[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pediatric-anesthesia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pediatric-anesthesia":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,20,0,[8,43,82,107,136,169,202,230,263,289,315,338,360,384,414,447,473,496,523,550],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100644888","effect-of-caudal-block-on-urethrocutaneous-fistula-after-distal-hypospadias-repair-100644888",false,"NCT07675798","Effect of Caudal Block on Urethrocutaneous Fistula After Distal Hypospadias Repair","The Effect of Caudal Block on the İncidence of Urethrocutaneous Fistula After Distal Hypospadias Repair: A Multicentre, Randomized Controlled Trial","Inclusion Criteria:\n\n* Male patients aged 6-60 months\n* Diagnosed with distal hypospadias\n* Scheduled for elective hypospadias repair\n* Written informed consent obtained from parent or legal guardian\n\nExclusion Criteria:\n\n* Age \\\u003C 6 months or \\> 60 months\n* Proximal or non-distal hypospadias\n* Previous hypospadias repair\n* Skin lesions at the epidural\u002Fcaudal injection site\n* Coagulopathy\n* Known allergy to anesthetic agents, particularly bupivacaine hydrochloride\n* Spinal anomalies\n* Chronic granulomatous disease\n* Diabetes mellitus\n* Patients receiving corticosteroid therapy\n* Refusal of informed consent by parent or guardian","MALE","6 Months","60 Months",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"NA","Hypospadias is one of the most common congenital urogenital anomalies in males, occurring in approximately 1 in every 200-300 male births. It is characterized by abnormal positioning of the urethral meatus on the ventral surface of the penis. Surgical repair is the standard treatment; however, urethrocutaneous fistula formation remains one of the most frequent and clinically significant postoperative complications, potentially requiring reoperation and causing considerable distress to both the patient and the family.\n\nCaudal nerve block is a widely used regional anesthesia technique in pediatric lower abdominal and genitourinary surgery, valued for its high analgesic efficacy, relative ease of application, and low complication profile. However, emerging evidence suggests that caudal block may be associated with an increased incidence of postoperative complications following hypospadias repair, including fistula formation and wound edema. Notably, Kundra et al. (2012) reported a fistula rate of 19.2% in patients who received caudal block, compared to 0% in those who received penile block, raising important questions about the routine use of caudal block in hypospadias surgery.\n\nThis prospective, multicenter, randomized controlled trial aims to evaluate the effect of caudal block on the incidence of urethrocutaneous fistula following distal hypospadias repair. A total of 80 male patients aged 6-60 months will be randomized 1:1 to either receive general anesthesia with caudal block or general anesthesia alone. The primary outcome is the incidence of urethrocutaneous fistula. Secondary outcomes include perioperative opioid consumption, postoperative pain scores, analgesic duration, and other surgical complications such as wound dehiscence and urethral stricture. Patients will be followed up for 3-6 months postoperatively. The study will be conducted across four centers in Turkey. Results are expected to provide evidence-based guidance on the role of caudal block in pediatric hypospadias repair.",[27,28,29],"Hypospadias","Caudal Block","Pediatric Anesthesia","RECRUITING","2026-06-23",{"date":33,"type":34},"2026-06-30","ACTUAL",{"date":36,"type":34},"2025-12-01",{"date":38,"type":21},"2026-08-15",{"name":40,"class":41},"Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital","OTHER",2,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":56,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":42},"100642003","transition-from-sevoflurane-to-total-intravenous-anesthesia-in-pediatric-patients-100642003","NCT07644260","Transition From Sevoflurane to Total Intravenous Anesthesia in Pediatric Patients","Observational Analysis of the Transition From Inhalational Anesthesia to Total Intravenous Anesthesia Guided by Bispectral Index and the Eleveld Model in Pediatric Patients","TSTP","Inclusion Criteria:\n\n* Age 2 to 12 years\n* Scheduled for elective low- or intermediate-risk surgery according to the National Institute for Health and Care Excellence (NICE) surgical risk stratification (e.g., tonsillectomy, adenoidectomy, postioplasty, orchidectomy, orchidopexy, inguinal herniorrhaphy)\n* American Society of Anesthesiologists (ASA) Physical Status Classification I or II\n\nExclusion Criteria:\n\n* Refusal of parents\u002Flegal guardians to sign informed consent, or refusal of the child to provide assent when applicable\n* Cardiovascular or neurological disease that may interfere with anesthesia or with the pharmacokinetic model\n* History of allergy or adverse reaction to inhalational or intravenous anesthetic agents used in the protocol\n* Airway malformations or conditions that complicate standard intubation or airway management\n* Psychological or neurological conditions requiring sedative or hypnotic premedication prior to the anesthetic procedure\n* Treatment with drugs that may alter the pharmacokinetics or pharmacodynamics of the anesthetic agents\n* Difficult peripheral venous access","ALL","2 Years","12 Years",{"count":55,"type":21},50,"1 Day","OBSERVATIONAL","his prospective, observational, exploratory, and multicenter study aims to describe the evolution of propofol effect-site concentration administered via target-controlled infusion (TCI) based on the Eleveld model-with adjustments for opioid co-administration-guided by the bispectral index (BIS) during the transition from inhalational anesthesia with sevoflurane to total intravenous anesthesia (TIVA) in pediatric patients.The study population will include 50 pediatric patients, aged 2 to 12 years, scheduled for elective low- or medium-complexity surgeries. Induction will be performed with sevoflurane, followed by intravenous access placement and transition to TIVA using propofol and remifentanil via TCI. As part of the neuromonitoring, the bispectral index, spectral edge frequency (SEF), and median frequency (MF) will be recorded. Additionally, hemodynamic parameters will be recorded on a minute-by-minute basis.The primary objective is to describe BIS-guided adjustments of propofol during the anesthetic transition. Secondary objectives include describing interindividual variability in propofol titration, time to reach a BIS of 40-60, burst suppression patterns, SEF, MF, drug consumption, hemodynamic stability, and clinical adverse events. Statistical analysis will be primarily descriptive, examining correlations between BIS, propofol, and the minimum alveolar concentration (MAC) of sevoflurane.",[60,29,61],"Anesthesia","Total Intravenous Anesthesia",[61,63,64,65,66,67,68,69,70,29,71],"TIVA","Bispectral Index","BIS","Propofol","Sevoflurane","Eleveld","Target-Controlled Infusion","TCI","Anesthesia Transition","NOT_YET_RECRUITING","2026-06-08",{"date":75,"type":34},"2026-06-12",{"date":77,"type":21},"2026-05-26",{"date":79,"type":21},"2027-03-28",{"name":81,"class":41},"Hospital de Clinicas José de San Martín",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":51,"minAge":52,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":22,"phases":92,"briefSummary":93,"conditions":94,"keywords":97,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},"100636394","intranasal-dexmedetomidine-vs-oral-midazolam-for-premedication-in-pediatric-surgery-100636394","NCT07565116","Intranasal