesia (PCA) pumps. Specifically, ESPB is expected to significantly reduce postoperative pain scores, decrease perioperative opioid consumption, and mitigate opioid-related side effects.\n\nThis study is a randomized controlled trial involving 40 participants undergoing scoliosis correction surgery, randomized into two groups: the ESPB group and the PCA group. The primary outcome measure is the resting pain score at 2 hours postoperatively, which will be used to evaluate the efficacy of ESPB. Secondary outcomes include perioperative opioid consumption and the incidence of opioid-related adverse effects. The study aims to provide evidence for ESPB as an innovative and effective method for postoperative analgesia in scoliosis correction surgery.",[204,95,31],"Idiopathic Scoliosis",[95,31,206],"Idiopathic Scoliosis Correction Surgery","NOT_YET_RECRUITING","2024-12-06",{"date":210,"type":42},"2024-12-11",{"date":212,"type":21},"2025-01-01",{"date":214,"type":21},"2027-05-31",{"name":216,"class":49},"West China Hospital"]