[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pediatric-obesity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pediatric-obesity":31},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,32,0,25,[9,44,71,96,124,153,178,213,236,263,289,316,342,403,429,455,481,509,531,553,582,605,640,667,688],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100642158","comparison-of-day-hospitalization-versus-full-time-hospitalization-in-the-treatment-of-severe-adolescent-obesity-100642158",false,"NCT07652190","Comparison of Day Hospitalization Versus Full-Time Hospitalization in the Treatment of Severe Adolescent Obesity","Comparison of Day Hospitalization and Full-Time Hospitalization in the Treatment of Severe Adolescent Obesity (MAROSA)","MAROSA","Inclusion Criteria:\n\n* Adolescents aged 12-20 years\n* Severe obesity (IOTF \\> 30)\n* Admitted to participating centers\n* Covered by health insurance\n* Signed informed consent (participant or legal guardian)\n\nExclusion Criteria:\n\n* Acute psychiatric disorder requiring hospitalization\n* Secondary obesity due to endocrine disorders\n* Age \\\u003C 12 or \\> 20 years\n* Inability to provide consent Emergency situation Refusal to participate","ALL","12 Years","20 Years",{"count":22,"type":23},126,"ESTIMATED","INTERVENTIONAL",[26],"NA","This multicenter prospective quasi-experimental study aims to compare the effectiveness of day hospitalization versus full-time hospitalization for adolescents with severe obesity. The primary outcome is the change in BMI z-score measured six months after the end of treatment.",[29,30,31],"Severe Adolescent Obesity","Adolescent Obesity","Pediatric Obesity","NOT_YET_RECRUITING","2026-06-11",{"date":35,"type":36},"2026-06-16","ACTUAL",{"date":38,"type":23},"2026-10-05",{"date":40,"type":23},"2027-11-10",{"name":42,"class":43},"Fondation Santé des Étudiants de France","OTHER",{"id":45,"slug":46,"hasResults":12,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":18,"minAge":19,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":24,"phases":55,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":70},"100611901","virtual-housecalls-redesigning-pediatric-primary-care-adolescent-obesity-treatment-100611901","NCT07246603","Virtual Housecalls: Redesigning Pediatric Primary Care Adolescent Obesity Treatment","VHC","Adolescent Inclusion Criteria:\n\n* English or Spanish-speaking\n* 12-15 years of age\n* Receiving care at a participating clinic\n* Body Mass Index (BMI) ≥95% and \\\u003C120% of the 95%\n* Access to a mobile device with a webcam that can receive texts\n\nParent Inclusion Criteria:\n\n* English or Spanish-speaking\n* Primary legal guardian ≥18 years of age living with the adolescent\n\nExclusion Criteria:\n\n* conflicts that would inhibit the ability to participate in all aspects of the study as outlined in the study protocol\n* family plans to move outside of the study area or plans to no longer be a patient at a participating clinic in the 12 month study period\n* the primary care provider or PI determines that the study is not clinically or medically appropriate (e.g., significant psychiatric, cognitive, physical or developmental conditions that would impair their ability to complete assessments, participate in study sessions, or conduct physical activity) based on screening at study onset\n* adolescent exhibits severe dietary restriction or compensatory behavior (e.g., vomiting, laxative abuse) based on screening at study onset and clinical interview by a study psychologist\n* adolescent is currently pregnant\u002Fplans to become pregnant during study period\n* adolescent is participating in another weight loss program, has had or plans to undergo weight loss surgery\n* adolescent has a chronic medical condition(s) and\u002For uses medication that substantially impacts or interferes with growth, appetite, weight or physical activity participation\n* adolescents taking anti-obesity medication are ineligible if they are not a stable dose for at least 3 months prior to study participation",true,"15 Years",{"count":54,"type":23},500,[26],"This pragmatic randomized clinical trial tests a novel intensive health behavior and lifestyle intervention, conducted via telehealth, to treat class I adolescent obesity in pediatric primary care. Results will inform scalable approaches that meet the recommended treatment dose and effectively treat obesity in this setting.",[58,31],"Class I Obesity",[60],"Lifestyle Intervention","2026-05-30",{"date":63,"type":36},"2026-06-02",{"date":65,"type":23},"2026-07-01",{"date":67,"type":23},"2030-01-31",{"name":69,"class":43},"Virginia Commonwealth University",1,{"id":72,"slug":73,"hasResults":12,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":51,"sex":18,"minAge":19,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":24,"phases":81,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":95},"100638872","ultrasound-assessment-of-tongue-characteristics-in-adolescents-with-obesity-and-obstructive-sleep-disorders-100638872","NCT07613944","Ultrasound Assessment of Tongue Characteristics in Adolescents With Obesity and Obstructive Sleep Disorders","Standardised Ultrasound Assessment of Tongue Characteristics in Adolescents With Obesity and Obstructive Sleep Disordered Breathing: a Research Protocol","Inclusion Criteria:\n\n* Aged 12-18 years\n* Already enrolled in Zeepreventorium weight-loss program as Standard Care Diagnosed Obstructive Sleep Apnea (AHI ≥ 1)1 or any Obstructive sleep disordered breathing detected by any of the specific sleep questionnaire (OSA-18, ESS, SSS-Ad, PDSS)\n\nExclusion Criteria:\n\n* Any other orthopedic, traumatic, or rheumatologic condition affecting the cervicocephalic region\n* Syndromic or neuromuscular disorders\n* Cognitive impairment limiting compliance with study procedures\n* Inability to provide informed consent\n* Self-reported alcohol or recreational drug consumption within 48 hours preceding the experimental session","18 Years",{"count":80,"type":23},80,[26],"Obstructive sleep-disordered breathing, including obstructive sleep apnea (OSA), represents a significant yet underdiagnosed condition in the pediatric population, particularly among adolescents with obesity. The tongue is a central anatomical contributor to upper airway collapsibility; however, its biomechanical properties have been investigated almost exclusively in adult populations, leaving a critical gap in knowledge regarding younger individuals.\n\nThis study aims to assess tongue biomechanical and echographic characteristics using quantitative ultrasound modalities - shear-wave elastography (SWE), acoustic attenuation, and echo intensity - in adolescents aged 12 to 18 years with obesity and obstructive sleep disorders. The study adopts a mixed design combining (1) an observational cross-sectional comparison between participants with obesity and OSDB and age- and sex-matched healthy controls at baseline, and (2) a prospective longitudinal cohort component evaluating changes in tongue ultrasound characteristics over the course of a 30-week multidisciplinary inpatient weight-loss program delivered as standard care at the Zeepreventorium (De Haan, Belgium). An additionnal methodological objective consists in determining intra-rater and inter-rater reliability of the ultrasound acquisition protocol providing a reproducible framework for future studies.",[84,85,31],"Obesity & Overweight Sleep","Obstructive Sleep Disordered Breathing","2026-05-21",{"date":88,"type":36},"2026-05-29",{"date":90,"type":23},"2026-09",{"date":92,"type":23},"2027-12-31",{"name":94,"class":43},"Vrije Universiteit Brussel",2,{"id":97,"slug":98,"hasResults":12,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":12,"sex":18,"minAge":103,"maxAge":104,"enrollmentInfo":105,"targetDuration":4,"studyType":24,"phases":107,"briefSummary":108,"conditions":109,"keywords":4,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":70},"100365290","dyad-plus-effectivenessfeasibility-100365290","NCT04036331","Dyad Plus Effectiveness\u002FFeasibility","Effectiveness\u002FFeasibility of A Coordinated Parent\u002FChild Dyad Weight Loss Intervention:","Inclusion Criteria:\n\n* Eligible for enrollment in Brenner FIT and\u002For By Design Essentials\n* Caregiver who lives in the house with a BMI \\> 30\n* No contraindication for physical activity or caloric restriction\n* Must be able to read and write English\n\nExclusion Criteria:\n\n* BMI \\\u003C 30\n* Contraindication for physical activity or caloric restriction\n* Cannot read or write English","13 Years","65 Years",{"count":106,"type":23},90,[26],"The purpose of this research is to determine the effectiveness of a coordinated program (Dyad Plus) that would help to facilitate self-monitoring, positive communication, joint problem solving, and social support to increase physical activity, healthy eating, and weight loss. Participants of the Brenner FIT (Families In Training) pediatric weight management program and their parent\u002Fguardian will co-enroll in weight loss programs. Parents\u002Fguardians will receive the components of By Design Essentials.",[110,31,111,112,113],"Weight Loss","Overweight Adolescents","Parent-Child Relations","Family and Household","RECRUITING","2026-04-27",{"date":117,"type":36},"2026-04-28",{"date":119,"type":36},"2021-07-30",{"date":121,"type":23},"2026-07",{"name":123,"class":43},"Wake Forest University Health Sciences",{"id":125,"slug":126,"hasResults":12,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":12,"sex":18,"minAge":131,"maxAge":4,"enrollmentInfo":132,"targetDuration":4,"studyType":24,"phases":133,"briefSummary":134,"conditions":135,"keywords":139,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":70},"100621722","weight-gain-in-pediatric-leukemia-survivors-100621722","NCT07374315","Weight Gain in Pediatric Leukemia Survivors","A Family-based Intervention Approach to Address Weight Gain in Pediatric Leukemia Survivors","Patient Eligibility Criteria:\n\n* Must have a diagnosis of ALL (T or B cell).