[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pelvic-organ-prolapse-vaginal-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pelvic-organ-prolapse-vaginal-surgery":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,44,77,105,134,162],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100624839","the-amper-study-evaluation-of-the-efficacy-of-human-amniotic-membrane-grafting-in-preventing-mesh-exposure-in-vaginal-reconstructive-surgery-using-polypropylene-mesh-100624839",false,"NCT07414849","The AMPER Study: Evaluation of the Efficacy of Human Amniotic Membrane Grafting in Preventing Mesh Exposure in Vaginal Reconstructive Surgery Using Polypropylene Mesh.","The Amper Study: Amniotic Membrane for the Prevention of Mesh Exposure in Vaginal Reconstructive Surgery","AMPER","Inclusion Criteria:\n\n* Pelvic organ prolapse (POP) stage II C or greater, defined as C ≥ +1, in women without prior hysterectomy and\u002For with a diagnosis of stress urinary incontinence seeking surgical treatment.\n* Ability to understand study information and provide written informed consent.\n* Availability for follow-up for a minimum of 12 months.\n\nExclusion Criteria:\n\n* Previous surgery with synthetic mesh (via vaginal or abdominal approach) for POP repair.\n* Known adverse reaction to synthetic meshes.\n* Unresolved or active chronic pelvic pain.\n* History of prior abdominal or pelvic radiation.\n* Contraindication to the planned surgical procedure.\n* Current pregnancy.","FEMALE",{"count":19,"type":20},330,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study evaluates the efficacy of adding a human amniotic membrane graft to polypropylene mesh surgery for pelvic prolapse and stress urinary incontinence. The goal is to assess improvements in tissue integration and the reduction of surgical complications",[26,27],"Pelvic Organ Prolapse Vaginal Surgery","Stress Urinary Incontinence in Women",[29,30],"amniotic membrane graft","polypropylene mesh","RECRUITING","2026-06-15",{"date":34,"type":35},"2026-06-17","ACTUAL",{"date":37,"type":35},"2026-03-01",{"date":39,"type":20},"2028-12-31",{"name":41,"class":42},"Hospital General de Agudos J. M. Penna","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":54,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100638472","urinary-continence-after-vaginal-surgery-for-genital-prolapse-in-the-spanish-population-100638472","NCT07628036","Urinary Continence After Vaginal Surgery for Genital Prolapse in the Spanish Population.","Inclusion Criteria:\n\n* Women who will undergo vaginal surgery for pelvic organ prolapse\n\nExclusion Criteria:\n\n* inhability to give consent to the study","18 Years","99 Years",{"count":53,"type":20},1042,"1 Year","OBSERVATIONAL","Surgical correction of pelvic organ prolapse (POP) may be associated with the development of postoperative stress urinary incontinence (SUI). This clearly affects women's satisfaction and their quality of life, and may require subsequent medical and\u002For surgical treatments.\n\nOn the other hand, pre-existing SUI could resolve after corrective prolapse surgery. Similarly, urge urinary incontinence (UUI) could appear or improve after vaginal POP surgery. Therefore, it is of paramount importance to know the prevalence of urinary incontinence after POP vaginal surgery and incontinence resolution in our population. Identifying the risk factors for the development of urinary incontinence may allow to provide individualized treatment.",[58,26,59],"Pelvic Organ Prolapse (POP)","Urinary Incontinence (UI)",[61,62,63,64,65],"Pelvic organ prolapse","Vaginal surgery","Urinary incontinence","Stress urinary incontinence","Urge-urinary incontinence","NOT_YET_RECRUITING","2026-06-01",{"date":69,"type":35},"2026-06-04",{"date":71,"type":20},"2026-08-01",{"date":73,"type":20},"2028-05-30",{"name":75,"class":42},"Hospital Universitari Vall d'Hebron Research Institute",4,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":17,"minAge":50,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":21,"phases":88,"briefSummary":89,"conditions":90,"keywords":92,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":5},"100636535","the-finnish-uterine-prolapse-surgery-trial-the-fin-up-trial-100636535","NCT07566949","The Finnish Uterine Prolapse Surgery Trial (The Fin-UP Trial)","Manchester Procedure Versus Vaginal Hysterectomy for Women With Uterine Prolapse: A Multi-Center Randomized Controlled Study (The Fin-UP Trial)","Fin-UP","Inclusion Criteria:\n\n* Fit for elective vaginal surgery according to standard preoperative assessment\n* Women aged over 18 years\n* No previous POP surgery\n* Symptomatic POP stage 2 or higher, with uterine descent of at least stage 2 (POP-Q point C ≥ minus 1) and with POP-Q point D ≤ minus 1. Patients with concurrent anterior or posterior compartment defects will be included.