[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pediatric-patients\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pediatric-patients":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,47,85,118],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100624367","neurocognitive-deficit-after-paediatric-transplantation-understanding-the-role-of-environment-and-physical-function-100624367",false,"NCT07408713","Neurocognitive Deficit After Paediatric Transplantation: Understanding the Role of Environment and Physical Function","The NATURE Study (Neurocognitive Deficit After Paediatric Transplantation: Understanding the Role of Environment and Physical Function)","NATURE","Inclusion Criteria:\n\n1. Recipient of allogeneic HSCT in the study period\n2. HSCT at the pediatric ward\n3. Age \\\u003C18 years at referral to HSCT\n4. Signed informed consent\n\nExclusion Criteria:\n\n1\\) Inability of legal guardian to speak and understand Danish","ALL","0 Years","18 Years",{"count":21,"type":22},100,"ESTIMATED","OBSERVATIONAL","Hematopoietic stem cell transplantation (HSCT) is a potentially life-saving treatment for children with relapsed or resistant leukemia and other life-threatening hematological and hereditary disorders. In Denmark, around 25 children undergo allogeneic HSCT every year, of these approximately 85-90% survive into adulthood.\n\nThe goal of this observational study is to learn about neurocognitive outcomes in children undergoing (HSCT) and to understand which clinical, physical, and environmental factors may affect neurocognitive development during the first year after transplant. The main questions it aims to answer are:\n\nHow does neurocognitive function change from before HSCT to one year after transplantation in pediatric patients?\n\nWhich clinical, physical, and environmental factors are linked to better or worse neurocognitive outcomes?\n\nParticipants will:\n\nComplete neurocognitive tests before HSCT and at 1-year follow-up, covering intelligence, memory, attention, executive function, processing speed, and motor skills.\n\nUndergo physical tests before HSCT, at hospital discharge, at 6-months follow-up, and at 1-year follow-up, including muscle strength, mobility, endurance, balance, and cardiopulmonary fitness (only at 1-year follow-up).\n\nWear activity trackers to measure physical activity and sedentary time during hospitalization at 6 months and 1-year post-HSCT.\n\nComplete questionnaires about sleep, pain, quality of life, fatigue, family background, and exposure to outdoor and green spaces.\n\nHave medical records reviewed for treatment-related side effects, immune recovery, inflammation, and pain management.\n\nThis study will help understand how neurocognitive function develops after HSCT in children and which factors (clinical, physical, or environmental) may support better recovery and well-being.",[26,27,28,29,30,31,32,33],"HSCT","Pediatric Cancer","Pediatric Patients","Late Effect","Toxicity","Neurocognitive Dysfunction","Physical Function","Physical Capacity","NOT_YET_RECRUITING","2026-02-18",{"date":37,"type":38},"2026-02-20","ACTUAL",{"date":40,"type":22},"2026-02-15",{"date":42,"type":22},"2031-12-31",{"name":44,"class":45},"Rigshospitalet, Denmark","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":68,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":46},"100624315","preoperative-gamified-breathing-exercise-on-anxiety-and-delirium-in-children-100624315","NCT07408037","Preoperative Gamified Breathing Exercise on Anxiety and Delirium in Children.","Preoperative Anxiety and Postoperative Recovery Delirium Observation in Children Who Underwent Gamified Breathing Exercise","PED-ANX-DEL","Inclusion Criteria:\n\n* Children aged 3 to 7 years (preschool age).\n\nScheduled for elective (planned) surgery at Bursa Uludag University Hospital.\n\nPhysical status classified as ASA I or ASA II.\n\nChildren and parents who volunteer to participate and provide written informed consent.\n\nExclusion Criteria:\n\nChildren with chronic neurological or psychiatric disorders.\n\nChildren with existing respiratory system diseases that prevent breathing exercises.\n\nChildren or parents with communication barriers (e.g., severe hearing or speech impairment).\n\nChildren undergoing emergency (non-elective) surgery.\n\n\\-",true,"3 Years","7 Years",{"count":59,"type":22},80,"INTERVENTIONAL",[62],"NA","This study aims to evaluate the effect of preoperative gamified breathing exercises on preoperative anxiety and postoperative emergence delirium in children. The intervention includes games like ball blowing and bubble blowing. Anxiety is measured using the mYPAS-SF scale, and delirium is assessed with the PAED scale.",[65,66,67,28],"Preoperative Anxiety (Ameliyat Öncesi Anksiyete)","Emergence Delirium (Derlenme Deliryumu)","Postoperative Complications",[69,70,71,72,73,74],"Preoperative Anxiety","Emergence Delirium","Gamification","Breathing Exercises","Pediatric Nursing","Postoperative Recovery","RECRUITING","2026-02-10",{"date":78,"type":38},"2026-02-12",{"date":80,"type":38},"2024-03-03",{"date":82,"type":22},"2026-12-12",{"name":84,"class":45},"Bozok University",{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":55,"sex":17,"minAge":93,"maxAge":94,"enrollmentInfo":95,"targetDuration":4,"studyType":60,"phases":97,"briefSummary":98,"conditions":99,"keywords":102,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":46},"100622921","impact-of-conversational-approaches-in-pediatric-social-robot-mediated-interventions-100622921","NCT07389902","Impact of Conversational Approaches in