Dexmedetomidine vs Oral Midazolam for Premedication in Pediatric Surgery","Comparison of Intranasal Dexmedetomidine and Oral Midazolam for Premedication in Pediatric Patients Undergoing Elective Inguinal and Urological Surgery: A Prospective, Randomized, Double-Blind, Controlled Trial","Inclusion Criteria:\n\n* Pediatric patients aged 2-10 years\n* ASA physical status I-II\n* Scheduled for elective inguinal or urological surgery under general anesthesia\n* Both male and female patients\n* Written informed consent obtained from parents or legal guardians\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to dexmedetomidine or midazolam\n* Presence of significant systemic disease or organ dysfunction\n* Cardiac arrhythmia or congenital heart disease\n* Neurological or behavioral disorders, including developmental delay\n* Chronic use of analgesics or other medications that may affect study outcomes\n* Anticipated difficult airway\n* Nasal pathology that may interfere with intranasal drug administration\n* Emergency surgery\n* Inability to obtain written informed consent from parents or legal guardians","10 Years",{"count":91,"type":21},84,[24],"This study aims to compare the effects of intranasal dexmedetomidine and oral midazolam as premedication in pediatric patients undergoing elective inguinal and urological surgery under general anesthesia.\n\nPremedication plays a critical role in reducing preoperative anxiety, facilitating parent-child separation, and improving cooperation during anesthesia induction in pediatric patients. While oral midazolam is widely used, it has several limitations, including variable bioavailability and the risk of paradoxical reactions. Intranasal dexmedetomidine has emerged as a promising alternative due to its sedative, anxiolytic, and minimal respiratory depressant effects.\n\nIn this prospective, randomized, double-blind, controlled study, patients aged 2-10 years will be assigned to receive either intranasal dexmedetomidine or oral midazolam prior to anesthesia induction. The primary outcome is the proportion of patients achieving adequate sedation at induction, defined as a Ramsay Sedation Score (RSS) ≥2.\n\nSecondary outcomes include perioperative hemodynamic stability, parent-child separation anxiety, mask acceptance during induction, postoperative emergence agitation, recovery time, and the need for rescue sedation.",[29,95,96],"Preoperative Anxiety","Emergence Agitation",[29,95,96],"2026-05-11",{"date":100,"type":34},"2026-05-14",{"date":102,"type":34},"2026-05-05",{"date":104,"type":21},"2026-09-26",{"name":40,"class":41},1,{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":51,"minAge":114,"maxAge":53,"enrollmentInfo":115,"targetDuration":4,"studyType":22,"phases":117,"briefSummary":119,"conditions":120,"keywords":124,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":106},"100639649","phase-4-effective-dose-of-alfentanil-combined-with-propofol-for-laryngeal-mask-airway-insertion-in-children-100639649","NCT07581665","Effective Dose of Alfentanil Combined With Propofol for Laryngeal Mask Airway Insertion in Children","Effective Dose of Alfentanil Combined With Propofol for Laryngeal Mask Airway Insertion in Children: A Prospective, Up-and-Down Sequential Allocation Study","Inclusion Criteria:\n\n* Aged 7 to 12 years\n* Undergoing elective day surgery\n* ASA physical status I-II\n* Body Mass Index (BMI) between 14 and 24 kg\u002Fm²\n* Accompanied by a fully capable guardian within 24 hours after discharge\n\nExclusion Criteria:\n\n* Allergy to opioids\n* Unresolved upper respiratory tract infection within the past 1 week\n* Abnormal heart, lung, liver, or kidney function, or metabolic diseases\n* Airway anatomical abnormalities (e.g., micrognathia, laryngomalacia, macroglossia) or OSAHS (Obstructive Sleep Apnea-Hypopnea Syndrome)\n* Use of analgesics, sedatives, or other psychotropic drugs within the past 2 weeks\n* Refusal to sign the informed consent form","7 Years",{"count":116,"type":21},40,[118],"PHASE4","This study uses a prospective, up-and-down sequential allocation method to determine the median effective dose (ED50) and 95% effective dose (ED95) of alfentanil combined with propofol for successful laryngeal mask airway (LMA) insertion in children aged 7-12 undergoing elective day surgery.",[29,121,122,123],"Airway Management","General Anesthesia","LMA",[125,66,29,123,126,127],"Alfentanil","Dixon Method","Effective dose",{"date":129,"type":34},"2026-05-12",{"date":131,"type":21},"2026-05-01",{"date":133,"type":21},"2027-03-30",{"name":135,"class":41},"Zhongshan Ophthalmic Center, Sun Yat-sen University",{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":142,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":51,"minAge":144,"maxAge":53,"enrollmentInfo":145,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":147,"conditions":148,"keywords":152,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":168},"100615172","pediatric-anesthesia-the-childs-voice-100615172","NCT07289152","Pediatric Anesthesia: The Childs Voice","Pediatric Health Empowerment: Improving Children´s Perioperative Experiences With Patient-Reported Measures","PHEASE","Inclusion Criteria:\n\n* Pediatric patients aged 4-12, American Society of\n* Anesthesiologists physical status classification (ASA) I-III\n* undergoing surgery\n\nExclusion Criteria:\n\n* Children with cognitive or sensory disorders\n* children or parents who do not speak Danish,\n* patients for whom there is no consent to participate.","4 Years",{"count":146,"type":21},250,"In Denmark, around 25,000 children under 18 undergo general anesthesia annually. Hospital stays and anesthesia can induce significant anxiety and stress in children due to unfamiliar environments, procedures, and communication issues. This anxiety can be linked to postoperative complications such as emergence delirium and may negatively impact both the child and their family's well-being. Engaging patients actively in their healthcare, including pediatric cases, is essential for improving outcomes. Assessing perioperative patient and family outcomes, particularly through patient-reported outcome measures (PROM) and patient-reported experience measures (PREM), can significantly enhance the quality of care provided to children. While PROMs are widely used in adults, they are less common in pediatric settings. The Pediatric Scale for Quality of Recovery (PedSQoR), developed by Australian and American researchers, is one such tool designed to measure recovery in children. This study aims to translate andvalidate the PedSQoR for Danish children aged 4-12. Furthermore, no existing instruments comprehensively assess pediatric surgery patients' experiences under general anesthesia, particularly from the child's perspective without relying on parents as proxies. Empowering children to express their healthcare experiences gives healthcare workers an insight into what matters for children and gives children a more positive outlook on healthcare, benefiting lifelong engagement.\n\nStudy Aims and Objectives: The study aims to enhance the assessment of children's outcomes and experiences in perioperative settings, ultimately improving pediatric perioperative healthcare. The objectives include:\n\n1. Translation and Adaptation: a. Translate and adapt the PedSQoR for Danish children aged 4-12. b. Validate the Danish PedSQoR version.