\n* Must be receiving standard of care maintenance chemotherapy or be within 6 months of having concluded maintenance chemotherapy at the time of enrollment.\n* Must be at least 6 years of age and no older than 18 years of age at time of enrollment.\n* Must be able to speak and understand English.\n* Must have a caregiver who is participating in this study.\n* Must be able to perform some level of exercise (e.g., a brisk walk for at least five minutes) as determined by self-report.\n* Must not have severe developmental delay\u002Fintellectual disabilities (such as Trisomy32, severe presentations of autism spectrum disorder) or significant mental illness (such as active suicidal ideation, psychotic symptoms, manic or hypomanic episodes, or severe substance use disorder) that may interfere with ability to participate in modified Family Based Therapy (FBT).\n* Patients 10 and older must have a negative SCOFF screen for disordered eating (Score of 2 or more would disqualify the patient and require discussion with primary team)\n* Must be able to understand and willing to sign an IRB-approved written informed consent document or be able to provide verbal assent along with written consent provided by a legally authorized representative.\n\nCaregiver Eligibility Criteria:\n\n* Self-reported as the primary caregiver of a pediatric patient diagnosed with ALL who is also participating in this study.\n* Must be at least 18 years of age.\n* Must be able to speak and understand English.\n* Must be able to perform some level of exercise (e.g., a brisk walk for at least five minutes) as determined by self-report\n* Must be able to understand willing to sign an Institutional Review Board (IRB)-approved written informed consent document.","6 Years",{"count":80,"type":23},[26],"This is a trial assessing the efficacy of two weight maintenance programs for children with acute lymphoblastic leukemia (ALL) and the patients' caregivers. Patients and their caregivers will be randomized 1:1 to Arm A, a non-intensive educational intervention using National Institute of Health (NIH) Educational Resources (We Can! for children 8-13 and Take Charge of Your Health for teenagers 14-18), or Arm B, a Modified Guided Self-Help Family Intervention for Leukemia patients (mL-GSH). Outcomes will be assessed through activity trackers, obesity biometrics, and nutrition and physical activity assessments.",[136,137,138,31],"Leukemia","Pediatric Acute Lymphoblastic Leukemia","Pediatric Acute Lymphoblastic Leukemia in Remission",[136,140,141,142,143,144],"Lymphoblastic Leukemia","Weight Management","Late Effects","Health Behaviors","Healthy Habits","2026-04-23",{"date":117,"type":36},{"date":148,"type":23},"2026-05-31",{"date":150,"type":23},"2029-02-28",{"name":152,"class":43},"Washington University School of Medicine",{"id":154,"slug":155,"hasResults":12,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":4,"eligibilityCriteria":159,"healthyVolunteers":12,"sex":18,"minAge":131,"maxAge":160,"enrollmentInfo":161,"targetDuration":4,"studyType":24,"phases":163,"briefSummary":164,"conditions":165,"keywords":4,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":177},"100584336","iamhealthy-clinical-practice-guideline-cpg-100584336","NCT06888011","iAmHealthy Clinical Practice Guideline (CPG)","Implementation of the New Pediatric Obesity Clinical Practice Guideline in Rural Families and Clinics: A Randomized Clinical Trial","Inclusion criteria for individual participants:\n\n* Child is ages 6-11 years at consent\n* Child BMI %ile is ≥85th\n* Child lives in a rural area\n* Child\u002Ffamily speaks English or Spanish\n\nExclusion criteria for individual participants:\n\n* Child has a physical limitation or injury that substantially limits physical mobility or has a planned medical treatment during the course of the trial that will substantially limit physical mobility\n* Child has a known medical issue that could affect protocol compliance (e.g., cancer)\n* Child and\u002For primary caregiver has a developmental delay or cognitive impairment that could affect protocol compliance\n* Child is enrolled in a weight-loss trial\n* Child has a sibling who has already consented in the trial\n\nInclusion criteria for clinics:\n\n* History of collaboration with site awardee in research or quality improvement projects\n* In the past year at least 300 eligible potential participants\n* The clinic must have an electronic medical records system\n\nExclusion criteria for clinics:\n\n* Unable to generate lists of children seen in clinic by date of visit, age, and zip code","11 Years",{"count":162,"type":23},1024,[26],"The current study is a multilevel factorial design RCT with interventions at the clinic (Healthy Clinic intervention period vs. Control period) and individual patient levels (iAmHealthy vs. Newsletter).",[31,166,167],"Rural Health","Clinical Practice Guideline","2026-04-07",{"date":170,"type":36},"2026-04-13",{"date":172,"type":36},"2025-09-02",{"date":174,"type":23},"2028-11",{"name":176,"class":43},"University of Kansas Medical Center",4,{"id":179,"slug":180,"hasResults":12,"nctId":181,"briefTitle":182,"officialTitle":183,"acronym":184,"eligibilityCriteria":185,"healthyVolunteers":12,"sex":18,"minAge":131,"maxAge":186,"enrollmentInfo":187,"targetDuration":4,"studyType":24,"phases":189,"briefSummary":190,"conditions":191,"keywords":194,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":70},"100619302","comparing-outcomes-among-children-with-obesity-in-a-community-healthy-lifestyle-program-100619302","NCT07342855","Comparing Outcomes Among Children With Obesity in a Community Healthy Lifestyle Program","Comparison Study to Evaluate the Outcomes Among Children Participating in a Community Healthy Lifestyle Program","73357","Inclusion Criteria:\n\n* BMI by report of ≥ 85th percentile\n* The child must be able to participate in physical activity comparable to an elementary school PE class and must be able to function cognitively at or above the level of a 6 year old\n\nExclusion Criteria:\n\n* BMI by report of below the 85th percentile\n* Inability to participate in physical activity comparable to an elementary school PE class and must be able to function cognitively at or above the level of a 6 year old\n\nParent will be invited but not required to be weighed and measured.","14 Years",{"count":188,"type":23},160,[26],"This study aims to evaluate the outcomes of an existing clinical program that teaches families of children with overweight and obesity healthy lifestyle. The design will be unblinded, randomized, waitlist control.",[31,192,193],"Pediatric Overweight","Overweight , Obesity",[195,196,197,198,199,200,201,202,203],"Obesity","FNPA","BAQ","Endurance","%BMIp95","Family Healthy Weight Program","Community Healthy Lifestyle Program","intensive health behavior and lifestyle treatment","PACER","2026-03-25",{"date":206,"type":36},"2026-03-30",{"date":208,"type":36},"2026-01-15",{"date":210,"type":23},"2027-06-30",{"name":212,"class":43},"University of Texas Southwestern Medical Center",{"id":214,"slug":215,"hasResults":12,"nctId":216,"briefTitle":217,"officialTitle":217,"acronym":4,"eligibilityCriteria":218,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":78,"enrollmentInfo":219,"targetDuration":4,"studyType":24,"phases":221,"briefSummary":223,"conditions":224,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":227,"lastUpdatePostDateStruct":228,"startDateStruct":230,"completionDateStruct":232,"leadSponsor":234,"locationsCount":70},"100587920","phase-3-early-re-initiation-of-semaglutide-post-sleeve-gastrectomy-in-youth-100587920","NCT06934655","Early Re-Initiation of Semaglutide Post Sleeve Gastrectomy in Youth","Inclusion Criteria:\n\n* ages 12 to 18 years\n* Tanner stage 3 or higher\n* severe obesity (defined as a BMI greater than 35 kg\u002Fm2 or BMI ≥140% of the 95th percentile)\n* currently undergoing primary surgical weight loss through the pediatric bariatric surgery pathway at Children's Hospital Los Angeles\n* be willing to have blood collected before and after surgical procedure at defined points\n* be willing to have clinical data entered into a prospective database; 8) presence of a consenting caregiver\n* be taking semaglutide 2.4 mg weekly as part of their routine medical care prior to surgery as part of their obesity treatment program, apart from any planned surgical procedure.