[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pcosinsulin-resistant\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pcosinsulin-resistant":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":5},"100616597","melatonin--metformin-on-clinical--biochemical-parameters-in-insulin-resistant-pcos-compared-to-metformin-100616597",false,"NCT07307677","Melatonin & Metformin on Clinical & Biochemical Parameters in Insulin Resistant PCOS Compared to Metformin","Effect of Melatonin and Metformin Combination Therapy on Clinical and Biochemical Parameters inInsulin Resistant Polycystic Ovary Syndrome Compared to Metformin Alone","Inclusion Criteria:\n\n* Diagnosed case of PCOS according to Rotterdam criteria\n* Women of age 18-35 years\n* Insulin resistance (HOMA-IR \\>2.6)\n\nExclusion Criteria:\n\n* BMI: ≤ 18.5 and ≥ 30 kg\u002Fm2\n* Uncontrolled endocrine disorders (Diabetis melitus, Hypothyroidism, Hyperprolactinemia)\n* Known case of any medical disease (Renal, hepatic or cardiac disease)\n* Any medication which would affect insulin resistance (Metformin, Myo- inositol, Pioglitazone) in last three months.\n* Hypersensitivity to melatonin.","FEMALE","18 Years","35 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","Women with polycystic ovary syndrome with HOMA-IR \\>2.6 fulfilling inclusion and exclusion criteria will be randomly allocated into two groups:experimental group: A (Melatonin 3mg and Metformin 500mg) and control group: B (Metformin 500mg). Each group will be contained 30 selected patients.\n\nGroup B:Tab. Metformin (500mg) once daily for 7days followed by twice daily for next 7 days followed by thrice daily for next 10 weeks.\n\nOutcome variables will be measured after three months, will be meticulously recorded for analysis and comparison.",[27],"PCOS(Insulin Resistant)",[29],"Melatonin in PCOS","RECRUITING","2026-01-05",{"date":33,"type":34},"2026-01-07","ACTUAL",{"date":36,"type":34},"2025-03-11",{"date":38,"type":21},"2026-08-10",{"name":40,"class":41},"Mst.Sumyara Khatun","OTHER"]