[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pediatric-open-heart-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pediatric-open-heart-surgery":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100623165","jafron-cytokine-adsorber-during-pediatric-open-heart-surgeries-100623165",false,"NCT07393087","Jafron Cytokine Adsorber During Pediatric Open-Heart Surgeries","JACKPOT","Inclusion Criteria:\n\n* Children ≤ 10 years old at study inclusion\n* Children weighing at least 5 kg at study inclusion\n* Planned for open-heart cardiac surgery with CPB-time ≥ 120 min and aortic clamping.\n* Informed consent obtained from parent(s)\u002Flegal representative\n\nExclusion Criteria:\n\n* Children having an indication to receive hemoadsorption during CPB for drugs removal or other medically justified reason\n* Previous enrolment into the current study\n* Off-pump procedure\n* Chronic immunosuppression (chronic corticosteroid therapy, chemotherapy, anti-leucocyte drugs, TNF blockers or else)\n* Known allergy to heparin or heparin induced thrombocytopenia.\n* Severe thrombopenia (platelets count before surgery \\\u003C 20G\u002FL)\n* Parent(s)\u002Flegal representative not able to understand\u002Fread French and\u002For English\n* Participation in another conflicting research study","ALL","10 Years",{"count":19,"type":20},20,"ESTIMATED","INTERVENTIONAL",[23],"NA","This prospective single-center randomized controlled trial aims at evaluating the safety and feasibility of an hemoadsorption protocol using Jafron HA-60 during cardio-pulmonary bypass in 20 pediatric patients undergoing open-heart surgery.",[26,27,28,29,30],"Cardiac Surgery Recovery","Inflammation","Complex Cardiovascular Surgery With Cardiopulmonary Bypass","Cytokine Storm","Pediatric Open Heart Surgery",[32,33,34],"Feasibility pilot study","Pediatric open heart surgery","Hemoadsorption","NOT_YET_RECRUITING","2026-02-06",{"date":38,"type":39},"2026-02-10","ACTUAL",{"date":41,"type":20},"2026-03",{"date":43,"type":20},"2029-04",{"name":45,"class":46},"Centre Hospitalier Universitaire Vaudois","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":21,"phases":59,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":5},"100583924","a-combination-of-intrathecal-fentanyl-and-pecto-intercostal-fascial-block-in-paediatric-cardiac-surgery-100583924","NCT06882655","A Combination of Intrathecal Fentanyl and Pecto-Intercostal Fascial Block in Paediatric Cardiac Surgery.","A Combination of Intrathecal Fentanyl and Ultrasound-Guided Pecto-Intercostal Fascial Block in Paediatric Cardiac Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* The enrolled patients ranged in age from 6 months to 6 years,\n* patients scheduled for surgical repair of congenital heart defects.\n\nExclusion Criteria:\n\n* The preoperative criteria include a history of previous cardiac surgery, hemodynamic instability, the need for mechanical ventilation, and the requirement for vasoactive drugs, opioids, or corticosteroids.\n* During the intraoperative phase, who use of deep hypothermic circulatory arrest and the necessity for vasoactive drugs, excluding the temporary use of dopamine and dobutamine at a maximum dose of 10 µg\u002Fkg\u002Fmin.\n* Postoperative exclusion conditions will include prolonged mechanical ventilation lasting more than 24 hours, hemodynamic instability, and the need for high doses of opioids or sedatives.","6 Months","6 Years",{"count":58,"type":20},90,[23],"Cardiac surgery is commonly performed via median sternotomy. Patients undergoing cardiac surgical procedures frequently experience intense acute pain in the post-sternotomy wound, which can potentially transition into persistent chronic pain in approximately 35% of cases after one year. Recently, thoracic myofascial plane blocks with ultrasound guidance as part of multimodal analgesia have contributed to a faster recovery after surgery.\n\nDe la Torre et al. first described pectointercostal fascial plane block (PIFPB) for breast surgery. Local anaesthetics are injected between the pectoralis major and internal intercostal muscles close to the sternum to block the anterior cutaneous branch of the second-to-sixth thoracic intercostal nerves.The use of intrathecal (IT) opioids with or without local anaesthetics (LA) is a popular analgesic technique around the world for the management of postoperative pain. Unlike IT administration of LA, IT opioids produce 'segmental' analgesia and are not associated with muscle weakness, loss of proprioception or sympathetic block. IT opioids can be administered as an adjunct to general anaesthesia or combined with LA and administered during spinal anaesthesia for surgery. It is one of the easiest, most reliable and cost-effective methods for pain relief. Intrathecal opioid administration can provide more intense analgesia than the IV route and has the advantages of simplicity and reliability",[62,30],"Postoperative Pain",[64,65,66],"Intercostal Fascial Block","intrathecal fentanyl","Paediatric Cardiac Surgery","2025-04-12",{"date":69,"type":39},"2025-04-15",{"date":71,"type":20},"2025-04-20",{"date":73,"type":20},"2025-10-10",{"name":75,"class":46},"Alexandria University"]