[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"perception-of-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:perception-of-pain":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,41],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100604392","perception-of-pain-during-gender-affirming-hormone-therapy-100604392",false,"NCT07148921","Perception of Pain During Gender Affirming Hormone Therapy","Changes in Pain and Perception Thresholds Due to Gender Affirming Hormone Therapy: a Prospective Exploratory Cohort Study","Inclusion Criteria:\n\n* ≥ 18 years of age\n* Assigned female at birth (AFAB)\n* Diagnosed gender identity disorder\u002Fgender dysphoria and planned therapy with testosterone OR\n* ≥ 18 years of age\n* Assigned male at birth (AMAB)\n* Diagnosed gender identity disorder\u002F gender dysphoria and planned therapy with estradiol\n\nExclusion Criteria:\n\n* Any sex hormone intake during the last 6 months\n* Acute or chronic pain\n* Polyneuropathy\n* Diagnosis of alcohol or drug addiction\n* BMI under 18 or over 35\n* Pregnancy\n* Breastfeeding\n* Pharmacological analgesic therapy within the previous 7 days before each examination\n* History of significant trauma or surgery to the hands with residual neurological deficit or pain.","ALL","18 Years",{"count":19,"type":20},40,"ESTIMATED","OBSERVATIONAL","It is known from the literature that women and men differ in their perception of pain. Why this is the case has not been conclusively clarified. Sex hormones could have a significant influence on this. The study team suspects that the classic hormone status of women is responsible for the lower pain threshold compared to men.\n\nPeople undergoing gender affirming therapy receive biologically opposite-sex hormones in order to adapt their external appearance as well as their voice, emotional life etc. to the desired gender. The aim of this study is to longitudinally record whether the intake of opposite-sex sex hormones leads to a change in pain and perception thresholds in this patient collective. To this end, potential study participants will be informed about the study and asked whether they would like to participate before the start of hormone therapy during their first visit to the transgender outpatient clinic.\n\nIf consent is given, a questionnaire on mental health (PHQ 9), a blood sample to determine the hormone status and the first QST (quantitative sensory testing) measurement are then carried out. The second measurement with blood sampling takes place 3-4 weeks after the first measurement. The 3rd and 4th measurements with blood sampling are taken 3 and 6 months respectively after the first measurement. The PHQ 9 is measured again at the time of the last measurement. Study participation ends after a total of 6 months. The blood samples, the PHQ 9 and the QST measurements have no influence on the treatment of the study participants.",[24,25,26,27],"Transgender Persons","Pain Threshold","Perception of Pain","Sex Hormones","RECRUITING","2025-08-22",{"date":31,"type":32},"2025-08-29","ACTUAL",{"date":34,"type":32},"2024-12-01",{"date":36,"type":20},"2026-03",{"name":38,"class":39},"Medical University of Vienna","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":47,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":50,"phases":51,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":40},"100561677","pain-perception-in-protection-of-the-palatal-donor-area-after-harvesting-a-free-gingival-graft-using-flowable-resin-versus-a-self-adhesive-dressing-100561677","NCT06593275","Pain Perception in Protection of the Palatal Donor Area After Harvesting a Free Gingival Graft Using Flowable Resin Versus a Self-adhesive Dressing","Inclusion Criteria:\n\n* Patients over 18 years of age\n* Patients with plaque control less than 20%\n* Patients with bleeding on probing less than 10%\n* Patients in need of periodontal or peri-implant surgery in the upper or lower jaw\n* Not having previous surgeries in the donor area\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding patients\n* Patients with lesions in the palate\n* Patients who use prostheses that cover the palate\n* Patients with active periodontal disease\n* Patients who smoke\n* Patients with systemic diseases\n* Torus palatinus\n* Patients with a history of chemotherapy and radiotherapy",true,{"count":49,"type":20},30,"INTERVENTIONAL",[52],"NA","The use of a connective tissue graft harvested from the palate is currently one of the most effective and predictable alternatives for the correction of periodontal and peri-implant defects, but the discomfort generated in the palate is sometimes greater than mucogingival surgery. For this reason, we found the need to use different materials for palatal protection. In one group we will use light-cured fluid resin compared to another group a self-adhesive dressing to check which of these materials provides less postoperative pain generated by the harvest of a free gingival graft.",[26,55],"Protection of the Palate",[57,58,59,60],"protection of the palate","pain palate","flow resine","self-adhesive dressing","NOT_YET_RECRUITING","2024-10-07",{"date":64,"type":32},"2024-10-10",{"date":66,"type":20},"2024-10-30",{"date":68,"type":20},"2029-12-15",{"name":70,"class":39},"Universidad de Especialidades Espiritu Santo"]