[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"peri-implant-mucositis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:peri-implant-mucositis":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,18,0,[8,48,73,106,127,148,174,195,216,244,269,292,317,343,369,393,418,447],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100616372","effect-of-probe-material-on-peri-implant-probing-100616372",false,"NCT07304752","Effect of Probe Material on Peri-implant Probing","Effect of Probe Material (Metallic vs. Plastic) on Peri-implant Probing: a Randomized Clinical Trial.","METPLA-PP","Inclusion Criteria:\n\n* Adults (≥18 years)\n* Presence of at least one single-unit bone-level implant rehabilitated with a screw-retained prosthesis directly connected to the implant (no intermediate abutment)\n* Implant in function for at least 1 year after prosthetic loading\n* No pathological bone loss on periapical radiograph (distance from the most coronal rough surface of the implant to the bone crest \\\u003C 3 mm)\n* Ability to understand and sign informed consent\n* Peri-implant health or mucositis, defined according to the 2017 World Workshop criteria:\n* Health: no clinical signs of inflammation, lack of profuse (line or drop) bleeding on probing, no increase in probing depth compared to previous records, and no progressive bone loss beyond initial remodeling (\\\u003C2 mm). In the absence of previous radiographs, radiographic bone level \\\u003C3 mm without bleeding and\u002For suppuration on probing.\n* Mucositis: presence of bleeding and\u002For suppuration on probing, no increase in probing depth compared to previous records, and no bone loss beyond initial remodeling (\\\u003C2 mm). In the absence of previous radiographs, radiographic bone level \\\u003C3 mm with bleeding and\u002For suppuration on probing.\n\nExclusion Criteria:\n\n* Cement-retained restorations or prostheses that cannot be removed\n* Systemic antibiotic or anti-inflammatory treatment within the previous 3 months\n* Pregnancy or lactation\n* Peri-implant treatment within the previous 3 months\n* Participation in another clinical trial within the last 30 days","ALL","18 Years",{"count":20,"type":21},64,"ESTIMATED","INTERVENTIONAL",[24],"NA","Evaluate whether the type of probe (plastic vs. metallic) modifies the accuracy of peri-implant probing in single-unit implants, by comparing the probing depth recorded with the prosthesis in place versus without the prosthesis (ΔPD, mm). Secondarily, explore the influence of prosthetic design and implant position on probing values and on other clinical and radiographic parameters.",[27,28],"Peri-implant Health","Peri-implant Mucositis",[30,31,32,33,34],"Visual Analogue Scale","Peri-implant probing","Probing depth","Emergency profile","Dental implant","RECRUITING","2026-06-21",{"date":38,"type":39},"2026-06-24","ACTUAL",{"date":41,"type":39},"2026-01-01",{"date":43,"type":21},"2026-10",{"name":45,"class":46},"University of Barcelona","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":72},"100366523","peri-implantitis-implantoplasty-treatment-100366523","NCT04052373","Peri-implantitis Implantoplasty Treatment","Surgical Peri-implantitis Treatment With and Without Implantoplasty","Inclusion Criteria:\n\n* Peri-implantitis (according to 2018 criteria) on minimum 2 implants of similar surface and defect type\n* Competent to give consent\n* Exposed, modified implant surface with loss \\>2mm\n\nExclusion Criteria:\n\n* Previous radiotherapy to the jaws, current use of chemotherapy, systemic long-term corticosteroid treatment\n* Present or past use of bisphosphonate treatment • Pregnant or nursing subjects\n* Patients classified as \\> class II according to ASA classification\n* Implant unavailable for implantoplasty treatment\n* Inhability to comprehend and respond to the quality of life questionnaire\n* Examiners\u002Foperators deem original placement of implant (angle, position) suboptimal and considered to play a major role in development of peri-implantitis\n* History of peri-implantitis surgery prior to 6 months of screening",true,"20 Years",{"count":58,"type":21},35,[24],"This double arm, split-mouth, single centre, controlled, randomised clinical study is designed to examine the effect of implantoplasty in treatment of peri-implantitis.\n\nPeri-implantitis will be treated with open flap debridement, with or without implantoplasty.",[62,28],"Peri-Implantitis","2026-04-28",{"date":65,"type":39},"2026-04-29",{"date":67,"type":39},"2019-10-15",{"date":69,"type":21},"2027-06-15",{"name":71,"class":46},"University of Oslo",2,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":22,"phases":84,"briefSummary":85,"conditions":86,"keywords":87,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":47},"100603717","trehalose-vs-glycine-air-polishing-in-peri-implant-mucositis-treatment-100603717","NCT07140146","Trehalose vs Glycine Air-Polishing in Peri-Implant Mucositis Treatment","Comparison of Trehalose and Glycine Air-Polishing Powders in the Supportive Treatment of Peri-Implant Mucositis and Their Effect on Implant Surface Integrity: A Randomized Controlled Clinical Trial","TREAL-G","Inclusion Criteria:\n\n* Adults aged between 18 and 70 years\n* Presence of peri-implant mucositis, defined as bleeding on probing (BoP) around implants without radiographic evidence of bone loss beyond initial remodeling\n* Visible biofilm on implant surfaces\n* Ability to understand and sign informed consent\n* Good oral hygiene and patient compliance\n* Availability for all follow-up visits (1, 3, and 6 months)\n\nExclusion Criteria:\n\n* Presence of systemic conditions that may affect healing (e.g., uncontrolled diabetes, immunosuppression)\n* Current smokers or former smokers who quit less than 6 months ago\n* Pregnant or breastfeeding women\n* Use of antibiotics or anti-inflammatory drugs in the 3 months prior to baseline\n* Presence of peri-implantitis (i.e., bleeding on probing with concomitant radiographic bone loss)\n* History of head and neck radiotherapy\n* Presence of pacemakers or cardiac stimulators\n* Neurological or psychological disorders affecting study compliance","70 Years",{"count":83,"type":21},40,[24],"This randomized controlled clinical trial investigates the effectiveness of trehalose powder compared to glycine powder when used in air-polishing during supportive therapy for peri-implant mucositis, a reversible inflammatory condition affecting the soft tissues around dental implants.