[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pediatric-inflammatory-bowel-diseases\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pediatric-inflammatory-bowel-diseases":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100642387","phase-2-vancomycin-efficacy-in-response-to-dysbiosis-in-atypical-colitis-100642387",false,"NCT07646223","Vancomycin Efficacy in Response to Dysbiosis in Atypical Colitis","The Efficacy of Oral Vancomycin Therapy in Managing Different Phenotypes of Paediatric Inflammatory Bowel Diseases by Correlating Treatment Response to Commensal Microbiota Composition and Function","VERDA","Inclusion criteria.\n\n* children aged 6-15 years\n* able to swallow capsules\n* are scheduled for diagnostic endoscopy at Tampere University\n* has not received oral vancomycin before\n* do not have active infection (such as clostridium or other bacteria)\n* has not received new interventions (medications or new conventional therapies) for treating IBD was given within the past 4 weeks before starting OVT.\n\nExclusion Criteria:\n\n* The presence of PSC without UC, Crohn's disease type of inflammatory bowel diseases.\n* Under the age of 6 years old.\n* Is unable to swallow capsules.\n* Had a previous allergic reaction to vancomycin (such as vancomycin allergy) and\u002For other related antibiotics similar to vancomycin.\n* Presence of malignant disease or potential need for liver transplantation within the following 12 months.\n* Pregnancy\n* Known renal insufficiency or chronic renal disease","ALL","6 Years","15 Years",{"count":21,"type":22},140,"ESTIMATED","INTERVENTIONAL",[25],"PHASE2","The goal of this clinical trial is to learn how oral vancomycin therapy may contribute in treating paediatric inflammatory bowel disease, particularly atypical ulcerative colitis and PSC-associated colitis. It will also give more information on how this treatment affects gut microbiota and metabolism.\n\nThe main questions it aims to answer are:\n\n1. Does oral vancomycin improve disease activity and lead to remission (based on symptoms, biomarkers, and endoscopy findings)?\n2. How does oral vancomycin change gut metabolism?\n3. Does different types of colitis respond differently to oral vancomycin?\n\nResearchers will compare children receiving oral vancomycin plus standard therapy to those receiving standard therapy alone. The gut metabolisim before and after oral vancmycin will also be compared, as well as to healthy controls and children with typical ulcerative colitis.\n\nParticipants will:\n\n1. Take oral vancomycin (if assigned) together with conventional treatment for at least 3 months and up to 12 months depending on response\n2. Visit the clinic approximately every 3 months for checkups, tests, and monitoring\n3. Provide blood, stool, and saliva samples to study disease activity and microbiota activity\n4. Undergo clinical assessments such as symptom scoring, imaging, and possibly endoscopy\n5. Complete questionnaires about quality of life\n6. Be monitored for side effects and treatment response throughout the study period",[28,29,30],"Ulcerative Colitis (UC)","Primary Sclerosing Cholangitis (PSC)","Pediatric Inflammatory Bowel Diseases",[32,33,34,35,36],"PSC-UC","atypical UC","oral vancomycin","colitis","PIBD","NOT_YET_RECRUITING","2026-06-09",{"date":40,"type":41},"2026-06-12","ACTUAL",{"date":43,"type":22},"2026-08-01",{"date":45,"type":22},"2035-12-31",{"name":47,"class":48},"Tampere University Hospital","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":58,"enrollmentInfo":59,"targetDuration":61,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":49},"100603801","microplastic-analysis-in-pediatric-inflammatory-bowel-disease-100603801","NCT07141238","Microplastic Analysis in Pediatric Inflammatory Bowel Disease","Analysis of Microplastics in Pediatric Inflammatory Bowel Disease Using Raman Spectroscopy: A Multi-Matrix Study","MAP-IBD","Inclusion Criteria:\n\n* Age \\\u003C18 years\n* Undergoing clinically indicated gastrointestinal endoscopy\n* For IBD group: confirmed diagnosis of Crohn's disease or ulcerative colitis\n* For control group: no current or past diagnosis of IBD\n\nExclusion Criteria:\n\n* Age 18 years or older\n* Lack of informed consent from legal guardian\n* Lack of written assent from the participant if age ≥13 years","18 Years",{"count":60,"type":22},40,"1 Day","OBSERVATIONAL","The goal of this observational study is to measure and compare the presence of microplastics in children with inflammatory bowel disease (IBD) and children without IBD. The main questions it aims to answer are:\n\nAre microplastics detectable in different biological samples from children? Are there differences in microplastic burden between children with and without IBD?\n\nResearchers will collect biological samples including: intestinal tissue (from routine endoscopy), stool, urine, blood.\n\nRaman spectroscopy will be used to detect and characterize microplastics in each sample type. Participants will not receive any medication or intervention as part of this study. All samples will be collected during standard clinical procedures.",[65,30,28,66],"Crohn Disease","Inflammatory Bowel Disease (IBD)",[68,69,70,71,72,73],"Microplastics","Pediatric Inflammatory Bowel Disease","Raman Spectroscopy","Environmental exposure","Ulcerative Colitis","Crohn's Disease","RECRUITING","2025-09-24",{"date":77,"type":41},"2025-09-30",{"date":79,"type":41},"2025-06-15",{"date":81,"type":22},"2026-06",{"name":83,"class":48},"Medical University of Gdansk"]