[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pelvic-varices\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pelvic-varices":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100528998","trial-of-ovarian-vein-and-pelvic-vein-embolization-in-women-with-chronic-pelvic-pain-and-pelvic-varices-100528998",false,"NCT06168058","Trial of Ovarian Vein and Pelvic Vein Embolization in Women With Chronic Pelvic Pain and Pelvic Varices","Randomized Controlled, Single-Blinded, Parallel-Group Trial of Ovarian Vein and Pelvic Vein Embolization in Women With Chronic Pelvic Pain and Pelvic Varices (EMBOLIZE) Trial","EMBOLIZE","Inclusion Criteria:\n\n1. Presence of venous origin chronic pelvic pain for greater than 6 months (VAS ≥7 as determined by 4 consecutive weeks of baseline self-assessments) despite non-vascular therapy as delineated by the following criteria:\n\n   * Pain exacerbated by walking, standing or lifting\n   * Symptoms are at least partially alleviated by lying down\n   * Prolonged post-coital ache\n   * Absence of non-venous origin CPP as determined by Gynecology examination\n2. Symptoms-Varices-Pathophysiology Classification18 including of one of the following:\n\n   •S2V2PBGV,R,NT, S2V2PRGV,R,NT , S2V2PLGV,R,NT, with or without S2V2 PBIIV,R,NT, S2V2 PLIIV,R,NT, S2V2 PRIIV,R,NT\n3. CT, TAUS and diagnostic venography (if needed) imaging review for pelvic venous imaging factors\n\n   * Left or right ovarian vein diameter greater than or equal to 6 mm as documented by TAUS or CT\n   * Presence of intrabdominal\u002Fpelvic varices as documented by TAUS or CT (≥1 veins, \\>5 mm diameter)\n   * Presence of venous reflux in ovarian and\u002For internal iliac veins without evidence of hemodynamically significant stenosis\n\nExclusion Criteria:\n\n* Female \\\u003C18 years of age\n* Pregnancy (positive pregnancy test)\n* Female subject who plans to become pregnant during study period\n* Female subject who is actively breastfeeding\n* Patient who is post-menopausal or anovulatory with hormone suppression\n* History of prior hysterectomy\n* Prior ovarian vein embolization or ovarian vein ligation\n* Inability to tolerate endovascular procedure due to acute illness or general health\n* Planned simultaneous treatment with nerve blocks during the duration of the study\n* Laparoscopy or planned surgical intervention during the duration of the study\n* Known allergy to sclerosant, coil, stent or catheter components including nickel allergy\n* Any iliac vein stenosis determined identified by the investigator on pelvic DUS, CT venogram, and\u002For Catheter Venography and deemed significant for exclusion by study patient review committee.\n* Any renal vein stenosis with resultant renal hilar varices\u002Fcollaterals and lumbar collaterals identified by the investigator on pelvic DUS, CT venogram, and\u002For Diagnostic Venography and deemed significant for exclusion by study patient review committee.\n* Presence of isolated extra-pelvic vulvar and\u002For lower extremity varices without intrabdominal pelvic varices. Primary S3 categorization study exclusion.\n* Serious medical conditions that might preclude full participation in the study to the desired endpoint (e.g., uncontrolled diabetes, malignancy, COPD, MI, CHF, etc.)\n* Severe allergy to iodinated or gadolinium-based contrast refractory to steroid premedication\n* Severe renal impairment (on chronic dialysis or estimated GFR \\\u003C30 mL\u002Fmin)\n* Hemoglobin \\\u003C8.0 g\u002FdL, uncorrectable INR \\>3.0 or platelet count \\\u003C75,000\u002Fmicroliter\n* Inability to provide informed consent or to comply with study assessments\n* Post thrombotic IVC, iliac or ovarian vein changes",true,"FEMALE","18 Years","75 Years",{"count":22,"type":23},40,"ESTIMATED","INTERVENTIONAL",[26],"NA","The purpose of this study is to see if a randomized controlled trial of ovarian vein and pelvic vein embolization versus venography alone could determine outcomes for women with chronic pelvic pain and pelvic varicose veins.\n\nThe data gathered will assist in addressing changes in quality of life in patients who have ovarian\u002Fpelvic vein embolization versus no embolization.",[29,30,31,32,33],"Chronic Pelvic Pain Syndrome","Pelvic Pain","Pelvic Varices","Pelvic Congestive Syndrome","Pelvic Pain Syndrome","RECRUITING","2026-03-11",{"date":37,"type":38},"2026-03-13","ACTUAL",{"date":40,"type":38},"2025-08-07",{"date":42,"type":23},"2027-06",{"name":44,"class":45},"Weill Medical College of Cornell University","OTHER",3,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":74,"locationsCount":76},"100525663","study-of-venous-outflow-from-the-lower-limbs-in-patients-with-pelvic-varicosities-100525663","NCT06124664","Study of Venous Outflow From the Lower Limbs in Patients With Pelvic Varicosities","Study of Venous Outflow From the Lower Limbs in Patients With Pelvic Varicosities as a New Strategy for Compression Treatment of Pelvic Varicose Veins and Varicose Veins of the Lower Limb","Inclusion Criteria:\n\n* Patient age from 18 to 40 years;\n* Presence of pelvic varicose veins according to DUS data;\n* Reflux in the pelvic veins for more than 1 second before this DUS;\n* Reflux in the superficial veins of the lower limbs.\n\nExclusion Criteria:\n\n* Menopause;\n* Pregnancy;\n* Postthrombotic disease;\n* Suspicion of May-Turner syndrome;\n* Ultrasound signs of nutcracker syndrome","40 Years",{"count":56,"type":23},90,"OBSERVATIONAL","Compression therapy is basic treatment for chronic venous disease (CVD) of the lower limbs. Numerous studies have demonstrated the efficacy and safety of compression therapy in relieving symptoms such as pain, venous edema, leg heaviness and fatigue, as well as accelerating the healing of venous ulcers. It has been established that сompression therapy is indicated for patients with both minimally expressed manifestations of CVD and severe forms of the disease. At the same only one study has been conducted to assess the correction of venous outflow from the lower limbs and pelvis in patients with pelvic varicose vein (PVV) and pelvic congestion syndrome (PCS). However, the incidence of this pathology ranges from 15 to 30% in the female population. The cost to the healthcare system of treating these patients in the United States exceeds $2 billion. To date, the options and indications for compression therapy in patients with concomitant PVV and CVD have not been defined. The rational use of compression in this cohort of patients may contribute to the improvement of effective conservative treatment. In addition, inappropriate prescription of compression to patients with pelvic venous disease (which can be observed in real clinical practice) may discredit this simple, effective and safe therapeutic method. In addition, the research devoted to the problem of compression treatment of PVV will contribute to the development of new special compression products aimed at accelerating venous outflow from the pelvic organs. It can be assumed that this will serve as a stimulus for obtaining new data on the therapeutic effects of compression and create conditions for the creation of new technological directions in the production of compression knitwear.",[31,60,33,32],"Varicose Veins of Lower Limb",[62,63,64,65,66,67],"pelvic varicose vein","venous outflow","chronic venous disease","compression treatment","duplex ultrasound","single-photon emission computed tomography","2024-12-25",{"date":70,"type":38},"2024-12-27",{"date":72,"type":38},"2023-05-12",{"date":68,"type":23},{"name":75,"class":45},"Pirogov Russian National Research Medical University",1]