\n\nExclusion Criteria:\n\n* have a previous diagnosis of type 1 diabetes\n* taking any medications known to influence body composition or prevent weight loss or promote weight gain (e.g. prednisone)\n* have been diagnosed with syndromes or diseases that may influence the postoperative course (e.g., Cushing syndrome, Down syndrome, Prader Willi Syndrome)\n* have significant comorbid medical conditions necessitating frequent hospitalization that may require interruption of medications and\u002For that would make early re-initiation of semaglutide unsafe due to the other medical comorbidities\n* refuse to comply with eligibility criteria.",{"count":220,"type":23},150,[222],"PHASE3","This is a Phase 3a, randomized, parallel-controlled trial designed to compare the early re-initiation of semaglutide, starting two weeks after sleeve gastrectomy, to standard care (no pharmacotherapy following surgery). The trial will involve 150 youth with severe obesity who have been on semaglutide 2.4 mg weekly for at least 3 months prior to surgery. Participants will be randomized to either (1) semaglutide 2.4 mg weekly or (2) standard care for 24 months. Primary, secondary, and tertiary outcomes will be assessed at multiple time points: 1-month, day of surgery, and 1-, 3-, 6-, 9-, 12-, 18-, and 24-months postoperatively. We hypothesize that early re-initiation of semaglutide will be safe, well-tolerated, and lead to greater improvements in obesity, cardiometabolic risk, and eating behaviors.",[31,225,226],"Metabolic and Bariatric Surgery","Semaglutide","2026-03-16",{"date":229,"type":36},"2026-03-17",{"date":231,"type":23},"2026-06-01",{"date":233,"type":23},"2033-11-01",{"name":235,"class":43},"Children's Hospital Los Angeles",{"id":237,"slug":238,"hasResults":12,"nctId":239,"briefTitle":240,"officialTitle":240,"acronym":241,"eligibilityCriteria":242,"healthyVolunteers":51,"sex":18,"minAge":131,"maxAge":243,"enrollmentInfo":244,"targetDuration":4,"studyType":24,"phases":246,"briefSummary":247,"conditions":248,"keywords":249,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":254,"lastUpdatePostDateStruct":255,"startDateStruct":257,"completionDateStruct":259,"leadSponsor":261,"locationsCount":70},"100600259","monitoring-eating-across-locations-meal---timing-intake-and-mealtime-evaluation-time-100600259","NCT07095166","Monitoring Eating Across Locations (MEAL) - Timing, Intake, and Mealtime Evaluation (TIME)","MEAL-TIME","Inclusion Criteria:\n\n* children must be between the ages of 6-9 years-old\n* children are of good health with no learning disabilities (e.g., ADHD, determined by parent report)\n* children are not on any medications known to impact body weight, taste, food intake, behavior, or blood flow\n* parents report that children like and are willing to eat study foods\n\nExclusion Criteria:\n\n* Children are not within the age requirements (\\\u003C6 years old or \\> 9 years old)\n* If children are taking cold or allergy medication, or other medications known to influence cognitive function, taste, appetite, or blood flow.\n* If children don't speak English.\n* If children are colorblind.\n* If children have a learning disability, ADD\u002FADHD, language delays, autism or other neurological or psychological conditions.\n* If children have a pre-existing medical condition such as type I or type II diabetes, rheumatoid arthritis, Cushing's syndrome, Down's syndrome, severe lactose intolerance, Prader-Willi syndrome, HIV, cancer, renal failure, or cerebral palsy.\n* If children are allergic to foods or ingredients used in the study.\n* child received an X-ray in the previous year (to avoid excess radiation exposure due to the DXA scans performed in the research)","9 Years",{"count":245,"type":23},100,[26],"Increased availability of high-energy dense foods has contributed to a pediatric obesity epidemic, with 23% of United States children currently presenting with the disease. How children eat contributes to both overconsumption and greater adiposity. However, it is unclear if laboratory measures of children's eating style generalize to the home environment, where children consume two thirds of their total energy. The study will 1) test if child eating styles observed in the lab generalize to more ecologically valid home environments and 2) identify aspects of home food environment that amplify obesogenic eating behaviors. We will assess laboratory and home eating styles (e.g., bite rate) in 100 prepubertal 6-9-year-old children to constrain variability in energy requirements. Children will be video-recorded while consuming identical study-provided meals at home and in the laboratory (counter-balanced order) in addition to a 'typical' meal at home. To study how adiposity relates to \"obesogenic\" styles of eating, gold standard dual x-ray absorptiometry will be used.",[31],[250,251,252,253],"eating behavior","meal microstructure","child","obesity","2026-03-04",{"date":256,"type":36},"2026-03-06",{"date":258,"type":36},"2025-11-15",{"date":260,"type":23},"2027-10-15",{"name":262,"class":43},"Penn State University",{"id":264,"slug":265,"hasResults":12,"nctId":266,"briefTitle":267,"officialTitle":267,"acronym":4,"eligibilityCriteria":268,"healthyVolunteers":51,"sex":18,"minAge":269,"maxAge":4,"enrollmentInfo":270,"targetDuration":4,"studyType":24,"phases":272,"briefSummary":273,"conditions":274,"keywords":276,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":282,"startDateStruct":284,"completionDateStruct":285,"leadSponsor":287,"locationsCount":70},"100559540","growing-healthy-children-and-families-in-rural-arkansas-100559540","NCT06565455","Growing Healthy Children and Families in Rural Arkansas","Inclusion Criteria:\n\n* Aged 18 to 45 years old\n* Living in the United States for at least one year\n* At least one child aged 7 to 12 years old, and\n* English and\u002For Spanish speaker\n\nExclusion Criteria:\n\n* Unable to read or write in English or Spanish.","7 Years",{"count":271,"type":23},64,[26],"Childhood obesity is a national problem with racial and ethnic disparities specifically among Hispanic children. The primary purpose of this study is to develop and implement a culturally appropriate healthy eating intervention called Growing Healthy Children and Families in Rural Arkansas.\n\nSpecific Aim (SA) 1. To develop a culturally appropriate healthy eating promotion intervention (Growing Healthy Children and Families in Rural Arkansas) in collaboration with Hispanic churches and their congregants.\n\nSA2. To conduct the Growing Healthy Children and Families in Rural Arkansas intervention in eight churches (four churches in the intervention vs four in the control\u002Fattention group), and to assess the feasibility and acceptability of implementing the intervention.\n\nSA3. To assess the impact of the Growing Healthy Children and Families in Rural Arkansas intervention on healthy food preparation (mothers) and intake of fruits and vegetables (child).\n\nThe investigators will compare between the intervention group (16 mother-child dyads) versus the control\u002Fattention group (16 mother-child dyad) to see if the intervention is effective in improving diet quality and changing cooking behaviors.\n\nParticipants will:\n\n1. Participate in cooking workshops and one to one learning activities\n2. Report on diet and physical activity\n3. Will measure fruit and vegetable intake",[31,275],"Health Behavior, Risky",[277,278,279,280],"Healthy Diet","Community Health","Faith Based Organizations","Cultural Adaptation","2026-02-02",{"date":283,"type":36},"2026-02-05",{"date":281,"type":36},{"date":286,"type":23},"2026-08-31",{"name":288,"class":43},"University of Arkansas",{"id":290,"slug":291,"hasResults":12,"nctId":292,"briefTitle":293,"officialTitle":294,"acronym":4,"eligibilityCriteria":295,"healthyVolunteers":51,"sex":18,"minAge":131,"maxAge":78,"enrollmentInfo":296,"targetDuration":4,"studyType":297,"phases":4,"briefSummary":298,"conditions":299,"keywords":302,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":307,"lastUpdatePostDateStruct":308,"startDateStruct":310,"completionDateStruct":312,"leadSponsor":314,"locationsCount":95},"100621417","ultrasound-assessment-of-tongue-characteristics-in-children-and-adolescents-with-obesity-100621417","NCT07370350","Ultrasound Assessment of Tongue Characteristics in Children and Adolescents With Obesity","Standardized Tongue Ultrasound Protocol for Tongue Characteristics in Children and Adolescents With Obesity After a 30-week Inpatient Weight Loss Program","Inclusion Criteria:\n\n* Children and adolescents aged 6 to 18 years\n* Diagnosis of obesity\n* Already enrolled in the inpatient weight-loss rehabilitation program at the Zeepreventorium\n* Written informed consent from legal guardian and assent from the participant, following the legal requirements\n\nExclusion Criteria:\n\n* Known orthopedic, traumatic, or rheumatologic conditions affecting the cervicocephalic region\n* Contraindication to ultrasound examination\n* Inability to comply with study procedures\n* Inability to understand the procedures",{"count":245,"type":23},"OBSERVATIONAL","This longitudinal observational study aims to validate ultrasound-based tongue markers related to tongue characteristics, including fat accumulation, morphologic and mechanical properties of the tongue in children and adolescents with obesity. Participants are assessed at baseline and after completion of a standardized 30-week inpatient weight-loss rehabilitation program at the Zeepreventorium (De Haan, Belgium). Tongue ultrasound parameters are examined in relation to anthropometric characteristics and obstructive sleep apnea condition.",[300,31,301],"Obesity & Overweight","Obstructive Sleep Apnea (OSA)",[303,304,305,306],"Tongue ultrasound","Shear-wave elastography","Pediatric obesity","Obstructive sleep apnea","2026-01-17",{"date":309,"type":36},"2026-01-27",{"date":311,"type":36},"2025-04-01",{"date":313,"type":23},"2026-08-01",{"name":315,"class":43},"Haute Ecole Bruxelles-Brabant",{"id":317,"slug":318,"hasResults":12,"nctId":319,"briefTitle":320,"officialTitle":321,"acronym":322,"eligibilityCriteria":323,"healthyVolunteers":51,"sex":18,"minAge":324,"maxAge":325,"enrollmentInfo":326,"targetDuration":4,"studyType":24,"phases":328,"briefSummary":329,"conditions":330,"keywords":4,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":334,"lastUpdatePostDateStruct":335,"startDateStruct":337,"completionDateStruct":339,"leadSponsor":340,"locationsCount":70},"100525029","nutrition-and-obesity-in-under-represented-populations-food-insecurity-research-to-advance-science-and-improve-health-100525029","NCT06116422","Nutrition and Obesity in Under-Represented Populations: Food Insecurity Research to Advance Science and Improve Health","Nutrition and Obesity in Under-Represented Populations: Food Insecurity Research to Advance Science and Improve Health: A Multi-disciplinary Approach for Study and Mitigation of Food Insecurity and Obesity","NOURISH","Inclusion:\n\n* Aged 9-12 months and their primary caregiver \"parent\".