[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pbc\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pbc":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100443111","phase-2-a-study-to-evaluate-efficacy-and-safety-of-an-investigational-drug-named-volixibat-in-patients-with-itching-caused-by-primary-biliary-cholangitis-100443111",false,"NCT05050136","A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Biliary Cholangitis","A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Volixibat in the Treatment of Cholestatic Pruritus in Patients With Primary Biliary Cholangitis","VANTAGE","Inclusion Criteria:\n\n* Provide signed informed consent at the screening visit as well as comply with all study visits and requirements through the end of the study\n* Male or female, age ≥18 years at the screening visit\n* Confirmed diagnosis of PBC in line with the AASLD guidelines\n* UDCA, anti-pruritic medication and PPAR agonist use will be allowed if meeting additional criteria\n* Qualified pruritus associated with PBC as assessed by Adult ItchRO\n\nExclusion Criteria:\n\n* Pruritus associated with an etiology other than PBC\n* Evidence or clinical suspicion of decompensated cirrhosis or a history of decompensation events\n* Current symptomatic cholelithiasis or inflammatory gallbladder disease\n* History of small bowel surgery\u002Fresection impacting the terminal ileum that may disrupt the enterohepatic circulation.\n* Evidence, history, or suspicion of other liver diseases; PBC patients with AIH are not excluded\n* History of Liver transplantation","ALL","18 Years",{"count":20,"type":21},260,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","The purpose of this clinical research study is to learn more about the use of the study medicine, volixibat, for the treatment of pruritus (itching) associated with Primary Biliary Cholangitis (PBC), and to assess the possible impact on the disease progression of PBC.",[27,28],"Primary Biliary Cholangitis","PBC",[30,28,31,32,27,33],"Pruritus","Itching","Cholangitis","Hepatobiliary disorders","RECRUITING","2026-05-12",{"date":37,"type":38},"2026-05-14","ACTUAL",{"date":40,"type":38},"2021-09-22",{"date":42,"type":21},"2027-07",{"name":44,"class":45},"Mirum Pharmaceuticals, Inc.","INDUSTRY",130,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":55,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":59,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":72},"100297047","swiss-primary-biliary-cholangitis-cohort-study-100297047","NCT03146910","Swiss Primary Biliary Cholangitis Cohort Study","Inclusion Criteria:\n\n* diagnose of Primary biliary cholangitis (according to EASL Clinical Practice Guidelines: management of cholestatic liver diseases).\n* Subjects with isolated anti-mitochondrial antibodies and\u002For isolated PBC-specific anti-nuclear antibodies are also included\n* Patients\u002Fsubjects aged at least 18 years and living in Switzerland are included\n\nExclusion Criteria:\n\n* N\u002FA",{"count":54,"type":21},500,"10 Years","OBSERVATIONAL","Research project in which biological material is sampled and health-related medical data is collected. In addition, already existing health-related medical data are used for further research. Coded data are used.",[28,27],[28,27,60,61],"Cohort","AILD","2025-08-13",{"date":64,"type":38},"2025-08-17",{"date":66,"type":38},"2017-02-15",{"date":68,"type":21},"2030-12-31",{"name":70,"class":71},"Fondazione Epatocentro Ticino","OTHER",13]