\n\nA total of 40 adult patients with peri-implant mucositis will be enrolled and randomly assigned to receive non-surgical periodontal therapy combined with air-polishing using either trehalose powder (test group) or glycine powder (control group). Clinical parameters will be evaluated at baseline, 1 month, 3 months, and 6 months. These include Plaque Index (PI), Bleeding on Probing (BoP), Probing Pocket Depth (PPD), and Bleeding Score (BS), in order to assess plaque accumulation, inflammation, and bleeding.\n\nThe primary objective is to compare the reduction in plaque levels between the two groups over the study period. Secondary outcomes include evaluation of changes in gingival inflammation and probing depths, as well as assessment of implant surface integrity through in vitro scanning electron microscopy (SEM) after treatment.\n\nThe aim of the study is to determine whether trehalose powder offers improved clinical outcomes and greater implant surface preservation compared to glycine powder in the non-surgical management of peri-implant mucositis.",[28],[88,89,90,91,92,93,94,95,96],"Peri-Implant Mucositis","Trehalose Powder","Glycine Powder","Air Polishing","Dental Implants","Implant Surface Integrity","Biofilm Removal","Randomized Controlled Trial","Scanning Electron Microscopy (SEM)","2026-02-19",{"date":99,"type":39},"2026-02-20",{"date":101,"type":39},"2025-08-30",{"date":103,"type":21},"2026-06-10",{"name":105,"class":46},"University of Pavia",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":55,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":113,"targetDuration":4,"studyType":22,"phases":115,"briefSummary":116,"conditions":117,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":47},"100539527","impact-of-keratinized-mucosa-augmentation-on-treatment-outcomes-of-peri-implant-mucositis-100539527","NCT06305000","Impact of Keratinized Mucosa Augmentation on Treatment Outcomes of Peri-implant Mucositis","Impact of Keratinized Mucosa Augmentation Following Non-surgical Therapy on Treatment Outcomes of Peri-implant Mucositis.","Inclusion Criteria:\n\n* Individual dental implants with a fixed prosthetic restoration that has been functional for at least 1 year\n* No systemic disease and medication use that may affect periodontal or peri-implanter tissues\n* Not receiving periodontal treatment in the last 6 months\n* Volunteering to participate in the study\n\nExclusion Criteria:\n\n* Prosthetic restorations with an excessive contour which do not allow peri-implant pocket measurement\n* Being pregnant or breastfeeding,\n* Autoimmune and\u002For inflammatory diseases of the oral cavity,\n* Active periodontal disease\n* Smokers (≥ 10 cigarettes per day)\n* Improperly positioned implants",{"count":114,"type":21},48,[24],"This study aims to observe the effects of keratinized mucosa width on peri-implant tissues by evaluating clinical and biochemical parameters. The main question it aims to answer is:\n\nWould increasing the width of the keratinized mucosa with free gingival graft (FGG) in peri-implant mucositis be beneficial in terms of clinical periodontal parameters and peri-implant crevicular fluid levels of inflammatory cytokines compared to non-surgical therapy alone?\n\nOur study consists of 4 groups:\n\nPeri-implant healthy group with sufficient keratinized mucosa (≥ 2mm) (n=16), peri-implant mucositis group with sufficient keratinized mucosa (n=16), peri-implant mucositis group with insufficient keratinized mucosa (\\\u003C 2mm) receiving only non-surgical treatment (n=16), peri-implant mucositis group with insufficient keratinized mucosa receiving FGG in addition to non-surgical treatment (n=16). Clinical and biochemical measurements will be recorded at the baseline, 1st month, 4th month and 7th month of the study. Peri-implant crevicular fluid samples will be collected at baseline, 1st month, 4th month and 7th month. IL-1β, RANKL, OPG levels, and RANKL\u002FOPG ratio will be analyzed from collected samples.\n\nResearchers will evaluate the possible benefits of FGG application in addition to non-surgical therapy by comparing the biochemical and clinical changes in areas with and without FGG application in the treatment of peri-implant mucositis.",[28],"2026-02-06",{"date":120,"type":39},"2026-02-10",{"date":122,"type":39},"2024-03-27",{"date":124,"type":21},"2026-09-10",{"name":126,"class":46},"Biruni University",{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":4,"eligibilityCriteria":133,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":134,"targetDuration":4,"studyType":22,"phases":136,"briefSummary":137,"conditions":138,"keywords":4,"overallStatus":139,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":4},"100623222","effectiveness-of-interproximal-cleaning-devices-for-biofilm-removal-around-posterior-single-implants-with-peri-implant-mucositis-100623222","NCT07393828","Effectiveness of Interproximal Cleaning Devices for Biofilm Removal Around Posterior Single Implants With Peri-Implant Mucositis","Efficacy of Biofilm Removal of Different Interproximal Oral Hygiene Devices Around Posterior Single Implants in Peri-Implant Mucositis: A Randomized Clinical Trial","Inclusion Criteria:\n\nAdults aged ≥18 years. Presence of at least one posterior single dental implant in function for ≥12 months.\n\nDiagnosis of peri-implant mucositis, defined as bleeding on probing with probing depths ≤5 mm and no radiographic bone loss beyond initial remodeling.\n\nGood general health (ASA I-II). Ability and willingness to comply with study procedures and follow-up visits. Provision of written informed consent.\n\nExclusion Criteria:\n\nDiagnosis of peri-implantitis (radiographic bone loss beyond initial remodeling).\n\nUncontrolled systemic diseases affecting periodontal or peri-implant health (e.g., uncontrolled diabetes mellitus).\n\nUse of systemic antibiotics or anti-inflammatory drugs within the previous 3 months.