\n* Medicaid and WIC-eligible (proxy for \"at risk for food insecurity\")\n* World Health Organization BMI ≥ 85%ile at current or most recent encounter (early-onset obesity) OR ≥ 20 pounds at 9 months old.\n* Caregiver speaks either English or Spanish as their primary language.\n* Infant was born as a singleton infant.\n\nExclusion:\n\n* Diagnosed with monogenic obesity.\n* Plans to move from the area in the next 12 months.\n* Parent is currently pregnant.","12 Months","24 Months",{"count":327,"type":23},228,[26],"Food insecurity is associated with obesity in children, and childhood obesity leads to long term health consequences. While existing research shows that food benefit programs reduce food insecurity, little is known about the mediating factors between food benefit programs and child health. The purpose of this study is to understand if the resolution of food insecurity in young children with early onset obesity can improve body mass index (BMI) over one year, and if so, by what mechanisms. The investigators will conduct a randomized comparative effectiveness study among infants (n=228) aged 12 months at risk for food insecurity and deliver two different food security interventions. Both will provide families with $50\u002Fweek for one year of study enrollment. The first group will receive this as an unrestricted cash benefit (\"cash benefit group\") and the second group will receive this as a benefit in the form of weekly grocery purchases with the support of a trained nutrition expert to guide healthy grocery purchasing (\"grocery benefit group\"). The investigators will also construct a contemporary comparison cohort of infants meeting the inclusion\u002Fexclusion criteria from the electronic health record, using propensity score matching to allow comparisons between both intervention groups and usual care. The primary endpoint is difference in BMI at 12 months post-enrollment (24 months of age). Secondary outcomes include measures of nutrition, food security, electronic health record data related to general child health, and other factors related to parental stress and unmet social needs. Patients will have the opportunity to participate in post-study interviews to report on intervention satisfaction, and facilitators and barriers of infant feeding. Data analysis will be conducted by a trained statistician (Duke Biostatistics, Epidemiology, and Research Design; BERD) and will employ a two-means test for a repeated-measures design. The benefits to participants outweigh the minimal risks of loss of privacy, and confidential information will be managed carefully to minimize this risk.",[31,331,332,333],"Food Insecurity","Nutrition, Healthy","Nutrition Poor","2026-01-14",{"date":336,"type":36},"2026-01-16",{"date":338,"type":36},"2024-05-30",{"date":92,"type":23},{"name":341,"class":43},"Duke University",{"id":343,"slug":344,"hasResults":12,"nctId":345,"briefTitle":346,"officialTitle":347,"acronym":348,"eligibilityCriteria":349,"healthyVolunteers":51,"sex":18,"minAge":269,"maxAge":78,"enrollmentInfo":350,"targetDuration":4,"studyType":297,"phases":4,"briefSummary":352,"conditions":353,"keywords":371,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":395,"lastUpdatePostDateStruct":396,"startDateStruct":398,"completionDateStruct":400,"leadSponsor":402,"locationsCount":70},"100420250","pediatric-hypertension-and-the-renin-angiotensin-system-phrase-100420250","NCT04752293","Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)","Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE): The Role of Angiotensin-(1-7) in Hypertension and Hypertension-Induced Heart and Kidney Damage","PHRASE","INCLUSION CRITERIA: HYPERTENSION COHORT\n\n* 7-18 years of age at time of enrollment\n* Confirmed new diagnosis of primary hypertension: no identifiable secondary cause, referred to hypertension or nephrology clinic\n\n  * Age \\\u003C13 years: BP ≥95th %ile or ≥130\u002F80 mmHg (whichever is lower)\n  * Age ≥13 years: BP ≥130\u002F80 mmHg\n* Participants and their caregivers must be willing and able to commit to completing the study assessments\n\nEXCLUSION CRITERIA: HYPERTENSION COHORT\n\n* \\\u003C7 years or \\>18 years of age at time of enrollment\n* BP confirmed as normal or in the elevated BP category based on ≥3 prior office BP measurements on separate days;\n\n  * Age \\\u003C13 years: BP \\\u003C95th %ile or \\\u003C130\u002F80 mmHg (whichever is lower)\n  * Age ≥13 years: BP \\\u003C130\u002F80 mmHg\n* A confirmed secondary cause of hypertension\n* Confounding medical condition (heart or kidney disease \\[except hypertension-associated heart changes on echocardiogram or albuminuria\\], vascular\u002Finflammatory disease, or diabetes)\n* Inability to complete study assessments\n* Non-English\u002FSpanish speakers\n* Current pregnancy\n* Ward of the State\n\nINCLUSION CRITERIA: CONTROL COHORT\n\n* 7-18 years of age at time of enrollment\n* Normal BP based on ≥3 prior office BP measurements on separate days;\n\n  * Age \\\u003C13 years: BP \\\u003C90th %ile or \\\u003C120\u002F80 mmHg (whichever is lower)\n  * Age ≥13 years: BP \\\u003C120\u002F80 mmHg\n* Participants and their caregivers must be willing and able to commit to completing the study assessments\n\nEXCLUSION CRITERIA: CONTROL COHORT\n\n* \\\u003C7 or \\>18 years of age at time of enrollment\n* Elevated BP or hypertension, based on ≥3 prior office BP measurements on separate days:\n\n  * Age \\\u003C13 years: BP ≥90th %ile or ≥120\u002F80 mmHg (whichever is lower)\n  * Age ≥13 years: BP ≥120\u002F80 mmHg\n* History of elevated BP or hypertension\n* Current use of BP-lowering medications\n* Confounding medical condition (heart or kidney disease, vascular\u002Finflammatory disease, or diabetes)\n* Inability to complete study assessments\n* Non-English\u002FSpanish speakers\n* Current pregnancy\n* Ward of the State",{"count":351,"type":23},125,"Studying the causal roles of components of the renin-angiotensin-aldosterone system (including angiotensin-(1-7) (Ang-(1-7)), angiotensin-converting enzyme 2 (ACE2), Ang II, and ACE), uric acid, and klotho in pediatric hypertension and related target organ injury, including in the heart, kidneys, vasculature, and brain. Recruiting children with a new hypertension diagnosis over a 2-year period from the Hypertension and Pediatric Nephrology Clinics affiliated with Brenner Children's Hospital at Atrium Health Wake Forest Baptist and Atrium Health Levine Children's Hospital. Healthy control participants will be recruited from local general primary care practices. Collecting blood and urine samples to analyze components of the renin-angiotensin-aldosterone system (Ang-(1-7), ACE2, Ang II, ACE), uric acid, and klotho, and measuring blood pressure, heart structure and function, autonomic function, vascular function, and kidney function at baseline, year 1, and year 2. Objectives are to investigate phenotypic and treatment response variability and to causally infer if Ang-(1-7), ACE2, Ang II, ACE, uric acid, and klotho contribute to target organ injury due to hypertension.",[354,355,356,357,358,359,360,361,362,363,364,365,366,367,368,31,369,370],"Hypertension","Left Ventricular Hypertrophy","Left Ventricular Dysfunction","Left Atrial Dilatation","Left Ventricular Diastolic Dysfunction","Kidney Diseases","Kidney Injury","Kidney Dysfunction","Sodium Urine High","Blood Pressure Disorders","Uric Acid Retention","Angiotensin Hypertension","Autonomic Dysfunction","Autonomic Imbalance","Pediatric Kidney Disease","Proteinuria","Albuminuria",[372,373,354,374,375,355,370,376,377,378,379,380,381,382,383,384,385,386,387,388,358,360,389,390,31,391,392,393,394],"High Blood Pressure","Elevated Blood Pressure","Pediatric Hypertension","Target Organ Damage","Uric Acid","Klotho","Fibroblast Growth Factor 23","Renin-Angiotensin-Aldosterone System","Renin-Angiotensin System","Angiotensin-(1-7)","Angiotensin II","Angiotensin-Converting Enzyme 2","Angiotensin-Converting Enzyme","Causal Inference","Causal Mediation Analysis","Sensitivity Analysis","Predictive Analysis","Heart Rate Variability","Sodium","Lifecourse","Kidney Function","Ambulatory Blood Pressure Monitoring","Echocardiogram","2025-12-04",{"date":397,"type":36},"2025-12-11",{"date":399,"type":36},"2021-05-19",{"date":401,"type":23},"2026-12",{"name":123,"class":43},{"id":404,"slug":405,"hasResults":12,"nctId":406,"briefTitle":407,"officialTitle":408,"acronym":409,"eligibilityCriteria":410,"healthyVolunteers":51,"sex":18,"minAge":411,"maxAge":160,"enrollmentInfo":412,"targetDuration":4,"studyType":297,"phases":4,"briefSummary":414,"conditions":415,"keywords":416,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":420,"lastUpdatePostDateStruct":421,"startDateStruct":423,"completionDateStruct":425,"leadSponsor":427,"locationsCount":70},"100610586","developmental-trajectories-of-reinforcer-pathology-and-childhood-obesity-100610586","NCT07229508","Developmental