[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pediatric-intensive-care-unit\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pediatric-intensive-care-unit":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,52,76,108],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":34,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100626902","comfort-intervention-in-picu-children-100626902",false,"NCT07441668","Comfort Intervention in PICU Children","The Effect of a Kolcaba Comfort Theory-Based Child Comfort Intervention on Comfort, Anxiety, Fear, and Sleep in the Pediatric Intensive Care Unit: A Randomized Controlled Trial","CCI-PICU","Inclusion Criteria:\n\n* Child aged 5-10 years\n* Has not received intravenous sedation or anesthetic medication in the past 12 hours\n* Expected to stay in the Pediatric Intensive Care Unit (PICU) for at least 48-72 hours\n* Conscious and able to communicate\n* Glasgow Coma Scale score of 15\n* No pain as assessed by the Wong-Baker FACES Pain Rating Scale\n* Written informed consent obtained from parent\u002Flegal guardian\n* Child and parent able to communicate in Turkish\n* No medical contraindications to non-pharmacological, non-interactive interventions\n\nExclusion Criteria:\n\n* Mechanically ventilated or intubated\n* Hearing impairment\n* Visual impairment\n* Hand motor limitations\n* Severe or profound intellectual disability\n* Epilepsy or history of seizures\n* Severe underweight\n* Chronic respiratory disease\n* Chronic cardiovascular disease\n* Surgical implants\n* Osteoporosis\n* Diagnosis of sleep disorder\n* Use of sleep medication\n* Any physical or mental health condition that prevents communication",true,"ALL","5 Years","10 Years",{"count":22,"type":23},86,"ESTIMATED","INTERVENTIONAL",[26],"NA","This randomized controlled trial evaluates a family-centered comfort intervention for children hospitalized in a pediatric intensive care unit. The intervention consists of listening to the mother's voice, environmental light regulation, and use of a weighted blanket, delivered in addition to routine nursing care. Outcomes include child comfort, anxiety, fear, and sleep parameters, as well as parental anxiety and satisfaction with care. The study will determine whether the intervention improves child and parent outcomes compared with routine care.",[29,30,31,32,33],"Pediatric Intensive Care Unit","Comfort","Anxiety in Children","Fear","Sleep",[35,36,37,38,32,33],"Pediatric intensive care","Child comfort","Kolcaba Comfort Theory","Anxiety","RECRUITING","2026-05-09",{"date":42,"type":43},"2026-05-12","ACTUAL",{"date":45,"type":43},"2026-02-20",{"date":47,"type":23},"2027-07-01",{"name":49,"class":50},"Ankara Yildirim Beyazıt University","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":18,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":24,"phases":63,"briefSummary":56,"conditions":64,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":75},"100602817","copm-based-goal-setting-strategies-in-the-picu-100602817","NCT07128446","COPM-Based Goal Setting Strategies in the PICU","Development and Feasibility Evaluation of Canadian Occupational Performance Measure-Based Goal Setting Strategies for Pediatric Intensive Care Unit Patients: A Multi-Phase Mixed-Methods Study","Inclusion Criteria:\n\nPhase 1-2 (Delphi Survey - Experts)\n\n* Physicians specializing in pediatrics or physical medicine and rehabilitation, occupational therapists, physical therapists, and nursing staff\n* Minimum of 2 years of direct clinical experience in a Pediatric Intensive Care Unit (PICU)\n\nPhase 3 (Pilot Testing - Caregivers \\& PICU Clinicians)\n\nCaregivers:\n\n* Legal guardian of a child aged 1-18 years admitted to PICU\n* ≥24 hours post-admission\n\nPICU clinicians:\n\n\\- Treating occupational or physical therapist involved in the child's care during PICU admission\n\nExclusion Criteria:\n\nPhase 1-2 (Delphi Survey - Experts)\n\n* Rehabilitation professionals without prior PICU clinical experience\n* Inability to read or respond to Korean-language surveys\n\nPhase 3 (Pilot Testing - Caregivers \\& PICU Clinicians)\n\n* Caregivers experiencing severe emotional distress, or deemed inappropriate for participation by the treating clinician\n* Non-Korean-speaking caregivers\n* Refusal or withdrawal of informed consent at any stage","1 Year","18 Years",{"count":62,"type":23},5,[26],[65,29],"Critical Illness","2026-03-09",{"date":68,"type":43},"2026-03-10",{"date":70,"type":43},"2025-08-29",{"date":72,"type":23},"2026-12-31",{"name":74,"class":50},"Samsung Medical