[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pelvic-organ-prolapse\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pelvic-organ-prolapse":26},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,37,0,25,[9,43,67,89,113,144,168,199,229,256,283,308,332,369,396,421,443,470,491,513,539,563,592,615,641],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100426144","ethicon-pelvic-mesh-post-market-clinical-follow-up-registry-100426144",false,"NCT04829175","Ethicon Pelvic Mesh Post Market Clinical Follow-up Registry","A Long Term Prospective Observational Post Market Clinical Follow-Up (PMCF) Registry of Ethicon Gynecare Pelvic Mesh Products for The Treatment of Stress Urinary Incontinence and Pelvic Organ Prolapse","Inclusion Criteria:\n\nPatients who satisfy all of the following criteria will be considered eligible for enrollment in this registry:\n\nSUI\n\n1. Stress urinary incontinence symptoms\n2. Urodynamic stress incontinence confirmed with urodynamic testing\n3. Female patient ≥ 21 years of age\n4. Desired surgical correction of SUI using synthetic pubo-urethral vaginal sling\n5. Planned surgery for primary SUI\n6. Patient able and willing to participate in follow-up\n7. Patient or authorized representative has signed the approved Informed consent POP\n\n1\\. Uterine or vaginal vault prolapse symptoms 2. Urodynamic testing (optional) 3. Female patient ≥ 21 years of age 4. Desired surgical correction of POP using synthetic mesh 5. Planned surgery for uterine or vaginal vault prolapse with or without concomitant SUI surgery 6. Patient able and willing to participate in follow-up 7. Patient or authorized representative has signed the approved Informed consent\n\nExclusion Criteria\n\nPatients meeting any of the following criteria will be considered not eligible for enrollment in this registry:\n\n1. Physical or psychological condition which would impair registry participation or are unwilling or unable to participate in all required registry visits and are unable to complete the questionnaires\n2. Any pre-operative or intra-operative findings identified by the surgeon that may preclude the use of registry products\n3. History of previous synthetic, biologic or fascial sub-urethral sling (SUI) or pelvic mesh (POP)\n4. Pregnancy or plans for future pregnancy\n5. History of bleeding diathesis or current anti-coagulation therapy which cannot be suspended peri-operatively according to site's standard practice\n6. Current genitourinary fistula or urethral diverticulum\n7. Reversible cause of incontinence (i.e. drug effect) for SUI only\n8. Severe vaginal atrophy\n9. History of pelvic irradiation therapy\n10. Contraindication to surgery","FEMALE","21 Years",{"count":20,"type":21},1000,"ESTIMATED","OBSERVATIONAL","The objective of this post market, clinical registry is to evaluate the performance of the products of the TVT family of products or vaginal vault or uterine prolapse repair (with laparotomic or laparoscopic approach including robotic assisted) using either Gynemesh PS Mesh or Artisyn Mesh in women undergoing surgery for SUI and POP.",[25,26],"Stress Urinary Incontinence","Pelvic Organ Prolapse",[25,26,28,29],"SUI","POP","RECRUITING","2026-06-25",{"date":33,"type":34},"2026-06-26","ACTUAL",{"date":36,"type":34},"2022-04-11",{"date":38,"type":21},"2038-03-31",{"name":40,"class":41},"Ethicon, Inc.","INDUSTRY",10,{"id":44,"slug":45,"hasResults":12,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":12,"sex":49,"minAge":50,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":53,"conditions":54,"keywords":55,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":61,"leadSponsor":63,"locationsCount":66},"100629191","centered-surgery---preoperative-counseling-and-patient-satisfaction-100629191","NCT07471464","Centered Surgery - Preoperative Counseling and Patient Satisfaction","Inclusion Criteria:\n\n* Age \\>18y\n* Has decision-making capacity and able to provide informed consent for research participation\n* For patients undergoing SMA: Has active MyChart\n* Able to speak and read English\n\nExclusion Criteria:\n\n* Unable to consent","ALL","18 Years",{"count":52,"type":21},106,"This study is a prospective cohort study which aims to assess patient satisfaction and preparedness for surgery through two methods of preoperative counseling: standard individual phone calls versus virtual group sessions called Shared Medical Appointments (SMAs). The study will focus on patients undergoing urogynecology prolapse surgeries at Cleveland Clinic. Researchers hypothesize that virtual group counseling will improve patient satisfaction and preparedness compared to individual phone calls. Additionally, the study will evaluate healthcare resource utilization as a secondary outcome.\n\nParticipants will complete surveys before and after surgery to measure satisfaction and preparedness using validated tools. The study will enroll patients aged 18 and older who can provide informed consent and are scheduled for specific prolapse surgeries. Findings may help improve preoperative counseling practices and enhance patient-centered care.",[26],[56],"surgical counseling","2026-06-11",{"date":59,"type":34},"2026-06-12",{"date":57,"type":34},{"date":62,"type":21},"2027-12-31",{"name":64,"class":65},"The Cleveland Clinic","OTHER",1,{"id":68,"slug":69,"hasResults":12,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":4,"eligibilityCriteria":73,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":74,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":76,"conditions":77,"keywords":78,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},"100426135","gynemesh-ps-mesh-post-marketing-clinical-follow-up-study-100426135","NCT04829058","GYNEMESH PS Mesh Post Marketing Clinical Follow-Up Study","A Retrospective and Long-Term Prospective Post Market Clinical Follow-up (PMCF) Study of the GYNECARE GYNEMESH® PS Nonabsorbable PROLENE® Soft Mesh","Inclusion Criteria:\n\nSubjects who satisfy all of the following criteria will be considered eligible for enrollment in this study:\n\n1. Female subjects who had laparotomic or laparoscopic abdominal sacrocolpopexy, including robotic-assisted, for apical vaginal or uterine prolapse\n2. GYNEMESH PS Mesh was used as a bridging material according to the IFU.\n3. Able and willing to participate in follow-up\n4. Subject or authorized representative has signed the approved informed consent\n\nExclusion Criteria\n\nSubjects meeting any of the following criteria will be considered not eligible for enrollment in this study:\n\n1. Subjects \\\u003C 21 years of age at the time of informed consent\n2. Subjects who had transvaginal approach for surgery\n3. Had undergone a uterus-sparing procedure (sacrohystero or sacrocervicopexy)",{"count":75,"type":21},100,"The objective of this retrospective and prospective, single-arm, observational, multicenter, post-market study is to evaluate outcomes in women who underwent surgery for vaginal or uterine prolapse with a GYNEMESH PS Mesh.",[26],[79,29],"GYNECARE GYNEMESH® PS Nonabsorbable PROLENE® Soft Mesh","2026-06-04",{"date":82,"type":34},"2026-06-05",{"date":84,"type":34},"2021-11-24",{"date":86,"type":21},"2032-03-31",{"name":40,"class":41},3,{"id":90,"slug":91,"hasResults":12,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":4,"eligibilityCriteria":95,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":96,"targetDuration":4,"studyType":97,"phases":98,"briefSummary":100,"conditions":101,"keywords":102,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":108,"completionDateStruct":109,"leadSponsor":111,"locationsCount":66},"100632767","vaginal-vault-native-tissue-suspension-100632767","NCT07517965","Vaginal Vault Native Tissue Suspension","Efficacy of a Novel Mackenrodt Uterosacral Double Ligaments Vault Suspension for Treatment of Pelvic Organ Prolapse","Inclusion Criteria:\n\n* women undergoing hysterectomy\n* Stage 1 or more pelvic organ prolapse\n\nExclusion Criteria:\n\n* pregnacy or 6 months postpartum\n* previous