\n\nExclusion Criteria:\n\n* Pregnancy or future plans of pregnancy\n* Active malignancy of any kind\n* Contraindications for uterine preservation, i.e. suspected cervical or uterine malignancy, abnormal cervical cytology, abnormal uterine bleeding, a history of endometrial hyperplasia with atypia, or a known hereditary cancer syndrome involving the uterus (e.g., Lynch syndrome). All patients will undergo a clinical examination and ultrasound assessment prior to recruitment. If clinically indicated, a Pap-smear and\u002For endometrial biopsy will be performed prior to inclusion.\n* Contraindication to vaginal hysterectomy (e.g. extensive intra-abdominal adhesions)\n* Patient's preference for uterine removal or preservation\n* Planned concomitant incontinence procedure\n* Inability to speak Finnish or Swedish, understand the purpose of the study, or commit to follow-up","100 Years",{"count":87,"type":20},426,[23],"The goal of this clinical trial is to compare the Manchester procedure and vaginal hysterectomy in treating patients with symptomatic uterine prolapse.\n\nThe main question it aims to answer is:\n\n• What is the difference in the success rates at the the two year follow-up\n\nParticipants will:\n\n* be randomized in either the Manchester procedure or vaginal hysterectomy group and operated as such\n* visit the clinic at 2 and 5 years after the operation\n* fill in questionnaires at 1, 2, 5 and 10 years after the operation",[91,26,58],"Uterine Prolapse",[93,61,94,95,62],"Uterine prolapse","Manchester procedure","Vaginal hysterectomy","2026-05-06",{"date":98,"type":35},"2026-05-11",{"date":100,"type":20},"2026-05",{"date":102,"type":20},"2041-12",{"name":104,"class":42},"Tampere University Hospital",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":17,"minAge":50,"maxAge":51,"enrollmentInfo":112,"targetDuration":4,"studyType":21,"phases":114,"briefSummary":115,"conditions":116,"keywords":119,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":133},"100609702","accelerometer-measured-early-recovery-after-prolapse-surgery-100609702","NCT07218016","Accelerometer Measured Early Recovery After Prolapse Surgery","AccelERate","Inclusion Criteria:\n\n* Subject has provided written informed consent\n* Ambulatory women undergoing laparoscopic, robotic, or vaginal reconstructive or obliterative surgery for apical prolapse\n* POP-Q \\>= Stage III\n* Willing to participate in a postoperative exercise regimen\n* Able to read and consent in English or Spanish\n* Willing and able to wear an accelerometer prior to and after surgery (including agreeing to the terms of service), use an electronic data capture software, and record daily events\n* Willing and able to install and use study-related smartphone app(s)\n* Anticipated hospital discharge \\\u003C= postoperative day 1\n\nExclusion Criteria:\n\n* Inability or unwillingness to adhere to the exercise intervention\n* Contraindication to medium-intensity exercise\n* Comorbidities preventing physical activity\n* Planned abdominal approach with laparotomy",{"count":113,"type":20},288,[23],"The AccelERate study will evaluate the physical recovery of patients who have undergone Pelvic Organ Prolapse (POP) surgery. This will be evaluated via a self-reported recovery questionnaire completed daily. Participants will wear an accelerometer device on their non-dominant wrist and be given either routine or exercise-focused postoperative instructions. The primary outcome will be a comparison of the number of days needed to reach self-reported \"mostly recovered\" status between randomly assigned instruction groups.",[117,58,26,118],"Pelvic Organ Prolapse","Pelvic Organ Prolapse, Patient Education",[120,58,121,122],"accelerometer","Post-operative Recovery","recovery activities","2026-04-24",{"date":125,"type":35},"2026-04-27",{"date":127,"type":35},"2025-10-02",{"date":129,"type":20},"2028-03-31",{"name":131,"class":132},"NICHD Pelvic Floor Disorders