Trajectories of Reinforcer Pathology and Childhood Obesity","Trajectories of Reinforcement, Activity, and Consumption in Kids","TRACK","Inclusion Criteria:\n\n* Male and female children\n* Black, Indigenous, and People of Color (BIPOC) or Hispanic families\n* Children from low SES families (as defined by household education, eligibility for government assistance)\n* Children in overweight\u002Fobese category (defined by range in each cohort)\n\nExclusion Criteria:\n\n* Medical causes for obesity\n* Stature below the 5th percentile\n* Physical activity restrictions\n* Psychopathology\n* Medication use that affects activity or appetite\n* Children that spend less than 65% of their time in participating parent's household\n* BMI percentile criteria\n* Liking of study foods and activities\n* Dietary restrictions and food allergies","8 Years",{"count":413,"type":23},250,"The goal of this observational study is to understand how children's food preferences, physical activity, and decision-making change over time and how these behaviors relate to body weight and overall health.",[31],[417,418,419],"Reinforcer Pathology Theory","Reinforcing Value","Delay Discounting","2025-11-13",{"date":422,"type":36},"2025-11-17",{"date":424,"type":36},"2025-11-06",{"date":426,"type":23},"2030-10-01",{"name":428,"class":43},"State University of New York at Buffalo",{"id":430,"slug":431,"hasResults":12,"nctId":432,"briefTitle":433,"officialTitle":434,"acronym":4,"eligibilityCriteria":435,"healthyVolunteers":51,"sex":18,"minAge":436,"maxAge":437,"enrollmentInfo":438,"targetDuration":4,"studyType":24,"phases":440,"briefSummary":441,"conditions":442,"keywords":4,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":446,"lastUpdatePostDateStruct":447,"startDateStruct":449,"completionDateStruct":451,"leadSponsor":453,"locationsCount":95},"100524615","nurturing-needs-study-parenting-food-motivated-children-100524615","NCT06111040","Nurturing Needs Study: Parenting Food Motivated Children","Deconstructing Food Parenting Approaches to Obesity Prevention for the Highly Food Motivated Child","Inclusion Criteria:\n\n1. Child ages 4 or 5 years at baseline;\n2. Parent\u002F primary caregiver with legal representation (having 50% or more custody of child);\n3. Parent\u002Fprimary caregiver reporting primary responsibility for child feeding outside of childcare (being with child when they are eating at least two times daily);\n4. Caregiver with a cell phone that can be used to send and receive text messages. If there is more than one age-eligible child in the family, we will ask the caregiver to pick the index child.\n\nExclusion Criteria:\n\n1. Parent\u002Fprimary caregiver \\\u003C18 years of age;\n2. Child history of major food allergies (e.g., peanuts);\n3. Child medication use (e.g., insulin), developmental disability (e.g., autism) or medical condition(s) (e.g., diabetes) known to affect food intake and growth;\n4. Foster child.","4 Years","5 Years",{"count":439,"type":23},416,[26],"High food motivation among children is trait-like and increases risks of unhealthy dietary intake and obesity. Scientific knowledge of how parenting can best support healthy eating habits and growth among children who are predisposed to overeating is surprisingly limited. This investigation will identify supportive food parenting approaches for obesity prevention that address the needs of highly food motivated children.",[443,444,445,31],"Parenting","Eating Behavior","Diet, Healthy","2025-11-03",{"date":448,"type":36},"2025-11-05",{"date":450,"type":36},"2023-09-07",{"date":452,"type":23},"2027-10-31",{"name":454,"class":43},"Temple University",{"id":456,"slug":457,"hasResults":12,"nctId":458,"briefTitle":459,"officialTitle":460,"acronym":4,"eligibilityCriteria":461,"healthyVolunteers":51,"sex":18,"minAge":243,"maxAge":19,"enrollmentInfo":462,"targetDuration":4,"studyType":24,"phases":464,"briefSummary":465,"conditions":466,"keywords":469,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":472,"lastUpdatePostDateStruct":473,"startDateStruct":475,"completionDateStruct":477,"leadSponsor":478,"locationsCount":70},"100607225","multidimensional-intervention-in-mexican-schoolchildren-100607225","NCT07185789","Multidimensional Intervention in Mexican Schoolchildren","Multidimensional Intervention to Improve Healthy Lifestyle Practices and Nutrition and Health Status in Mexican Schoolchildren: Development of an Intervention Platform, Randomized Clinical Trial and Scaling Proposal","Inclusion Criteria:\n\n* Fourth grade elementary schools children from schools that belong to Federal entities: Campeche, Morelos and Mexico City, with morning schedule, from 8:00 to 12:30 or extended schedule, from 8:00 to 14:00hrs.\n* For Morelos State, elementary schools will be sought to be private, with at least 1000 enrollement students, with morning schedule, from 8:00 to 12:30 or extended schedule, from 8:00 to 14:00hrs.\n\nExclusion Criteria:\n\n* Children that don´t correspond to the selected shifts.",{"count":463,"type":23},200,[26],"The aims is to evaluate the effects of an multidimensional intervention on the physical-built and social environment around schools and the nutritional status of the school population, through a randomized community trial, in schools in 3 states of the Mexican Republic, using anthropometric indicators, biological, psychological, behavioral and environmental.\n\nThe main questions it aims to answer are:\n\n1. What are the main risk and protective factors for overweight and obesity in the school environment and in the environments around schools in primary education schools in three states of the Mexican Republic?\n2. Is there a relationship between risky eating behaviors and the body mass index of schoolchildren?\n3. Are the strategies that are being implemented effective in reducing the presence of risk factors and increasing the presence of protective factors for overweight and obesity in the school environment and in the environments around schools?\n4. Are the strategies that are being implemented effective in reducing the presence of risk factors and increasing the protective factors for overweight and obesity in the family environment?",[467,31,468],"Childhood Obesity","Childhood Overweight",[470,471],"Childhood obesity","School children","2025-09-15",{"date":474,"type":36},"2025-09-22",{"date":476,"type":36},"2023-11-07",{"date":206,"type":23},{"name":479,"class":480},"Mexican National Institute of Public Health","OTHER_GOV",{"id":482,"slug":483,"hasResults":12,"nctId":484,"briefTitle":485,"officialTitle":486,"acronym":487,"eligibilityCriteria":488,"healthyVolunteers":12,"sex":18,"minAge":269,"maxAge":489,"enrollmentInfo":490,"targetDuration":4,"studyType":24,"phases":492,"briefSummary":493,"conditions":494,"keywords":496,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":501,"lastUpdatePostDateStruct":502,"startDateStruct":504,"completionDateStruct":505,"leadSponsor":507,"locationsCount":70},"100571995","effects-of-hiit-and-concurrent-hittplyometric-training-on-muscle-tendon-structure-function-and-metabolism-in-pediatric-population-with-obesity-at-different-biological-maturation-states-hiit-pro-kids-100571995","NCT06727500","Effects of HIIT and Concurrent HITT\u002FPlyometric Training on Muscle-tendon Structure, Function and Metabolism in Pediatric Population With Obesity at Different Biological Maturation States (HIIT-PRO Kids).","Effects of HIIT and Concurrent HITT\u002FPlyometric Training on Muscle-tendon Structure, Function and Metabolism in Pediatric Population With Obesity at Different Biological Maturation States (HIIT-PRO Kids): A Study Protocol of Randomized Controlled Trial","HIIT-PRO-kids","Inclusion Criteria:\n\n* Pediatric population with obesity determined by the body mass index by z-score (BMI-z) ≥ 2 standard deviations (SD) and ≤ 3.5 SD of the median for age and sex.\n* Pediatric population with -1 to -3 APHV (pre-APHV) and +1 to +3 APHV (post-APHV).\n\nExclusion Criteria:\n\n* Cognitive Disabilities.\n* Musculoskeletal condition that prevents regular physical activity.\n* Severe heart diseases that contraindicate the practice of physical activity.