[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pediatric-brain-tumors\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pediatric-brain-tumors":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,42,70],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":4},"100625798","role-of-arterial-spin-labelling-magnetic-resonance-prefusion-in-grading-of-pediatric-brain-tumors-100625798",false,"NCT07427316","Role of Arterial Spin Labelling Magnetic Resonance Prefusion in Grading of Pediatric Brain Tumors","Role of Arterial Spin Labelling Magnetic Resonance Perfusion in The Grading of Pediatric Brain Tumors","Inclusion Criteria:\n\n1. Pediatric patients aged 18 years or younger.\n2. Patients with radiological diagnosis of intracranial brain tumors.\n\nExclusion Criteria:\n\n1. Patients who have received prior surgery, chemotherapy or radiotherapy for brain tumors.\n2. Patients with contraindications to magnetic resonance imaging (MRI) examination.","ALL","0 Years","18 Years",{"count":20,"type":21},20,"ESTIMATED","OBSERVATIONAL","To evaluate the diagnostic performance of arterial spin labelling (ASL) magnetic resonance perfusion in preoperative grading of pediatric brain tumors.",[25],"Pediatric Brain Tumors",[27,28,29],"ASL MRI","arterial spin labelling","magnetic resonance perfusion","NOT_YET_RECRUITING","2026-02-20",{"date":33,"type":34},"2026-02-23","ACTUAL",{"date":36,"type":21},"2026-03",{"date":38,"type":21},"2028-04",{"name":40,"class":41},"Assiut University","OTHER",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":18,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":69},"100625010","genodrugp-2025-study-on-three-dimensional-models-derived-from-brain-tumors-in-pediatric-patients-100625010","NCT07417072","GenoDrugP 2025: Study on Three-dimensional Models Derived From Brain Tumors in Pediatric Patients","Preliminary Study With Biological Samples, Single-center, Non-profit, to Identify Biological Mechanisms and Resistance to Therapies in Three-dimensional Models Derived From Brain Tumors in Pediatric Patients.","Inclusion Criteria:\n\n* Patients aged 3-18 years with suspected brain tumours undergoing neurosurgery\n* No previous bone marrow transplants or other haematological procedures that could potentially interfere with germline analysis.\n* Patients who have not received any systemic anticancer treatment (including chemotherapy, radiotherapy or targeted therapies) prior to enrolment surgery.\n* Signature of informed consent\n\nExclusion Criteria:\n\n* Subsequent histological confirmation of non-neoplastic brain pathology (e.g. malformations, inflammatory lesions, demyelinating processes).\n* Insufficient quantity or quality of tumour tissue or peripheral blood for the analyses required by the protocol.\n* Presence of serious clinical conditions, systemic infections or haemodynamic instability that contraindicate the collection of biological samples or inclusion in the study.","3 Years",{"count":51,"type":21},50,"INTERVENTIONAL",[54],"NA","Central nervous system tumours are the most common solid tumours and the leading cause of cancer mortality in children, with high biological and prognostic heterogeneity. Despite advances in the 2021 WHO molecular classifications, treatment options remain limited and often ineffective in high-grade tumours. New third-generation sequencing technologies and three-dimensional models derived from patient tumours offer promising tools for more comprehensive genomic characterisation and preclinical evaluation of drug responses. However, the lack of integrated preclinical studies remains a limitation, necessitating coordinated projects to develop personalised therapeutic strategies. The study aims to investigate the genetic and biological characteristics of paediatric brain tumours. To this end, tumour tissue samples taken during planned surgery and peripheral blood samples will be analysed. Advanced genetic analyses will be performed on these materials to identify tumour alterations and the patient's genetic characteristics. In addition, experimental in vitro models derived from the tumour will be developed to evaluate the response to different chemotherapy drugs. The information obtained will be used to better understand the mechanisms of tumour growth and resistance and to promote the future development of more targeted and personalised therapies.",[25,57,58],"Genomics","Epigenetic","RECRUITING","2026-02-10",{"date":62,"type":34},"2026-02-18",{"date":64,"type":34},"2025-10-21",{"date":66,"type":21},"2026-10",{"name":68,"class":41},"Meyer Children's Hospital IRCCS",1,{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":76,"enrollmentInfo":77,"targetDuration":79,"studyType":22,"phases":4,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":99},"100602884","pediatric-radiation-therapy-registry-100602884","NCT07129317","Pediatric Radiation Therapy Registry","Inclusion Criteria:\n\n* Treatment with either proton or photon radiation therapy.\n\nExclusion Criteria:\n\n* Greater than 26 years old","26 Years",{"count":78,"type":21},5000,"10 Years","The Johns Hopkins Pediatric Radiation Oncology Program is creating a registry that will capture the full 3D radiation dosimetry delivered to its pediatric patients to manage the quality of care provided, as well as to examine the long-term outcomes and toxicity of each patient. The registry will capture baseline clinical data, disease, toxicity, and quality of life outcomes. The goal is to include all pediatric patients undergoing proton therapy and photon therapy to enable future comparisons of treatment outcomes.",[82,25],"Sarcoma",[84,85,86,87,88,89],"Pediatric","Brain tumor","Registry","Proton radiation","Radiation therapy","Photon radiation","2025-11-04",{"date":92,"type":34},"2025-11-05",{"date":94,"type":34},"2025-10-31",{"date":96,"type":21},"2040-09",{"name":98,"class":41},"Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins",2]