\n2. Development of a PREM Instrument: a. Develop a comprehensive PREM for children's experiences during surgery and anesthesia. b. Pilot-test and adjust the PREM questionnaire with a group of children aged 4-12.\n\nStudy Methods:\n\n1. PedSQoR Translation and Validation:\n\n   A single-center prospective cohort study will adapt and test the PedSQoR for Danish children. The process involves translating the 21-item scale, validating it with a sample size of 150, and ensuring reliability through various statistical methods, including Cronbach's Alpha and test-retest reliability. Data will be collected from the Department of Anesthesiology and Intensive Care at Gødstrup Hospital.\n2. PREM Instrument Development:\n\nThis study will develop a PREM instrument using the Warwick Patient Experiences Framework (WaPEF), which encompasses seven dimensions of patient experience. The process will involve forming a panel of child experts, conducting focus groups, and translating insights into a pictorial questionnaire. The PREM will undergo pilot testing with 20 children to validate its effectiveness in capturing the dimensions of the WaPEF.\n\nResearch Ethics: Given the vulnerability of children in research, this study will prioritize their safety and comfort, ensuring the study's benefits outweigh any potential risks. Informed consent will be obtained from both parents and children. The study will be registered with the Region Central Denmark's list of research projects and will not require approval from the Scientific Ethics Committee.",[29,149,150,151],"Pediatric Surgery","PROMs","PREMs",[153,154,155,156,157,158],"PROM","Patient-reported outcom measues","Children","child","PREM","Patient-reported experience measures","2026-04-22",{"date":161,"type":34},"2026-04-23",{"date":163,"type":34},"2026-01-01",{"date":165,"type":21},"2030-12-31",{"name":167,"class":41},"Gødstrup Hospital",3,{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":174,"acronym":4,"eligibilityCriteria":175,"healthyVolunteers":176,"sex":51,"minAge":177,"maxAge":89,"enrollmentInfo":178,"targetDuration":4,"studyType":22,"phases":180,"briefSummary":181,"conditions":182,"keywords":186,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":200,"locationsCount":42},"100634074","the-effect-of-paedfusor-tci-eleveld-tci-and-sevoflurane-anesthesia-on-postoperative-awakening-agitation-in-pediatric-patients-100634074","NCT07534956","The Effect of Paedfusor TCI, Eleveld TCI, and Sevoflurane Anesthesia on Postoperative Awakening Agitation in Pediatric Patients","Investigation of the Effects of Two Different TCI (Target Controlled Infusion) Models (Paedfusor and Eleveld) and Inhalation Anesthesia on Postoperative Awakening Agitation\u002FDelirium in Pediatric Patients","Inclusion Criteria:\n\n* Children aged 3-10 years\n* Children weighing over 10 kg\n* American Society of Anesthesiologists (ASA) physical condition classification I-II\n* Those who will undergo planned urogenital surgery under general anesthesia\n* Those who have obtained written informed consent from their parents or legal guardians\n\nExclusion Criteria:\n\n* Patients assessed as ASA III or higher\n* Known neurological or psychiatric disorders\n* Developmental delay or cognitive impairment\n* Use of sedatives or psychoactive drugs\n* Allergy or contraindication to the study drugs (propofol or sevoflurane)\n* History of previous adverse reactions to anesthesia\n* Patients requiring emergency surgery\n* Significant liver, kidney, or cardiovascular disease\n* Patients whose parents or legal guardians have not given consent",true,"3 Years",{"count":179,"type":21},150,[24],"Emergence delirium is a common complication in pediatric patients undergoing general anesthesia. The aim of this study is to investigate the incidence of postoperative awakening delirium and agitation in pediatric patients aged 3-10 years (ASA I-II) using two different target-controlled infusion (TCI) methods (Paedfusor and Eleveld) for TIVA, compared to inhalation anesthesia. This study will examine the effect of two different TCI models on postoperative awakening agitation\u002Fdelirium by comparing them with each other and with inhalation anesthesia.",[183,29,184,185],"Emergence Delirium in Pediatric Anesthesia","Postoperative Agitations in Pediatric Patients","Postoperative Nausea and Vomiting (PONV)",[187,188,189,190,191,192],"pediatric anesthesia","paedfusor","eleveld","target controlled infusion","sevoflurane","postoperative agitation","2026-04-11",{"date":195,"type":34},"2026-04-16",{"date":197,"type":34},"2026-01-13",{"date":199,"type":21},"2027-11-30",{"name":201,"class":41},"Marmara University Pendik Training and Research Hospital",{"id":203,"slug":204,"hasResults":11,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":208,"eligibilityCriteria":209,"healthyVolunteers":11,"sex":51,"minAge":52,"maxAge":210,"enrollmentInfo":211,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":213,"conditions":214,"keywords":217,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":221,"lastUpdatePostDateStruct":222,"startDateStruct":224,"completionDateStruct":226,"leadSponsor":228,"locationsCount":42},"100633504","turkish-adaptation-of-the-pediatric-quality-of-recovery-scale-pedsqor-t-100633504","NCT07527546","Turkish Adaptation of the Pediatric Quality of Recovery Scale (PedSQoR-T)","Adaptation of the Pediatric Postoperative Quality of Recovery Scale to the Turkish Population (PedSQoR-T): A Validity and Reliability Study","PedSQoR-T","Inclusion Criteria:\n\n* Pediatric patients aged 2 to 17 years undergoing outpatient surgery or surgery requiring postoperative hospitalization under general anesthesia\n* Patients with an American Society of Anesthesiologists physical status classification of I, II, or III\n* A parent or legal guardian who is the patient's primary caregiver; in cases where there are two parents or caregivers, one parent will complete the form for children aged 2 to 7 years, and for children aged 8 to 17 years, one parent together with the child will complete the form\n* Patients whose parent or legal guardian has provided informed consent and who have provided child assent, when applicable\n\nExclusion Criteria:\n\n* Patients, parents, or legal guardians who do not speak Turkish, or those with a medical history affecting comprehension or communication skills\n* Patients requiring emergency or urgent surgical intervention\n* Developmental delay or severe systemic disease affecting activities of daily living\n* Children using any medication that may affect the central nervous system\n* Parents, legal guardians, or patients who, in the opinion of the investigator, may be unavailable or unlikely to complete the study\n* Patients with severe visual or hearing impairment, or significant cognitive or developmental disorders\n* Patients undergoing surgery under regional anesthesia\n* Patients with severe psychiatric illness, severe anxiety disorders unresponsive to non-pharmacological interventions, or use of psychoactive medications","17 Years",{"count":212,"type":21},300,"This multicenter prospective observational study aims to culturally adapt the Pediatric Quality of Recovery Scale into Turkish and to evaluate the validity and reliability of the Turkish version in pediatric surgical patients. Children aged 2 to 17 years undergoing elective outpatient or inpatient surgery under general anesthesia will be included. Postoperative recovery will be assessed using the Turkish version of the Pediatric Quality of Recovery Scale and a 0 to 100 millimeter visual analog scale, with age-appropriate child self-report or