\n\nCurrent pregnancy or lactation. Current smoker of \\>10 cigarettes\u002Fday. History of periodontal therapy or professional implant maintenance within the previous 3 months.\n\nUse of medications known to affect bone metabolism (e.g., bisphosphonates). Inability to perform adequate oral hygiene or to attend scheduled study visits.",{"count":135,"type":21},75,[24],"This randomized clinical trial aims to evaluate and compare the efficacy of different interproximal oral hygiene devices for biofilm removal around posterior single dental implants in patients diagnosed with peri-implant mucositis.\n\nPeri-implant mucositis is a reversible inflammatory condition of the peri-implant soft tissues caused primarily by bacterial biofilm accumulation. Effective plaque control is essential for the prevention of disease progression to peri-implantitis. However, there is limited clinical evidence regarding the comparative effectiveness of different interproximal oral hygiene devices in implant-supported sites.\n\nA total of approximately 75 patients with posterior single implants and peri-implant mucositis will be recruited. Participants will be randomly allocated to one of the study groups, each using a specific interproximal oral hygiene device as part of their daily oral hygiene regimen. All participants will receive standardized oral hygiene instructions at baseline.\n\nClinical parameters related to peri-implant inflammation and plaque accumulation will be assessed at baseline and at follow-up visits at 1, 3, and 6 months. The primary outcome is the reduction of peri-implant biofilm accumulation. Secondary outcomes include changes in clinical inflammatory parameters around the implants.\n\nThe results of this study are expected to provide clinically relevant evidence to support evidence-based recommendations for interproximal oral hygiene in patients with dental implants affected by peri-implant mucositis.",[28],"NOT_YET_RECRUITING","2026-02-02",{"date":118,"type":39},{"date":143,"type":21},"2026-02",{"date":145,"type":21},"2027-06",{"name":147,"class":46},"Universitat Internacional de Catalunya",{"id":149,"slug":150,"hasResults":11,"nctId":151,"briefTitle":152,"officialTitle":153,"acronym":4,"eligibilityCriteria":154,"healthyVolunteers":55,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":155,"targetDuration":4,"studyType":22,"phases":157,"briefSummary":158,"conditions":159,"keywords":161,"overallStatus":139,"whyStopped":4,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":167,"startDateStruct":169,"completionDateStruct":170,"leadSponsor":172,"locationsCount":4},"100620999","effect-of-water-flossing-on-gingival-inflammation-around-single-implants-100620999","NCT07364916","Effect of Water Flossing on Gingival Inflammation Around Single Implants","Effect of Water Flossing on Gingival Inflammation Around Single Implants: Randomized Clinical Trial","Inclusion Criteria:\n\n* 18 years of age or older\n* Medically cleared\n* Have at least one implant-supported crown.\n\nExclusion Criteria:\n\n1. Smoking\n2. Any systemic or localized illness that would interfere with dental implant therapy\n3. On medications\n4. Pregnancy\n5. History of periodontitis\u002F or peri-implant disease\n6. Poor oral hygiene\n7. Probing depth is \\>5",{"count":156,"type":21},20,[24],"This study aims to evaluate the effect of water floss in reversing peri- implant mucositis around dental implants",[160],"Peri Implant Mucositis",[162,163,164,165],"Peri- implant","Mucositis","Water irrigation","Water flosser","2026-01-18",{"date":168,"type":39},"2026-01-23",{"date":41,"type":21},{"date":171,"type":21},"2026-09-30",{"name":173,"class":46},"King Abdulaziz University",{"id":175,"slug":176,"hasResults":11,"nctId":177,"briefTitle":178,"officialTitle":179,"acronym":4,"eligibilityCriteria":180,"healthyVolunteers":55,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":181,"targetDuration":4,"studyType":22,"phases":183,"briefSummary":184,"conditions":185,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":47},"100619782","ai-assisted-colorimetric-diagnosis-of-peri-implant-mucosal-erythema-100619782","NCT07349095","AI-Assisted Colorimetric Diagnosis of Peri-Implant Mucosal Erythema","A Diagnostic Study to Develop and Validate an Artificial Intelligence-Based Colorimetric System for the Objective Diagnosis of Peri-Implant Mucosal Erythema and to Evaluate Its Impact on Clinician Performance","Consecutive patients aged 18 and above, with single or splinted implant-supported restorations visiting the Department of Oral and Maxillofacial Implantology Shanghai Ninth People's Hospital for regular implant maintenance will be included. Participants were excluded if i) pregnancy or intention to become pregnant; ii) with any systemic diseases\u002Fconditions that are contraindications to dental implant treatment; and iii) inability or unwillingness to give written informed consent.",{"count":182,"type":21},200,[24],"1. Background and Rationale The visual diagnosis of peri-implant mucosal erythema (redness), a key sign of inflammation, is highly subjective and varies significantly among clinicians, leading to inconsistencies in early detection and monitoring of peri-implant diseases. There is a critical need for an objective, quantitative, and reliable tool to standardize this assessment. Recent advances in artificial intelligence (AI) and colorimetric analysis of digital intraoral scans offer a promising solution to this clinical challenge.\n2. Primary Objectives\n\n   This diagnostic study aims to:\n\n   Develop and validate a core colorimetric index that objectively quantifies mucosal erythema from digital intraoral scan data.\n\n   Develop and validate an AI model that automatically calculates this index and provides a binary diagnosis (erythema present\u002Fabsent) at the image level.\n\n   Develop and validate a second AI model for precise localization (object detection) of erythematous regions on standard clinical software screenshots.\n\n   Evaluate the clinical utility of the AI system by assessing its impact on the diagnostic accuracy, consistency, and confidence of clinicians with varying experience levels.