suspension surgery",{"count":42,"type":21},"INTERVENTIONAL",[99],"NA","Vaginal vault suspension at time of abdominal hysterectomy using Mackenrodt and uterosacral ligaments.",[26],[103,104,105],"Vault Suspension","Mackenrodt ligaments","Uterosacral ligaments","2026-06-03",{"date":80,"type":34},{"date":106,"type":34},{"date":110,"type":21},"2027-06",{"name":112,"class":65},"Assiut University",{"id":114,"slug":115,"hasResults":12,"nctId":116,"briefTitle":117,"officialTitle":117,"acronym":118,"eligibilityCriteria":119,"healthyVolunteers":12,"sex":17,"minAge":50,"maxAge":120,"enrollmentInfo":121,"targetDuration":4,"studyType":97,"phases":123,"briefSummary":124,"conditions":125,"keywords":129,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":143},"100609702","accelerometer-measured-early-recovery-after-prolapse-surgery-100609702","NCT07218016","Accelerometer Measured Early Recovery After Prolapse Surgery","AccelERate","Inclusion Criteria:\n\n* Subject has provided written informed consent\n* Ambulatory women undergoing laparoscopic, robotic, or vaginal reconstructive or obliterative surgery for apical prolapse\n* POP-Q \\>= Stage III\n* Willing to participate in a postoperative exercise regimen\n* Able to read and consent in English or Spanish\n* Willing and able to wear an accelerometer prior to and after surgery (including agreeing to the terms of service), use an electronic data capture software, and record daily events\n* Willing and able to install and use study-related smartphone app(s)\n* Anticipated hospital discharge \\\u003C= postoperative day 1\n\nExclusion Criteria:\n\n* Inability or unwillingness to adhere to the exercise intervention\n* Contraindication to medium-intensity exercise\n* Comorbidities preventing physical activity\n* Planned abdominal approach with laparotomy","99 Years",{"count":122,"type":21},288,[99],"The AccelERate study will evaluate the physical recovery of patients who have undergone Pelvic Organ Prolapse (POP) surgery. This will be evaluated via a self-reported recovery questionnaire completed daily. Participants will wear an accelerometer device on their non-dominant wrist and be given either routine or exercise-focused postoperative instructions. The primary outcome will be a comparison of the number of days needed to reach self-reported \"mostly recovered\" status between randomly assigned instruction groups.",[26,126,127,128],"Pelvic Organ Prolapse (POP)","Pelvic Organ Prolapse Vaginal Surgery","Pelvic Organ Prolapse, Patient Education",[130,126,131,132],"accelerometer","Post-operative Recovery","recovery activities","2026-04-24",{"date":135,"type":34},"2026-04-27",{"date":137,"type":34},"2025-10-02",{"date":139,"type":21},"2028-03-31",{"name":141,"class":142},"NICHD Pelvic Floor Disorders Network","NETWORK",7,{"id":145,"slug":146,"hasResults":12,"nctId":147,"briefTitle":148,"officialTitle":149,"acronym":150,"eligibilityCriteria":151,"healthyVolunteers":12,"sex":17,"minAge":50,"maxAge":4,"enrollmentInfo":152,"targetDuration":4,"studyType":97,"phases":154,"briefSummary":155,"conditions":156,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":167},"100564844","pomegranate-trial-comparing-reia-pessary-versus-standard-of-care-pessary-for-pelvic-organ-prolapse-treatment-100564844","NCT06634459","POMEGRANATE Trial: Comparing Reia Pessary Versus Standard of Care Pessary for Pelvic Organ Prolapse Treatment","The POMEGRANATE Trial: A Randomized Controlled Trial Comparing Pessary Home Management of Reia Pessary Versus Standard of Care Pessary for Treatment of Pelvic Organ Prolapse","POMEGRANATE","Inclusion Criteria:\n\n* English-speaking natal females ≥ 18 years of age\n* Willing to self-maintain (insert\u002Fremove) pessary\n* Pessary naïve with Stage II-IV POP desiring conservative management with a pessary\n* Primary indication for use of pessary is treatment of pelvic organ prolapse\n\nExclusion Criteria:\n\n* Primary indication for pessary use is for management of stress urinary incontinence\n* Prior mesh-augmented prolapse repair (i.e. transvaginal mesh, sacrocolpopexy)\n* Short vaginal length (TVL \\\u003C 8cm) or subjective vaginal narrowing\n* Vaginal fistula (e.g. rectovaginal, vesicovaginal or any type of fistula involving the vagina)\n* Vaginal, rectal or bladder malignancy\n* Genitourinary infection requiring treatment (See below 1)\n* Ongoing treatment for vaginal infections (e.g., chronic bacterial vaginosis) (See below 2)\n* Inflammatory bowel disease (Crohn's or ulcerative colitis)\n* Pelvic or anorectal chronic pain\n* Pelvic floor surgery within the past 6 months or planning to undergo pelvic floor surgery\n* Congenital malformation of the bladder, rectum or vagina\n* Pregnant or planning pregnancy in the next 6 months\n* Prior failure of pessary for POP\n* History of hydroureter, hydronephrosis, or impaired renal function secondary to prolapse\n\n  1. Patients with acute vaginal infections will be eligible for enrollment 2 weeks after completing treatment with resolution of symptoms\n  2. OK to be on prophylactic\u002Fsuppressive therapy for HSV",{"count":153,"type":21},218,[99],"This multi-centered, randomized controlled trial will evaluate the safety and efficacy of home use of the novel Reia System (RS), which includes the Reia pessary and applicator, compared to standard pessary care (Gellhorn or ring with\u002Fwithout support without knob) among women with stage II-IV pelvic organ prolapse (POP). A total of 200 participants will be recruited among pessary naïve patients who are symptomatic and choose a vaginal pessary for management of their POP from study sites specializing in Urogynecology and Reconstructive Pelvic Surgery (URPS). Participants will be assigned via 1:1 randomization using computer generated numbers in permutated groups of variable block sizes to either the intervention (the Reia System, RS) or standard pessary care (SPC) stratified by site. Participation in this trial will involve a total of four visits over six months. The primary outcome measure will be satisfaction measured at the six-month time point. Secondary outcomes will include validated surveys to assess quality of life, number of self-management events, ease\u002Fdifficulty of pessary insertion\u002Fremoval, importance of ability to self-manage pessary, and adverse events.\n\nSpecific Aims\n\nAim 1: To compare satisfaction with pessary use and management between subjects randomized to the Reia System and those randomized to standard of care pessary.\n\nAim 2: To assess successful fitting, number of refitting visits, number of self-management events and continued pessary use over a 6-month period between subjects randomized to the Reia System and those randomized to standard of care pessary.\n\nAim 3: To compare ease\u002Fdifficulty of pessary use and importance of ability to self-manage, as well as quality of life over a 6-month period between subjects randomized to the Reia System and those randomized to standard of care pessary.