[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"peri-dialytic-cardiac-rhythms\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:peri-dialytic-cardiac-rhythms":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100501814","trial-of-variable-dialysate-bicarbonate-100501814",false,"NCT05814146","Trial of Variable Dialysate Bicarbonate","Randomized, Controlled, Double-blind Trial of Lower Versus Higher Dialysate Bicarbonate in Hospitalized Maintenance Hemodialysis Patients","Inclusion Criteria:\n\n* prevalent end-stage renal disease, on maintenance HD \\> 90 days\n* age ≥ 18 years old\n* thrice weekly HD\n\nExclusion Criteria:\n\n* hemoglobin \\\u003C 8.0 g\u002FdL\n* pregnancy\n* any physical, mental or medical condition which limited the ability to provide written informed consent","ALL","18 Years","120 Years",{"count":20,"type":21},141,"ESTIMATED","INTERVENTIONAL",[24],"NA","QTc prolongation and premature ventricular contractions (PVCs) are common in hemodialysis (HD) patients and are associated with sudden cardiac death.\n\nIt is known that higher dialysate bicarbonate is associated with more QTc prolongation during HD sessions.\n\nThis study aims to assess the effects of lower (30 mEq\u002FL) versus higher (35 mEq\u002FL) dialysate bicarbonate in adult maintenance HD patients admitted to the hospital.\n\nThe investigators will randomly assign subjects to lower versus higher dialysate bicarbonate concentrations during their hospital stay for up to a maximum of six HD sessions or until their hospital discharge.",[27,28,29,30,31],"Peri-dialytic Cardiac Rhythms","Intradialytic Hypotension","Electrolyte Changes","pH Changes","Adverse Symptoms","RECRUITING","2025-11-19",{"date":35,"type":36},"2025-11-24","ACTUAL",{"date":38,"type":36},"2023-08-24",{"date":40,"type":21},"2026-10-01",{"name":42,"class":43},"Brigham and Women's Hospital","OTHER"]