\n3. Study Design\n\n   This is a multiphase diagnostic accuracy study conducted at a single academic center. It comprises three sequential phases with independent validation:\n\n   Phase 1 (Development \\& Internal Validation): Analysis of intraoral scans to derive the color index and train the AI models using an internal dataset.\n\n   Phase 2 (External Technical Validation): Prospective validation of the trained AI models on an independent cohort of patients from a separate branch of the hospital.\n\n   Phase 3 (Clinical Utility Assessment): A prospective, controlled, observer study where clinicians perform diagnoses with and without AI assistance.\n4. Participants and Methods\n\n   Data Source: Adult patients with dental implants who received intraoral scans using a 3Shape TRIOS 3 scanner.\n\n   Image Data: Two formats are used: 1) Processed 3D surface files (PLY format) for colorimetric analysis, and 2) Standardized 2D screenshots from the 3Shape software for object detection.\n\n   Reference Standards: Expert consensus on erythema (primary) and Bleeding on Probing (BOP, clinical inflammatory standard).\n\n   AI Development: Deep learning models (e.g., convolutional neural networks) will be trained for index calculation, image-level diagnosis, and region localization.\n\n   Observer Study: Participating clinicians (experts, general dentists, and students) will diagnose a set of test images both unaided and with AI assistance (which displays the color index value and\u002For bounding boxes).\n5. Key Outcome Measures\n\n   Diagnostic Accuracy: Area under the receiver operating characteristic curve (AUC), sensitivity, specificity (with 95% confidence intervals).\n\n   Technical Performance: Intraclass correlation coefficient (ICC) for automated measurement agreement; Mean Average Precision (mAP) and Dice Similarity Coefficient for object detection.\n\n   Clinical Impact: Change in diagnostic accuracy (AUC), inter-observer agreement (Kappa), and diagnostic confidence scores when using AI assistance.\n6. Significance This study seeks to translate a subjective clinical sign into an objective, AI-powered diagnostic biomarker. If successful, the proposed system could become a valuable decision-support tool in daily practice and clinical research, promoting earlier, more consistent, and standardized monitoring of peri-implant tissue health, ultimately improving patient care.",[28],"2026-01-09",{"date":188,"type":39},"2026-01-16",{"date":190,"type":39},"2025-09-01",{"date":192,"type":21},"2026-02-27",{"name":194,"class":46},"Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University",{"id":196,"slug":197,"hasResults":11,"nctId":198,"briefTitle":199,"officialTitle":200,"acronym":4,"eligibilityCriteria":201,"healthyVolunteers":11,"sex":17,"minAge":202,"maxAge":4,"enrollmentInfo":203,"targetDuration":4,"studyType":22,"phases":205,"briefSummary":206,"conditions":207,"keywords":4,"overallStatus":139,"whyStopped":4,"lastUpdateSubmitDate":209,"lastUpdatePostDateStruct":210,"startDateStruct":211,"completionDateStruct":212,"leadSponsor":214,"locationsCount":47},"100618360","clinical-radiographic-and-digital-evaluation-of-the-effects-of-autogenous-grafts-on-peri-implant-mucosa-100618360","NCT07330609","Clinical, Radiographic, and Digital Evaluation of the Effects of Autogenous Grafts on Peri-implant Mucosa","Clinical, Radiographic, and Digital Evaluation of the Effects of Autogenous Grafts Harvested From Different Palatal Sites and Applied During Second-stage Implant Surgery on the Peri-implant Mucosa","Inclusion Criteria:\n\n* Age over 18 years\n* Systemically healthy patients\n* Presence of premolar or molar tooth loss in the mandible\n* Adequate mesiodistal and interocclusal space for implant and restoration placement\n* At least four months elapsed since tooth extraction\n* Alveolar bone width of at least 6 mm and sufficient alveolar bone height to allow implant placement without compromising anatomical structures\n* Full-mouth plaque and bleeding scores less than 20%\n* Presence of opposing teeth in occlusion\n* Keratinized mucosa width in the relevant region less than 2 mm\n* Keratinized mucosa thickness in the relevant region of 2 mm or less\n* Presence of a healthy second premolar in the maxilla\n* Provision of written informed consent and permission for the use of data for research purposes\n\nExclusion Criteria:\n\n* Poor oral hygiene\n* Uncontrolled periodontal disease\n* Pregnancy or lactation at any stage of the study\n* Uncontrolled diabetes mellitus\n* Immunocompromised patients\n* Previous radiotherapy to the head and neck region\n* Diseases or medications affecting bone metabolism\n* Antibiotic use within the three months prior to the procedure\n* Smoking more than 10 cigarettes per day\n* Pre- or simultaneous bone augmentation prior to implant placement\n* Lack of primary stability at the time of implant placement","18 Months",{"count":204,"type":21},30,[24],"This study aims to evaluate the effects of autogenous grafts harvested from different palatal regions on the peri-implant mucosa when applied during second-stage dental implant surgery.\n\nClinical, radiographic, and digital assessment methods will be used to investigate the early effects of these grafts on peri-implant mucosal width and thickness. In addition, peri-implant tissue health and patient-reported outcomes will be evaluated to compare the effectiveness of the grafting techniques in peri-implant soft tissue management.",[27,208,28],"Free Gingival Graft","2025-12-29",{"date":186,"type":39},{"date":140,"type":21},{"date":213,"type":21},"2027-11-01",{"name":215,"class":46},"Kutahya Health Sciences University",{"id":217,"slug":218,"hasResults":11,"nctId":219,"briefTitle":220,"officialTitle":221,"acronym":4,"eligibilityCriteria":222,"healthyVolunteers":55,"sex":17,"minAge":18,"maxAge":223,"enrollmentInfo":224,"targetDuration":4,"studyType":226,"phases":4,"briefSummary":227,"conditions":228,"keywords":230,"overallStatus":139,"whyStopped":4,"lastUpdateSubmitDate":235,"lastUpdatePostDateStruct":236,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":242,"locationsCount":4},"100614527","evaluation-of-25ohd3-and-ll-37-levels-in-periimplant-sulcus-fluid-100614527","NCT07280754","Evaluation of 25(OH)D3 and LL-37 Levels in Periimplant Sulcus Fluid","Evaluation of 25(OH)D3 and LL-37 Levels in Peri-implant Sulcus Fluid in Peri-implant Diseases","Inclusion Criteria:\n\n* Being between the ages of 18-65,\n* Having dental implants and using implant-supported prostheses for at least one year,\n* Not having used systemic and\u002For topical antibiotics\u002Fanti-inflammatory drugs or mouthwashes in the last three months,\n* Not having received periodontal\u002Fperi-implant treatment in the last six months.