\n\nAim 4: To measure rates of adverse events and risk factors for adverse events over a 6-month period between subjects randomized to the Reia System and those randomized to standard of care pessary.",[26,157],"Prolapse","2026-04-08",{"date":160,"type":34},"2026-04-13",{"date":162,"type":34},"2024-11-01",{"date":164,"type":21},"2026-10-30",{"name":166,"class":65},"Medstar Health Research Institute",9,{"id":169,"slug":170,"hasResults":12,"nctId":171,"briefTitle":172,"officialTitle":172,"acronym":173,"eligibilityCriteria":174,"healthyVolunteers":12,"sex":17,"minAge":175,"maxAge":4,"enrollmentInfo":176,"targetDuration":4,"studyType":97,"phases":178,"briefSummary":179,"conditions":180,"keywords":183,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":192,"completionDateStruct":194,"leadSponsor":196,"locationsCount":198},"100485528","study-comparing-transobturator-cystocele-vs-anterior-vaginal-repairs-100485528","NCT05602246","Study Comparing Transobturator Cystocele vs. Anterior Vaginal RepairS","STARS","Inclusion Criteria:\n\n* (at least) 2nd stage prolapse of the anterior compartment (Ba ≥ -1)\n* Age ≥ 50 years\n* Symptom bulge\n* Ability to speak Czech or English\n\nExclusion Criteria:\n\n* Malignancy","50 Years",{"count":177,"type":21},592,[99],"Surgical correction of the prolapse in the anterior compartment remains one of the major challenges in urogynecology. Paravaginal defect in level II of vaginal fixation results in the majority of cystoceles. Clinically, these defects are often combined and\u002For may be bilateral. Hence, careful assessment and individualized planning of the surgical procedure is essential to optimize cystocele repair outcome. Several surgical techniques and approaches have been used for cystocele repair. After the ban on transvaginal meshes, the interest in native tissue repair has risen. Paravaginal defect repair is an effective surgery for paravaginal defect reconstruction. There is a current trend to utilize transvaginal surgery instead of more invasive transabdominal surgery. A novel method of transvaginal paravaginal defect repair - TOCR (transobturator cystocele repair) was suggested. The principle objective of the present trial is to compare its efficacy and safety to preexisting method of native tissue cystocele repair.",[26,181,182],"Cystocele","Cystocele and Incomplete Uterovaginal Prolapse",[184,185,186,187,188],"Pelvic organ prolapse","Quality of life","TOCR","Anterior vaginal wall repair","Transobturator cystocele repair","2026-03-18",{"date":191,"type":34},"2026-03-19",{"date":193,"type":34},"2022-12-01",{"date":195,"type":21},"2034-11-01",{"name":197,"class":65},"Charles University, Czech Republic",8,{"id":200,"slug":201,"hasResults":12,"nctId":202,"briefTitle":203,"officialTitle":204,"acronym":4,"eligibilityCriteria":205,"healthyVolunteers":206,"sex":17,"minAge":207,"maxAge":208,"enrollmentInfo":209,"targetDuration":4,"studyType":97,"phases":211,"briefSummary":212,"conditions":213,"keywords":214,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":220,"lastUpdatePostDateStruct":221,"startDateStruct":223,"completionDateStruct":225,"leadSponsor":227,"locationsCount":66},"100626841","effects-of-pelvic-floor-muscle-training-with--without-hypopressive-exercises-100626841","NCT07440875","Effects of Pelvic Floor Muscle Training With & Without Hypopressive Exercises","Effects of Pelvic Floor Muscle Training With & Without Hypopressive Exercises On Strength, Dyspareunia and Quality Of Life in Pelvic Organ Prolapse","Inclusion Criteria:\n\n* Married women\n* Age 45-65 years\n* Post menopausal\n* uterine prolapse\n* Stage I \\& II\n\nExclusion Criteria:\n\n* Pregnancy or Postpartum (within last 6 months)\n* History of Pelvic floor surgery e.g.hysterectomy\n* Pts with other comorbidities e.g. neuromuscluar disease\n* Participating in other pelvic floor muscle program.e.g. pilates , yoga, Psychiatric disorders effecting compliance.e.g. schizopherenia",true,"45 Years","65 Years",{"count":210,"type":21},51,[99],"Pelvic Organ Prolapse (POP) is a prevalent condition affecting women's quality of life due to the descent of pelvic organs caused by weak pelvic floor muscles (PFMs). This randomized controlled trial aims to compare the effects of pelvic floor muscle training (PFMT) alone and PFMT combined with hypopressive exercises in improving pelvic floor muscle strength, reducing dyspareunia, and enhancing overall quality of life in women aged 45-65 diagnosed with stage I-II POP.This study will be randomized controlled trial and will be conducted in Qasim Sandhu Hospital, Muhammadi Medical Trust and Clinic 1. This will undergo 4 sessions totaling 1 month of treatment. . Non-probability convenience sampling technique will be used and 46 participants will be recruited in study after randomization.The subjects will be divided into two groups. Group A will receive pelvic floor muscle training with hypopressive exercises and Group B will receive pelvic floor muscle training without hypopressive exercises receiving baseline treatment.",[26],[215,216,217,218,219,26],"Female","Pelvic Floor","Quality of Life","Dyspareunia","Exercise","2026-02-23",{"date":222,"type":34},"2026-02-27",{"date":224,"type":34},"2025-08-01",{"date":226,"type":21},"2026-04",{"name":228,"class":65},"Riphah International University",{"id":230,"slug":231,"hasResults":12,"nctId":232,"briefTitle":233,"officialTitle":233,"acronym":4,"eligibilityCriteria":234,"healthyVolunteers":12,"sex":17,"minAge":50,"maxAge":4,"enrollmentInfo":235,"targetDuration":4,"studyType":97,"phases":237,"briefSummary":238,"conditions":239,"keywords":241,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":247,"lastUpdatePostDateStruct":248,"startDateStruct":250,"completionDateStruct":252,"leadSponsor":253,"locationsCount":255},"100593627","sequence-of-midurethral-sling-placement-during-robotic-sacrocolpopexy-100593627","NCT07008898","Sequence of Midurethral Sling Placement During Robotic Sacrocolpopexy","Inclusion Criteria:\n\n* At least 18 years of age\n* Able to speak and read English and Spanish\n\n  * Diagnosis of pelvic organ prolapse stage 2-4\n  * Planning to undergo a robotic-assisted sacrocolpopexy\n  * Demonstrable SUI (either by CST, with or without prolapse reduction, or UDS) within the year prior to enrollment\n  * Planning to undergo concomitant SUI correction with MUS at the time of RSC\n\nExclusion Criteria:\n\n* Less than 18 years of age\n* Unable to speak and read English or Spanish\n* No diagnosis of SUI (prophylactic slings)\n* History of prior surgery for SUI\n* Bladder capacity \\\u003C200 mL or post-void residual (PVR) \\>150 mL\n* Current genitourinary fistula or urethral diverticulum",{"count":236,"type":21},110,[99],"This study looks at the best time to place a midurethral sling (MUS), which is a small piece of mesh used to treat stress urinary incontinence (SUI) (leaking urine when you cough, laugh, or exercise). The sling is placed during a type of surgery called robotic sacrocolpopexy (RSC). This surgery helps fix pelvic organ prolapse, when organs like the bladder or uterus drop from their normal place.\n\nDoctors can place the sling either before or after they lift and support the top of the vagina during surgery, but they aren't sure which timing works better. In this study, investigators are comparing what is the best time to place the sling, how the patient feels after surgery and if a patient's symptoms got better or worse.",[240,26],"Stress Incontinence Female",[242,184,243,244,245,246],"Stress incontinence","Midurethral sling","Sucess rates","Complication rates","Patient satisfaction","2026-02-12",{"date":249,"type":34},"2026-02-17",{"date":251,"type":34},"2025-07-08",{"date":110,"type":21},{"name":254,"class":65},"University of Alabama at Birmingham",2,{"id":257,"slug":258,"hasResults":12,"nctId":259,"briefTitle":260,"officialTitle":261,"acronym":262,"eligibilityCriteria":263,"healthyVolunteers":12,"sex":17,"minAge":264,"maxAge":265,"enrollmentInfo":266,"targetDuration":4,"studyType":97,"phases":268,"briefSummary":269,"conditions":270,"keywords":271,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":276,"completionDateStruct":278,"leadSponsor":280,"locationsCount":282},"100344452","ambulapse-study-feasibility-study-on-laparoscopic-double-mesh-sacrocolpopexy-with-or-without-robotic-assistance-in-female-patients-presenting-with-symptomatic-pelvic-organ-prolapse-based-on-an-outpatient-treatment-model-100344452","NCT03764852","AMBULAPSE STUDY Feasibility Study on Laparoscopic Double-mesh Sacrocolpopexy With or Without Robotic Assistance, in Female Patients Presenting With Symptomatic Pelvic Organ Prolapse, Based on an Outpatient Treatment Model.","Feasibility Study on Laparoscopic Double-mesh Sacrocolpopexy With or Without Robotic Assistance, in Female Patients Presenting With Symptomatic Pelvic Organ Prolapse, Based on an Outpatient Treatment Model.","AMBULAPSE","Inclusion Criteria:\n\n* woman between 40 and 80 years old\n* Patient with significant prolapse POP-Q ≥ 2\n* BMI \\\u003C30\n* ASA score ≤ 2\n* sterile ECBU\n\nExclusion Criteria:\n\n* Criteria related to the pathology or the organ:\n\n  * History of pelvic cancer surgery\n  * History of prolapse surgery\n  * History of pelvic irradiation\n  * Laying a concomitant urethral strip\n  * Cervico-vaginal smear test not up to date.