[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"perforated-appendicitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:perforated-appendicitis":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100641222","perforated-appendicitis-and-postoperative-antibiotics-pilot-trial-100641222",false,"NCT07656636","Perforated Appendicitis and Postoperative Antibiotics Pilot Trial","PAPA Pilot","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Scheduled to undergo an open or laparoscopic appendectomy\n* Complicated appendicitis confirmed intra-operatively (AAST Appendicitis Grade III or IV)\n\nExclusion Criteria:\n\n* Patients demonstrating signs of septic shock for whom the omission of systemic antibiotics is contraindicated\n* Patients with positive blood cultures for whom antibiotics are required for treatment of the bacteremia\n* Immunosuppressed patients\n* AAST Appendicitis Grade V","ALL","18 Years",{"count":19,"type":20},100,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical trial is to learn if not giving antibiotics is as effective as giving antibiotics after surgery for patients who have surgery for a perforated (burst) appendix. This pilot study will also help determine whether a larger, multi-centre study can be successfully conducted. The main questions it aims to answer are:\n\n* Do patients who do not receive antibiotics after surgery have similar rates of infection after surgery as patients who do?\n* Is it feasible to enroll and randomize patients and collect complete health data for a larger multi-centre study?\n\nResearchers will compare patients who do not receive antibiotics after surgery to patients who do to see whether avoiding antibiotics is as effective as using antibiotics for preventing infections after surgery.\n\nParticipants will:\n\n* Be randomly assigned to either receive or not receive antibiotics after surgery for their perforated (burst) appendix.\n* Be contacted 30 and 90 days after surgery to check for infections and other health outcomes.",[26],"Perforated Appendicitis",[28,29,30,31,32,33,34],"Perforated appendicitis","Complicated appendicitis","Postoperative antibiotics","Randomized controlled trial","Pilot trial","Acute care surgery","Emergency general surgery","NOT_YET_RECRUITING","2026-06-15",{"date":38,"type":39},"2026-06-18","ACTUAL",{"date":41,"type":20},"2026-08-01",{"date":43,"type":20},"2027-11-01",{"name":45,"class":46},"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":21,"phases":56,"briefSummary":58,"conditions":59,"keywords":60,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100570330","phase-4-appi-cost-trial-for-perforated-appendicitis-100570330","NCT06705842","APPI-Cost Trial for Perforated Appendicitis","The APPI-Cost Trial: Cost Assessment of Povidone-Iodine Irrigation for Prevention of Intra-abdominal Abscess in Perforated Appendicitis","Eligibility for Enrollment\n\nInclusion Criteria:\n\n* Plan to undergo appendectomy for acute appendicitis\n\nExclusion Criteria:\n\n* Preoperative hemodynamic instability requiring ongoing infusion of vasopressors\n* Allergy to iodine\n* Uncontrolled hyper- or hypothyroidism\n* Renal dysfunction\n* Pregnant or breastfeeding\n* Primary language neither English nor Spanish\n* Lack of functioning telephone or email account\n* Incarcerated or in police custody\n\nEligibility for Randomization\n\nInclusion Criteria:\n\n* Enrolled in study preoperatively\n* Intraoperative diagnosis of perforated appendicitis\n\nExclusion Criteria:\n\n* Non-perforated appendicitis",{"count":55,"type":20},346,[57],"PHASE4","The purpose of this study to assess the clinical effectiveness and cost-effectiveness of povidone-iodine (PVI) irrigation in perforated appendicitis, to investigate barriers and facilitators to future implementation of PVI irrigation, and to collect costs and clinical and patient-reported outcomes among patients with non-perforated appendicitis.",[26],[26,61,62,63,64,65],"Povidone Iodine","Cost effectiveness","Intra-abdominal abscess","Appendectomy","Implementation science","RECRUITING","2025-12-04",{"date":69,"type":39},"2025-12-11",{"date":71,"type":39},"2025-04-07",{"date":73,"type":20},"2027-03-31",{"name":75,"class":46},"The University of Texas Health Science Center, Houston",1]