parent-proxy report.",[29,215,216],"Pediatric Postoperative Recovery","Pediatric Enhanced Recovery After Surgery",[218,219,220],"Pediatric Quality of Recovery Scale","Validity","PedSQoR","2026-04-09",{"date":223,"type":34},"2026-04-14",{"date":225,"type":21},"2026-04-10",{"date":227,"type":21},"2026-07-25",{"name":229,"class":41},"Istanbul University - Cerrahpasa",{"id":231,"slug":232,"hasResults":11,"nctId":233,"briefTitle":234,"officialTitle":235,"acronym":236,"eligibilityCriteria":237,"healthyVolunteers":176,"sex":51,"minAge":238,"maxAge":4,"enrollmentInfo":239,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":241,"conditions":242,"keywords":248,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":221,"lastUpdatePostDateStruct":254,"startDateStruct":256,"completionDateStruct":258,"leadSponsor":260,"locationsCount":262},"100633235","giving-children-a-voice-in-paediatric-anaesthesia-100633235","NCT07524049","Giving Children a Voice in Paediatric Anaesthesia","Patient, Parent and Clinician Voices - Establishing National and International Research Priorities for Paediatric Anaesthesia and Perioperative Medicine","TR-VP26","Inclusion Criteria:\n\n* Patients aged 6-16 years\n* Caregivers of patients aged 6-16 years\n* Clinicians working in paediatric perioperative medicine\n\nExclusion Criteria:\n\n* Patients \\\u003C6 and \\>16 years\n* Residence not in Switzerland\n* Inability to understand one of the 3 study languages (german, french, italian)","6 Years",{"count":240,"type":21},1040,"This project will identify the research priorities for paediatric anaesthesia and perioperative medicine in participating countries and highlight areas where further research and information can be provided to optimise the experience of children undergoing medical interventions.\n\nThis is expected to have significant positive impacts on patient and family engagement and interest in research within the community and aids to plan patient\u002F family-centred studies.",[243,29,244,245,246,247],"Perioperative Care","Pain Management","Anxiety","Research Agenda","Research Subjects",[249,187,250,251,252,253],"perioperative medicine","patient perspective","parent perspective","research priorities","survey",{"date":255,"type":34},"2026-04-13",{"date":257,"type":21},"2026-04-27",{"date":259,"type":21},"2027-12-31",{"name":261,"class":41},"Insel Gruppe AG, University Hospital Bern",7,{"id":264,"slug":265,"hasResults":11,"nctId":266,"briefTitle":267,"officialTitle":268,"acronym":4,"eligibilityCriteria":269,"healthyVolunteers":176,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":270,"targetDuration":56,"studyType":57,"phases":4,"briefSummary":272,"conditions":273,"keywords":275,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":282,"startDateStruct":283,"completionDateStruct":285,"leadSponsor":287,"locationsCount":106},"100617807","effects-of-different-inspiratoryexpiratory-ratios-on-respiratory-and-recovery-outcomes-during-dental-procedures-under-general-anesthesia-in-pediatric-patients-100617807","NCT07323420","Effects of Different Inspiratory:Expiratory Ratios on Respiratory and Recovery Outcomes During Dental Procedures Under General Anesthesia in Pediatric Patients","A Clinical Study on the Effects of Different Inspiratory:Expiratory Ratios on Respiratory Function and Recovery in Pediatric Patients Undergoing Dental Procedures Under General Anesthesia","Inclusion Criteria:\n\n* Pediatric patients scheduled for dental procedures under general anesthesia at our faculty.\n* American Society of Anesthesiologists (ASA) Physical Status I or II.\n* Age between 2 and 12 years.\n* Written informed consent obtained from parents or legal guardians.\n\nExclusion Criteria:\n\n* Patients whose parents or legal guardians decline participation.\n* Presence of adenoid hypertrophy \\>30%.\n* Macroglossia or retrognathia.\n* Severe obesity or developmental delay.\n* History of delayed emergence from anesthesia.\n* ASA Physical Status III or higher.\n* Anesthesia duration less than 1 hour or more than 3 hours.\n* Patients with difficult airway management or ventilation.\n* Known pulmonary or airway diseases or anomalies.\n* Use of pharmacological agents that may affect spontaneous respiratory quality.\n* Presence of neuromuscular disorders affecting respiratory function.\n* Age \\\u003C2 years or \\>12 years.\n* Administration of medications intraoperatively or preoperatively that may influence respiratory dynamics during emergence (e.g., atropine, lidocaine, steroids).",{"count":271,"type":21},75,"This observational study aims to evaluate the effects of different inspiratory to expiratory (I:E) ratios (1:2 vs. 1:3) during mechanical ventilation in pediatric patients undergoing dental procedures under general anesthesia. Due to behavioral challenges, dental phobia, or medical conditions, general anesthesia is often required to ensure immobility and cooperation during dental treatments in children.\n\nIn the clinic where the study will be conducted, the I:E ratio is routinely adjusted approximately 20-30 minutes before the end of the procedure to facilitate a smoother transition to spontaneous breathing during emergence from anesthesia. While 1:2 is commonly used, the 1:3 ratio may improve respiratory efficiency and recovery by prolonging the expiratory phase.\n\nThe study aims to compare vital signs, respiratory parameters (heart rate, blood pressure, SpO₂, EtCO₂, respiratory rate), recovery quality, and respiratory complications between the two I:E ratios. The findings aim to optimize ventilation strategies and improve patient comfort and safety during emergence from anesthesia.",[274,29,122],"Respiratory Function",[122,276,277,278,279,280],"Anesthesia Recovery","Emergence from Anesthesia","Mechanical Ventilation","I:E Ratio","Recovery Quality","2026-04-03",{"date":221,"type":34},{"date":284,"type":34},"2026-04-01",{"date":286,"type":21},"2026-11-30",{"name":288,"class":41},"Kırıkkale University",{"id":290,"slug":291,"hasResults":11,"nctId":292,"briefTitle":293,"officialTitle":294,"acronym":4,"eligibilityCriteria":295,"healthyVolunteers":11,"sex":51,"minAge":144,"maxAge":53,"enrollmentInfo":296,"targetDuration":4,"studyType":22,"phases":298,"briefSummary":299,"conditions":300,"keywords":302,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":308,"completionDateStruct":310,"leadSponsor":312,"locationsCount":106},"100624472","comparative-assessment-of-oral-premedication-regimens-in-pediatric-ambulatory-surgery-100624472","NCT07410078","Comparative Assessment of Oral Premedication Regimens in Pediatric Ambulatory Surgery","A Comparative Evaluation of Oral Premedication Regimens in Pediatric Patients Undergoing Ambulatory Surgery","Inclusion Criteria:\n\n* Pediatric patients aged 4-12 years\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Scheduled for elective ambulatory (day-case) surgery\n* Eligible to receive oral premedication\n* Cognitive ability sufficient to complete behavioral and pain scale assessments\n* Written informed consent obtained from a parent or legal guardian\n\nExclusion Criteria:\n\n* ASA physical status III or higher\n* Moderate to severe intellectual disability\n* Moderate to severe autism spectrum disorder\n* Known allergy or contraindication to midazolam, ketamine, or ibuprofen\n* History of sedative or opioid use within the previous 24 hours\n* Complete loss of premedication due to vomiting",{"count":297,"type":21},135,[24],"This prospective, three-arm study aims to evaluate the effects of different oral premedication regimens on venipuncture