\n  * Patient pregnant or having a desire for pregnancy\n* Criteria related to concomitant treatments:\n\n  * Cefazoline allergy\n  * Taking the following medications within 48 hours\n* Plavix®\n* Vitamin K \u002F Low Molecular Weight Healing Heparin\n\n  * Contraindication to ambulatory care for medical reasons\n* Sleep apnea syndrome\n* Cardiopulmonary pathology\n* Psychiatric pathology\n* Hemorrhagic risk\n* Diabetes imbalanced\n* Unbalanced Hypertension","40 Years","80 Years",{"count":267,"type":21},80,[99],"Pelvic organ prolapse is an increasingly common functional disorder which affects approximately 30 to 40% of the female population, 12% of whom have a symptomatic form, with a psychological, physical and social impact. Laparoscopic sacrocolpopexy represents the surgical \"gold standard\" for the treatment of this functional disorder. It aims to suspend the vaginal vault by means of a prosthesis. The patient satisfaction rate is evaluated at 94% with low overall complication rate, evaluated at 11%.\n\nPelvic organ prolapse surgery is a common, with an estimated 30,000 procedures carried out in France in 2013 (excluding hysterectomy) (2013 ATIH data), and the number will increase in the future due to increasing life expectancy. 13% of women will undergo this type of procedure. The French General Directorate of Health Care Supply (DGOS) deems outpatient surgery to be the benchmark for surgical activity in all eligible patients, and has expressed the need for recommendations and tools for supporting its development. The rate of outpatient surgery for prolapse remains low in France (6.1%, 2015 ATIH data), while it is 25% in the US and 56% in Denmark. The average duration of hospital stays for DRG N81.2 (first degree uterine prolapse) in 2015 was 3.43 days. These procedures have been the subject of publications concerning outpatient care and involving low numbers of patients, with the exception of the publication by Sinhal which involved 111 patients.",[26],[272],"outpatient","2025-11-27",{"date":275,"type":34},"2025-12-04",{"date":277,"type":34},"2019-12-14",{"date":279,"type":21},"2026-12",{"name":281,"class":65},"Centre Hospitalier Universitaire de Nice",5,{"id":284,"slug":285,"hasResults":12,"nctId":286,"briefTitle":287,"officialTitle":287,"acronym":288,"eligibilityCriteria":289,"healthyVolunteers":12,"sex":17,"minAge":50,"maxAge":4,"enrollmentInfo":290,"targetDuration":4,"studyType":97,"phases":292,"briefSummary":293,"conditions":294,"keywords":297,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":299,"lastUpdatePostDateStruct":300,"startDateStruct":302,"completionDateStruct":304,"leadSponsor":305,"locationsCount":307},"100609530","sore-study-sitz-baths-after-urogynecologic-reconstruction-100609530","NCT07215780","SORE Study: Sitz Baths After Urogynecologic Reconstruction","SORE","Inclusion Criteria:\n\n* Female ≥ 18 years of age at time of surgery\n* English or Spanish-speaking\n* Documentation of pelvic organ prolapse as evidenced by Stage 2, 3, or 4 prolapse on preoperative Pelvic Organ Prolapse Quantification system (POP-Q) examination\n* Surgery to be performed by a urogynecologist\n* Ambulatory or inpatient surgery acceptable\n\nExclusion Criteria:\n\n* Mesh-augmented prolapse repair (robotic, laparoscopic, or open sacrocolpopexy or sacrohysteropexy, vaginal mesh)\n* Urogynecologic surgery without prolapse repair (i.e. midurethral sling, intravesicular botox, hysterectomy only)\n* Suspected genital herpes simplex virus (HSV), molluscum contagiosum virus (MCV), condyloma acuminata, or vulvar\u002Fvaginal skin and soft tissue infection at recruitment by patient report\n* Daily opioid use (short or long-acting)\n* Concurrent non-urogynecologic surgery (i.e. rectopexy, staging or debulking for malignancy)\n* Lack of access to operative report\n* Pregnant (as determined by positive urine pregnancy test on the day of surgery via standard testing or current pregnancy documented in the preoperative note)\n* Incarcerated\n* Unable to give consent\u002Fconserved\n* Unable to complete study intervention or assessment per investigators",{"count":291,"type":21},112,[99],"The purpose of this study is to evaluate the utility of postoperative sitz baths in patient pain perception and recovery following surgical repair of prolapse. The SORE Study is a prospective, randomized controlled trial that aims to compare postoperative pain intensity one week after native tissue repair of pelvic organ prolapse for patients undergoing a sitz bath regimen versus usual care. Findings from this study may contribute to more robust, multimodal postoperative pain management plans if proven efficacious or, alternatively, reduce plastic medical waste and simplify postoperative pain plans if found to be ineffective.",[26,295,296],"Postoperative Pain Management","Gynecologic Surgeries",[298],"Pelvic organ prolapse surgical repair","2025-11-25",{"date":301,"type":34},"2025-12-03",{"date":303,"type":34},"2025-10-28",{"date":110,"type":21},{"name":306,"class":65},"Yale University",4,{"id":309,"slug":310,"hasResults":12,"nctId":311,"briefTitle":312,"officialTitle":313,"acronym":4,"eligibilityCriteria":314,"healthyVolunteers":206,"sex":17,"minAge":50,"maxAge":4,"enrollmentInfo":315,"targetDuration":4,"studyType":97,"phases":317,"briefSummary":318,"conditions":319,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":323,"lastUpdatePostDateStruct":324,"startDateStruct":326,"completionDateStruct":328,"leadSponsor":330,"locationsCount":66},"100600961","pelvic-floor-muscle-training-during-pregnancy-100600961","NCT07104292","Pelvic Floor Muscle Training During Pregnancy","PFMT During Pregnancy - Its Implementation and Effects on Pelvic Floor Disorders, Sexual Function and Obstetric Outcomes: a Hybrid Type 1 Design Randomised Controlled Trial","Inclusion Criteria:\n\n* Woman in the 1st trimester of pregnancy (up to 12+6 weeks of gestation)\n* Para 0 (no previous birth or pregnancy \\> 16 weeks of gestation)\n* Understands, writes, and reads fluently in Danish or English\n* Has a smart phone or computer\u002Ftablet to reach the training program\n\nExclusion Criteria:\n\n* Severe psychiatric illness (e.g. schizophrenia, bipolar disorder, severe depression or anxiety)\n* Active substance abuse\n* Acute social crises (e.g. homelessness, ongoing domestic violence, severe financial instability, lack of social support)\n* Women with limited capacity to provide informed consent (due to cognitive impairment or language barriers)\n* Previous pregnancy of \\> 16 weeks of gestation",{"count":316,"type":21},734,[99],"The project seeks to investigate effectiveness of PFMT during pregnancy.",[216,320,321,26,322],"Urinary Incontinence","Anal Incontinence","Sexual Dysfunction","2025-11-21",{"date":325,"type":34},"2025-11-28",{"date":327,"type":34},"2025-10-27",{"date":329,"type":21},"2028-08-01",{"name":331,"class":65},"University of Southern Denmark",{"id":333,"slug":334,"hasResults":12,"nctId":335,"briefTitle":336,"officialTitle":336,"acronym":4,"eligibilityCriteria":337,"healthyVolunteers":206,"sex":17,"minAge":50,"maxAge":338,"enrollmentInfo":339,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":341,"conditions":342,"keywords":350,"overallStatus":360,"whyStopped":4,"lastUpdateSubmitDate":361,"lastUpdatePostDateStruct":362,"startDateStruct":364,"completionDateStruct":366,"leadSponsor":367,"locationsCount":66},"100606457","pelvic-floor-disorder-symptoms-in-women-seeking-weight-loss-therapy-100606457","NCT07175805","Pelvic Floor Disorder Symptoms in Women Seeking Weight Loss Therapy","Inclusion Criteria:\n\n* female\n* 18-89 years old\n* any race\u002Fethnicity\n* BMI ≥30 kg\u002Fm2\n* current medical weight loss or surgical weight loss patient of Obesity Medicine and Metabolic \\& Bariatric Surgery\n* able\u002Fwilling to give informed consent\n* have a home scale to measure weight\n\nPatients meeting all the following criteria will be eligible to participate in the medical weight loss therapy arm:\n\n* prescribed and start a glucagon-like peptide-1 receptor agonist (GLP-1 RA) or a GLP-1\u002Fgastric inhibitory peptide (GIP1)\n* taking other weight loss agents (such as metformin)\n\nPatients meeting all the following criteria will be eligible to participate in the bariatric surgery arm:\n\n* plan to undergo gastric sleeve or gastric bypass surgery\n* taking weight loss agents which are not GLP-1 RA or GLP-1\u002FGIP1 medications at the start of the study. Patients will not be excluded if they are started on GLP-1 RA or GLP-1\u002FGIP1 medications after surgery.