\n\nExclusion Criteria:\n\n* Having a systemic disease or condition that affects peri-implant status,\n* Having a metabolic bone disease,\n* Bruxism,\n* Being pregnant or lactating,\n* Having received periodontal\u002Fperi-implant treatment within the last 6 months,\n* Smoking and alcohol use,\n* Taking vitamin D supplements.","65 Years",{"count":225,"type":21},72,"OBSERVATIONAL","Despite technological advances that have significantly improved dental implant osseointegration and survival rates, biological complications such as peri-implantitis and peri-implant mucositis are common around the implant. The active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), can be induced by the expression of leucine-lysine-37 (LL-37), a human antimicrobial peptide in the cathelicidin family. Studies have shown that 1,25(OH)2D3 and its precursor, 25(OH)D3, significantly reduce inflammation by suppressing the release of receptor activator nuclear factor kappa b ligand (RANKL), tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1, and IL-6, and by preventing alveolar bone loss. To date, many cytokines have been investigated in peri-implant sulcus fluid (PIOS). The lack of a direct study investigating vitamin D and LL-37 levels in PIOS constitutes the unique value of this project. This study aims to compare LL-37 and 25(OH)D3 levels in PIOS and examine their correlation with markers such as IL-6, IL-10, and MMP-8, as well as clinical parameters. Volunteers aged 18-65 who have received dental implants at the Recep Tayyip Erdoğan University Faculty of Dentistry and have been using their implant-supported prosthesis for at least one year and who have been informed about this study will be included in the study. The groups will be formed as peri-implant health, peri-implant mucositis, and peri-implantitis. The implants of the patients included in the study will be evaluated for probed pocket depth (PPD), clinical attachment level (CAL), suppuration (S), modified gingival index (mGI), plaque index (mPI), bleeding index (mBI), keratinized gingival amount, and attached gingival amount. PIOS and serum samples will be obtained from patients, and their relationship to periodontal status and each other will be statistically evaluated.\n\nThis project may help discover new biomarkers that can be used in the early diagnosis of peri-implantar diseases. This study could contribute to earlier treatment, lower patient costs, and even the development of new treatment plans for these diseases.",[229,160],"Peri Implantitis",[231,232,233,234],"LL-37","peri-implanter sulcus fluid","peri-implantitis","vitamin D","2025-12-12",{"date":237,"type":39},"2025-12-19",{"date":239,"type":21},"2025-12-30",{"date":241,"type":21},"2026-06-01",{"name":243,"class":46},"Recep Tayyip Erdogan University",{"id":245,"slug":246,"hasResults":11,"nctId":247,"briefTitle":248,"officialTitle":249,"acronym":4,"eligibilityCriteria":250,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":251,"targetDuration":4,"studyType":22,"phases":252,"briefSummary":253,"conditions":254,"keywords":255,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":260,"startDateStruct":262,"completionDateStruct":264,"leadSponsor":266,"locationsCount":47},"100582173","efficacy-of-adjunctive-at-home-photodynamic-therapy-apdt-in-the-treatment-of-peri-implant-mucositis-100582173","NCT06859866","Efficacy of Adjunctive At-Home Photodynamic Therapy (aPDT) in the Treatment of Peri-Implant Mucositis","Efficacy of Adjunctive At-Home Photodynamic Therapy (aPDT) in the Treatment of Peri-Implant Mucositis: A Post-Marketing Interventional Pilot Study With a Medical Device","Inclusion Criteria:\n\n* Presence of at least 20 teeth within the oral cavity.\n* Diagnosis of peri-implant mucositis: bleeding or suppuration upon gentle probing with or without increased probing depth compared to previous evaluations, and no bone loss beyond the changes in the crestal bone level resulting from initial bone remodeling.\n* Patients willing and able to provide written informed consent.\n\nExclusion Criteria:\n\n* Pregnancy.\n* Patients with a history of periodontitis.\n* Use of medications that could affect soft tissues within the past 6 months (e.g., antibiotics, anti-inflammatories, anticonvulsants, immunosuppressants, or calcium channel blockers, including doxycycline and bisphosphonates).\n* Allergy to the photosensitizer.\n* Patients with removable major prostheses or orthodontic appliances.\n* Patients with untreated carious lesions.",{"count":204,"type":21},[24],"The study aims to establish a validated protocol enabling an alternative approach for bacterial biofilm control through the application of a novel at-home photodynamic\u002Fantibacterial blue light therapy in addition to non-surgical professional treatment (NST) for peri-implant mucositis. The primary outcomes will include reductions in plaque and bleeding scores, decreases in probing pocket depth, and lower aMMP-8 levels in PISF. Secondary outcomes will include changes in keratinized peri-implant mucosa (KPIM) and patient-reported outcome measures (PROMs).",[28],[256,257,258],"APDT","aMMP-8","antibacterial","2025-08-04",{"date":261,"type":39},"2025-08-05",{"date":263,"type":39},"2025-04-29",{"date":265,"type":21},"2027-02",{"name":267,"class":268},"Koite Health Oy","INDUSTRY",{"id":270,"slug":271,"hasResults":11,"nctId":272,"briefTitle":273,"officialTitle":274,"acronym":4,"eligibilityCriteria":275,"healthyVolunteers":55,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":276,"targetDuration":4,"studyType":22,"phases":278,"briefSummary":279,"conditions":280,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":283,"lastUpdatePostDateStruct":284,"startDateStruct":286,"completionDateStruct":288,"leadSponsor":290,"locationsCount":47},"100508929","impact-of-non-surgical-periodontal-therapy-in-the-improvement-of-early-endothelial-dysfunction-in-subjects-with-peri-implantitis-and-peri-implant-mucositis-100508929","NCT05906810","Impact of Non-surgical Periodontal Therapy in the Improvement of Early Endothelial Dysfunction in Subjects With Peri-implantitis and Peri-implant Mucositis","Impact of Non-surgical Periodontal Therapy in the Improvement of Early Endothelial Dysfunction in Subjects With Peri-implantitis and Peri-implant Mucositis: a Randomized-controlled Clinical Trial.","PERI-IMPLANTITIS GROUP\n\nInclusion Criteria:\n\n• Clinically diagnosed with peri-implantitis according to the EFP\u002FAAP 2017 criteria.