\n* Individuals who perform supervised exercise in the past six months.","17 Years",{"count":491,"type":23},40,[26],"The randomized controlled trial will compare the effects of a High-intensity interval training (HIIT) protocol versus a HIIT plus plyometric training in the muscle-tendon structure function and metabolism of the pediatric population with obesity at different biological maturational stages (pre-to-age peak velocity \\[APHV\\] and post-APHV). Both groups perform baseline evaluations of the main and secondary outcomes and receive the intervention for twelve weeks, three times per week. Once the interventions are completed, the participants undergo the same evaluations they performed at baseline.",[31,495],"Training Effectiveness",[305,497,498,499,500],"High-intensity interval training","Tendon mechanical properties","Plyometric training","Biological maturation stages","2025-08-28",{"date":503,"type":36},"2025-09-05",{"date":311,"type":36},{"date":506,"type":23},"2026-09-01",{"name":508,"class":43},"Universidad Nacional Andres Bello",{"id":510,"slug":511,"hasResults":12,"nctId":512,"briefTitle":513,"officialTitle":513,"acronym":514,"eligibilityCriteria":515,"healthyVolunteers":12,"sex":18,"minAge":131,"maxAge":489,"enrollmentInfo":516,"targetDuration":4,"studyType":24,"phases":518,"briefSummary":519,"conditions":520,"keywords":4,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":523,"lastUpdatePostDateStruct":524,"startDateStruct":526,"completionDateStruct":528,"leadSponsor":530,"locationsCount":95},"100511892","mechanistic-study-of-inspiratory-training-in-childhood-asthma-mica-100511892","NCT05945355","Mechanistic Study of Inspiratory Training in Childhood Asthma (MICA)","MICA","Inclusion Criteria:\n\n* 6-17 years of age\n* Documented clinician-diagnosed asthma\n* Currently requiring 2 or more controller prescriptions to treat disease (i.e. moderate to severe persistent disease)\n* Either obese (≥95th percentile BMI and less than 170% of the 95th CDC percentile) or have a normal BMI (BMI 5th to 84th CDC percentile)\n\nExclusion Criteria:\n\n* ACT (asthma control test) score \\\u003C17\n* Ever intubated for asthma\n* FEV1 \\\u003C 50% of predicted at enrollment\n* Currently pregnant\n* Legal guardian unable to consent in English or Spanish\n* Any major chronic illness that, in the opinion of the PI, would interfere with participation\n* Younger than 6 years of age",{"count":517,"type":23},76,[26],"This is single-center cross-sectional mechanistic study in lean and obese children with moderate-severe asthma, followed by a randomized, SHAM-controlled trial of Inspiratory Training (IT). The primary outcome is to describe the contributions of inspiratory muscle dysfunction (IMD) and Small Airway Dysfunction (SAD) to obesity-related versus non-obesity-related asthma. The study will involve training (IT) for 8 weeks at three intensity levels (SHAM, low and high). Target dose: 150 inspirations three times weekly. The population includes 6 to 17-year-old children with moderate to severe asthma and with a body mass index qualifying as normal habitus (BMI 5th to 84th CDC percentile) or obese habitus (≥95th percentile BMI and less than 170% of the 95th CDC percentile). Participants will be involved for 10 weeks. The investigators will use analysis of covariance (ANCOVA) to estimate and test the difference in mean values of baseline measures between obese and non-obese cohorts. Covariates will include age, sex (male\u002Ffemale), race\u002Fethnicity, baseline asthma severity (NAEPP step 2 vs ≥3), and atopy status",[521,195,31,522],"Asthma in Children","Pediatric Asthma","2025-08-18",{"date":525,"type":36},"2025-08-19",{"date":527,"type":36},"2024-08-01",{"date":529,"type":23},"2027-10-30",{"name":341,"class":43},{"id":532,"slug":533,"hasResults":12,"nctId":534,"briefTitle":535,"officialTitle":535,"acronym":536,"eligibilityCriteria":537,"healthyVolunteers":12,"sex":18,"minAge":411,"maxAge":489,"enrollmentInfo":538,"targetDuration":4,"studyType":24,"phases":540,"briefSummary":541,"conditions":542,"keywords":543,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":523,"lastUpdatePostDateStruct":546,"startDateStruct":548,"completionDateStruct":550,"leadSponsor":552,"locationsCount":70},"100486022","inspiratory-pulmonary-rehabilitation-for-children-with-obesity-and-asthma-100486022","NCT05608668","Inspiratory Pulmonary Rehabilitation for Children With Obesity and Asthma","iPro","Inclusion Criteria:\n\n* Documented informed consent from legal guardian and assent from participant as appropriate.\n* Children 8 to 17 years of age with obesity (BMI ≥ 95th percentile for age and sex) and mild asthma.\n* Participants (or parent\u002Fguardian) must have access to the internet and an approved smart device\u002Fcomputer.\n* Child must have a designated caregiver who expresses a commitment to encourage the participant to complete the study procedures.\n* Participant and legal guardian must speak and read English.\n* Child is currently taking prescription medicine for asthma (Any type of albuterol or inhaled steroid)\n\nExclusion Criteria:\n\n* Prior intubation for asthma\n* Current self-reported pregnancy or planning to become pregnant.\n* Have an FEV1 \\\u003C 50% of predicted at screening\n* History of lung surgery in the past two years,\n* History of pulmonary embolism in the past two years,\n* Any history of recurrent spontaneous pneumothorax, or pneumothorax in the past 12 months\n* Current undiagnosed chest pain,\n* History of inner ear surgery in the past 12 months,\n* Undiagnosed syncopal episodes in the past two years,\n* Progressive neurological or neuromuscular disorders or need for chronic O2 therapy.\n* Inability to complete baseline measurements satisfactorily according to the research coordinator's or PI's judgment.\n* Any condition in the opinion of the PI that would not allow safe conduct of study procedures (including IMR, MIP testing or step-test), such as a physical disability, recent musculoskeletal injury or illness, current and ongoing evaluation for undiagnosed cardiopulmonary or neurologic symptoms",{"count":539,"type":23},60,[26],"This is a single-center, randomized, SHAM-controlled, parallel assignment, double-masked,8-week interventional study among children aged 8-17 years (not yet 18 years old) of age with obesity and asthma. (n=60), recruited from Duke Health Center Creekstone, to test the effectiveness of inspiratory muscle rehabilitation (IMR) as an acceptable add-on intervention to reduce dyspnea (feeling short-of-breath or breathless) and to promote greater activity in children with obesity and asthma.\n\nClinic to test the effectiveness of inspiratory muscle rehabilitation (IMR) as an acceptable add-on intervention to reduce dyspnea (feeling short-of-breath or breathless) and to promote greater activity in children with obesity",[31,522],[544,195,545],"Asthma","Pediatric",{"date":547,"type":36},"2025-08-22",{"date":549,"type":36},"2023-07-27",{"date":551,"type":23},"2026-06",{"name":341,"class":43},{"id":554,"slug":555,"hasResults":12,"nctId":556,"briefTitle":557,"officialTitle":558,"acronym":559,"eligibilityCriteria":560,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":489,"enrollmentInfo":561,"targetDuration":4,"studyType":24,"phases":563,"briefSummary":564,"conditions":565,"keywords":567,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":573,"lastUpdatePostDateStruct":574,"startDateStruct":576,"completionDateStruct":578,"leadSponsor":580,"locationsCount":70},"100560069","low-energy-diet-in-adolescents-with-obesity-and-type-2-diabetes-the-legend-study-100560069","NCT06572345","Low EnerGy DiEt iN Adolescents With Obesity and Type 2 Diabetes: The LEGEND Study","A Multicentre Open-Label, Feasibility Study of the Use of a Short-Term Low-Energy Diet in Adolescents With Obesity and Type-2 Diabetes Mellitus","LEGEND","Inclusion criteria\n\nLED intervention\n\n* Diagnosis of T2DM (defined as an HbA1C ≥48mmol\u002Fmol, in the absence of features of type 1 or monogenic\u002Fsyndromic diabetes).\n* Current HbA1C ≥48 (or ≥42 on antidiabetic medication) and ≤ 80 mmol\u002Fmol.\n* Aged 12 to 17 years old.\n* BMI ≥98th centile (+2 SD) for age and sex (UK90 growth reference data).\n* Informed consent:\n\n  * Received from the young person (age 16-17) OR\n  * Received from young person's parent\u002Fcarer, with patient assent (age 12-15).\n* Willing to engage in and commit to low energy diet, FR and weight management phases including follow-up and attending study visits.\n\nLED Intervention Interviews\n\nThe same interview inclusion criteria for LED intervention, with the following additional requirements:\n\nPatients:\n\n* Informed consent:\n\n  * Received from the young person (age 16-17) OR\n  * Received from young person's parent\u002Fcarer, with patient assent (age 12-15).\n* Willing to take part in a qualitative interview alongside a parent\u002Fcarer.\n\nRelative\u002FCarer:\n\n* A relative\u002Fcarer for a young person meeting the above LED participant eligibility criteria.\n* Informed consent from the relative\u002Fcarer to participate in the interview.\n* Willing to take part in a qualitative interview alongside the young person.\n\nNon-LED Qualitative Interview only participants\n\n* Diagnosis of T2DM (defined as an HbA1C ≥48mmol\u002Fmol, in the absence of features of type 1 or monogenic\u002Fsyndromic diabetes).\n* Current HbA1C ≥48 (or ≥42 on antidiabetic medication) and ≤80 mmol\u002Fmol.\n* Aged 12 to 17 years old.\n* BMI ≥98th centile (+2 SD) for age and sex (UK90 growth reference data).\n* Informed consent:\n\n  * Received from the young person (age 16-17) OR\n  * Received from young person's parent\u002Fcarer, with patient assent (age 12-15).\n* Willing to take part in a qualitative interview alongside a parent\u002Fcarer only.\n\nHCPs\n\n* Registered HCP.\n* Experience of delivering this trial to the adolescents.\n* Willing to take part in a qualitative interview about undertaking motivational interviewing training and conducting\u002Fdelivering the LED intervention study.\n\nExclusion criteria\n\nLED intervention\n\n* HbA1C greater than 80mmol\u002Fmol.\n* Presence of diabetes-related autoantibodies, as per local centre guidelines.\n* Confirmed mono-genetic cause of obesity (e.g. SIM1 mutation) or diabetes-associated syndrome such as Prader-Willi syndrome, Bardet-Biedl or Wolfram's syndrome.\n* Secondary diabetes (post bone marrow transplant\u002Fchemotherapy).\n* Significant psychiatric co-morbidity.