\n\nExclusion Criteria:\n\n* Pregnant\n* ≥90 years old\n* \\\u003C18 years old\n* BMI \\\u003C30 kg\u002Fm2\n* A history of bariatric surgery prior to enrollment\n* No home scale to measure weight\n* Active cancer","90 Years",{"count":340,"type":21},200,"The purpose of this study is to compare change in pelvic floor symptoms between patients receiving medical therapy for weight loss and surgical treatment for weight loss. Examples of pelvic floor symptoms include urinary incontinence, urinary urgency, urinary frequency, fecal incontinence, and vaginal prolapse. Participants in this study do not need to have any pelvic floor symptoms to enroll in the study. Understanding how different types of weight loss treatment impact pelvic floor symptoms will help clinicians guide which weight loss treatments are recommended for patients with pelvic floor symptoms in the future.",[343,25,344,345,26,346,347,348,349],"Lower Urinary Tract Symptoms","Urge Urinary Incontinence","Overactive Bladder","Weight Loss","Fecal Incontinence","Bariatric Surgery","glp1 Agonist",[351,352,353,354,355,356,357,358,359],"lower urinary tract symtpoms","stress urinary incontinence","urge urinary incontinence","overactive bladder","pelvic organ prolapse","weight loss","fecal incontinence","bariatric surgery","glp1 agonist","NOT_YET_RECRUITING","2025-09-15",{"date":363,"type":34},"2025-09-16",{"date":365,"type":21},"2025-10",{"date":110,"type":21},{"name":368,"class":65},"Hartford HealthCare",{"id":370,"slug":371,"hasResults":12,"nctId":372,"briefTitle":373,"officialTitle":374,"acronym":375,"eligibilityCriteria":376,"healthyVolunteers":12,"sex":17,"minAge":50,"maxAge":377,"enrollmentInfo":378,"targetDuration":4,"studyType":97,"phases":380,"briefSummary":381,"conditions":382,"keywords":383,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":386,"lastUpdatePostDateStruct":387,"startDateStruct":389,"completionDateStruct":391,"leadSponsor":393,"locationsCount":255},"100601710","vnotes-approach-in-mesh-free-sacrocolpopexy-a-functional-and-anatomic-evaluation-100601710","NCT07114029","VNOTES Approach in Mesh Free Sacrocolpopexy: A Functional and Anatomic Evaluation","Anatomic and Functional Comparison of Preoperative and Postoperative Outcomes of Mesh Free Sacrocolpopexy Performed Via Vaginal Natural Orifice Transluminal Endoscopic Surgery (VNOTES)","vnotes","Inclusion Criteria:\n\nPatients who applied to Gaziosmanpasa Education and Research Hospital, Gynecology and Obstetrics Clinic, have apical and anterior POP Q stage 2 and above, and have undergone surgery due to symptomatic pelvic organ prolapse, Patients who are over the age of 18 and who are citizens of the Republic of Turkey, and who have undergone surgery by experienced surgeons will be included in the study.\n\nExclusion Criteria:\n\nHaving previously received KT and\u002For RT due to any malignancy Having previously undergone surgery due to prolapse Patients with severe cardiovascular or respiratory diseases will not be included in the study.","75 Years",{"count":379,"type":21},26,[99],"This study aims to evaluate the effectiveness of mesh-free sacrocolpopexy performed using the VNOTES (Vaginal Natural Orifice Transluminal Endoscopic Surgery) technique in the surgical treatment of pelvic organ prolapse. Anatomical and functional outcomes will be assessed over a 6-month period before and after the operation. Evaluation tools will include the Pelvic Floor Distress Inventory-20 (PFDI-20), Pelvic Organ Prolapse Quantification (POP-Q) system, and the Pelvic Organ Prolapse\u002FUrinary Incontinence Sexual Questionnaire (PISQ-12).\n\nThe findings of this study are expected to provide important data on the anatomical improvement, functional outcomes, and impact on sexual function of mesh-free sacrocolpopexy performed via the VNOTES approach.",[26],[384,385],"sacrocolpopexy","mesh-free","2025-08-03",{"date":388,"type":34},"2025-08-11",{"date":390,"type":34},"2025-07-01",{"date":392,"type":21},"2026-01-01",{"name":394,"class":395},"Gaziosmanpasa Research and Education Hospital","OTHER_GOV",{"id":397,"slug":398,"hasResults":12,"nctId":399,"briefTitle":400,"officialTitle":401,"acronym":4,"eligibilityCriteria":402,"healthyVolunteers":12,"sex":17,"minAge":50,"maxAge":4,"enrollmentInfo":403,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":405,"conditions":406,"keywords":408,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":413,"lastUpdatePostDateStruct":414,"startDateStruct":415,"completionDateStruct":417,"leadSponsor":419,"locationsCount":66},"100551526","pelvic-floor-rehabilitation-of-female-pelvic-floor-dysfunction-100551526","NCT06461234","Pelvic Floor Rehabilitation of Female Pelvic Floor Dysfunction","Establishment of an Artificial Intelligence Multidimensional Early Warning Diagnostic and Prognostic Model of Pelvic Floor Rehabilitation Therapy in the Chinese Population: a Prospective Cohort Study.","Inclusion Criteria:\n\n1. knowledge of the study, voluntary enrolment in the study, and signing of informed consent;\n2. postpartum pelvic floor weakness (pelvic floor muscle strength less than grade 3), or mild to moderate pelvic organ prolapse (POP-Q staging less than stage III), or pelvic organ prolapse combined with dysfunction (bowel or bladder dysfunction).\n\nExclusion Criteria:\n\n1. history of comorbid serious medical or surgical illness;\n2. comorbid psychiatric disorders;\n3. contraindications to electrical and magnetic stimulation such as implanted pacemakers;\n4. pelvic malignancy, acute genitourinary infection or vaginal bleeding, and genital tract malformation.",{"count":404,"type":21},1360,"The goal of this observational study is to learn about the therapeutic effects of different pelvic floor rehabilitation treatments, including pelvic floor muscle training , pelvic floor biofeedback electrical stimulation, and magnetic stimulation, in a population of Chinese patients with female pelvic floor dysfunction disorders. The study aims to find out the individualised pelvic floor rehabilitation treatment plan suitable for the Chinese population. The main question it aims to answer is:\n\n1. Do patients with reduced pelvic floor muscle strength after childbirth, or patients with mild to moderate pelvic organ prolapse and symptomatic pelvic organ prolapse benefit from pelvic floor rehabilitation?\n2. Is the combination of biofeedback electrical stimulation plus pelvic floor magnetic stimulation superior to single electrical stimulation, magnetic stimulation or pelvic floor muscle training?\n3. Which pelvic floor rehabilitation therapy is most suitable for Chinese patients with female pelvic floor dysfunction?