\n\nExclusion Criteria:\n\n* Periodontal treatment, implant surgery, antibiotics, NSAIDs, immunosuppressants during the last 6 months.\n* Pregnancy.\n* Cardiovascular Diseases.\n\nPERI-IMPLANT MUCOSITIS GROUP\n\nInclusion Criteria:\n\n• Clinically diagnosed with peri-implant mucositis according to the EFP\u002FAAP 2017 criteria.\n\nExclusion Criteria:\n\n* Periodontal treatment, implant surgery, antibiotics, NSAIDs, immunosuppressants during the last 6 months.\n* Pregnancy.\n* Cardiovascular Diseases.\n\nHEALTHY GROUP\n\nInclusion Criteria:\n\n• Clinically diagnosed with healthy periodontum withouth periodontitis history according to the EFP\u002FAAP 2017 criteria.\n\nExclusion Criteria:\n\n* Scaling, antibiotics, NSAIDs, immunosuppressants during the last 6 months.\n* Pregnancy.\n* Cardiovascular Diseases.",{"count":277,"type":21},90,[24],"A double-blind randomized-controlled clinical trial is conducted in order to evaluate the impact of non-surgical periodontal treatment on endothelial dysfunction parameters in subjects with peri-implantitis\u002Fperi-implant mucositis and without any cardiovascular disease.",[281,282,62,28],"Atherosclerosis","Endothelial Dysfunction","2025-05-18",{"date":285,"type":39},"2025-05-21",{"date":287,"type":39},"2020-10-05",{"date":289,"type":21},"2025-12-20",{"name":291,"class":46},"University of Catania",{"id":293,"slug":294,"hasResults":11,"nctId":295,"briefTitle":296,"officialTitle":296,"acronym":4,"eligibilityCriteria":297,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":298,"enrollmentInfo":299,"targetDuration":4,"studyType":22,"phases":301,"briefSummary":303,"conditions":304,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":307,"lastUpdatePostDateStruct":308,"startDateStruct":310,"completionDateStruct":312,"leadSponsor":314,"locationsCount":47},"100441163","early-phase-1-antiseptic-effects-on-the-dental-implant-internal-surface-microbiome-100441163","NCT05024760","Antiseptic Effects on the Dental Implant Internal Surface Microbiome","Inclusion Criteria:\n\n* Active duty military\n* 18-55 years old\n* Over 6 months remaining at local duty station\n\nExclusion Criteria:\n\n* Tobacco user\n* Medications that affect soft tissue or bone healing\n* Metabolic disorder that affects soft tissue or bone healing\n* Active periodontal disease","55 Years",{"count":300,"type":21},150,[302],"EARLY_PHASE1","Soldiers operate in environments that are more likely to lead to oral trauma, risking poor dentition which can directly impact military readiness. Dental restoration can often be accomplished via dental implant insertion. Microbiome-associated complications that result in bone loss, including the micro-leakage of bacterial species proliferating in the dental implant internal cavity, frequently lead to implant failure. Reduction in implant bacterial load may result in a shift of the composition of the microbiome in favor of less pathogenic species, potentially improving dental implant success rates, reducing surgical revisions, and associated cost savings. This study aims to determine how disinfectant gel (hydrogen peroxide or chlorhexidine) insertion into dental implant internal cavities affects implant failure rates, bacterial load and microbiome composition.",[62,28,305,306],"Implant Infection","Dental Implant Failed","2024-12-19",{"date":309,"type":39},"2024-12-27",{"date":311,"type":39},"2022-07-28",{"date":313,"type":21},"2025-11",{"name":315,"class":316},"Madigan Army Medical Center","FED",{"id":318,"slug":319,"hasResults":11,"nctId":320,"briefTitle":321,"officialTitle":322,"acronym":323,"eligibilityCriteria":324,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":325,"targetDuration":4,"studyType":226,"phases":4,"briefSummary":327,"conditions":328,"keywords":329,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":334,"lastUpdatePostDateStruct":335,"startDateStruct":337,"completionDateStruct":339,"leadSponsor":341,"locationsCount":47},"100466674","incidence-of-peri-implant-mucositis-in-patients-with-treated-periodontitis-100466674","NCT05356806","Incidence of Peri-implant Mucositis in Patients With Treated Periodontitis","Incidence of Peri-implant Mucositis in Patients With Treated Periodontitis: a Prospective Study.","PiM_Inc","Inclusion Criteria:\n\n* Over 18 years of age, able to comply with the protocol and comply with the established visits.\n* Patients with treated periodontitis and enrolled in periodontal maintenance (last maintenance therapy received between 4 and 6 months maximum before inclusion in the study) (Chapple et al., 2018, Sanz et al., 2020).\n* Patients with osseointegrated dental implants waiting for their prosthodontic rehabilitation (fixed prosthesis \\[individual, partial or complete\\], hybrid or overdenture).\n* Physical or mental conditions that make it possible to perform appropiate oral hygiene\n\nExclusion Criteria:\n\n* Patients with untreated periodontitis.\n* Totally edentulous patients.\n* Patients with peri-implant diseases.\n* Pregnant or in lactating-period patients.\n* Patients undergoing treatment with medication that affects the periodontal\u002Fperi-implant status or the immune system (phenytoin, calcium antagonists, corticosteroids or anti-inflammatories).