[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"perfusion\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:perfusion":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,43,81,121,142],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100612618","anesthesia-perfusion-and-surgical-practices-in-cardiac-surgery-100612618",false,"NCT07255924","Anesthesia, Perfusion, and Surgical practicEs in Cardiac Surgery","Anesthesia, Perfusion, and Surgical practicEs in Cardiac Surgery: an Adaptive, Prospective, International, Multicenter, Observational Study.","APECx","Inclusion Criteria:\n\n* 18 years or older\n* Undergoing cardiac surgery at a participating center\n\nExclusion Criteria:\n\n\\- Transcatheter cardiac interventions or endovascular procedures","ALL","18 Years",{"count":20,"type":21},15000,"ESTIMATED","OBSERVATIONAL","Perioperative management in cardiac surgery, particularly the use of anesthesia, cardiopulmonary bypass (CPB), and surgical techniques, remains highly variable across institutions. Current international guidelines lack clear recommendations due to insufficient high-quality comparative data. APECx is an adaptive, international, multicenter, prospective, observational study designed to address multiple of these evidence gaps. The adaptive design allows the study to proceed through subsequent phases. Each phase will collect comprehensive global data on specific peri-operative practices and their associated patient outcomes, all within a single, continuously evolving study.",[25,26,27,28],"Cardiac Anaesthesia","Cardiac Surgery","Perfusion","Anesthesia",[26,25,28,27],"NOT_YET_RECRUITING","2025-11-27",{"date":33,"type":34},"2025-12-01","ACTUAL",{"date":36,"type":21},"2026-04-01",{"date":38,"type":21},"2036-01",{"name":40,"class":41},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":62,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":80},"100533194","ppg-vs-icg-in-gastrointestinal-resections-100533194","NCT06222645","PPG vs. ICG in Gastrointestinal Resections","Comparison Between Fluorescenceimaging With Photoplethysmography （PPG） and Indocyaningreen (ICG) for Tissue Perfusion in Gastrointestinal Resections","Inclusion Criteria:\n\n* Adult patients (age ≥ 18 years).\n* Scheduled to undergo an elective gastrointestinal resection requiring a primary gastro-intestinal or entero-enteric anastomosis.\n* Able to understand and provide written informed consent.\n\nExclusion Criteria:\n\n* Known hypersensitivity or allergy to indocyanine green (ICG), iodine, or any component of the ICG formulation.\n* Severe hepatic impairment (e.g., Child-Pugh Class C).\n* Pregnancy or lactation.\n* Emergency surgery.\n* Inability to comply with the study protocol or follow-up schedule in the investigator's judgment.",{"count":51,"type":21},200,"INTERVENTIONAL",[54],"NA","This randomized controlled trial compares a novel optical technique against the standard of care for assessing tissue perfusion in gastrointestinal surgery. Participants are randomized to receive either intraoperative imaging photoplethysmography (iPPG) or indocyanine green (ICG) fluorescence imaging. In the ICG group, the fluorescence data are comprehensively analyzed in two distinct ways: (1) Qualitative Assessment: real-time visual interpretation of the angiogram flow by the operating surgeon; and (2) Quantitative Assessment: software-based analysis of fluorescence kinetics (e.g., time-to-peak, maximum intensity) to generate objective perfusion parameters. The study aims to determine the agreement between the iPPG-based evaluations and both the qualitative and quantitative dimensions of the ICG standard.",[57,27,58,59,60,61],"Anastomosis","Postoperative Complications","Gastrointestinal Neoplasms","Gastric Cancer (GC)","Colorectal Cancer",[63,64,65,66,67,68,69],"Photoplethysmography","Indocyanine Green","Fluorescence Imaging","Anastomotic Leak","Gastrointestinal Surgery","Tissue Perfusion","Intraoperative Monitoring","RECRUITING","2025-11-14",{"date":73,"type":34},"2025-11-18",{"date":75,"type":34},"2023-11-01",{"date":77,"type":21},"2026-05-31",{"name":79,"class":41},"Saint Petersburg State University, Russia",3,{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":89,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":91,"conditions":92,"keywords":97,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":42},"100507900","brain-perfusion-evaluation-by-contrast-enhanced-ultrasound-100507900","NCT05893407","Brain PERfusion Evaluation by Contrast-Enhanced UltraSound","Quantification of Cerebral Perfusion at the Patient's Bedside When Performing Contrast-enhanced Ultrasound in Neurointensive Care Patients","PerCEUS","Inclusion Criteria:\n\n* Age ≥18\n* Intensive care unit admission for acute brain injury\n* Proven acute brain injury by CT and\u002For MRI\n* Requiring a contrast ultrasound imaging\n* Informed consent of patient or relative\n\nExclusion Criteria:\n\n* Pregnancy\n* Not sufficient temporal window\n* Contraindications to Sonovue ® : acute coronary syndromes, severe ischemic heart disease (requiring revascularization), pulmonary arterial hypertension \\> 90 mmHg, right-left shunt, ARDS, dobutamine's use, known allergy or adverse reaction to Sonovue®\n* Patient on State Medical Assistance",{"count":90,"type":21},60,"The objective of the study is to assess brain tissue perfusion by contrast-enhanced ultrasound perfusion imaging (PerCEUS) in acute brain injuries. More precisely, it aims :\n\n* to evaluate the heterogeneity of brain perfusion and thus diagnose brain tissue hypoperfusion with contrast-enhanced ultrasound.