Center",2,{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":18,"minAge":84,"maxAge":60,"enrollmentInfo":85,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":51},"100250488","population-pharmacokinetics-of-anti-infectives-in-critically-ill-children-100250488","NCT02539407","Population Pharmacokinetics of Anti-infectives in Critically Ill Children","Population Pharmacokinetics and Rationalization of Anti-infectives Administration in Critically Ill Children","OPTIMOME","Inclusion Criteria:\n\n* Minor patient requiring the administration of an anti-infective belonging to the following classes : β-lactam antibiotics; aminoglycosides, glycopeptides; fluoroquinolones; other antibiotics (daptomycin, rifampin, trimethoprim, sulfamethoxazole, clarithromycin); fungal; antivirals, during its follow-up or hospitalization\n\nExclusion Criteria:\n\n* Patient and parents having notified to the doctor that they refuse data recovery.","1 Day",{"count":86,"type":23},3000,"OBSERVATIONAL","Concentrations and effects of anti-infectives in critically ill children are unpredictable and the risk of under-exposure may be associated with poor clinical outcomes. In addition, between-subject variability (BSV) is known to be substantial in critically ill children. Rationalisation of anti-infectives in children is therefore desirable.\n\nThe investigators aim to investigate, using a population approach, the pharmacokinetics (PK) and pharmacodynamics (PD) of anti-infectives including PK\u002FPD targets (fT(%) \\> minimal inhibitory concentration (MIC)) and PD endpoints (clinical outcomes) in critically ill children. Covariates The effects of covariates on anti-infectives PK and PK\u002FPDs are investigated in order to better explain the BSV and to ultimately suggest individualized dosage regimens.\n\nIt will be a prospective PK study including 11 anti-infectives antibiotics. Six blood samples were taken from each patient during dosing interval. The primary PK\u002F PD targets were anti-infectives concentrations above the MIC of the pathogen at both 50% (50% f T\\>MIC) and 100% (100% f T\\>MIC) of the dosing interval. The investigators used skewed logistic regression to describe the effect of anti-infectives exposure on patient outcome.",[29,90],"Pediatric Immuno-hematology Department",[92,93,94,95,96,97,98],"β-lactam antibiotics","Children","Anti-infectives","Aminoglycosides, glycopeptides","Fluoroquinolone","Fungal","Antiviral","2025-11-17",{"date":101,"type":43},"2025-11-20",{"date":103,"type":43},"2015-09-11",{"date":105,"type":23},"2028-12",{"name":107,"class":50},"Assistance Publique - Hôpitaux de Paris",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":18,"minAge":115,"maxAge":116,"enrollmentInfo":117,"targetDuration":84,"studyType":87,"phases":4,"briefSummary":119,"conditions":120,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":51},"100610878","complications-of-the-alveolar-opening-maneuver-in-children-on-mechanical-ventilation-100610878","NCT07233304","Complications of the Alveolar Opening Maneuver in Children on Mechanical Ventilation","Incidence of Complications From the Alveolar Opening Maneuver in Mechanically Ventilated Children With Respiratory Distress Syndrome","Inclusion criteria:\n\n* Patients under 14 years of age admitted to the HCANK PICU\n* More than 4 hours of invasive mechanical ventilation (IMV)\n* An oxygenation index (OI) ≥4 or an oxygen saturation index (OSI) ≥5\n* Indication for ARM and PEEP as determined by the treating team\n\nExclusion criteria:\n\n* Predicted body weight (PBW) \\>45.5 kg\n* Recent pulmonary resection surgery (\\\u003C7 days)\n* Presence of broncho-pleural fistula or peri-tube leak \\>25% of the tidal volume\n* Hemoglobin decline \\\u003C7 g\u002FdL\n* Patients with congenital or acquired heart diseases with significant intracardiac shunt.","1 Month","14 Years",{"count":118,"type":23},143,"The objective of this research is to analyze the overall incidence of complications associated with a therapeutic maneuver known as alveolar opening and subsequent titration of positive end-expiratory pressure (PEEP) in pediatric patients with acute respiratory distress syndrome (ARDS). These procedures are part of the standard care provided in the Pediatric Intensive Care Unit (PICU) and are used to improve pulmonary oxygenation and respiratory mechanics. Through this study, we aim to gather information that will help improve the safety and effectiveness of these interventions in critically ill patients.",[121,122,29,123,124,125],"Positive End-expiratory Pressure (PEEP)","Oxygenation Index","Pediatric Acute Lung Injury","Respiratory Distress Syndrome, Pediatric","Complication","2025-11-14",{"date":128,"type":43},"2025-11-18",{"date":130,"type":43},"2025-08-18",{"date":132,"type":23},"2026-08",{"name":134,"class":50},"Hospital de Alta Complejidad en Red"]