\n* Patients who have taken antibiotics in the last month.",{"count":326,"type":21},277,"the objective of this study is to determine the incidence of peri-implant mucositis in patients with treated periodontitis and enrolled in periodontal maintenance and to evaluate the associated risk indicators. An analytical prospective observational study will be carried out, with an initial follow-up of 12 months.",[28],[330,331,332,333],"peri-implant mucositis","incidence","biofilm","periodontitis","2024-12-11",{"date":336,"type":39},"2024-12-12",{"date":338,"type":39},"2022-01-10",{"date":340,"type":21},"2026-06",{"name":342,"class":46},"Universidad Complutense de Madrid",{"id":344,"slug":345,"hasResults":11,"nctId":346,"briefTitle":347,"officialTitle":347,"acronym":4,"eligibilityCriteria":348,"healthyVolunteers":55,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":349,"targetDuration":4,"studyType":22,"phases":350,"briefSummary":351,"conditions":352,"keywords":356,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":361,"lastUpdatePostDateStruct":362,"startDateStruct":364,"completionDateStruct":366,"leadSponsor":367,"locationsCount":47},"100558662","soft-tissue-response-to-different-restorative-materials-used-in-implant-dentistry-100558662","NCT06554041","Soft Tissue Response to Different Restorative Materials Used in Implant Dentistry","Inclusion Criteria:\n\n* Participants must be 18 years or older.\n* Participants must be edentulous with at least four missing teeth in the posterior region of the mandible or maxillae.\n* Participants must have appropriate oral hygiene and periodontal status of natural teeth, with a pocket depth of 4mm or less and no bleeding.\n* Dental implants must be fully integrated with no bone resorption or inflammation after three months of implant placement, confirmed by X-ray and clinical examination.\n* Implant placement must be into natural bone without additional procedures such as sinus lift or bone augmentation.\n* The procedure must be a standard implantation with no immediate implant placement.\n* The height of the gingiva must be at least 3mm or more.\n\nExclusion Criteria:\n\n* Patients with systemic diseases such as malignancy, diabetes, osteoporosis, or rheumatoid arthritis.\n* Patients with a history of periodontal treatment.\n* Patients who smoke or use tobacco.\n* Patients who have received antibiotic treatment within three months prior to implantation.\n* Pregnant individuals.",{"count":83,"type":21},[24],"The goal of this clinical trial is to learn how different materials used in dental implants affect the surrounding gum tissue in adults who need dental implants. The main questions it aims to answer are:\n\nHow do different materials (titanium, PEEK, zirconia, and lithium disilicate) affect inflammation around dental implants? What changes occur in inflammation markers in the gum tissue after 3 and 6 months? Researchers will compare the different materials to see which one causes the least amount of inflammation.\n\nParticipants will:\n\nReceive dental implants made from different materials. Have samples of fluid from around their implants collected for analysis at 3 and 6 months.\n\nUndergo regular dental check-ups to measure gum health, such as bleeding and pocket depth around the implants.",[353,62,28,354,355],"Edentulous Alveolar Ridge","Prosthetic Infection","Prosthetic Complication",[92,357,358,359,360],"Peri-Implant Soft Tissue","Prosthetic Materials","Inflammation Markers","Oral Health","2024-08-12",{"date":363,"type":39},"2024-08-14",{"date":365,"type":39},"2023-08-23",{"date":41,"type":21},{"name":368,"class":46},"Harvard Medical School (HMS and HSDM)",{"id":370,"slug":371,"hasResults":11,"nctId":372,"briefTitle":373,"officialTitle":374,"acronym":4,"eligibilityCriteria":375,"healthyVolunteers":55,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":376,"targetDuration":4,"studyType":226,"phases":4,"briefSummary":378,"conditions":379,"keywords":380,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":385,"lastUpdatePostDateStruct":386,"startDateStruct":388,"completionDateStruct":390,"leadSponsor":392,"locationsCount":47},"100544138","distance-between-dental-implants-as-a-risk-indicator-for-peri-implant-disease-100544138","NCT06364982","Distance Between Dental Implants as a Risk Indicator for Peri-implant Disease.","Distance Between Dental Implants as a Risk Indicator for Peri-implant Disease. A Multi-center Cross-sectional Study","Inclusion Criteria:\n\n* The patient must be ≥18 years of age and systemically healthy;\n* Partially edentulous patients, rehabilitated until 2020 (i.e., a minimum of 3 years of function time) with at least two contiguous implant-supported restorations in the maxilla or mandible;\n* Screw or cemented-retained prosthesis;\n* Fixed dental prosthesis (i.e., single crowns and partial prosthesis);\n* No implant mobility.\n\nExclusion Criteria:\n\n* Pregnant and lactating women;\n* Patients who have taken systemic antibiotics during the 3 months prior to the examination;\n* Patients being treated with drugs that may induce a gingival overgrowth;\n* Patients undergoing orthodontic treatment (since it can influence periodontal diagnosis);\n* Patients who have received mechanical debridement during the 3 months prior to the exam;\n* Patients who have received surgical treatment for peri-implantitis;\n* Psychophysical inability to carry out study procedures.",{"count":377,"type":21},180,"The aim of this study is to analyse contiguous dental implants and its peri-implant status depending on different inter-implant distances.",[28,62],[381,382,383,384],"Peri-implantitis","Peri-implant diseases","Peri-implant mucositis","Inter-implant distances","2024-07-16",{"date":387,"type":39},"2024-07-17",{"date":389,"type":39},"2024-04-05",{"date":391,"type":21},"2024-12-31",{"name":147,"class":46},{"id":394,"slug":395,"hasResults":11,"nctId":396,"briefTitle":397,"officialTitle":398,"acronym":4,"eligibilityCriteria":399,"healthyVolunteers":55,"sex":17,"minAge":18,"maxAge":400,"enrollmentInfo":401,"targetDuration":4,"studyType":22,"phases":403,"briefSummary":404,"conditions":405,"keywords":406,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":409,"lastUpdatePostDateStruct":410,"startDateStruct":412,"completionDateStruct":414,"leadSponsor":416,"locationsCount":47},"100551070","erythritol-air-polishing-in-mucositis-treatment-100551070","NCT06455306","Erythritol Air Polishing in Mucositis Treatment","Erythritol Air Polishing in Mucositis Treatment: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults with at least one implant in function for a minimum of one year affected by peri-implant mucositis.