[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pediatric-acute-respiratory-failure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pediatric-acute-respiratory-failure":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,54],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100592516","phase-3-optimizing-pain-treatment-in-children-on-mechanical-ventilation-100592516",false,"NCT06994442","Optimizing Pain Treatment in Children On Mechanical Ventilation","OPTICOM","Inclusion Criteria:\n\n1. At least 2 months of age to 17 years 6 months; AND\n2. Acute Respiratory Failure requiring endotracheal intubation; AND\n3. Opioid infusion planned or started; AND\n4. Expected duration of Invasive Mechanical Ventilation \\> 48 hours\n\nExclusion Criteria:\n\n1. History of allergic-type reaction to either acetaminophen or non-steroidal anti-inflammatory (NSAID) medications; OR\n2. Active peptic ulcer disease, recent gastrointestinal bleeding or perforation, or history of peptic ulcer disease or gastrointestinal bleeding; OR\n3. Expected need for continuous neuromuscular blockade for more than 24 hours following intubation; OR\n4. Requirement for tight temperature control (defined as the requirement for continuous administration of antipyretic medications to prevent secondary injuries associated with fever); OR\n5. Platelet count \\\u003C 100,000\u002Fmicroliter; OR\n6. Known liver disease (defined as pre-existing diagnosis of hepatic insufficiency, or a serum ALT \\> 5 times upper limit of normal or serum total bilirubin \\> 2 times the upper limit of normal, as defined by hospital laboratory standards); OR\n7. Known kidney disease (defined as pre-existing diagnosis of renal insufficiency, or an estimated creatinine clearance \\\u003C 30 mL\u002Fmin\u002Fm2 obtained within the previous 24-hours prior to eligibility, or high risk of renal failure due to volume depletion); OR\n8. Current treatment with extracorporeal therapies (e.g., ECMO, CVVH, plasma exchange); OR\n9. Cardiac bypass surgery within the past 24 hours prior to eligibility; OR\n10. Requirement for the patient to receive lithium, pentoxifylline or probenecid as part of their routine care; OR\n11. Unable to obtain consent and randomize within 12 hours of eligibility, OR\n12. Positive pregnancy test; OR\n13. Coma, Vegetative State, or Brain Death (Pediatric Cerebral Performance Category (PCPC) score of 5 or 6) suspected or confirmed; OR\n14. Cardiac arrest has occurred within 72 hours of eligibility criteria being met; OR\n15. Limitations in care in place at the time of eligibility, or anticipated to be considered during the 5-day study period, OR\n16. Use of high dose NSAIDS within the prior 6 months, OR\n17. Suspected or confirmed cerebrovascular bleeding or hemorrhagic diathesis","ALL","2 Months","17 Years",{"count":20,"type":21},644,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","In this clinical trial, investigators want to learn more about using non-opioid pain medications for children with acute respiratory failure. Right now, doctors give these children opioids to help with pain while they are on the ventilator, but investigators don't know if this is the best way to manage their pain. Even with strong doses of opioids, more than 90% of these children still feel pain. Other pain medicines, like acetaminophen (also called Tylenol) and ketorolac (also called Toradol), are available but aren't commonly used because we don't know if they help. The goal of this clinical trial is to test if acetaminophen and\u002For ketorolac can improve pain control and reduce the need for stronger pain medications (opioids) in these children.