\n* Breastfeeding, pregnant or planning to conceive during the LED and FR phases (female participants will be advised on need for effective contraceptive methods during the 12-month study period, section 5.1.1.10).\n* Any other condition which, in the opinion of the study investigator, would make it inappropriate to undertake a period of LED. (All reasons for not approaching patients will be recorded and analysed anonymously. Cases can be discussed with the core study group if there is doubt).\n* Participation in another interventional trial within 6 months.\n* Informed consent and\u002For assent not received.\n* Pre-existing retinopathy.\n* Dietary avoidance (including, but not limited to, due to allergies, intolerances, religious reasons and lifestyle choices) to any ingredients in the meal replacement products, including lactose.\n* Previous scoliosis repair.\n\nNon-LED Qualitative Interview only participants\n\n* HbA1C greater than 80mmol\u002Fmol.\n* Presence of diabetes-related autoantibodies, as per local centre guidelines.\n* Confirmed mono-genetic cause of obesity (e.g. SIM1 mutation) or diabetes-associated syndrome such as Prader-Willi syndrome, Bardet-Biedl or Wolfram's syndrome.\n* Secondary diabetes (post bone marrow transplant\u002Fchemotherapy).\n* Significant psychiatric co-morbidity.\n* Breastfeeding, pregnant or planning to conceive during the LED and FR phases (female participants will be advised on need for effective contraceptive methods during the 12-month study period, section 5.1.1.10).\n* Any other condition which, in the opinion of the study investigator, would either make it inappropriate to undertake a period of LED. (All reasons for not approaching patients will be recorded and analysed anonymously. Cases can be discussed with the core study group if there is doubt).\n* Participation in another interventional trial within 6 months.\n* Informed consent and\u002For assent not received.\n* Pre-existing retinopathy.\n* Dietary avoidance (including, but not limited to, due to allergies, intolerances, religious reasons and lifestyle choices) to any ingredients in the meal replacement products, including lactose.\n* Previous scoliosis repair.\n\nHCPs\n\n• None.",{"count":562,"type":23},73,[26],"This is a multicentre, single-arm, feasibility study in adolescents with T2DM and obesity to investigate the recruitment and retention rates to a study using Low Energy Diets(LED). It will also provide estimates of weight loss needed to bring about remission to inform a larger randomised study. In addition a subgroup of participants and their parents\u002Fcarers undertaking a period of LED will be interviewed to understand the participants experience of taking part. Two further groups will also be interviewed: participants and their parents\u002Fcarers who have declined to take part in the LED to understand their motivations and barriers and healthcare practitioners who have participated in conducting the trial to understand their experience of the study.",[31,566],"Type 2 Diabetes",[568,569,195,570,571,572],"Type 2 diabetes mellitus","Paediatric","Low-energy diet","Adolescent","Remission","2025-08-01",{"date":575,"type":36},"2025-08-03",{"date":577,"type":36},"2025-06-30",{"date":579,"type":23},"2026-12-31",{"name":581,"class":43},"Nottingham University Hospitals NHS Trust",{"id":583,"slug":584,"hasResults":12,"nctId":585,"briefTitle":586,"officialTitle":586,"acronym":4,"eligibilityCriteria":587,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":588,"enrollmentInfo":589,"targetDuration":4,"studyType":24,"phases":590,"briefSummary":591,"conditions":592,"keywords":594,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":597,"lastUpdatePostDateStruct":598,"startDateStruct":600,"completionDateStruct":602,"leadSponsor":604,"locationsCount":70},"100403681","time-limited-eating-in-adolescents-with-type-2-diabetes-kt2d-100403681","NCT04536480","Time Limited Eating in Adolescents With Type 2 Diabetes (KT2D)","All adolescents with T2D and referred to the endocrinology clinic at CHLA will be screened. Inclusion criteria are: (1) age 12-21 years; (2) Tanner stage III and above; (3) diagnosis of T2D based on the ADA diagnostic guidelines; (4) hemoglobin A1c \\\u003C 9%; and (5) participant must be willing and able to adhere to the assessments, visit schedules, and eating\u002Ffasting periods. To limit confounding factors, individuals will be considered ineligible to participate if they meet any of the following exclusion criteria: (1) previous diagnosis of Prader-Willi Syndrome, brain tumor or hypothalamic obesity; (2) serious developmental or intellectual disability; (3) previous diagnosis or subthreshold symptoms of an eating disorder (anorexia nervosa, bulimia nervosa, binge-eating disorder); (4) parent\u002Fguardian-reported physical, mental of other inability to participate in the assessments (e.g., inability to wear CGM, inability to undergo imaging testing without sedation); (5) previous or planned bariatric surgery; (6) current planned use of an anti-obesity or other diabetes medication (e.g., phentermine, topiramate, orlistat, glucagon-like-peptide-1 agonist, naltrexone, or bupropion); or (7) current participation in other interventional weight loss studies.","21 Years",{"count":245,"type":23},[26],"To find the effectiveness of a diet plan (Time Limited Eating or TLE) on glycemic control, B-cell function, body fat, and body mass index (BMI) in adolescents with type 2 diabetes.",[31,566,593],"Time Restricted Eating",[595,566,596],"Intermitted-fasting","Time Limited Eating","2025-06-18",{"date":599,"type":36},"2025-06-24",{"date":601,"type":36},"2023-04-15",{"date":603,"type":23},"2027-12-01",{"name":235,"class":43},{"id":606,"slug":607,"hasResults":12,"nctId":608,"briefTitle":609,"officialTitle":610,"acronym":611,"eligibilityCriteria":612,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":186,"enrollmentInfo":613,"targetDuration":4,"studyType":24,"phases":614,"briefSummary":615,"conditions":616,"keywords":625,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":631,"lastUpdatePostDateStruct":632,"startDateStruct":634,"completionDateStruct":636,"leadSponsor":638,"locationsCount":70},"100587090","controlled-evaluation-of-an-exercise-program-for-overweight-adolescents-100587090","NCT06923865","Controlled Evaluation of an Exercise Program for Overweight Adolescents","Now! Project - a Controlled Evaluation of a Physical Activity Program for Adolescents With Overweight","Now!","Inclusion Criteria:\n\n* BMI above the 90th percentile for their age and gender (WHO reference table)\n* Deficits in movement motivation and motor skills\n* No health complaints or movement-restricting conditions\n* No health risks for maximal exertion\n* Ability to verbally communicate pain or discomfort\n* Unremarkable PAR-Q questionnaire\n* Signed parental consent form\n\nExclusion Criteria:\n\n* Acute or chronic illness\n* Inability to follow the study procedures (e.g., language barriers, psychological disorders)",{"count":220,"type":23},[26],"Physical activity decreases as young people get older, especially during the shift from early to late adolescence. Unfortunately, around 81% of school-aged children worldwide between the ages of 11 and 17 do not meet the recommendation of at least one hour of physical activity per day - and this is also true in Switzerland. Not being active enough, whether normal weight or overweight, can lead to long-term health problems and is a major factor in becoming overweight over time. This results in healthcare costs and negatively affects quality of life. Supporting physical activity in overweight youth requires well-rounded, thoughtful programs.\n\nThe investigators studying the impact of the movement programs now! and now!+ on the physical activity and health of young people. The goal is to look at both physical and mental changes equally.\n\nTaking part in this study involves minimal physical or mental risk for the participants. These small risks from the testing methods and activities are taken into account in how the program is explained and carried out.\n\nThe benefits for the participants - feeling healthier and fitter physically, and more confident and capable mentally - clearly outweigh any potential risks, thanks to the additional, guided, and personalized exercise program.\n\nThe participants take part in the now! and now!+ exercise programs run by the Basel-Stadt Sports Office and the DSBG. now! is a 90-minute group session with up to 14 young people, while now!+ is a 90-minute small-group session with 2 to 4 participants. Both programs take place once a week over a 12-month period and pause during school holidays (38 training weeks in total).\n\nEach session includes a warm-up, a strength or endurance training block, and a coordination phase. The program is modular and adapted to the physical and personal needs of each participant. This ensures that overweight adolescents are not overstrained and don't develop symptoms like pain, frustration, or lack of motivation (Behringer et al., 2011), while still allowing for a training stimulus that supports physical improvement.\n\nThe results of the evaluations are directly used to improve and further develop the exercise program. The overall project includes three rounds, each consisting of one year of training and three test sessions, each lasting about two hours. The now! and now!+ programs are held weekly for a total of 38 weeks per year, with breaks during school holidays.