tolerance in pediatric patients undergoing ambulatory surgery. Children aged 4-12 years scheduled for elective day-case procedures will receive oral midazolam alone, midazolam combined with ibuprofen, or midazolam combined with ketamine prior to anesthesia induction. The primary outcome is the proportion of children with well-tolerated venipuncture, assessed using standardized behavioral and pain scales. Secondary outcomes include anxiety levels, venipuncture success parameters, time to successful intravenous access, and parent and anesthesiologist satisfaction. In cases of inadequate premedication or failed venipuncture, a predefined rescue inhalational induction protocol will be applied to ensure patient safety. The study aims to identify clinically effective premedication strategies that may improve cooperation and reduce distress during intravenous cannulation in pediatric ambulatory anesthesia.",[29,301],"Premedication",[29,301,303,304,245],"Ambulatory surgery","Venipuncture tolerance","2026-03-03",{"date":307,"type":34},"2026-03-05",{"date":309,"type":21},"2026-02-19",{"date":311,"type":21},"2026-09-01",{"name":313,"class":314},"Diskapi Yildirim Beyazit Education and Research Hospital","OTHER_GOV",{"id":316,"slug":317,"hasResults":11,"nctId":318,"briefTitle":319,"officialTitle":320,"acronym":4,"eligibilityCriteria":321,"healthyVolunteers":176,"sex":16,"minAge":52,"maxAge":53,"enrollmentInfo":322,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":324,"conditions":325,"keywords":328,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":330,"lastUpdatePostDateStruct":331,"startDateStruct":333,"completionDateStruct":335,"leadSponsor":336,"locationsCount":106},"100617812","inflammatory-biomarkers-and-postoperative-delirium-in-pediatric-circumcision-100617812","NCT07323485","Inflammatory Biomarkers and Postoperative Delirium in Pediatric Circumcision","Effect of Preoperative Inflammatory Biomarkers on Postoperative Delirium in Children Undergoing Circumcision","Inclusion Criteria:\n\n* Children aged 2-12 years.\n* Patients scheduled to undergo elective circumcision under general anesthesia.\n* Patients classified as ASA physical status I-II.\n* Patients whose parents or legal guardians provide written informed consent, and whose age-appropriate verbal assent is obtained from the child.\n* Patients in whom anesthesia and surgical procedures are performed according to standard institutional protocols throughout the study period.\n\nExclusion Criteria:\n\n* Children with a history of neurological or psychiatric disorders (e.g., epilepsy, developmental delay, autism spectrum disorder, anxiety disorders).\n* Patients classified as ASA physical status III-IV.\n* Patients with incomplete preoperative laboratory data or with hematological or hormonal disorders that may affect inflammatory parameters.\n* Patients who develop excessive sedation after premedication or whose preoperative assessment cannot be completed.\n* Patients with protocol deviations during surgery or anesthesia (e.g., additional medications, prolonged surgical duration, or changes in procedure due to complications).\n* Patients whose parents or legal guardians do not provide consent or who decline participation.",{"count":323,"type":21},140,"Postoperative delirium may occur in children after general anesthesia, even following short procedures such as circumcision. Preoperative systemic inflammation has been associated with postoperative delirium in adults, but data in pediatric patients are limited. This prospective observational study aims to evaluate the association between preoperative inflammatory biomarkers and postoperative delirium in children aged 2-12 years undergoing elective circumcision under general anesthesia. Inflammatory biomarkers derived from routine complete blood count parameters, including NLR, PLR, MLR, SII, and SIRI, will be analyzed. Postoperative delirium will be assessed using the Pediatric Anesthesia Emergence Delirium (PAED) scale in the post-anesthesia care unit. The relationship between inflammatory biomarkers and delirium development and severity will be evaluated. This study seeks to identify simple preoperative markers that may help predict postoperative delirium risk in pediatric patients.",[326,29,327],"Postoperative Delirium","Inflammatory Biomarkers",[329,29,327,326],"Circumcision","2026-02-18",{"date":332,"type":34},"2026-02-20",{"date":334,"type":34},"2026-01-18",{"date":227,"type":21},{"name":337,"class":314},"Ankara Etlik City Hospital",{"id":339,"slug":340,"hasResults":11,"nctId":341,"briefTitle":342,"officialTitle":343,"acronym":4,"eligibilityCriteria":344,"healthyVolunteers":11,"sex":51,"minAge":56,"maxAge":53,"enrollmentInfo":345,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":347,"conditions":348,"keywords":350,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":352,"lastUpdatePostDateStruct":353,"startDateStruct":355,"completionDateStruct":357,"leadSponsor":359,"locationsCount":106},"100622514","preoperative-prediction-of-difficult-airway-in-children-100622514","NCT07384611","Preoperative Prediction of Difficult Airway in Children","Prediction of Difficult Airway in Pediatric Patients Using Preoperative Clinical Parameters","Inclusion Criteria:\n\n* Pediatric patients aged 0-12 years\n* Scheduled for elective surgery requiring endotracheal intubation under general anesthesia\n* ASA physical status I-III\n* Written informed consent obtained from parent(s) or legal guardian(s)\n\nExclusion Criteria:\n\n* Patients older than 12 years\n* ASA physical status IV or higher\n* Emergency situations that do not allow systematic documentation of the airway management process\n* Presence of a congenital or acquired tracheostomy\n* Surgical procedures planned to be performed using a supraglottic airway without endotracheal intubation\n* Surgical procedures planned to be performed using face mask ventilation without endotracheal intubation\n* Inability to obtain parental or legal guardian consent",{"count":346,"type":21},1000,"This prospective observational study aims to evaluate the predictive value of preoperative clinical airway assessment parameters for difficult airway management in pediatric patients undergoing elective surgery under general anesthesia. Preoperative clinical measurements and bedside airway tests will be recorded, and their association with intraoperative airway outcomes, including difficult laryngoscopy and difficult intubation, will be analyzed. Difficult laryngoscopy will be defined as Cormack-Lehane grade III-IV, while secondary outcomes will include difficult intubation, difficult mask ventilation, and airway-related complications. The study seeks to identify clinically applicable predictors and improve preoperative risk stratification for pediatric airway management. The findings may contribute to safer anesthetic practice in children by facilitating early identification of patients at increased airway risk.",[29,349],"Difficult Laryngoscopy",[29,349,351],"Difficult Airway","2026-02-10",{"date":354,"type":34},"2026-02-11",{"date":356,"type":34},"2026-02-02",{"date":358,"type":21},"2027-05-20",{"name":313,"class":314},{"id":361,"slug":362,"hasResults":11,"nctId":363,"briefTitle":364,"officialTitle":365,"acronym":4,"eligibilityCriteria":366,"healthyVolunteers":11,"sex":51,"minAge":367,"maxAge":238,"enrollmentInfo":368,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":370,"conditions":371,"keywords":376,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":356,"lastUpdatePostDateStruct":379,"startDateStruct":380,"completionDateStruct":381,"leadSponsor":383,"locationsCount":106},"100623587","comparison-of-caudal-and-quadratus-lumborum-blocks-with-pain-monitoring-in-children-100623587","NCT07398573","Comparison