\n4. What factors are early predictors of developing female pelvic floor dysfunction? And what factors can predict the prognostic status of patients treated with pelvic floor rehabilitation? Participants in the multicenter will be treated with different rehabilitation therapies, during which the researchers will collect clinical symptoms using the PFDI20 questionnaire, and POP-Q scores, pelvic floor muscle strength, and electromyography results from participants before, at the end of, and 3 months and 1 year after the end of treatment.",[407,26],"Pelvic Floor Disorders",[26,409,410,411,412],"pelvic floor rehabilitation","pelvic floor muscle training","biofeedback electrical stimulation","magnetic stimulation","2025-07-29",{"date":224,"type":34},{"date":416,"type":34},"2024-05-20",{"date":418,"type":21},"2026-11-30",{"name":420,"class":65},"Mingfu Wu",{"id":422,"slug":423,"hasResults":12,"nctId":424,"briefTitle":425,"officialTitle":426,"acronym":375,"eligibilityCriteria":427,"healthyVolunteers":12,"sex":17,"minAge":50,"maxAge":377,"enrollmentInfo":428,"targetDuration":4,"studyType":97,"phases":430,"briefSummary":431,"conditions":432,"keywords":433,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":436,"lastUpdatePostDateStruct":437,"startDateStruct":439,"completionDateStruct":440,"leadSponsor":441,"locationsCount":66},"100599248","comparison-of-v-notes-and-laparoscopic-mesh-free-sacrocolpopexy-techniques-100599248","NCT07082023","Comparison of V-NOTES and Laparoscopic Mesh-Free Sacrocolpopexy Techniques","Comparison of V-NOTES (Vaginal Natural Orifice Transluminal Endoscopic Surgery) Mesh-Free Sacrocolpopexy and Laparoscopic Mesh-Free Sacrocolpopexy","Inclusion Criteria:\n\n* Patients who applied to Gaziosmanpaşa Education and Research Hospital, Gynecology and Obstetrics Clinic, who underwent surgery due to symptomatic pelvic organ prolapse with apical and anterior POP Q stage 2 and above, Being over 18 years old Patients who underwent surgery by experienced surgeons\n\nExclusion Criteria:\n\n* Having previously received KT and\u002For RT due to any malignancy Having previously undergone surgery due to proplasus Patients with severe cardiovascular or respiratory disease",{"count":429,"type":21},52,[99],"This study aims to compare the surgical outcomes, safety profiles, and patient satisfaction between two minimally invasive techniques for pelvic organ prolapse repair: Vaginal Natural Orifice Transluminal Endoscopic Surgery (V-NOTES) mesh-free sacrocolpopexy and laparoscopic mesh-free sacrocolpopexy. By evaluating perioperative data, complication rates, anatomical and functional outcomes, this trial seeks to determine whether the V-NOTES approach provides comparable or superior results to the traditional laparoscopic technique, without the use of synthetic mesh.",[26],[434,435],"Sacrocolpopexy","vNOTES","2025-07-15",{"date":438,"type":34},"2025-07-24",{"date":390,"type":34},{"date":392,"type":21},{"name":442,"class":395},"Havva Betül Bacak",{"id":444,"slug":445,"hasResults":12,"nctId":446,"briefTitle":447,"officialTitle":448,"acronym":449,"eligibilityCriteria":450,"healthyVolunteers":206,"sex":17,"minAge":451,"maxAge":208,"enrollmentInfo":452,"targetDuration":4,"studyType":97,"phases":454,"briefSummary":455,"conditions":456,"keywords":457,"overallStatus":360,"whyStopped":4,"lastUpdateSubmitDate":461,"lastUpdatePostDateStruct":462,"startDateStruct":464,"completionDateStruct":466,"leadSponsor":468,"locationsCount":66},"100564617","perioperative-follow-up-protocols-for-pelvic-organ-prolapse-surgery-100564617","NCT06631508","Perioperative Follow-up Protocols for Pelvic Organ Prolapse Surgery","Development of Perioperative Follow-up Protocols and Evaluation of Their Effectiveness for Women Aged 30-65 Having Pelvic Organ Prolapse Surgery","POPFollowup","Inclusion Criteria:\n\n* Being stage ≥2 according to POP Classification (POP-Q),\n* Being between 30-65 years old,\n* Being sexually active,\n* Ability to read and write,\n* Ability to speak Turkish,\n* Ability to use phone\n* Having a phone that can be reached at all times and\n* Agreeing to participate in the study\n\nExclusion Criteria:\n\n* Being stage \\\u003C2 according to POP Classification (POP-Q),\n* Being between \\\u003C30 and \\>65 years of age,\n* Not being sexually active,\n* Not being able to read and write,\n* Not being able to speak Turkish,\n* Inability to use the phone\n* Not having a phone that can be reached at all times and\n* Not agreeing to participate in the study\n* Discontinue the research for any reason","30 Years",{"count":453,"type":21},102,[99],"The goal of this clinical trial is to develop perioperative follow-up and evaluation of their effectiveness protocols in women aged 30-65 having pelvic organ prolapse surgery.\n\nThe main questions it aims to answer are:\n\n* Is the perioperative follow up protocol developed for women aged 30-65 having pelvic organ prolapse surgery effective?\n* Does the developed perioperative follow up protocol for women aged 30-65 having pelvic organ prolapse surgery have an effect on quality of life, pelvic organ symptom score, sexual function, functional health patterns and anxiety?",[26],[355,458,459,460],"perioperative care","follow up protocol","nursing care","2025-02-24",{"date":463,"type":34},"2025-02-25",{"date":465,"type":21},"2025-03-01",{"date":467,"type":21},"2025-12-31",{"name":469,"class":65},"Saglik Bilimleri Universitesi",{"id":471,"slug":472,"hasResults":12,"nctId":473,"briefTitle":474,"officialTitle":475,"acronym":4,"eligibilityCriteria":476,"healthyVolunteers":206,"sex":17,"minAge":50,"maxAge":4,"enrollmentInfo":477,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":479,"conditions":480,"keywords":481,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":483,"lastUpdatePostDateStruct":484,"startDateStruct":486,"completionDateStruct":488,"leadSponsor":489,"locationsCount":66},"100517763","pessary-experience-study-100517763","NCT06021769","Pessary Experience Study","Longitudinal Assessment of Pessary Experience","Inclusion Criteria:\n\n* English-speaking women aged 18 years or older\n* Choosing to undergo a pessary fitting for symptomatic pelvic organ prolapse and\u002For stress urinary incontinence at the University of Virginia Pelvic Medicine and Reconstructive Surgery clinic\n* Willingness and ability to comply with scheduled visits and study procedures.\n* Successful pessary fitting\n\nExclusion Criteria:\n\n* Pregnant women\n* Prisoners\n* Cognitively impaired\n* Non-English speaking subjects\n* Patients who cannot comply with pessary check visits\n* Active vaginal infection\n* Vaginal malignancy\n* Genitourinary tract fistula",{"count":478,"type":21},30,"Pessaries are silicone devices inserted into the vagina for treatment of pelvic organ prolapse or stress urinary incontinence. They are adequate treatment options for patients who are poor surgical candidates, those who decline surgical intervention, or as a temporizing measure in those ultimately planning surgery. Most studies suggest that about 75% of patients are able to be successfully fit with a pessary, but about 50% discontinue pessary use within 12 months of initiation. The purpose of this study is to determine why pessaries are discontinued.",[26,25],[482],"pessary","2025-01-26",{"date":485,"type":34},"2025-01-28",{"date":487,"type":34},"2023-06-12",{"date":279,"type":21},{"name":490,"class":65},"University of Virginia",{"id":492,"slug":493,"hasResults":12,"nctId":494,"briefTitle":495,"officialTitle":496,"acronym":4,"eligibilityCriteria":497,"healthyVolunteers":12,"sex":17,"minAge":50,"maxAge":377,"enrollmentInfo":498,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":500,"conditions":501,"keywords":502,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":505,"lastUpdatePostDateStruct":506,"startDateStruct":508,"completionDateStruct":510,"leadSponsor":512,"locationsCount":66},"100577761","comparison-of-postoperative-outcomes-of-laparoscopic-lateral-suspension-and-v-notes-lateral-suspension-with-the-salman-ketenci-gencer-technique-100577761","NCT06802497","Comparison of Postoperative Outcomes of Laparoscopic Lateral Suspension and V-NOTES Lateral Suspension With the Salman Ketenci Gencer Technique","Comparison of Early Postoperative Outcomes of Patients Undergoing Laparoscopic Lateral Suspension and V-NOTES Lateral Suspension With the Salman Ketenci Gencer Technique","Inclusion Criteria:\n\n* Patients with stage 3 or 4 pelvic organ prolapse Sexually active patients\n\nExclusion Criteria:\n\n* Cervical pathology History of loop electrosurgical excision