[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pediatric-acute-respiratory-distress-syndrome-pards\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pediatric-acute-respiratory-distress-syndrome-pards":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,57],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100602473","phase-2-pediatric-acute-respiratory-distress-syndrome-ards-management-trial-100602473",false,"NCT07123961","Pediatric Acute Respiratory Distress Syndrome (ARDS) Management Trial","Pediatric Acute Respiratory Distress Syndrome (ARDS) Management (PARMA) Trial","PARMA","Inclusion:\n\n1. age \\> 2 weeks (\\> 38 weeks corrected gestational age) and \\\u003C 18 years (not yet had 18th birthday)\n2. acute (≤ 7 days of risk factor) respiratory failure requiring invasive mechanical ventilation\n3. ventilated with endotracheal tube or tracheostomy for ≤ 7 days from risk factor onset\n4. hypoxemia defined as PaO2\u002FFIO2 (measurement of the amount of oxygen dissolved in the blood plasma\u002Fconcentration of inhaled oxygen) \\> 300 (or SpO2\u002FFIO2 (measurement of the percentage of hemoglobin in your blood that is carrying oxygen\u002Fconcentration of inhaled oxygen) \\> 315 on Positive End-Expiratory Pressure (PEEP) ≥ 5 cmH2O (rate of pressure delivery) on two consecutive measurements 4 hours apart and sustained at the time of consent and randomization\n5. bilateral opacities on chest radiograph as determined by radiologist, clinical attending, or PI\n\nExclusion:\n\n1. hypoxemia caused primarily by hydrostatic pulmonary edema from heart failure or fluid overload\n2. non-palliated or unrepaired cyanotic congenital heart disease\n3. ventilated via tracheostomy at baseline prior to acute illness\n4. obstructive airway disease determined to be the primary cause of respiratory failure\n5. severe moribund state not expected to survive \\> 72 hours\n6. any limitations of care at time of screening\n7. escalation to high frequency oscillatory ventilation or extracorporeal support (i.e., meeting PARMA protocol failure criteria) at time of screening\n8. previous enrollment in this study","ALL","2 Weeks","17 Years",{"count":21,"type":22},160,"ESTIMATED","INTERVENTIONAL",[25],"PHASE2","Acute respiratory distress syndrome (ARDS) is a serious and potentially life-threatening lung condition that can affect children. Currently, ventilator settings commonly used in treatment are based on approaches developed for adults, and it remains unclear whether these settings are equally effective for children. Because children's bodies respond differently than adults', it is important to determine the most effective ventilator strategies specifically for pediatric patients. This study will compare two different ventilator approaches in children with ARDS to identify which method provides the greatest benefit. The findings will also help inform the design of a larger study in the future.",[28,29,30,31],"Acute Respiratory Distress Syndrome (ARDS)","Ventilator Management","Lung-protective Ventilation","Pediatric Acute Respiratory Distress Syndrome (PARDS)",[33,34,35,36,29,37,38,39,40,41,42,43],"Acute Respiratory Distress Syndrome","ARDS","Vent","Ventilator","Pediatric ARDS","Pediatric Ventilator Management","PARDS","Pediatric ARDS Protocolized Treatment","Invasive Mechanical Ventilation","IMV","Pediatric Acute Respiratory Distress Syndrome","RECRUITING","2026-03-13",{"date":47,"type":48},"2026-03-16","ACTUAL",{"date":50,"type":48},"2025-11-07",{"date":52,"type":22},"2030-06-30",{"name":54,"class":55},"Children's Hospital of Philadelphia","OTHER",1,{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":11,"sex":17,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":4,"studyType":23,"phases":69,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":87},"100520033","decremental-esophageal-catheter-filling-volume-titration-for-transpulmonary-pressure-measurement-100520033","NCT06051292","Decremental Esophageal Catheter Filling Volume Titration For Transpulmonary Pressure Measurement","Decremental Esophageal Catheter Filling Volume Titration For Esophageal Pressure Measurement","DECFVTTPM","Inclusion Criteria:\n\n* Pediatric patients between 1 months and 18 years\n* Patients need mechanical ventilation support without modification of ventilation settings within the upcoming 2 hours\n* Informed consent was signed by next of kin\n* Requiring esophageal catheter application\n\nExclusion Criteria:\n\n* Patients eligible for extubation or modification of ventilation settings within the upcoming 2 hours\n* Patient included in another interventional study in the last 30 days\n* Patients unable to undergo esophageal catheter insertion due to congenital or acquired pathologies\n* Patient included in another interventional research study under consent\n* Patient already enrolled in the present study in a previous episode of acute respiratory failure","1 Month","18 Years",{"count":68,"type":22},27,[70],"NA","Mechanical ventilation is a critical intervention in the management of pediatric patients with respiratory distress. During this process, accurate measurement of transpulmonary pressure (PL) is essential to ensure the safety and efficacy of ventilation. PL is defined as the difference between alveolar pressure (Palv) and pleural pressure (Ppl). While the direct measurement of Ppl is possible, it poses a risk to tissue integrity. Thus, the primary surrogate for Ppl measurement today is esophageal pressure (Pes).\n\nHowever, the measurement of Pes is not without challenges. This abstract outlines the pitfalls associated with Pes measurement, emphasizing the importance of employing well-defined procedures to mitigate potential errors. These errors can range from underestimation of Pes due to underfilled catheters to overestimation resulting from overfilled catheters.\n\nTo address these challenges and optimize Pes measurement, various methods have been proposed for titrating the filling volume of the esophageal catheter. In this study, investigators aim to assess a faster decremental filling method and compare it to the traditionally accepted Mojoli method in the context of pediatric patients. This research seeks to enhance the intensivists' understanding of the most efficient and accurate approach to Pes measurement during mechanical ventilation in the pediatric population, ultimately contributing to improved patient care and outcomes",[31,73,33],"Acute Respiratory Failure",[75,76,77],"Acute respiratory failure (ARF)","esophageal catheter","transpulmonary pressure","2025-03-18",{"date":80,"type":48},"2025-03-20",{"date":82,"type":48},"2023-09-18",{"date":84,"type":22},"2025-12-30",{"name":86,"class":55},"Dr. Behcet Uz Children's Hospital",4]