[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pediatric-cancer-patients\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pediatric-cancer-patients":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,50,89],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100642389","evaluation-of-an-exercise-intervention-during-intensive-medical-treatment-in-pediatric-oncology-100642389",false,"NCT07647471","Evaluation of an Exercise Intervention During Intensive Medical Treatment in Pediatric Oncology.","Evaluation of an Exercise Intervention During Intensive Medical Treatment in Pediatric Oncology (Evaluation BEwegungs- Und sPorttherapeutischer Interventionen Unter Medizinischer Therapie in Der Pädiatrischen Onkologie)","BEPPO","Inclusion Criteria:\n\n* Patients aged ≥3 and ≤18 years\n* Oncological diagnosis with curative treatment intent\n* ≤6 weeks since cancer diagnosis (diagnosis can be initial, secondary or relapse diagnosis)\n* Information and consent procedures feasible in German, English or with using local site resources (e.g., interpreters or multilingual staff)\n* Communication with the patient is possible in German, English or with using local site resources (e.g., interpreters or multilingual staff) during the assessments and intervention\n* Patients insured by German statutory health insurers\n\nExclusion Criteria:\n\n* Patients aged \\\u003C3 and \\>18 years\n* No active medical oncological treatment (e.g., watch-and-wait strategy, surgery without ongoing oncological acute treatment at a pediatric oncology center)\n* Medical limitations that do not allow implementation of the study protocol\n* Life expectancy \\\u003C 6 months\n* Patients not insured by German statutory health insurers (e.g., Privatly insured patients, self-paying patients)","ALL","3 Years","18 Years",{"count":21,"type":22},346,"ESTIMATED","INTERVENTIONAL",[25],"NA","The BEPPO study is a Germany-wide clinical trial investigating whether a structured exercise program can improve physical and mental health in children and adolescents undergoing cancer treatment. Although exercise is known to support recovery and well-being, it is not yet a standard part of pediatric oncology care. The study aims to generate evidence to support the integration of exercise into routine treatment.\n\nA total of 346 patients aged 3 to 18 years are recruited across 13 pediatric oncology centers in Germany. Participants are randomly assigned to either an exercise intervention group or a standard care control group.\n\nChildren in the intervention group take part in a 6-month individualized exercise program with 3-5 sessions per week. The program is delivered across different settings, including inpatient hospital care, outpatient treatment, and home-based training supported by telemedicine. This ensures continuous support throughout the course of medical treatment.\n\nIn addition to supervised exercise sessions, participants receive four structured counseling sessions. These sessions aim to strengthen motivation, address individual barriers to participation, and support long-term engagement in physical activity. The counseling also helps build a strong therapeutic relationship and promotes adherence to the program.\n\nThe exercise intervention is based on established principles of sports science but is individually adapted to each patient's health status, treatment phase, and personal preferences. Each training session follows a structured plan with specific goals, while also considering individual physical and psychological conditions to ensure safety, feasibility, and effectiveness.\n\nThe main objective of the BEPPO study is to improve physical performance, particularly leg strength, which is the primary endpoint. Secondary outcomes include endurance, functional mobility, balance, physical activity levels, fatigue, quality of life, mental well-being, frailty, and treatment-related symptoms and side effects.\n\nIn addition to clinical effectiveness, the study also evaluates how well the intervention can be implemented in routine healthcare settings. This includes assessing adherence, feasibility, and potential barriers and facilitators for integrating exercise into standard care. A health economic evaluation is also conducted in collaboration with health insurance providers to determine cost implications.\n\nOverall, the BEPPO study aims to provide robust scientific evidence on the benefits and feasibility of structured exercise during pediatric cancer treatment. The long-term goal is to establish exercise as a standard component of supportive care in pediatric oncology, improving both short- and long-term outcomes for patients.",[28],"Pediatric Cancer Patients",[30,31,32,33,34,35,36],"Knee extensor strength","Quality of Life","Fatigue","Health economics","Implementation","Physical activity","Exercise","NOT_YET_RECRUITING","2026-06-09",{"date":40,"type":41},"2026-06-15","ACTUAL",{"date":43,"type":22},"2026-07-01",{"date":45,"type":22},"2028-12-31",{"name":47,"class":48},"Universität Duisburg-Essen","OTHER",13,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":70,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":49},"100621281","real-world-pediatric-oncology-rehabilitation-in-italy--rewori--100621281","NCT07368582","Real World Pediatric Oncology Rehabilitation in Italy ( ReWori )","Real World Pediatric Oncology Rehabilitation in Italy (ReWori) Study Protocol: Prognostic Factors of Functional Abilities in Children, Adolescents and Young Adults With Cancer Undergoing Rehabilitation","REWORI","Inclusion Criteria:\n\n* Diagnosis of cancer,\n* Children, adolescents and young adults aged between 0 and 24 years old,\n* Children, adolescents and young adults at any stage of treatment and off therapy,\n* Children, adolescents and young adults referred to the Rehabilitation Service of AIEOP centres and Rehabilitation Centres that provide rehabilitation care for paediatric and young adult cancer patients involved in the study.