of Caudal and Quadratus Lumborum Blocks With Pain Monitoring in Children","Comparison of the Analgesic Efficacy of Caudal and Quadratus Lumborum Blocks With Pain Monitoring in Lower Abdominal Surgery in Children","Inclusion Criteria:\n\n1. Pediatric patients between 2 months and 6 years of age\n2. Pediatric patients undergoing lower abdominal surgery\n3. Family consent must be obtained\n4. No contraindications to block (infection at the block site), coagulopathy (INR \\\u003C1.4, platelets \\>100,000), local anesthetic allergy)\n5. ASA I-II patients\n\nExclusion Criteria:\n\n1. Severe systemic disease (ASA ≥III)\n2. Infection at the block site\n3. Coagulopathy (INR \\>1.4, platelets \\\u003C100,000)\n4. Local anesthetic allergy\n5. Parental refusal\n6. Children aged \\\u003C2 months or \\>6 years","2 Months",{"count":369,"type":21},68,"Study Type: Prospective, Randomized, Observational Clinical Study\n\nPrimary Purpose:\n\nThe primary objective of this study is to compare the analgesic efficacy of caudal block (CB) and quadratus lumborum block (QLB) in children undergoing lower abdominal surgery using objective pain monitoring methods.\n\nKey Questions Addressed:\n\nDoes the quadratus lumborum block provide superior intraoperative and postoperative analgesia compared to the caudal block, as measured by the Pain Monitor (PAM) and the FLACC scale?\n\nIs the PAM monitor a reliable tool for objectively assessing nociception and pain in children who are unable to verbally express pain?\n\nWhich regional anesthesia technique more effectively delays the time to first postoperative analgesic requirement and reduces total analgesic consumption?\n\nWhich method is associated with higher parental satisfaction and fewer postoperative side effects, such as postoperative nausea and vomiting?\n\nComparison Groups:\n\nChildren receiving ultrasound-guided quadratus lumborum block will be compared with those receiving caudal block.\n\nIntervention Group:\n\nBilateral quadratus lumborum block with 0.5 mL\u002Fkg of 0.25% bupivacaine.\n\nActive Comparator Group:\n\nCaudal block with 1 mL\u002Fkg of 0.125% bupivacaine.\n\nParticipant Population:\n\nA total of 68 children, aged 2 months to 6 years, with ASA physical status I-II, scheduled for elective lower abdominal surgeries (e.g., inguinal hernia repair, orchiopexy, hydrocele).\n\nWhat Participants Will Do:\n\nParticipants will receive the assigned regional block as part of standard anesthetic care. Observational data will be collected as follows:\n\nIntraoperative: Continuous nociception monitoring using the PAM device at predefined time points (during laryngeal mask airway insertion, block performance, surgical incision, 20 minutes after block performance, and extubation).\n\nPostoperative: Pain assessment using the FLACC scale at 1, 2, and 4 hours in the post-anesthesia care unit.\n\nRescue analgesia (intravenous paracetamol) will be administered if the FLACC score is ≥4. Time to first analgesic administration and total analgesic consumption will be recorded.\n\nAdditional outcomes include postoperative nausea and vomiting (PONV) scores, Steward recovery scores, and parental satisfaction scores assessed using the Pediatric Parental Satisfaction Scale (PPPS).\n\nPrimary Outcome:\n\nIntraoperative PAM index scores.\n\nSecondary Outcomes:\n\nPostoperative FLACC scores, time to first analgesic requirement, total postoperative analgesic consumption, incidence and severity of PONV, Steward recovery scores, and parental satisfaction (PPPS) scores.",[372,373,374,375,29],"Regional Anesthesia Success","Pain Monitor During Anesthesia","Quadratus Lumborum Nerve Block","Caudal Block for Postoperative Analgesia",[29,377,378],"Regional Block","Pain Monitoring",{"date":352,"type":34},{"date":356,"type":21},{"date":382,"type":21},"2026-04-30",{"name":337,"class":314},{"id":385,"slug":386,"hasResults":11,"nctId":387,"briefTitle":388,"officialTitle":389,"acronym":4,"eligibilityCriteria":390,"healthyVolunteers":176,"sex":51,"minAge":4,"maxAge":391,"enrollmentInfo":392,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":393,"conditions":394,"keywords":398,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":405,"lastUpdatePostDateStruct":406,"startDateStruct":408,"completionDateStruct":410,"leadSponsor":412,"locationsCount":106},"100618609","a-new-landmark-formula-for-cephalic-vein-in-children-100618609","NCT07333846","A New Landmark-formula for Cephalic Vein in Children","Development of a Landmark-formula for Distal Cephalic Vein Localization and Validation Study of Accuracy in Pediatric Patients","Inclusion Criteria:\n\n* Children under the age of 6 years\n* Scheduled elective procedure under general anesthesia\n* Admission via the surgical day clinic\n* Written informed consent by the parents (and by the child if capable of judgment)\n\nExclusion Criteria:\n\n* pre-existing intravenous access at the investigation site\n* Skin conditions or infections at the forearm site\n* Known allergy to EMLA or any of its components","5 Years",{"count":271,"type":21},"In children undergoing surgery, a venous access line almost always has to be placed. Through this line, medications and fluids can be administered during anesthesia or later during the hospital stay. In young children, it is often difficult to find a suitable vein. This can lead to multiple puncture attempts and may be a traumatic experience for both children and their parents. With ultrasound, however, in such difficult cases a specific vein on the forearm (the \"cephalic vein\") can usually be visualized and cannulated. Mostly, this vein is not visible to the naked eye.\n\nIn our research project, we aim to determine whether it is possible to identify a simple and reliable anatomical orientation aid (\"landmark\") on the forearm that enables parents to place a topical anesthetic EMLA patch precisely at the correct location where the vein can subsequently be found using ultrasound. In this way, we want to assess whether this method simplifies the preparation for venipuncture and thereby increases the success rate. The examination is carried out during the routine preparation for anesthesia.\n\nIn a first step, the course of the vein is identified by ultrasound, marked on the skin in a controlled manner, and photographic documentation of the forearm region is created. From this, a visual orientation guide describing the landmark is developed. In a second step, parents and staff of the anesthesia department mark the defined landmark using this visual orientation guide. Ultrasound is then used again to verify whether the vein is located at the marked site. No additional needle puncture is performed and no additional blood sample is taken.",[395,396,397,29],"Venipuncture","Ultrasound","Difficult Intravenous Access in Pediatrics",[399,400,401,402,403,404],"landmark","peripheral venous access","cephalic vein","vena cephalica","ultrasound-guided venipuncture","ultrasound-guided placement intravenous line","2026-01-27",{"date":407,"type":34},"2026-01-29",{"date":409,"type":34},"2026-01-06",{"date":411,"type":21},"2027-05-31",{"name":413,"class":41},"Alexander