[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"patients-with-aterosclerotic-carotid-stenosis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:patients-with-aterosclerotic-carotid-stenosis":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":5},"100459018","carotid-revascularization-with-micronet-covered-stent-comparing-early-neurological-outcomes-with-distal-versus-proximal-eps-100459018",false,"NCT05257161","Carotid Revascularization With MicroNet Covered Stent Comparing Early Neurological Outcomes With Distal Versus Proximal EPS","Independent Randomized Clinical Trial in Carotid Revascularization With MicroNet Covered Stent (CGuard) Comparing Early Neurological Outcomes With Distal EPS Versus Proximal EPS","SIBERIA-2","Inclusion Criteria\n\n1. Consecutive patients 45-80 years old accepted for CAS following neurological consultation and qualification for the procedure according to center's routine practice.\n2. More than 6-month life expectancy\n3. Suitable clinical conditions for performing DW-MRI\n4. Written Informed consent approved by the Ethics Committee\n5. Subject agrees to all required follow-up procedures and visits\n\nExclusion Criteria:\n\n1. Currently enrolled in another investigational device or drug study that has not completed the study or that clinically interferes with the current study endpoints\n2. Recent surgical procedure within 30-days before or planned surgery within 30-days after the stenting procedure\n3. Hepatic active disease (bilirubin\\> 35 mmol \u002F l) or renal insufficiency (serum creatinine \\> 2.5 mg\u002FdL or glomerular filtration rate \\\u003C60 ml \u002F min)\n4. Recent evolving acute stroke within 30-days of study evaluation\n5. Myocardial infarction within 72 hours prior to carotid stenting procedure (CPK-MB \\> 3 times normal)\n6. Female patients of childbearing potential or known to be pregnant\n7. Any known factor for potential stroke other than carotid stenosis, such as atrial fibrillation or atrial flutter (paroxysmal, permanent or persistent) or thrombophilia\n8. Patient on VKA or new oral anticoagulants","ALL","45 Years","80 Years",{"count":21,"type":22},366,"ESTIMATED","INTERVENTIONAL",[25],"NA","The SIBERIA study demonstrated a clear advantage of CGuard stent implantation over the existing classical stent when using a distal anti-embolic device. At the same time, there is no Level 1 evidence for a difference between the proximal and distal anti-embolic device for the CGuard stent.",[28,29,30],"Patients With Aterosclerotic Carotid Stenosis","Symptomatic Patients (Stenosis > 50%)","Asymptomatic Patients (Stenosis ≥80%)",[32],"Carotid artery stenting. CGuard stent. Protection Device.","RECRUITING","2022-02-16",{"date":36,"type":37},"2022-02-25","ACTUAL",{"date":39,"type":37},"2021-11-01",{"date":41,"type":22},"2027-01-01",{"name":43,"class":44},"Meshalkin Research Institute of Pathology of Circulation","NETWORK"]