\n\nEach of the three test sessions includes the same set of assessments (see \"Study Intervention\") and follows a set order: The process begins with measuring body size and blood pressure, followed by a static retinal vessel analysis. After these medical checks, participants do a 5-minute warm-up on a stationary bike at a set resistance level. Then, strength tests are performed: knee extension on the IsoMed 2000, handgrip strength, and jump power on the Leonardo force plate. The endurance test using spiroergometry marks the end of the physical assessments.\n\nFinally, impulse control is tested, and participants complete a set of questionnaires. At the end of the session, each participant is given an actigraph (a small motion sensor worn on the body) to track their physical activity over the following seven days.",[571,31,617,618,619,620,621,622,623,624],"Exercise Therapy","Health Promotion","Program Evaluation","Impulse Control Disorders","Quality of Life","Retinal Vessels","Strength Training Effects","Aerobic Capacity",[626,627,628,629,630],"Overweight adolescents","Youth physical activity","Motor performance in children","Impulse control and fitness","training in peer groups","2025-04-04",{"date":633,"type":36},"2025-04-11",{"date":635,"type":23},"2025-06-01",{"date":637,"type":23},"2029-12",{"name":639,"class":43},"University Hospital, Basel, Switzerland",{"id":641,"slug":642,"hasResults":12,"nctId":643,"briefTitle":644,"officialTitle":645,"acronym":4,"eligibilityCriteria":646,"healthyVolunteers":51,"sex":18,"minAge":131,"maxAge":19,"enrollmentInfo":647,"targetDuration":4,"studyType":24,"phases":648,"briefSummary":649,"conditions":650,"keywords":651,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":658,"lastUpdatePostDateStruct":659,"startDateStruct":661,"completionDateStruct":663,"leadSponsor":665,"locationsCount":70},"100460852","integrating-community-lite-programme-as-an-online-family-based-intervention-to-combat-childhood-obesity-100460852","NCT05281016","Integrating Community LITE Programme as an Online Family-based Intervention to Combat Childhood Obesity","Integrating Community LITE Programme Into a School-clinic-community Partnership as an Online Family-based Intervention to Combat Childhood Obesity","Inclusion Criteria:\n\n* Overweight as defined by BMI percentile of above 90th percentile\n* Age 6- 12 years old\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Patients with secondary causes of obesity especially genetic syndromes e.g. Trisomy 21, Prader-Willi, and those who are taking medications that can affect weight status.\n* Intellectual disability, poor level of spoken English (including their parent\u002Fcarer)\n* Significant medical illness that precludes physical activity and significant psychiatric illness\n* Sibling who is already participating in the study",{"count":245,"type":23},[26],"Childhood obesity in Singapore is rising with a record prevalence of 13% in 2017 (1). Given that 70% of overweight children remain so into adulthood (2), this will further increase the public health epidemic of diabetes among Singaporeans. Early intervention is thus critical to improve the weight trajectory of overweight children and foster life long healthy lifestyle habits. Family-based interventions combining dietary, physical activity and behavioural interventions are currently recommended as the best practice in the management of childhood obesity in children younger than 12 years old (3-7). Our pilot study on family-based intervention in the tertiary setting demonstrated feasibility and short-term effectiveness. However, its outreach and sustainable results are limited. Currently, school-based screening, weight management clinics and community recreational facilities are operating in silos with limited effectiveness. Here, the investigators will integrate our family-based intervention into a school, clinic and community partnership to achieve an impactful and sustainable outcome for families with overweight children.\n\nThe community Lifestyle InTervention for Everyone (LITE) program is a structured, group family-based multicomponent lifestyle intervention. Community LITE program will introduce various exercise programs within the family based online sessions to reduce perceived barrier and promote self-efficacy of community sports facilities to increase physical activity. Children have minimal control over their food and physical activity choices especially in current obesogenic environment (8). Parents are the most important influencers(9) to impose interventions for childhood obesity through parental practices and parenting style(10). Therefore, they are the main focus of the community-based intervention program.",[31],[652,653,654,655,656,657,443],"child health","Body Mass Index","Healthy Lifestyle","Community Networks","internet-based intervention","Diet, Food, and Nutrition","2024-11-24",{"date":660,"type":36},"2024-11-27",{"date":662,"type":36},"2022-04-22",{"date":664,"type":23},"2025-12",{"name":666,"class":480},"KK Women's and Children's Hospital",{"id":668,"slug":669,"hasResults":12,"nctId":670,"briefTitle":671,"officialTitle":671,"acronym":4,"eligibilityCriteria":672,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":588,"enrollmentInfo":673,"targetDuration":4,"studyType":24,"phases":675,"briefSummary":676,"conditions":677,"keywords":679,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":680,"lastUpdatePostDateStruct":681,"startDateStruct":683,"completionDateStruct":685,"leadSponsor":687,"locationsCount":70},"100496132","early-vs-late-time-restricted-eating-in-adolescents-with-obesity-el-trea-100496132","NCT05740254","Early vs. Late Time-Restricted Eating in Adolescents With Obesity (EL TREA)","Inclusion Criteria:\n\n* 12-21 years with obesity (BMI\\>95th percentile)\n* participant must be willing and able to adhere to the assessments, visit schedules, and eating\u002Ffasting periods\n* baseline eating window greater than 12 hours.\n\nExclusion Criteria:\n\n* diagnosis of Prader-Willi Syndrome, brain tumor, or diabetes serious intellectual disability\n* previous diagnosis or subthreshold symptoms of an eating disorder (anorexia nervosa, bulimia nervosa, binge-eating disorder)\n* parent\u002Fguardian-reported physical, mental of other inability to participate in the assessments\n* previous bariatric surgery\n* current participation in other interventional weight loss studies.",{"count":674,"type":23},120,[26],"Determine the effectiveness of how limiting the time you eat within an early or late eating window and fasting for remainder of the day will impact weight loss and body mass index (BMI).",[31,678,593],"Time Restricted Feeding",[195,595,596],"2024-10-19",{"date":682,"type":36},"2024-10-22",{"date":684,"type":36},"2023-03-27",{"date":686,"type":23},"2027-01-01",{"name":235,"class":43},{"id":689,"slug":690,"hasResults":12,"nctId":691,"briefTitle":692,"officialTitle":693,"acronym":694,"eligibilityCriteria":695,"healthyVolunteers":12,"sex":696,"minAge":19,"maxAge":78,"enrollmentInfo":697,"targetDuration":4,"studyType":24,"phases":698,"briefSummary":699,"conditions":700,"keywords":711,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":716,"lastUpdatePostDateStruct":717,"startDateStruct":719,"completionDateStruct":721,"leadSponsor":723,"locationsCount":70},"100558914","in-person-lifestyle-program-for-black-adolescent-girls-at-risk-for-type-2-diabetes-100558914","NCT06557317","In-Person Lifestyle Program for Black Adolescent Girls at Risk for Type 2 Diabetes","Examining the Preliminary Efficacy of an In-Person Lifestyle Intervention for Black Female Adolescent\u002FCaregiver Dyads at Risk for Type 2 Diabetes Mellitus","BGW In-Person","Inclusion Criteria for adolescent participants:\n\n* 12-18 years of age\n* self-identify as Black or African American\n* have obesity (\\>=95th percentile BMI)\n\nExclusion Criteria for adolescent participants:\n\n* pregnant or within 3 months postpartum.\n* participated in a formal weight management program within 6 months prior to study.\n* currently taking medications or diagnosed with a condition known to influence metabolism, physical activity ability, or cognitive function.\n* have previously undergone bariatric surgery.\n* have type 2 diabetes.\n* unable to speak English or have developmental conditions that interfere with ability to communicate.\n\nInclusion Criteria for caregiver participants:\n\n* 18 years or older.\n* proficiency in speaking English.\n* live in the same household as the adolescent who will also be enrolled.\n* prepares the majority (\\>50%) of meals in the household.\n\nExclusion Criteria for caregiver participants:\n\n* pregnant or within 3 months postpartum.\n* unable to speak English or have developmental conditions that interfere with ability to communicate.","FEMALE",{"count":539,"type":23},[26],"The aim of this study is to look at changes in diabetes-related risk factors in Black adolescent girls who are at risk for type 2 diabetes and their primary female caregiver after both participating in a 12-week in-person lifestyle program.",[701,467,702,31,703,704,705,706,707,708,709,710],"Behavior, Adolescent","Diabetes Mellitus, Type 2","Glucose Metabolism Disorders","Metabolic Disease","Endocrine System Diseases","Overweight","Overnutrition","Nutrition Disorders","Body Weight","Diabetes Mellitus",[712,713,714,715,195],"Adolescents","In-Person Lifestyle Program","Diabetes prevention","Black girls","2024-08-14",{"date":718,"type":36},"2024-08-16",{"date":720,"type":23},"2024-08",{"date":722,"type":23},"2024-12-31",{"name":724,"class":43},"Cornell University"]