Schmidt",{"id":415,"slug":416,"hasResults":11,"nctId":417,"briefTitle":418,"officialTitle":419,"acronym":420,"eligibilityCriteria":421,"healthyVolunteers":11,"sex":51,"minAge":391,"maxAge":422,"enrollmentInfo":423,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":425,"conditions":426,"keywords":431,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":438,"lastUpdatePostDateStruct":439,"startDateStruct":441,"completionDateStruct":443,"leadSponsor":445,"locationsCount":106},"100611817","comparison-of-vidiac-pediac-and-intubation-difficulty-scale-in-pediatric-patients-undergoing-videolaryngoscopic-intubation-100611817","NCT07245511","Comparison of VIDIAC, PeDiAC and Intubation Difficulty Scale in Pediatric Patients Undergoing Videolaryngoscopic Intubation","A Prospective Observational Study Comparing the VIDIAC, PeDiAC, and Intubation Difficulty Scale (IDS) in Pediatric Patients Aged 5-18 Years Undergoing Tracheal Intubation With Videolaryngoscopy","VIDIPEDIDS","Eligible participants will be pediatric patients aged 5 to 18 years who are undergoing general anesthesia for any surgical procedure. All included patients must undergo tracheal intubation using a videolaryngoscope (C-MAC). Patients must have an ASA physical status classification of I to IV and written informed consent must be obtained from a parent or legal guardian prior to participation.\n\nInclusion Criteria:\n\n* Pediatric patients between 5 and 18 years of age\n* Undergoing general anesthesia for any type of surgical procedure\n* ASA physical status classification I to IV\n* Written informed consent obtained from parents or legal guardians\n\nExclusion Criteria:\n\n* Patients undergoing awake fiberoptic intubation\n* History of tracheal resection or reconstruction surgery\n* Refusal to participate or absence of informed consent","18 Years",{"count":424,"type":21},450,"This prospective observational study aims to evaluate three scoring systems (VIDIAC (Video Laryngoscopic Intubation and Difficult Airway Classification), PeDiAC (Pediatric Difficult Airway Classification), and the Intubation Difficulty Scale (IDS)).\n\nA total of 450 children undergoing general anesthesia with videolaryngoscopic intubation will be included in the study. Demographic data, intraoperative parameters, and glottic imaging, as well as detailed intubation-related variables such as total intubation time, number of attempts, complications, and subjective intubation ease scores will be recorded.",[427,428,429,430,29],"Videolaryngoscopy","Intubation Difficulty Scale","Vidiac Score","Difficult Airway Intubation",[432,433,434,435,436,437],"intubation difficulty scale (IDS)","VIDIAC","PeDiAC","Pediatric anesthesia","videolaryngoscopy","airway management","2025-11-17",{"date":440,"type":34},"2025-11-24",{"date":442,"type":34},"2025-10-16",{"date":444,"type":21},"2026-04-15",{"name":446,"class":41},"Ankara City Hospital Bilkent",{"id":448,"slug":449,"hasResults":11,"nctId":450,"briefTitle":451,"officialTitle":451,"acronym":4,"eligibilityCriteria":452,"healthyVolunteers":176,"sex":51,"minAge":453,"maxAge":454,"enrollmentInfo":455,"targetDuration":4,"studyType":22,"phases":457,"briefSummary":458,"conditions":459,"keywords":460,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":464,"lastUpdatePostDateStruct":465,"startDateStruct":467,"completionDateStruct":469,"leadSponsor":471,"locationsCount":106},"100315287","phase-4-effect-of-dexmedetomidine-on-the-minimum-alveolar-concentration-of-sevoflurane-100315287","NCT03384563","Effect of Dexmedetomidine on the Minimum Alveolar Concentration of Sevoflurane","Exclusion Criteria:\n\n1. Interstitial lung disease, chest wall disease, or bronchospastic disease with no flare-ups in the past 2 weeks of presentation\n2. History of difficult intubation or ventilation\n3. Airway malformation\n4. Congenital heart disease\n5. Cardiac arrhythmias\n6. Central nervous system disease, including developmental delay, cerebral palsy, or seizure disorder\n7. History of or family history of malignant hyperthermia\n8. Electrolyte disorders\n9. Gastrointestinal disease\n10. Hepatic dysfunction\n11. Renal dysfunction\n12. Metabolic disease, such as diabetes\n13. Obesity, defined as a body mass index greater than the 95% percentile for age\n14. Preterm infant (less than 37 weeks gestational age) 15. Use of any medications (anticonvulsants, opioids, benzodiazepines, antibiotics, antihistamines drugs that induce hepatic enzymes) that may affect MAC.\n\nInclusion Criteria\n\nAll patients age 1 month- 3 years presenting for surgery.","1 Month","36 Months",{"count":456,"type":21},180,[118],"The purpose of this protocol is to determine the effect of two clinically applicable Dexmedetomidine dosages (0.5mcg\u002Fkg and 1mcg\u002Fkg) on the minimum alveolar concentration (MAC) of Sevoflurane in children between the age ranges of: 1-6 months; 6-12 months of age and 12 months-36 months years of age.",[29],[461,462,463],"pediatric","anesthesia","dexmedetomidine","2025-09-17",{"date":466,"type":34},"2025-09-22",{"date":468,"type":34},"2018-02-18",{"date":470,"type":21},"2025-12-31",{"name":472,"class":41},"Baylor College of Medicine",{"id":474,"slug":475,"hasResults":11,"nctId":476,"briefTitle":477,"officialTitle":478,"acronym":4,"eligibilityCriteria":479,"healthyVolunteers":11,"sex":51,"minAge":480,"maxAge":481,"enrollmentInfo":482,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":484,"conditions":485,"keywords":486,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":489,"lastUpdatePostDateStruct":490,"startDateStruct":492,"completionDateStruct":493,"leadSponsor":495,"locationsCount":106},"100604326","inflammatory-biomarkers-as-predictors-of-ponv-following-pediatric-orchiopexy-100604326","NCT07148063","Inflammatory Biomarkers as Predictors of PONV Following Pediatric Orchiopexy","Association of Preoperative Inflammatory Biomarkers With Postoperative Nausea and Vomiting in Children Undergoing Orchiopexy","Inclusion Criteria:\n\n* Patients aged between 1 and 8 years\n* Patients with ASA physical status I-II\n* Patients scheduled for elective orchiopexy\n* Obtained written informed consent from parents\u002Fguardians\n\nExclusion Criteria:\n\n* Patients younger than 1 year or older than 8 years\n* Patients with ASA physical status III or higher\n* Presence of acute infection signs\n* History of previous nausea or vomiting","1 Year","8 Years",{"count":483,"type":21},170,"Orchiopexy is a common surgical procedure for the treatment of cryptorchidism in the pediatric population, with a high incidence of postoperative nausea and vomiting (PONV).\n\nRecent evidence suggests that systemic inflammation may contribute to PONV pathogenesis, and preoperative inflammatory biomarkers such as NLR, PLR, SII, MLR, and SIRI could serve as predictive indicators.\n\nThis prospective observational study aims to evaluate the relationship between these biomarkers and PONV incidence in children undergoing orchiopexy.",[29,185,327],[435,487,185,488],"Orchiopexy","Inflammatory biomarkers","2025-09-08",{"date":491,"type":34},"2025-09-09",{"date":489,"type":34},{"date":494,"type":21},"2026-03-27",{"name":313,"class":314},{"id":497,"slug":498,"hasResults":11,"nctId":499,"briefTitle":500,"officialTitle":501,"acronym":502,"eligibilityCriteria":503,"healthyVolunteers":11,"sex":51,"minAge":480,"maxAge":53,"enrollmentInfo":504,"targetDuration":56,"studyType":57,"phases":4,"briefSummary":505,"conditions":506,"keywords":509,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":514,"lastUpdatePostDateStruct":515,"startDateStruct":517,"completionDateStruct":519,"leadSponsor":521,"locationsCount":106},"100599472","comparison-of-the-surgical-pleth-index-and-the-nociception-level-index-in-the-pediatric-population-100599472","NCT07084935","Comparison of the Surgical Pleth Index and the Nociception Level Index in the Pediatric Population","Comparison of the Surgical Pleth Index and the Nociception Level Index in the Pediatric Population: An Observational Study","NOLvsSPI","Inclusion Criteria:\n\n* Male or female\n* ASA I, ASA II and ASA III\n* Aged 1 to 12 years old\n* Scheduled to undergo elective surgery with general anaesthesia\n\nExclusion Criteria:\n\n* Patients with chronic pain\n* Patients with chronic analgesia usage.