[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"peri-implantitis-and-peri-implant-mucositis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:peri-implantitis-and-peri-implant-mucositis":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,39,67,84,108,133],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":4,"maxAge":17,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100643579","occurrence-of-peri-implant-complications-a-multifactorial-cross-sectional-study-100643579",false,"NCT07638969","Occurrence of Peri-Implant Complications: A Multifactorial Cross-Sectional Study","Inclusion Criteria:\n\n* Implants placed \\>12 months\n* TICARE dental implants\n\nExclusion Criteria:\n\n* Implants placed \\\u003C 12months\n* Other implant systems",true,"ALL","90 Years",{"count":19,"type":20},150,"ESTIMATED","12 Months","OBSERVATIONAL","Dental implants have become, over recent decades, one of the most effective and predictable therapeutic options for replacing missing teeth. Due to their high survival rates and their ability to restore both function and aesthetics, implants are now a fundamental component of modern restorative dentistry. However, despite their widely documented success, implant-supported rehabilitations are not exempt from complications, especially biological ones, which may compromise long-term prognosis. Understanding these events and the factors that influence them represents a significant clinical and scientific need.\n\nAmong the most frequent biological complications are peri-implant mucositis and peri-implantitis, inflammatory conditions that affect the soft and hard tissues surrounding the implant. Their onset is closely related to the formation and accumulation of bacterial biofilm on the prosthetic and implant surfaces, triggering an inflammatory response that, in advanced cases, can lead to progressive marginal bone loss. The literature suggests that the prevalence of these pathologies has increased as implant treatments have become more common, reinforcing the importance of evaluating the biological behavior of implants in various clinical contexts.\n\nIn this regard, microbiological assessment is a cornerstone for understanding the etiology and progression of peri-implant complications. The structural characteristics of biofilm around implants differ partially from those observed around natural teeth, which may influence the virulence of the microorganisms involved and their ability to induce inflammation. Moreover, patient-related factors-such as systemic health status, habits like smoking, or oral biofilm control-as well as implant-related variables-such as surface characteristics, macro-geometry, and prosthetic design-can modify microbial composition and tissue response. Therefore, microbiological evaluation not only identifies predominant pathogens but also provides essential information for developing individualized preventive and therapeutic strategies.\n\nAlongside biological and microbiological assessment, radiographic evaluation has become an indispensable method for assessing bone stability around dental implants. Conventional and digital radiographic techniques allow clinicians to objectively monitor marginal bone loss, considered one of the most important parameters for determining the long-term success or failure of implants. Correlating radiographic findings with clinical indicators of inflammation provides a comprehensive understanding of implant health and enables early detection of potential complications. Additionally, radiographic interpretation helps identify surgical and prosthetic factors associated with bone remodeling, such as the three-dimensional position of the implant, crown-to-implant ratio, abutment design, or the patient's bone quality.\n\nDespite the extensive knowledge available on implant therapy, uncertainties remain regarding the interplay between biological, microbiological, and radiographic factors in the development and progression of peri-implant complications. Evidence suggests that these elements do not act independently but rather form an integrated system where biofilm, immune response, and bone stability influence one another. For this reason, research that combines these three dimensions is essential to achieving a more complete understanding of implant behavior in real clinical scenarios.\n\nThe present research project aims to evaluate the behavior of dental implants in relation to biological complications, microbiological findings, and radiographic outcomes, with the goal of identifying patterns, associations, and potential risk factors that may affect treatment success. This multidimensional approach will allow the analysis not only of inflammation or bone loss but also of the microbial composition associated with these conditions and its relationship with clinical and radiographic findings. By integrating these components, the study seeks to generate evidence that contributes to improving diagnostic, maintenance, and treatment protocols for patients rehabilitated with dental implants.