[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pcia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pcia":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100589373","impact-of-frailty-on-nalbuphine-dose-for-postoperative-analgesia-in-elderly-patients-undergoing-laparoscopic-gi-surgery-100589373",false,"NCT06953570","Impact of Frailty on Nalbuphine Dose for Postoperative Analgesia in Elderly Patients Undergoing Laparoscopic GI Surgery","Impact of Frailty on the Median Effective Dose of Nalbuphine in Patient-Controlled Intravenous Analgesia for Postoperative Pain in Elderly Patients Undergoing Laparoscopic Gastrointestinal Surgery: A Prospective, Double-Blind, Cohort Study","Inclusion Criteria:\n\n1. Patients who plan to undergo elective gastrointestinal surgery and are expected to stay in hospital for ≥3 days after surgery \\[except abdominal perineal combined with radical resection of rectal cancer (MILES)\\];\n2. ASA grade I-Ⅳ;\n3. Age ≥65 years (2);\n4. 18.5 kg\u002Fm²≤BMI\\\u003C30 kg\u002Fm²;\n5. Sign the informed consent form.\n\nExclusion Criteria:\n\n1. Severe cardiopulmonary, liver, kidney and coagulation dysfunction\n2. Chemotherapy and radiotherapy were administered 1 month before surgery, and sedatives, antiemetic or antipruritic drugs were administered 24 hours before surgery\n3. History of drug abuse, chronic pain, mental illness, or allergy to the drugs used in this study\n4. Plan postoperative intubation or transfer to ICU;\n5. Participated in other clinical studies within the past 3 months.","ALL","65 Years",{"count":19,"type":20},120,"ESTIMATED","OBSERVATIONAL","This study aims to investigate the ED50 and ED95 of nalbuphine combined with dexmedetomidine in patient-controlled intravenous analgesia (PCIA) for elderly patients with different degrees of frailty, as well as their analgesic effects and complications. The results of this study can provide safe and effective dosage guidance for postoperative analgesia in frail patients, help optimize analgesic regimens, reduce the risk of complications, and improve the quality of postoperative recovery.",[24,25,26],"PCIA","Frailty","Laparoscopic Gastrointestinal Surgery",[28,29,24,30,31],"nalbuphine","ED50","laparoscopic gastrointestinal surgery","frailty","NOT_YET_RECRUITING","2025-04-23",{"date":35,"type":36},"2025-05-01","ACTUAL",{"date":38,"type":20},"2025-10-01",{"date":40,"type":20},"2026-10-10",{"name":42,"class":43},"Yongtao Sun","OTHER"]