\n\nExclusion Criteria:\n\n* Failure to sign the consent\u002Fassent form for participation in the study by the subject and\u002For by the person exercising parental authority.","0 Months","24 Years",{"count":61,"type":22},249,"OBSERVATIONAL","This observational study aims to describe changes in the functional abilities of children, adolescents and young adults with cancer who are undergoing physiotherapy or neuropsychomotor rehabilitation. This is real-world study aiming to describe normal rehabilitation pathways in many different hospitals or rehabilitation centres in Italy.\n\nThe primary research question is:\n\n1\\) What are the longitudinal changes in functional abilities among these patients receiving physiotherapy or neuropsychomotor rehabilitation?\n\nThe secondary research questions are:\n\n1. What types of rehabilitation practices are implemented across AIEOP centres?\n2. What are the rehabilitation needs among patients undergoing physiotherapy or neuropsychomotor rehabilitation?\n3. How does health-related quality of life differ across the various stages of the rehabilitation pathway? Participants undergoing usual rehabilitation treatment are evaluated on their functional abilities on a monthly basis. If they agree to participate in this study, the main characteristics of the rehabilitation treatment and the monthly evaluation are collected.",[65,28,66,67,68,69],"Pediatric Cancer","Pediatric Oncology","Rehabilitation","Motor Outcomes","Physical Therapy",[71,72,73,74,75,76,77,78],"pediatric oncology","rehabilitation","motor performance","physical therapy","children","adolescents","young adults","exercise","RECRUITING","2026-03-24",{"date":82,"type":41},"2026-03-25",{"date":84,"type":41},"2024-07-19",{"date":86,"type":22},"2029-09-30",{"name":88,"class":48},"Associazione Italiana Ematologia Oncologia Pediatrica",{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":95,"eligibilityCriteria":96,"healthyVolunteers":11,"sex":17,"minAge":97,"maxAge":98,"enrollmentInfo":99,"targetDuration":4,"studyType":23,"phases":101,"briefSummary":102,"conditions":103,"keywords":104,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":118},"100609318","social-and-physical-activity-as-rehabilitation-for-preschool-kids-with-cancer-100609318","NCT07213024","Social and Physical Activity as Rehabilitation for Preschool Kids With Cancer","Social and Physical Activity as Rehabilitation for Preschool Kids With Cancer (SPARK)","SPARK","Inclusion Criteria:\n\n* Children newly diagnosed with cancer or cancer-like benign disorders.\n* Children between the ages of ≥12 to \\\u003C72 months at the time of treatment initiation.\n* Children undergoing intravenous chemotherapy and\u002For radiation therapy and\u002For immuno-therapy at the Department for Pediatrics and Adolescent Medicine at Copenhagen Univer-sity Hospital-Rigshospitalet.\n\nExclusion Criteria:\n\n* Children diagnosed with severe mental or physical disorders that prevent them from follow-ing instructions in relation to the intervention and testing.\n* Children where neither of the parents\u002Fguardians can communicate in Danish without a translator.","12 Months","71 Months",{"count":100,"type":22},82,[25],"Physical activity and play in early childhood are positively associated with healthy growth and gross motor, social, and cognitive development. Preschool children with cancer are at risk of impairments or delays in these interdependent developmental areas. Therefore, it is imperative to find new rehabilitation approaches to ensure preschool children's development during and after treatment. This study is based on the RePlay trial, where results highlight a demand from families for physical activity during cancer treatment and show that preschoolers want to participate. However, there is a need for a more flexible and accessible physical activity initiative at the hospital and greater support and collaboration with parents, also at home.\n\nThe purpose of this randomized controlled study is to investigate the effect of 9 months of physical activity at the hospital and at home for 82 preschool children with cancer, aged 1-5 years. The rehabilitation program includes the following components:\n\n1. Facilitated structured active play as group sessions at the hospital\n2. A parent education program\n3. Online facilitated structured active play in the families' homes The included children will be randomized to either a group only receiving structured active play at the hospital (part 1), or a group receiving both structured active play at the hospital, the parent education program, and online structured active play in the families' homes (parts 1-3).\n\nWe will measure the children's in gross motor function 9 months after the start of treatment (primary outcome), as well as parents' attitudes towards physical activity and the children's general physical function (secondary outcomes). We will measure at treatment initiation, and 6, 9, and 12 months after treatment initiation. Additionally, we will qualitatively investigate the parents and children's experiences, the potential of the rehabilitation program for the children's social development, and the importance of the professional in facilitating structured active play.",[65,28],[35,105,75,106,107,108],"preschool","cancer","gross motor function","active play","2026-02-24",{"date":111,"type":41},"2026-02-25",{"date":113,"type":22},"2026-03",{"date":115,"type":22},"2030-12",{"name":117,"class":48},"Rigshospitalet, Denmark",1]