\n\nThe importance of this investigation lies in the need to optimize the long-term predictability of implant-supported treatments. Early detection of complications, identification of key microorganisms involved in peri-implant diseases, and precise evaluation of bone stability are essential tools for ensuring successful outcomes. Furthermore, the results of this study may support patient education regarding biofilm control and enhance clinical strategies aimed at preventing peri-implant pathology.\n\nTaken together, the simultaneous analysis of biological, microbiological, and radiographic aspects will provide a comprehensive perspective on peri-implant conditions and a deeper understanding of the factors that determine the performance of dental implants. Ultimately, the study intends to genera",[25],"Peri-Implantitis and Peri-implant Mucositis","RECRUITING","2026-06-05",{"date":29,"type":30},"2026-06-10","ACTUAL",{"date":32,"type":30},"2026-06-06",{"date":34,"type":20},"2027-07-01",{"name":36,"class":37},"Center of Implantology, Oral and Maxillofacial Surgery, Badajoz, Spain","OTHER",1,{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":43,"acronym":4,"eligibilityCriteria":44,"healthyVolunteers":11,"sex":16,"minAge":45,"maxAge":4,"enrollmentInfo":46,"targetDuration":4,"studyType":48,"phases":49,"briefSummary":51,"conditions":52,"keywords":53,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":38},"100572750","spit-frequency-iperi-implant-mucositis-100572750","NCT06737328","SPiT-frequency I_Peri-implant Mucositis","Inclusion Criteria:\n\n* Subject must be ≥ 20 years, diagnosed with peri-implant mucositis as defined by the World Workshop 2017 criteria (Berglundh et al., 2018) at an adequate (\\\u003C0.5mm) bone level Peri-implant mucositis: Bleeding after gentle probing at an implant and no radiographic bone loss)\n\nExclusion Criteria:\n\n* Previous radiotherapy in the affected area, current use of chemotherapy, systemic long-term corticosteroid treatment.\n\n  * No pregnant or nursing subjects.\n  * \\> class 2 according to the ASA (American Society of Anesthesiologists) physical status classification.\n  * HIV positive or other disease severely affecting the immune system\n  * If examiners\u002Foperators agree the placement of the implant (angle, position, proximity to adjacent implant or tooth) or suprastructure was suboptimal and considered to play a major role in the development of inflammation.\n  * Anatomical abnormalities.","20 Years",{"count":47,"type":20},60,"INTERVENTIONAL",[50],"NA","This is an interventional clinical study on the peri-implant treatment necessary to improve the clinical conditions surrounding dental implants registered with peri-implant inflammation. The focus of this double-armed, examiner blinded, controlled, randomized clinical trial is to examine the effect of short-term increased frequency of a SPiT (supportive peri-implant treatment) protocol on implants diagnosed with peri-implant mucositis.\n\nThe study is a part of a project assessing the frequency of supportive peri-implant therapy. The current is on treatment of peri-implant mucositis (inflammation and no attachment loss at the implants) and secondary prevention of peri-implant mucositis. The other study is a RCT on non-surgical treatment of peri-implantitis (inflammation and exposed implant surface) (REK 790240). Exposure of rough surface may dramatically change the frequency of maintenance needed to improve the inflammatory condition. Thus, a segregation between adequate and low bone level at the implant is necessary.\n\nSubjects with more than one implant and both diagnoses, may be enrolled in both studies, following the frequency of treatment randomized in the peri-implant mucositis study.",[25],[54,55,56],"Peri-implant mucositis","Supportive peri-implant treatment","Frequency","NOT_YET_RECRUITING","2024-12-11",{"date":60,"type":30},"2024-12-17",{"date":62,"type":20},"2025-01-01",{"date":64,"type":20},"2028-01-19",{"name":66,"class":37},"University of Oslo",{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":16,"minAge":45,"maxAge":4,"enrollmentInfo":73,"targetDuration":4,"studyType":48,"phases":74,"briefSummary":75,"conditions":76,"keywords":77,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":80,"startDateStruct":81,"completionDateStruct":82,"leadSponsor":83,"locationsCount":38},"100572749","spit-frequency-iiperi-implantitis-100572749","NCT06737315","SPiT-frequency II_Peri-implantitis","Inclusion Criteria:\n\n* \\- Subject must be ≥ 20 years, diagnosed with peri-implantitis as defined by the World Workshop 2017 criteria (Berglundh et al., 2018) with a bone level \\> 3 mm from the expected initial bone level Peri-implantitis: Bleeding after gentle probing at an implant and radiographic bone level \\> 3 mm\n\nExclusion Criteria:\n\n* \\- Previous radiotherapy in the affected area, current use of chemotherapy, systemic long-term corticosteroid treatment.\n\n  * No pregnant or nursing subjects.\n  * \\> class 2 according to the ASA (American Society of Anesthesiologists) physical status classification.