procedure (LEEP) or conization Presence of vaginal, pelvic, or adnexal mass Suspicious abdominal malignancy Morbid obesity Any pelvic infection Signs of pregnancy",{"count":499,"type":21},84,"Comparison of Early Postoperative Outcomes of Patients Undergoing Laparoscopic Lateral Suspension and V-NOTES Lateral Suspension with the Salman Ketenci Gencer Technique",[26],[503,504,355],"laparoscopy","v-notes lateral suspension","2025-01-25",{"date":507,"type":34},"2025-01-31",{"date":509,"type":34},"2024-07-12",{"date":511,"type":21},"2025-12-01",{"name":394,"class":395},{"id":514,"slug":515,"hasResults":12,"nctId":516,"briefTitle":517,"officialTitle":518,"acronym":519,"eligibilityCriteria":520,"healthyVolunteers":12,"sex":17,"minAge":50,"maxAge":4,"enrollmentInfo":521,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":523,"conditions":524,"keywords":525,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":530,"lastUpdatePostDateStruct":531,"startDateStruct":533,"completionDateStruct":535,"leadSponsor":537,"locationsCount":143},"100442520","long-term-evaluation-of-the-efficacy-and-safety-of-splentis-for-the-treatment-of-primary-apical-pelvic-organ-prolapse-100442520","NCT05042453","Long-term Evaluation of the Efficacy and Safety of Splentis for the Treatment of Primary Apical Pelvic Organ Prolapse","Prospective, Multicenter, 60 Months, Single-arm Cohort Trial for Evaluation of the Efficacy and Safety of Transvaginal Sacrospinous Ligament Fixation With Splentis for the Treatment of Primary Apical Pelvic Organ Prolapse","SAXO","Inclusion Criteria:\n\n* non-fertile women\n* primary symptomatic uterine descent POP-Q≥2\n* Scheduled apical POP repair with Splentis\n* Willing and able to participate at study visits and to sign informed consent\n\nExclusion Criteria:\n\n* Fertile women\n* Recurrent apical prolapse\n* Women with post hysterectomy vaginal vault prolapse\n* Patients with active or latent infection of the vagina, cervix or uterus\n* Patients with previous or current vaginal, cervical or uterine cancer\n* Previous, current or planned pelvic radiation therapy\n* Known allergy to polypropylene.",{"count":522,"type":21},140,"This prospective, multi center cohort trial aims to evaluate the efficacy and safety of hysteropexy using Splentis via the vaginal route in primary uterine prolapse",[26],[526,527,528,529],"Apical Pelvic Organ Prolapse","Transvaginal repair","Mesh augmented repair","Sacrouterine ligament fixation","2024-11-19",{"date":532,"type":34},"2024-11-22",{"date":534,"type":34},"2022-12-19",{"date":536,"type":21},"2030-07",{"name":538,"class":41},"Promedon",{"id":540,"slug":541,"hasResults":12,"nctId":542,"briefTitle":543,"officialTitle":544,"acronym":4,"eligibilityCriteria":545,"healthyVolunteers":12,"sex":17,"minAge":50,"maxAge":4,"enrollmentInfo":546,"targetDuration":4,"studyType":97,"phases":547,"briefSummary":548,"conditions":549,"keywords":550,"overallStatus":360,"whyStopped":4,"lastUpdateSubmitDate":555,"lastUpdatePostDateStruct":556,"startDateStruct":558,"completionDateStruct":559,"leadSponsor":561,"locationsCount":4},"100565409","vaginal-prolapse-pessary-material-trial-pvc-vs-silicon-100565409","NCT06641804","Vaginal Prolapse Pessary Material Trial PVC vs Silicon","Effect of Materials of Vaginal Ring Pessary for Pelvic Organ Prolapse on the Effects of Complications and Patient's Satisfaction","Inclusion criteria\n\n* At least 18 years old who understand written traditional Chinese\n* Diagnosed with stage 1-4 POP according to the standard of Pelvic organ prolapse Quantification (POP-Q)\n* Using PVC pessary as long term management for POP\n* Willing to participate and provide a written informed consent.\n\nExclusion criteria\n\n* Do not understand or comprehend written traditional Chinese\n* Cannot provide written consent\n* Vaginal complication requiring discontinuation of pessary use\n* Unable to follow up clinic 6 months later\n* Pregnant or lactating\n* Recruited in other research studies",{"count":522,"type":21},[99],"The goal of this clinical trial is to determine the effect of vaginal ring pessary material on pessary complications and patients' satisfaction.\n\nParticipants who are using PVC (polyvinyl chloride) pessary will be randomized to\n\n1. PVC vaginal ring pessary\n2. Silicon vaginal ring pessary\n\nTheir pessary-related complications, patients' satisfaction, pain during pessary exchange and prolapse related symptoms with reference to PFDI-20 score will be assessed in a period of six months.",[26],[551,552,553,554],"pelvic organ prolpase","ring pessary","silicon ring pessary","PVC ring pessary","2024-10-10",{"date":557,"type":34},"2024-10-15",{"date":557,"type":21},{"date":560,"type":21},"2026-06-30",{"name":562,"class":395},"Princess Margaret Hospital, Hong Kong",{"id":564,"slug":565,"hasResults":12,"nctId":566,"briefTitle":567,"officialTitle":568,"acronym":4,"eligibilityCriteria":569,"healthyVolunteers":12,"sex":17,"minAge":50,"maxAge":570,"enrollmentInfo":571,"targetDuration":4,"studyType":97,"phases":572,"briefSummary":573,"conditions":574,"keywords":577,"overallStatus":360,"whyStopped":4,"lastUpdateSubmitDate":583,"lastUpdatePostDateStruct":584,"startDateStruct":586,"completionDateStruct":588,"leadSponsor":590,"locationsCount":4},"100562556","fat-injection-for-rectocele-treatment-a-novel-approach-100562556","NCT06604702","Fat Injection for Rectocele Treatment: A Novel Approach","Fat Injection for Treatment of Rectocele a Novel Technique for Treatment of Tectocele","Inclusion Criteria:\n\n* Female patients aged between 18 and 60 years.\n* Diagnosis of rectocele confirmed by defecography, with a rectocele size of 2 cm (mild) to 4 cm (moderate).\n* Presenting with symptoms of obstructive defecation syndrome, including constipation, incomplete defecation, and\u002For vaginal bulge.\n* Able to provide written informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Patients who have previously undergone surgical repair of rectocele.\n* Presence of thrombosed hemorrhoids.\n* History of sclerotherapy injection for rectocele.\n* Diagnosis of anal stenosis.\n* History of coagulopathy or current use of anticoagulant or antiplatelet medications.\n* Refusal or inability to provide informed consent.","60 Years",{"count":7,"type":21},[99],"This clinical trial aims to evaluate the effectiveness of autologous fat grafting as a novel treatment for rectocele, a condition characterized by the herniation of rectal tissue into the posterior vaginal wall. Women aged 18 to 60 years with mild to moderate rectocele, presenting with symptoms such as obstructive defecation or vaginal bulge, will undergo submucosal fat injections. The study will assess the procedure\\'s ability to alleviate symptoms and reduce prolapse recurrence. This prospective, single-arm trial will be conducted at Cairo University Hospitals.",[575,26,576],"Rectocele","Obstructive Defecation Syndrome",[575,578,579,580,581,26,582],"Pelvic Floor Dysfunction","Fat Grafting","Autologous Fat Injection","Obstructive Defecation","Vaginal Bulge","2024-09-17",{"date":585,"type":34},"2024-09-19",{"date":587,"type":21},"2024-10-20",{"date":589,"type":21},"2025-10-20",{"name":591,"class":65},"Cairo University",{"id":593,"slug":594,"hasResults":12,"nctId":595,"briefTitle":596,"officialTitle":597,"acronym":598,"eligibilityCriteria":599,"healthyVolunteers":12,"sex":49,"minAge":50,"maxAge":4,"enrollmentInfo":600,"targetDuration":602,"studyType":22,"phases":4,"briefSummary":603,"conditions":604,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":606,"lastUpdatePostDateStruct":607,"startDateStruct":609,"completionDateStruct":611,"leadSponsor":613,"locationsCount":66},"100371012","quality-of-life-after-conservative-and-surgical-treatment-of-pelvic-organ-prolapse-100371012","NCT04110821","Quality of Life After Conservative and Surgical Treatment of Pelvic Organ Prolapse","Quality of Life After Conservative and Surgical Treatment of Pelvic Organ","LOLIPOP","Inclusion Criteria:\n\n\\- Pelvic Organ Prolapse (POP)\n\nExclusion