[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"peep-titration-in-lung-protective-ventilation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:peep-titration-in-lung-protective-ventilation":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,57],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":27,"conditions":28,"keywords":39,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100630322","phase-1-influence-of-lung-volume-optimization-maneuver-on-cardiac-output-and-lung-compliance-in-ventilated-children-with-congenital-heart-disease-undergoing-surgical-repair-100630322",false,"NCT07486167","Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Compliance in Ventilated Children With Congenital Heart Disease Undergoing Surgical Repair","Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Mechanics in Children With Congenital Heart Disease","ILOCO-CHD","Inclusion Criteria:\n\n* Inclusion Criteria\n* congenital heart disease\n* surgery with cardiopulmonary bypass\n\nExclusion Criteria:\n\n* single ventricle physiology\n* ECMO\u002FVAD\n* \\\u003C36weeks of gestational age\n* chronic lung disease\n* Endotracheal tube leak \\> 15%\n* lack of informed consent from parents.","ALL","0 Days","18 Years",{"count":21,"type":22},80,"ESTIMATED","INTERVENTIONAL",[25,26],"PHASE1","PHASE2","The aim of this randomized interventional multi-center clinical trial is to determine whether a standardized lung volume optimization maneuver (LVOM), including PEEP titration, improves outcomes in children undergoing biventricular repair for congenital heart disease (CHD) with cardiopulmonary bypass.\n\nThe primary hypothesis is that optimizing end-expiratory lung volume through a standardized PEEP titration maneuver improves cardiac performance and lung function.\n\nSecondary objectives are to evaluate whether this strategy reduces duration of mechanical ventilation, improves hemodynamics and ventilation-perfusion matching, and decreases the need for vasopressor support.",[29,30,31,32,33,34,35,36,37,38],"Congenital Heart Disease","Cardiopulmonary Bypass","Mechanical Ventilation","Peep Titration in Lung Protective Ventilation","Positive End-expiratory Pressure (PEEP)","Lung Volume","Lung Mechanics","Children","Hemodynamic Changes","Cardiac Surgery",[40,41,42,43],"cardiopulmonary interactions","end-expiratory lung volume","electrical impedance tomography","PEEP titration","NOT_YET_RECRUITING","2026-04-26",{"date":47,"type":48},"2026-04-30","ACTUAL",{"date":50,"type":22},"2026-09-01",{"date":52,"type":22},"2028-12-31",{"name":54,"class":55},"Charite University, Berlin, Germany","OTHER",1,{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":4,"eligibilityCriteria":63,"healthyVolunteers":64,"sex":17,"minAge":19,"maxAge":65,"enrollmentInfo":66,"targetDuration":4,"studyType":68,"phases":4,"briefSummary":69,"conditions":70,"keywords":71,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":56},"100596333","lung-protective-ventilation-and-driving-pressure-guided-peep-titration-in-cabg-surgery-100596333","NCT07044089","Lung Protective Ventilation and Driving Pressure Guided PEEP Titration in CABG Surgery","Comparison of Individualized PEEP Application Versus Fixed PEEP Application for Lung-Protective Ventilation in Patients Undergoing On-Pump Coronary Artery Bypass Grafting Surgery","Inclusion Criteria:\n\n* Patients scheduled for elective on-pump coronary artery bypass graft surgery via median sternotomy\n* Patients between the ages of 18 and 70\n* ASA (American Society of Anesthesiologists) physical status classification II-III\n\nExclusion Criteria:\n\n* Patients with an ejection fraction below 35%\n* Patients who did not consent to participate in the study\n* Patients undergoing emergency surgery\n* Patients who are allergic to the anesthetic drugs used\n* Patients who have undergone lung resection\n* Those with a history of mechanical ventilation in the 2 months before surgery\n* Patients who have undergone total circulatory arrest and deep hypothermia\n* Patients with obstructive sleep apnea syndrome requiring long-term ventilation assistance\n* Morbid obesity (Body Mass Index\\>35kg\u002Fm2)\n* Patients with refractory hypoxemia (arterial oxygen saturation below 88% despite 100% oxygen inhalation)\n* COPD (FEV1\\\u003C70%)\n* Patients with chronic renal failure (serum creatine\\>1.8 mg\u002Fdl)\n* Anemia (Hg\\\u003C10 gr\u002Fdl)\n* Patients who have had an intraaortic balloon pump placed.",true,"70 Years",{"count":67,"type":22},86,"OBSERVATIONAL","Our aim in this study is to compare fixed and individualized PEEP (driving pressure guided ) application for intraoperative lung protective ventilation in patients undergoing on-pump CABG surgery.\n\nResearcher aimed to compare the effects of two different PEEP application methods on intraoperative hemodynamics, respiratory mechanics, and gas exchange, as well as postoperative extubation times, respiratory complications (atelectasis, need for non invasive mechanical ventilatıon, need for re-entubatıon) length of stay in the intensive care unit, and discharge times.",[32],[72,73,74],"Lung Protective Ventilation","Fixed PEEP","Individualized PEEP","RECRUITING","2025-08-06",{"date":78,"type":48},"2025-08-08",{"date":80,"type":48},"2025-07-23",{"date":82,"type":22},"2027-09-01",{"name":84,"class":55},"Kocaeli University"]