\n  * HIV positive or other disease severely affecting the immune system\n  * If examiners\u002Foperators agree the placement of the implant (angle, position, proximity to adjacent implant or tooth) or suprastructure was suboptimal and considered to play a major role in the development of inflammation.\n  * Anatomical abnormalities.",{"count":47,"type":20},[50],"This is an interventional clinical study on the peri-implant treatment necessary to improve the clinical conditions surrounding dental implants registered with peri-implant inflammation. The focus of this double-armed, examiner blinded, controlled, randomized clinical trial is to examine the effect of short-term increased frequency of a Non-surgical protocol on implants diagnosed with peri-implantitis.\n\nThe study is a part of a project assessing the frequency of supportive peri-implant therapy. The current is on non-surgical treatment of peri-implantitis (inflammation and exposed implant surface). The other study is a RCT on treatment of peri-implant mucositis (inflammation and no attachment loss at the implants) and secondary prevention of peri-implant mucositis (REK 790097). Exposure of rough surface may dramatically change the frequency of maintenance needed to improve the inflammatory condition. Thus, a segregation between adequate and low bone level at the implant is necessary.\n\nSubjects with more than one implant and both diagnoses, may be enrolled in both studies, following the frequency of treatment randomized in the peri-implant mucositis study",[25],[78,79,56],"Peri-implantitis","Non-surgical treatment",{"date":60,"type":30},{"date":62,"type":20},{"date":64,"type":20},{"name":66,"class":37},{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":4,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":16,"minAge":91,"maxAge":4,"enrollmentInfo":92,"targetDuration":4,"studyType":48,"phases":94,"briefSummary":95,"conditions":96,"keywords":97,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":38},"100563668","effectiveness-of-zirconia-glaze-removal-and-polish-in-the-treatment-of-peri-implant-mucositis-100563668","NCT06619158","Effectiveness of Zirconia Glaze Removal and Polish in the Treatment of Peri-implant Mucositis","Long-term Effectiveness of Zirconia Glaze Removal and Polish As an Adjunct to Non-surgical Therapy in Treatment of Persistent Peri-implant Mucositis","Inclusion Criteria:\n\n* At least 1 single screw-retained zirconia glazed implant crown which is in function for at least 1 year, with adequate contact points, submucosal crown margins, no adjacent implants, adequate keratinized tissue (2mm or more), and peri-implant mucositis that persists despite recent (within the past 6 months) non-surgical debridement\n\nExclusion Criteria:\n\n* Contraindications to routine dental treatment Open interproximal contacts, splinted implant prosthesis, peri-implant health, peri-implantitis, cemented crown , removable implant prosthesis, recession past the implant platform Systemic antibiotic use within the last 2 weeks heavy smokers (more than 10 cigarettes\u002Fday) uncontrolled diabetes (HbA1C more than 7.0%)","18 Years",{"count":93,"type":20},44,[50],"This clinical trial is being conducted to study peri-implant mucositis (inflammation in the gums around dental implant that does not extend into the implant-supporting bone). There are currently no available treatment options able to provide long-term resolution of implant gum inflammation even with our current gold standard treatment of non-surgical cleanings and oral hygiene instructions. The purpose of the study is to compare the effect of crown glaze removal and subsequent polishing in addition to mechanical debridement compared to only mechanical debridement on the implant affected by implant gum inflammation.\n\nIn this study, participants will be randomized (put into a group by chance) into one of 2 study groups, groups A and B.\n\nGroup A: The implant crown will be cleaned with titanium scaling instruments and powered instruments. The screw-retained crown will be removed and the remaining build-up on the crown will be photographed. The crown will then be sent to a lab technician who will remove the glaze and polish the crown only in the areas that sit under the gums.\n\nGroup B: The implant crown will be cleaned with titanium scaling instruments and powered instruments. The screw-retained crown will be removed and the remaining build-up on the crown will be photographed. The crown will then be sent to a lab technician to perform a superficial cleaning only.\n\nIn both groups, the crown will be placed back on the implant and customized oral hygiene instructions will be provided.\n\nThe study will require four appointment. Appointment #1 is the screening appointment and will take 30-60 minutes. Appointment #2 is when treatment is delivered and will occur within 4 weeks of appointment #1. Appointment #3 is for the short-term follow-up and will occur within 60-70 days of appointment #2. Appointment #4 is for the long-term follow-up and will occur within 12-13 months of appointment #2. All these appointment will be in an outpatient setting at the institutional graduate periodontics clinic.