Criteria:\n\n* \\\u003C 18 years\n* Patients unable to understand an informed consent\n* Patients unwilling to participate\n* emergency operations\n* pregnancy\n* Overactive Bladder without descensus\n* Stool incontinence without POP",{"count":601,"type":21},134,"5 Years","This is an observational study that gives baseline and follow-up information, that does not directly influence the allocation of patients to various treatment Options (conservative and surgical therapy of Pelvic Organ Prolapse) but the knowledge gained of the data will help to develop treatment strategies.",[26,217,605],"Incontinence","2024-07-29",{"date":608,"type":34},"2024-07-30",{"date":610,"type":34},"2019-09-15",{"date":612,"type":21},"2028-12",{"name":614,"class":65},"University Hospital, Basel, Switzerland",{"id":616,"slug":617,"hasResults":12,"nctId":618,"briefTitle":619,"officialTitle":620,"acronym":4,"eligibilityCriteria":621,"healthyVolunteers":12,"sex":17,"minAge":207,"maxAge":265,"enrollmentInfo":622,"targetDuration":4,"studyType":97,"phases":624,"briefSummary":625,"conditions":626,"keywords":627,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":632,"lastUpdatePostDateStruct":633,"startDateStruct":635,"completionDateStruct":637,"leadSponsor":639,"locationsCount":66},"100554122","the-influence-of-using-vascularized-vaginal-flap-on-the-efficacy-of-mesh-augmented-sacrospinous-hysteropexy-100554122","NCT06494982","The Influence of Using Vascularized Vaginal Flap on the Efficacy of Mesh-augmented Sacrospinous Hysteropexy","The Influence of Augmentation of the Anterior Vaginal Wall With a Vascularized Flap on the Effectiveness of Mesh-augmented Sacrospinous Hysteropexy and Anterior Subfascial Colporrhaphy During Reconstruction of the Pelvic Floor for POP","Inclusion Criteria:\n\n* The subject is a woman with anterior and apical compartment pelvic organ prolapse\n* The age of a subject is 45-80 years\n* Leading point of prolapse is at the level of the hymen or distal to the hymen (Ba, C\\>=1 according to POP-Q classification)\n* The subject gave written consent to participate in the study\n* The subject is able to evaluate the risks of the treatment and make an independent decision on participation in the study\n* The subject is able to fill up validated questionnaires and come to the control visit after the surgery\n\nExclusion Criteria:\n\n* The subject has an active urinary tract infection or skin infection in the region of surgery or acute infectious disease\n* The subject had prior hysterectomy\n* The subject has previously diagnosed or currently active cancer\n* The subject has chronic pelvic pain\n* The subject has cervical elongation\n* The subject has gynecological diseases (recurrent uterine bleeding, endometrial hyperplasia, the presence of atypical cells in cervical smears, adenomyosis, multiple uterine myoma)\n* The subject is planning pregnancy\n* The subject is unable to visit postoperative check-ups\n* Refusal from participation.",{"count":623,"type":21},60,[99],"This is a prospective randomized controlled trial designed to compare the effectiveness and safety of two methods of pelvic floor reconstruction in patients with pelvic organ prolapse (POP): sacrospinous hysteropexy (SSHP) with synthetic mesh, vascularized anterior vaginal wall flap, anterior colporrhaphy, and sacrospinous hysteropexy with synthetic mesh. , anterior colporrhaphy, as well as the impact of surgery on quality of life.",[26],[355,628,629,630,631],"vaginal repair","vaginal mesh","sacrospinous fixation","vaginal flap","2024-07-02",{"date":634,"type":34},"2024-07-10",{"date":636,"type":34},"2024-05-01",{"date":638,"type":21},"2025-10-01",{"name":640,"class":65},"Saint Petersburg State University, Russia",{"id":642,"slug":643,"hasResults":12,"nctId":644,"briefTitle":645,"officialTitle":645,"acronym":646,"eligibilityCriteria":647,"healthyVolunteers":12,"sex":17,"minAge":50,"maxAge":207,"enrollmentInfo":648,"targetDuration":4,"studyType":97,"phases":650,"briefSummary":651,"conditions":652,"keywords":657,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":665,"lastUpdatePostDateStruct":666,"startDateStruct":668,"completionDateStruct":670,"leadSponsor":672,"locationsCount":66},"100480030","correlation-pelvic-floor-function-and-ultrasound-findings-one-year-after-childbirth-100480030","NCT05530681","Correlation Pelvic Floor Function and Ultrasound Findings One Year After Childbirth","DeliverUU","Inclusion Criteria:\n\n* age = or \\> 18 years\n* Dutch\u002FEnglish-speaking\n* \\> 33 weeks gestation\n* delivering in UZ Leuven\n* vaginal delivery\n\nExclusion Criteria:\n\n* age \\\u003C 18 years\n* not Dutch\u002FEnglish-speaking\n* \\\u003C 33 weeks gestation\n* not delivering in UZ Leuven\n* non-vaginal delivery\n* Any disorder, that independently from delivery, affects pelvic floor function or structure, such as, but not limited to musculoskeletal or neurologic diseases.\n* any women with drug addiction, cognitive deficit, language-barrier and illiteracy\n* any disorder or timing or circumstances, which in the Investigator's opinion represents an obstacle to proper informed consent, or safe and\u002For compliant participation.\n* any prior or simultaneous treatment(s) potentially jeopardising safety or compromising trial integrity.",{"count":649,"type":21},320,[99],"This is a single-center prospective cohort study sponsored by the University Hospitals Leuven (UZ). Women will undergo a pelvic floor ultrasound and will be asked to fill out a questionnaire at the time of their admission into the labour suite, at the postpartum check-up and 12 months postpartum.\n\nThe primary objective is to correlate self-reported symptoms of Pelvic Floor Dysfunction (PFD) (binary outcome) at one year after delivery with structural changes to the Pelvic Floor Muscles (PFM) and postpartum evidence of levator avulsion (binary indicator) as measured by TransPerineal UltraSound (TPUS).\n\nSecondary objectives are to compare demographical and obstetrical variables between patients suffering from PFD symptoms or pelvic floor injury (documented one year after delivery) and those who do not; to record how patients manage and cope with PFD including recovery and compliance with Pelvic Floor Muscle Training (PFMT) as prescribed in the standard pathway of peripartum care; and to use of TPUS images for the development of artificial intelligence tools for automated image analysis.\n\nPrimary outcomes are PFD symptoms one year after delivery and injury to the PFM evidenced by POP-Q and TPUS. The demographic variables and information about the pregnancy and the delivery will be obtained from the medical records.\n\nThe presence and severity of PFD will be measured using standardized self-reporting tools: Pelvic Organ Prolapse Distress Index (POP-DI), Patient Assessment Constipation-SYMptoms (PAC-SYM), International Consultation on Incontinence Questionnaire - Urinary Incontinence - Short Form (ICIQ-SF), St. Mark's Incontinence Score (SMIS), Female Sexual Function Index (FSFI), Female Sexual Distress Scale - Revised (FSDS-R). FSFI is a widely used generic tool with sufficient granularity and validated in a large number of languages. FSDS-R assesses the construct \"personal distress\", which has been considered as an additional important aspect contributing to sexual dysfunction of women.\n\nPFD, as a clustered outcome, being the presence of any kind of pelvic floor dysfunction symptoms, will be defined as POP-DI score of ≥11 OR ICIQ-SF score of ≥1 OR SMIS score of ≥1 OR FSFI score ≤ 26.55 OR FSDS-R score ≥11.",[407,653,320,321,26,654,322,655,656],"Obstetric Trauma","Pelvic Pain","Constipation","Anal Sphincter Injury",[658,659,355,660,661,662,663,664],"urinary incontinence","anal incontinence","sexual dysfunction","constipation","postpartum","levator avulsion","anal sphincter injury","2024-06-28",{"date":667,"type":34},"2024-07-01",{"date":669,"type":34},"2022-08-17",{"date":671,"type":21},"2025-09-01",{"name":673,"class":65},"Universitaire Ziekenhuizen KU Leuven"]