Network","NETWORK",7,{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":4,"eligibilityCriteria":140,"healthyVolunteers":11,"sex":17,"minAge":50,"maxAge":4,"enrollmentInfo":141,"targetDuration":4,"studyType":21,"phases":143,"briefSummary":144,"conditions":145,"keywords":148,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":43},"100620602","vaginal-mesh-surgery-versus-robotic-assisted-abdominal-mesh-surgery-in-the-treatment-of-apical-prolapse---prospective-randomized-non-inferiority-study-100620602","NCT07359755","Vaginal Mesh Surgery Versus Robotic-assisted Abdominal Mesh Surgery in the Treatment of Apical Prolapse - Prospective Randomized Non-inferiority Study","A Comparative Analysis of Vaginal Mesh Surgery Versus Robotic-assisted Abdominal Mesh Surgery in the Treatment of Apical Genital Prolapse: a Prospective Randomized Non-inferiority Study.","Inclusion Criteria:\n\n* The study will include patients diagnosed with apical compartment genital prolapse of stage II or higher, who have an indication for surgical correction.\n\nExclusion Criteria:\n\n* The following exclusion criteria will apply: patients who are unable or unwilling to complete validated outcome assessment instruments; those requiring concomitant surgical procedures (e.g., hysterectomy or any other intervention that may alter pelvic floor anatomy);\n* individuals with a prior history of pelvic radiotherapy;\n* patients with congenital or acquired anomalies of the urogenital or gastrointestinal systems;\n* and those with medical conditions that constitute a contraindication to elective surgical intervention.",{"count":142,"type":20},86,[23],"The goal of this study is to compare vaginal mesh surgery with abdominal robotic-assisted mesh surgery for the treatment of genital prolapse in women. The main questions it seeks to answer are:\n\n* Is the objective cure rate for vaginal mesh surgery non-inferior to that of the abdominal approach?\n* Is the use of vaginal mesh as safe as abdominal mesh?",[58,26,146,147],"Mesh Reinforcement","Vaginal Apex\u002FUterine Prolapse",[61,149,150,151,152,93],"Vaginal prolapse","Vaginal mesh","Robotic-assisted sacrocolpopexy","Sacrocolpopexy","2026-01-15",{"date":155,"type":35},"2026-01-22",{"date":157,"type":35},"2025-09-15",{"date":159,"type":20},"2030-06",{"name":161,"class":42},"University of Sao Paulo General Hospital",{"id":163,"slug":164,"hasResults":11,"nctId":165,"briefTitle":166,"officialTitle":166,"acronym":167,"eligibilityCriteria":168,"healthyVolunteers":11,"sex":17,"minAge":169,"maxAge":170,"enrollmentInfo":171,"targetDuration":4,"studyType":21,"phases":173,"briefSummary":174,"conditions":175,"keywords":177,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":43},"100604509","the-effects-of-platelet-rich-plasma-adjuvant-to-type-iiii-collagen-ratio-matrix-metalloproteinase-2-and-matrix-metalloproteinase-9-in-pelvic-organ-prolapse-repair-100604509","NCT07150442","The Effects of Platelet Rich Plasma Adjuvant to Type I\u002FIII Collagen Ratio, Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 in Pelvic Organ Prolapse Repair","POP PRP MMP","Inclusion Criteria:\n\n1. Patients with second-degree or higher pelvic organ prolapse\n2. Postmenopausal pelvic organ prolapse patients\n3. Patients with pelvic organ prolapse who will undergo surgery\n4. Willingness to participate in the study\n\nExclusion Criteria:\n\n1. Patients with gynecological malignancies\n2. Patients with a history of collagen disease\n3. Patients with blood disorders","45 Years","65 Years",{"count":172,"type":20},30,[23],"The goal of this clinical trial is to analyze the effect of Platelet Rich Plasma (PRP) Adjuvant To Type I\u002FIII Colagen Ratio, MMP-2 and MMP-9 in Pelvic Organ Prolapse Repair.\n\nThe main questions it aims to answer are:\n\nDoes the PRP Adjuvant affect type I\u002FIII Colagen Ratio, MMP-2 and MMP-9 in Pelvic Organ Prolapse Repair? Researchers will compare patient who undergo prolapse surgery with PRP adjuvant versus patient who undergo prolapse surgery without PRP adjuvant (placeebo)\n\nParticipants will:\n\nPatient will undergo pelvic organ prolapse reconstrucion surgery and punch biopsy and injection of PRP will perform in anterior vaginal mucosa at Pubocervical area. The second biopsy will attempt in 8 weeks post operative. imunohistochemistry examination will be done to compare the type I\u002FIII Colagen Ratio, MMP-2 and MMP-9 before and after surgery.",[26,176],"Platelet Rich Plasma Injection",[178,179,180,181,182,183],"Pelvic organ prolapse surgery","Platelet rich plasma injection","Type I\u002FIII collagen ratio","MMP-2","MMP-9","Randomized controlled trial","2025-09-02",{"date":186,"type":35},"2025-09-08",{"date":188,"type":35},"2025-08-27",{"date":190,"type":20},"2026-08",{"name":192,"class":42},"Andalas University"]