\n\nExclusion Criteria:\n\n1. Pregnant or lactating women\n2. patients unable to understand the treatment protocol and sign informed consent and\u002For patients younger than 18 years old,\n3. medical conditions that prevents an oral examination,\n4. incapability to perform oral hygiene measures due to physical or mental disorders,\n5. patients with uncontrolled systemic diseases or neoplasms, infection with HIV or hepatitis, cardiovascular disease, blood disorders (e.g. coagulation disorders) and severe osteoporosis,\n6. patients who have received systemic antibiotics, corticosteroids, or immunosuppressive therapy within 3 months before periodontal evaluation (baseline), as well as those who chronically use nonsteroidal anti-inflammatory drugs, require antibiotic coverage for dental procedures, and those who are undergoing chronic treatment with medications known to affect periodontal health (such as phenytoin or cyclosporine),\n7. alcohol or drug addiction\n8. implants with mobility and\u002For occlusal overload.","80 Years",{"count":402,"type":21},24,[24],"This study aimed to evaluate the effectiveness of air polishing systems compared to the exclusive use of oral hygiene instruction in the treatment of peri-implant mucositis",[28],[330,407,408],"erythritol powder air-polishing","non-surgical treatment","2024-06-06",{"date":411,"type":39},"2024-06-12",{"date":413,"type":39},"2024-03-18",{"date":415,"type":21},"2025-12",{"name":417,"class":46},"University of Coimbra",{"id":419,"slug":420,"hasResults":11,"nctId":421,"briefTitle":422,"officialTitle":423,"acronym":424,"eligibilityCriteria":425,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":426,"targetDuration":428,"studyType":226,"phases":4,"briefSummary":429,"conditions":430,"keywords":434,"overallStatus":139,"whyStopped":4,"lastUpdateSubmitDate":438,"lastUpdatePostDateStruct":439,"startDateStruct":441,"completionDateStruct":443,"leadSponsor":445,"locationsCount":4},"100508232","salivary-minerals-in-patients-with-peri-implantitis-100508232","NCT05897736","Salivary Minerals in Patients With Peri-implantitis","Analysis of Salivary Minerals Level Variations in Patients With Peri-implantitis","mineral-perio","Inclusion Criteria:\n\n* diagnosed peri-implantitis\n\nExclusion Criteria:\n\n* uncooperative patient\n* younger then 18 years old",{"count":427,"type":21},25,"3 Weeks","Patients included in the study will be recruited after arriving at the Faculty of Dentistry of the University of Zagreb. During the clinical examination, the patient's periodontal status (bleeding during probing, and the depth of the pockets around the implant) and a control x-ray will be taken to check bone loss. Saliva sampling will occur at 3-time points, when establishing the diagnosis of periimplantitis, before the start of therapy, and at the first control after treatment.",[431,28,432,433,27],"Peri-Implantitis and Peri-implant Mucositis","Periimplant Bone Loss","Periimplant Diseases",[435,233,436,437],"salivary minerals","peri-implant health","salivary biomarkers","2023-06-01",{"date":440,"type":39},"2023-06-09",{"date":442,"type":21},"2023-10",{"date":444,"type":21},"2026-09",{"name":446,"class":46},"University of Zagreb",{"id":448,"slug":449,"hasResults":11,"nctId":450,"briefTitle":451,"officialTitle":452,"acronym":4,"eligibilityCriteria":453,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":400,"enrollmentInfo":454,"targetDuration":4,"studyType":22,"phases":456,"briefSummary":458,"conditions":459,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":460,"lastUpdatePostDateStruct":461,"startDateStruct":463,"completionDateStruct":465,"leadSponsor":467,"locationsCount":47},"100503677","phase-4-immediate-versus-delayed-loading-of-single-posterior-zirconia-implants-100503677","NCT05838365","Immediate Versus Delayed Loading of Single Posterior Zirconia Implants","Immediate Versus Delayed Loading of Single Posterior Zirconia Implants: A Multicenter Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Sistemically healthy patients\n* partial edentulism\n* premolar position\n* molar position\n* Bone width and height at least 6 and 10mm, respectively.\n* Keratinized tissue, at least 1 mm at implant site\n* Full understanding of the proposed surgical treatments and the protocol schedule\n* Full comprehension and availability to sign the informed consent form\n\nExclusion Criteria:\n\n* Heavy smokers (\\>10 cigarettes a day)\n* Serious kidney or liver diseases\n* Uncontrolled diabetes\n* Bisphosphonates intake\n* History of radiotherapy of the head and neck\n* Current antiblastic chemotherapy\n* Congenital (primary) or acquired (secondary) immunodeficiency\n* Pregnant women\n* Connective tissue disorders\n\nLocal exclusion criteria:\n\n* untreated stage III\u002FIV periodontitis\n* Autoimmune diseases\n* oral parafunctions",{"count":455,"type":21},220,[457],"PHASE4","The main aim of the present study is to investigate implant success rate after 5 years of function of immediate (Test group; within 7 days of implant placement) versus delayed (Control group; 8 weeks after implant placement) loading of two-pieces zirconia implant, placed in pristine bone without bone regeneration. Implant success rate will be defined according to Buser's criteria. Secondary endpoints: Marginal bone level (MBL) evaluation by means of standardized radiographs; Clinical evaluation of biological (e.g. Plaque Index, PI; Probing Pocket Depth, PPD, Bleeding on Probing, BOP; suppuration upon probing\u002Fpalpation) and prosthetic\u002Ftechnical complications; Clinical evaluation of soft tissue width, keratinized tissue, marginal and interproximal soft tissue recession; Patient reported outcome measures (PROMs) by questionnaire administration:",[306,28,62],"2023-04-26",{"date":462,"type":39},"2023-05-01",{"date":464,"type":39},"2022-12-01",{"date":466,"type":21},"2029-06-01",{"name":468,"class":46},"University of Milan"]