[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"peptic-ulcer-bleeding\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:peptic-ulcer-bleeding":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":5},"100584871","tegoprazan-and-lansoprazole-effectiveness-in-bleeding-peptic-ulcer-treatment-100584871",false,"NCT06894992","Tegoprazan And Lansoprazole Effectiveness in Bleeding Peptic Ulcer Treatment","A Comparison of The Effectiveness of Tegoprazan and Lansoprazole in Achieving Cure Rates in Patients With Bleeding Peptic Ulcers: A Double-Blind Randomized Trial","TALENT","Inclusion Criteria:\n\n* Subjects diagnosed with upper gastrointestinal bleeding caused by peptic ulcer through gastroscopic examination\n\nExclusion Criteria:\n\n* Allergic to Tegoprazan or Lansoprazole\n* Diagnosed with gastric or duodenal cancer, pregnant\n* History of H. pylori infection treatment failure\n* Presence of comorbidities such as chronic kidney disease or decompensated liver cirrhosis\n* Alcohol consumption\n* Undergoing chemotherapy","ALL","18 Years",{"count":20,"type":21},162,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to compare the effects of tegoprazan vs lansoprazole in healing bleeding peptic ulcers. It will also teach about the safety of both modalities. The main questions it aims to answer are:\n\nHow does the effectiveness of Tegoprazan compare with Lansoprazole in two weeks of healing rate bleeding peptic ulcer patients in the Indonesian population?\n\nResearchers will compare the drug tegoprazan to lansoprazole with a double-blind randomized control to see their effect on healing bleeding peptic ulcers.\n\nParticipants will:\n\nTake drug tegoprazan 50 mg OD or lansoprazole 30 mg OD every day for 2 weeks Endoscopic examination at the beginning before treatment and after completion of treatment within 2 weeks Record of their adverse effect occurrence",[27],"Peptic Ulcer Bleeding",[29,30,31,27,32],"Tegoprazan","Lansoprazole","Peptic Ulcer","Healing Rate","RECRUITING","2025-05-23",{"date":36,"type":37},"2025-05-29","ACTUAL",{"date":39,"type":37},"2025-05-01",{"date":41,"type":21},"2025-12-31",{"name":43,"class":44},"Mario Steffanus","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":50,"conditions":57,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":4},"100576281","phase-2-phase-ii-clinical-study-of-vonorasan-fumarate-injection-in-the-treatment-of-peptic-ulcer-bleeding-100576281","NCT06783257","Phase II Clinical Study of Vonorasan Fumarate Injection in the Treatment of Peptic Ulcer Bleeding","A Multicenter, Randomized, Double-Blind, Parallel-Group Phase II Clinical Trial to Evaluate the Efficacy and Safety of Vonoprazan Fumarate Injection for the Treatment of Peptic Ulcer Bleeding","Inclusion Criteria:\n\n1. Voluntarily participate and sign the informed consent form.\n2. Individuals aged between 18 and 75 years, regardless of gender.\n3. Clinical manifestations of upper gastrointestinal bleeding, such as hematemesis, melena, or positive fecal occult blood, within 48 hours prior to screening.\n4. Patients diagnosed with upper gastrointestinal bleeding caused by gastric and\u002For duodenal ulcers through endoscopic examination within 24 hours prior to random group selection, with ulcer maximum diameter ranging from 3 to 20 mm.\n5. The classification of peptic ulcers according to Forrest is as follows: Ia, Ib, IIa, IIb. For multiple ulcers, the higher Forrest grade is used for determination. After confirming the ability to achieve hemostasis through endoscopic treatment, the following requirements for endoscopic treatment are as follows:\n\n   * For Forrest Ia, Ib, IIa: Thermal hemostasis or mechanical hemostasis is the primary method, and it is also permissible to combine local epinephrine injection based on the aforementioned primary methods;\n   * For Forrest IIb: To confirm the specific grade, endoscopic irrigation to remove attached blood clots should be attempted first. If the blood clots are cleared, the Forrest grade should be reassessed. If it is classified as Forrest Ia, Ib, or IIa, endoscopic hemostatic treatment should be performed as per the above requirements. If the blood clots are not cleared and it is ultimately confirmed as Forrest IIb, direct grouping is permitted.\n\nExclusion Criteria:\n\n1. Individuals with a clinically significant history of drug allergies or known allergies to the components and excipients of the study drug;\n2. Subjects with other severe central nervous system, cardiovascular, respiratory, organ, renal, gastrointestinal, urinary, endocrine, or hematological diseases, which the investigator believes may confound the study results or affect the safety of the subjects;\n3. Hematological disorders: ① Platelet count \\\u003C80×10\\^9\u002FL; ② PT exceeds the upper limit of normal by 3 seconds; ③ APTT exceeds the upper limit of normal by 10 seconds; (If any of these criteria are met, the patient is not eligible for selection)\n4. Renal function abnormalities: ① ALT or AST ≥1.5×ULN; ② Total bilirubin \\>1.5×ULN; ③ Serum creatinine (Cr) \\> ULN; (If any of these criteria are met, the patient is not eligible for selection)\n5. A history of drug abuse within the last 5 years;\n6. Receipt of live vaccines or attenuated live vaccines within 30 days prior to the first administration, or plans to receive vaccinations during the study period;\n7. Hemorrhagic shock (occurring during the screening period with systolic blood pressure \\\u003C90 mmHg and heart rate \\>120 beats\u002Fmin, accompanied by symptoms such as pallor, cold and clammy extremities, restlessness, or altered mental status) or requiring arterial catheter embolization or surgical intervention due to unsuccessful endoscopic treatment;\n8. Concurrent upper gastrointestinal bleeding from other causes or suspected gastric malignancy under endoscopy; There is a clear history of surgery to reduce gastric acid or a history of gastric surgery (including but not limited to partial gastrectomy, gastric plasty, vagotomy, excluding simple perforation suturing);\n\n10\\. A history of malignant tumors within 5 years prior to screening (if the subject has been cured of skin basal cell carcinoma or cervical carcinoma in situ, he\u002Fshe may participate in this study); 11. Use of proton pump inhibitors (PPIs) or H2 receptor antagonists or P-CAB preparations exceeding a single dose of the standard dose within 24 hours prior to screening, or having undergone endoscopic treatment\u002Fintervention before signing the informed consent form, and having used PPIs, P-CAB preparations, H2 receptor antagonists, somatostatin, or hemostatic agents after endoscopic treatment\u002Fintervention until the selection for this study; 12. Patients currently using drugs with a clear risk of interaction with the investigational drug, such as azanavir sulfate, nelfinavir, saquinavir, or liponavir; 13. Use of hemostatic powder Endoclot AHP® or other local hemostatic agents during endoscopy that, in the investigator's judgment, affect the efficacy of the investigational drug; 14. Pregnant or breastfeeding women, as well as those with plans for pregnancy or sperm\u002Fegg donation within 3 months after the end of the study, who are unwilling to adopt a medically recognized contraceptive method (such as an intrauterine device or condom) during the study; 15. Participation in other drug\u002Fdevice clinical studies and use of investigational drugs\u002Fdevices within 3 months prior to randomization; 16. Other subjects deemed unsuitable for selection by the investigator.","75 Years",{"count":54,"type":21},150,[56],"PHASE2",[27],"NOT_YET_RECRUITING","2025-01-17",{"date":61,"type":37},"2025-01-20",{"date":63,"type":21},"2025-02",{"date":65,"type":21},"2027-02",{"name":67,"class":68},"Shandong New Time Pharmaceutical Co., LTD","INDUSTRY"]