\n\nA total of 2 x-rays will be taken of the implant. One will be taken during appointment #1 to assess the bone around the implant. One will be taken during appointment #2 to ensure that the crown is fully seated when the crown is re-inserted.\n\nThe following information will be collected in appointment #1: gum measurements around the implants, how tight the implant contacts adjacent teeth, when the crown was delivered, previous cleanings around the implant, age, sex, gender, previous systemic antibiotic use in the last 2 weeks, smoking habits, presence of diabetes and HbA1C values.\n\nAt appointments #2, 3, and 4, the following information will be collected: plaque around implant, gum measurements around implants, previous systemic antibiotic use in the last 2 weeks, smoking habits, presence of diabetes and HbA1C values, gum fluid samples around the implant crown. In appointment #4, additionally, information on how the implant has been cleaned throughout the year will be collected.",[25],[98],"zirconia glaze removal, crown modification","2024-09-26",{"date":101,"type":30},"2024-10-01",{"date":103,"type":20},"2024-11-01",{"date":105,"type":20},"2026-12-30",{"name":107,"class":37},"University of Manitoba",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":15,"sex":16,"minAge":91,"maxAge":4,"enrollmentInfo":114,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":116,"conditions":117,"keywords":118,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":38},"100552609","risk-assessment-of-proximal-contact-loss-between-implant-supported-prostheses-and-adjacent-teeth-100552609","NCT06475313","Risk Assessment of Proximal Contact Loss Between Implant-supported Prostheses and Adjacent Teeth.","Inclusion Criteria:\n\n* (1) Patients over the age of 18, can fully understand the nature of the proposed and be able to sign a consent form.\n* (2) patients who underwent dental implant surgery and delivered prostheses for more than 3 months in Nanjing First Hospital.\n\nExclusion Criteria:\n\n* (1) The implant site or adjacent teeth were severely injured and the adjacent teeth were extracted;\n* (2) the same quadrant orthodontic or splint treatment;\n* (3) the prostheses have been removed due to failure or need further treatment;\n* (4) implant-supported prostheses in both mesial and distal sites;\n* (5) the adjacent teeth were directly or indirectly fixed with the implant-supported prosthesis;\n* (6) patients with missing clinical records of PD, PCR and BOP.\n* (7) The prosthetic prosthesis with implant-supported prosthesis was delivered for less than 3 months in Nanjing First Hospital.",{"count":115,"type":20},100,"In this study, we collected and analysed the review results of 100 patients over 18 years of age who received implant fixed restorations in the Department of Stomatology of the First Hospital of Nanjing, China. The aim was to investigate the incidence of loss of contact between implant restorations and adjacent teeth and its influencing factors. Our findings may provide better insights for treatment planning and prevention of PCL.",[25],[119,120,121,122,123],"food impaction","proximal contact loss","Implant supported prosthesis","Dentition defect","risk factors","2024-06-20",{"date":126,"type":30},"2024-06-26",{"date":128,"type":20},"2024-07-01",{"date":130,"type":20},"2024-12-30",{"name":132,"class":37},"Nanjing First Hospital, Nanjing Medical University",{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":139,"eligibilityCriteria":140,"healthyVolunteers":11,"sex":16,"minAge":91,"maxAge":4,"enrollmentInfo":141,"targetDuration":143,"studyType":22,"phases":4,"briefSummary":144,"conditions":145,"keywords":150,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":4},"100508232","salivary-minerals-in-patients-with-peri-implantitis-100508232","NCT05897736","Salivary Minerals in Patients With Peri-implantitis","Analysis of Salivary Minerals Level Variations in Patients With Peri-implantitis","mineral-perio","Inclusion Criteria:\n\n* diagnosed peri-implantitis\n\nExclusion Criteria:\n\n* uncooperative patient\n* younger then 18 years old",{"count":142,"type":20},25,"3 Weeks","Patients included in the study will be recruited after arriving at the Faculty of Dentistry of the University of Zagreb. During the clinical examination, the patient's periodontal status (bleeding during probing, and the depth of the pockets around the implant) and a control x-ray will be taken to check bone loss. Saliva sampling will occur at 3-time points, when establishing the diagnosis of periimplantitis, before the start of therapy, and at the first control after treatment.",[25,146,147,148,149],"Peri-implant Mucositis","Periimplant Bone Loss","Periimplant Diseases","Peri-implant Health",[151,152,153,154],"salivary minerals","peri-implantitis","peri-implant health","salivary biomarkers","2023-06-01",{"date":157,"type":30},"2023-06-09",{"date":159,"type":20},"2023-10",{"date":161,"type":20},"2026-09",{"name":163,"class":37},"University of Zagreb"]