\n\nTo learn more about this, participants will be randomly placed in one of four study treatment groups. This means that a computer will decide by chance which group each participant is in, not the doctors running the study. Each group will receive a combination of intravenous acetaminophen, ketorolac or a harmless substance called a placebo. In this clinical trial, placebos help investigators see if the actual medications (acetaminophen and ketorolac) work better than something that doesn't contain medicine. By comparing participants who get the real medicine with those who get the placebo, investigators can find out if these medications effectively decrease pain.",[27,28,29,30],"Mechanical Ventilation","Pediatric Acute Respiratory Failure","Analgesics, Opioid","Sedation and Analgesia",[32,33,34,35,36,37,38,39,40],"Acetaminophen","Ketorolac","Non-opioids","Acute Respiratory Failure in Children","Mechanically Ventilated Children in the ICU","Pediatric Delirium","Pain Treatment","opioids","sedation","RECRUITING","2026-02-17",{"date":44,"type":45},"2026-02-20","ACTUAL",{"date":47,"type":45},"2025-12-29",{"date":49,"type":21},"2029-08-31",{"name":51,"class":52},"Weill Medical College of Cornell University","OTHER",15,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":16,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":22,"phases":65,"briefSummary":67,"conditions":68,"keywords":71,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":4},"100621469","the-effect-of-using-distractor-cards-and-thermochromic-cards-on-pain-fear-anxiety-and-procedure-time-in-children-receiving-inhaler-therapy-100621469","NCT07371026","The Effect of Using Distractor Cards and Thermochromic Cards on Pain, Fear, Anxiety and Procedure Time in Children Receiving Inhaler Therapy","CALM-INH","Inclusion Criteria:\n\n* The child must be between 4-6 years old,\n* The child must be receiving inhaler treatment,\n* The child must not have received IV or IM intervention before inhaler treatment,\n* The child's oxygen saturation must be 95% or higher,\n* The child's cognitive level and motor development must be appropriate for their age,\n* The child and parents must be willing to participate in the study,\n* The child and parents must be able to speak Turkish.\n\nExclusion Criteria:\n\n* The child must have a cognitive or mental problem,\n* The child must have special needs in terms of hearing, vision and\u002For speech,\n* The child must have a life-threatening condition,\n* The child's oxygen saturation level must be below 95%,\n* The child must not be routinely receiving inhaler treatment","3 Years","6 Years",{"count":64,"type":21},90,[66],"NA","THE EFFECT OF USİNG DİSTRACTOR CARDS AND THERMOCHROMİC CARDS ON PAİN, FEAR, ANXİETY AND PROCEDURE TİME İN CHİLDREN RECEİVİNG INHALER THERAPY.\n\nRespiratory illnesses in children are a leading cause of childhood morbidity and mortality worldwide. Organizations such as the World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC) report that millions of children are hospitalized each year due to respiratory illnesses (He, Wang, \\& Zhang, 2025). A large proportion of these illnesses are caused by viral agents, and pathogens such as Respiratory Syncytial Virus (RSV), influenza, and rhinoviruses pose serious health threats to young children (Chen, Zhang, \\& Li, 2024).\n\nThis study will be one of the rare studies in pediatric nursing that examines the effectiveness of non-pharmacological interventions that can be applied during inhaler therapy in young age groups. The findings will contribute to nurses developing effective methods to reduce the negative emotions experienced by children during treatment. Furthermore, the first-ever use of thermochromic cards in this context in pediatric nursing will provide an innovative perspective on pediatric nursing practices.\n\nH0: Thermochromic cards and distraction cards used during inhaler therapy have no effect on pain, fear, anxiety levels, or processing time.\n\nThermochromic cards used during inhaler therapy:\n\nH1: reduce the child's pain. H2: reduce the child's fear. H3: reduce the child's anxiety level.\n\nH4: shorten the child's processing time. Distraction cards used during inhaler therapy:\n\nH5: reduce the child's pain. H6: reduce the child's fear. H7: reduce the child's anxiety level. H8: shorten the child's processing time.",[69,70,28],"Pediatric Acute Upper Respiratory Tract Infection","Pediatric",[72,73,74,75,76],"pediatrics","nebulizer therapy","thermochromic card","child","distracting card","NOT_YET_RECRUITING","2026-01-28",{"date":80,"type":45},"2026-01-30",{"date":82,"type":21},"2026-03-01",{"date":84,"type":21},"2027-03-01",{"name":86,"class":52},"Muhammed Ata Nur GEÇER"]