\n* Known allergy to the adhesives used in the sensors.\n* No free available limb to attach the probes to.",{"count":116,"type":21},"This observational study aims to compare two nociception monitoring methods. The Nociception Level (NOL) index and the Surgical Pleth Index (SPI) in the pediatric population during general anesthesia. While both monitors are designed to assess nociceptive responses through autonomic nervous system activity, they differ in methodology and parameters measured. The NOL index integrates multiple physiological signals using a self-learning algorithm, while SPI focuses on heart rate variability and plethysmographic amplitude. Although both have been studied individually in children, a direct comparison has not yet been conducted. This study will evaluate and compare each monitor's ability to detect and quantify nociceptive stimuli (surgical and tetanic) in children.\n\nThe investigators hypothesize that the NOL monitor and SPI monitor will both be able to quantify surgical stimuli and tetanic stimuli with monitors response to surgical stimuli \\> monitors response to tetanic stimuli. However, the investigators also hypothesize that the NOL index will do this superiorly, as it utilizes a self-learning algorithm and more parameters are incorporated in its algorithm",[507,60,29,508],"Nociceptive Pain","Nociception Monitoring",[510,511,512,513],"Nociception monitoring","Pediatric population","NOL index","Surgical pleth index","2025-07-24",{"date":516,"type":34},"2025-07-25",{"date":518,"type":34},"2025-07-04",{"date":520,"type":21},"2026-07-31",{"name":522,"class":41},"Radboud University Medical Center",{"id":524,"slug":525,"hasResults":11,"nctId":526,"briefTitle":527,"officialTitle":527,"acronym":4,"eligibilityCriteria":528,"healthyVolunteers":176,"sex":51,"minAge":480,"maxAge":529,"enrollmentInfo":530,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":532,"conditions":533,"keywords":537,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":542,"lastUpdatePostDateStruct":543,"startDateStruct":545,"completionDateStruct":547,"leadSponsor":549,"locationsCount":4},"100592519","comparison-of-the-effects-of-endotracheal-intubation-and-laryngeal-mask-applications-on-optic-nerve-diameter-in-pediatric-patients-100592519","NCT06994481","Comparison of the Effects of Endotracheal Intubation and Laryngeal Mask Applications on Optic Nerve Diameter in Pediatric Patients","Inclusion Criteria:\n\n1. Classified as American Society of Anesthesiologists (ASA) physical status I or II,\n2. Aged between 1 and 11 years,\n3. Scheduled to receive general anesthesia,\n4. Planned to be ventilated via endotracheal intubation or laryngeal mask airway (LMA).\n\nExclusion Criteria:\n\n1. Families who do not provide informed consent,\n2. Patients with a tracheostomy,\n3. History of previous intracranial surgery (e.g., tumor resection or shunt placement),\n4. History of preoperative seizures,\n5. Presence of craniofacial deformities that may prevent accurate optic nerve sheath diameter (ONSD) measurement,\n6. Infection, wound, or any other condition in the measurement area that may interfere with ONSD assessment,\n7. Presence of conditions that may increase intracranial pressure and affect ONSD measurement (e.g., tumor, encephalitis, meningitis, or intracranial infection),\n8. Patients who require a change in the endotracheal tube or laryngeal mask airway (LMA) size during the operation, or who undergo a second intubation or insertion attempt,\n9. Patients who withdraw from the study.","11 Years",{"count":531,"type":21},200,"This clinical study aims to investigate the effects of breathing tubes, which we use to connect children aged 1-11 to a respiratory device under general anesthesia in the operating room, on intracranial pressure after they are inserted. No changes will be made to routine anesthesia practices for this purpose, and eye examinations will be performed with an USG device. This study has no undesirable effects or risks. This study does not include any invasive procedures. You have the right to refuse to participate in the study. You have the right to withdraw from the study at any time. If you decide not to participate in the study for any reason, there will be no disruption to your treatment. You will not be liable for any financial loss if you participate in the study, and you will not be paid. Your identity will be kept confidential if you participate in the study.",[534,29,535,536],"Optic Nerve Sheath Diameter","Intubation","Laryngeal Mask Airways",[538,539,540,541],"optic nerve sheath diameter","pediatric patients","intubation","laryngeal mask airway","2025-05-20",{"date":544,"type":34},"2025-05-29",{"date":546,"type":21},"2025-06-01",{"date":548,"type":21},"2026-06-01",{"name":201,"class":41},{"id":551,"slug":552,"hasResults":11,"nctId":553,"briefTitle":554,"officialTitle":555,"acronym":4,"eligibilityCriteria":556,"healthyVolunteers":11,"sex":51,"minAge":557,"maxAge":558,"enrollmentInfo":559,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":561,"conditions":562,"keywords":566,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":570,"lastUpdatePostDateStruct":571,"startDateStruct":573,"completionDateStruct":574,"leadSponsor":576,"locationsCount":106},"100551973","frequency-of-adverse-events-in-pediatric-patients-receiving-sedation-for-magnetic-resonance-imaging-100551973","NCT06467045","Frequency of Adverse Events in Pediatric Patients Receiving Sedation for Magnetic Resonance Imaging","Frequency of Adverse Events and Factors Causing Adverse Events in Pediatric Patients Receiving Sedation for Magnetic Resonance Imaging: Observational Study","Inclusion Criteria:\n\n* All non-intubated patients under the age of 16 were included in the study.\n\nExclusion Criteria:\n\n* Intubated pediatric patients or older than 16 years patients were excluded.","0 Days","16 Years",{"count":560,"type":21},500,"Introduction:The application of anesthesia outside the operating room for pediatric patients has increased in recent years. For diagnostic and treatment follow-up purposes, magnetic resonance imaging (MRI) requires the pediatric patient to remain still, necessitating sedation. The study aimed to determine the frequency of adverse effects and influencing factors in pediatric patients undergoing sedation during MRI.\n\nMethods: Between 19.06.2024 and 16.09.2024, estimated 500 pediatric patients who underwent MRI under sedation will be prospectively observed. All non-intubated patients under the age of 16 will be included in the study. The demographic data, comorbidities, and medications of the patients, the procedures performed, the anesthetic drugs used, the expertise duration of the anesthesiologist, and the adverse effects encountered will be recorded.",[563,29,564,565],"Sedation","Magnetic Resonance Imaging","Adverse Effect",[461,567,568,569,462],"adverse effects","magnetic resonance imaging","sedation","2024-06-24",{"date":572,"type":34},"2024-06-25",{"date":570,"type":34},{"date":575,"type":21},"2024-10-05",{"name":577,"class":41},"Sisli Hamidiye Etfal Training and Research Hospital"]