Pediatric Social Robot-Mediated Interventions","The Impact of Conversational Approaches in Pediatric Robot-Mediated Interventions on Children's Responses in Hospital Settings: A Comparative Study of Rule-Based vs. LLM-Based Systems","PRIA","Inclusion Criteria:\n\n* Pediatric patients aged 2-9 years\n* Currently admitted to or visiting Samsung Medical Center pediatric ward or outpatient clinic\n* Capable of cognitive communication as determined by experienced medical staff\n* Written informed consent from parent\u002Flegal guardian obtained\n* Verbal assent from child obtained (developmentally appropriate)\n* Not in acute emergency situation\n* Able to engage in stable interaction for at least 5 minutes in hospital environment\n\nExclusion Criteria:\n\n* Diagnosis of moderate to severe developmental delay (language or cognitive) documented in medical records\n* Currently in isolation treatment (e.g., due to infectious disease)\n* Experiencing acute pain, fever, or medical procedures that make study participation difficult\n* Parent\u002Fguardian or child declined participation or withdrew consent","2 Years","9 Years",{"count":96,"type":22},60,[62],"This study examines how different robot dialogue systems (rule-based vs. large language model-based) and content types (emotional support vs. safety education) affect pediatric patients' responses during hospital-based robot-mediated interventions.\n\nApproximately 60 pediatric patients aged 2-9 years will be randomly assigned to interact with a social robot (LIKU) using either rule-based or LLM-based dialogue. Each child will participate in two activity sessions (emotional content and safety content) in randomized order.\n\nPrimary outcomes include child engagement, emotional responses, robot perception, and activity preferences, assessed through standardized questionnaires (UEQ, Godspeed), child interviews, and behavioral observations. Additionally, 5 experts will evaluate content appropriateness and safety.\n\nThis pilot study aims to provide foundational data for developing personalized pediatric robot programs in hospital settings, optimizing both dialogue approaches and content design based on individual child characteristics.",[28,100,101],"Pediatric Patients in Hospital Settings","Hospitalized Children",[103,104,105,106,107,108],"Child-robot interaction","Social robot","Pediatric hospitalization","Large language models","Human-robot interaction","Pediatric care","2026-01-29",{"date":111,"type":38},"2026-02-05",{"date":113,"type":22},"2026-02-09",{"date":115,"type":22},"2027-07-30",{"name":117,"class":45},"Samsung Medical Center",{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":4,"eligibilityCriteria":124,"healthyVolunteers":11,"sex":17,"minAge":125,"maxAge":57,"enrollmentInfo":126,"targetDuration":4,"studyType":60,"phases":128,"briefSummary":129,"conditions":130,"keywords":4,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":46},"100591734","ultrasound-guided-bilateral-pectoral-nerve-block-versus-bilateral-transverse-thoracic-plane-block-in-pediatric-patients-undergoing-corrective-cardiac-surgeries-requiring-cardiopulmonary-bypass-via-median-sternotomy-100591734","NCT06984276","Ultrasound Guided Bilateral Pectoral Nerve Block Versus Bilateral Transverse Thoracic Plane Block In Pediatric Patients Undergoing Corrective Cardiac Surgeries Requiring Cardiopulmonary Bypass Via Median Sternotomy","Efficacy Of Ultrasound Guided Bilateral Pectoral Nerve Block Versus Bilateral Transverse Thoracic Plane Block In Pediatric Patients Undergoing Corrective Cardiac Surgeries Requiring Cardiopulmonary Bypass Via Median Sternotomy: A Randomized Controlled Trial.","Inclusion Criteria:\n\n* Age: 6 months - 7 years.\n* Gender: both sexs .\n* Risk Adjustment for Congenital Heart Surgery (RACHS) II and III.\n* Patients undergoing cardiac surgeries requiring cardiopulmonary bypass with midline sternotomy incision.\n\nExclusion Criteria:\n\n* Patients whose parents or legal guardians refuse to participate.\n* Preoperative mechanical ventilation.\n* Patients in coma, mental retardation, neurological disease, or on drugs affecting the behaviour.\n* Preoperative inotropic drug infusion.\n* (Bleeding disorders (drug induced i.e., coumadin; or genetic e.g. hemophilia; or acquired e.g. disseminated intravascular coagulation \\[DIC\\]), coagulopathy: Partial Thromboplastin Time (PTT) \\> 40 seconds, International Normalized Ratio (INR) \\> 1.4, platelet count \\\u003C 100x10⁹.\n* Known or suspected allergy to any of the studied drugs.\n* Severe pulmonary hypertension (mean resting blood pressure in pulmonary arteries is above 70mmHg).\n* Cardiopulmonary bypass time more than 90 minutes.\n* local infection.\n* Significant Renal impairment (creatinine more than 1.2mg\u002Fdl)\n* Aortic cross-clamp time more than 45 minutes.\n* Total time from induction till intensive Care Unit (ICU) transfer more than 4 hours and 30 mins.","6 Months",{"count":127,"type":22},81,[62],"This randomized, double-blinded, study aims to compare the efficacy of intraoperative and postoperative pain control while using bilateral ultrasound guided the pectoral nerves (PECS) versus transversus thoracic muscle plane block (TTPB) in pediatric patients undergoing corrective cardiac surgeries.",[131,132,133,28,134,135,136],"Ultrasound","Pectoral Nerve Block","Transverse Thoracic Plane Block","Corrective Cardiac Surgeries","Cardiopulmonary Bypass","Median Sternotomy","2025-05-26",{"date":139,"type":38},"2025-05-30",{"date":141,"type":38},"2024-09-30",{"date":143,"type":22},"2025-12-30",{"name":145,"class":45},"Cairo University"]