\n* to correlate contrast-enhanced ultrasound with perfusion measurements by usual multimodal monitoring.",[93,94,95,96,27],"Cerebral Hemorrhage","Subarachnoid Hemorrhage","Ischemic Stroke","Cerebrovascular Circulation",[98,99,100,101,102,103,104,105,106,107,108,109,110,111],"Brain perfusion","Cerebral blood flow","Diagnostic imaging","Ultrasonography Doppler","Doppler ultrasound","Transcranial Doppler","Contrast enhanced ultrasound","Contrast-enhanced ultrasonography","Contrast ultrasound","Ultrasound perfusion imaging","Ultrasound contrast agent","Intra-cranial pressure","Intracerebral hematoma","Neurocritical care","2025-06-16",{"date":114,"type":34},"2025-06-19",{"date":116,"type":34},"2023-07-21",{"date":118,"type":21},"2025-07",{"name":120,"class":41},"Assistance Publique - Hôpitaux de Paris",{"id":122,"slug":123,"hasResults":11,"nctId":124,"briefTitle":125,"officialTitle":125,"acronym":4,"eligibilityCriteria":126,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":127,"enrollmentInfo":128,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":130,"conditions":131,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":4},"100556462","foot-perfusion-by-dynamic-contrast-enhanced-mri-in-patients-with-peripheral-artery-disease-100556462","NCT06525415","Foot Perfusion by Dynamic Contrast Enhanced MRI in Patients With Peripheral Artery Disease","Inclusion Criteria:\n\n* 18 to 80 years old;\n* PAD patients with Fontaine grade II-IV or Rutherford grade 2-6 and underwent a successful revascularization;\n* Patients completed both pre- and post-operative MRI workups;\n* Patients signed the informed consent form and be able to complete the clinical follow-up for 1 months.\n\nExclusion Criteria:\n\n* Patients has participated in other clinical studies;\n* Patients with Heart failure (NYHA III\u002FIV)\u002Fright to left shunt heart disease\u002F severe aortic and mitral insufficiency\u002Facute coronary syndrome\u002Fmalignant arrhythmia\u002Fsevere pulmonary hypertension (pulmonary artery pressure at least 90 mmHg)\u002Fmoderate to severe renal insufficiency (creatinine clearance rate\\\u003C60 ml\u002Fmin)\n* Any allergic constitution;\n* Pregnancy and childbirth;\n* Life expectancy\\\u003C12 months.","80 Years",{"count":129,"type":21},30,"We investigate the peri-operative foot perfusion through dynamic contrast enhanced MRI in patients with peripheral artery disease",[132,27],"Peripheral Arterial Disease","2024-07-24",{"date":135,"type":34},"2024-07-29",{"date":137,"type":21},"2024-08-01",{"date":139,"type":21},"2024-11-30",{"name":141,"class":41},"Fudan University",{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":4,"eligibilityCriteria":148,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":18,"enrollmentInfo":149,"targetDuration":4,"studyType":52,"phases":151,"briefSummary":152,"conditions":153,"keywords":156,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":42},"100548446","micro-dosing-indocyanine-green-icg-in-children-100548446","NCT06421103","Micro-dosing Indocyanine Green (ICG) in Children","Investigating Micro-dosing of Indocyanine Green (ICG) for Intraoperative Perfusion Assessment in Children.","Inclusion Criteria:\n\n* Children aged ≤18 years of age\n* Elective surgery including gastrointestinal or genitourinary tract perfusion assessment\n\nExclusion Criteria:\n\n* Renal and liver dysfunction\n* Active infection\n* Coagulopathy\n* Complex congenital heart defect\n* Previous documented allergy to ICG injection or other iodinated contrast agents\n* Patients suffering from hyperthyroidism or autonomic thyroid adenomas\n* Premature infants or neonates in whom exchange transfusion is indicated, due to the hyperbilirubinaemia risk\n* Concurrent use of sodium bisulphite-containing preparations, such as certain heparin preparations",{"count":150,"type":21},90,[54],"The goal of this cohort study is to identify the lowest dose of Indocyanine Green (ICG) that achieves satisfactory intra-operative fluorescence for the assessment of gastrointestinal or genitourinary tract perfusion in children.",[27,65,154,155],"Gastrointestinal Tract Disorders","Genitourinary Disease",[157,158,159,160,161,162,64],"Paediatric Surgery","Pediatric Surgery","Fluorescence","Imaging","Fluorescence Guided Surgery (FGS)","Intra-operative perfusion assessment","2024-05-15",{"date":165,"type":34},"2024-05-20",{"date":167,"type":21},"2024-06",{"date":169,"type":21},"2028-08",{"name":171,"class":41},"Great Ormond Street Hospital for Children NHS Foundation Trust"]