[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"perianal-fistula\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:perianal-fistula":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,51,90,110,139],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100645321","laser-ablation-versus-conventional-fistulectomy-for-uncomplicated-perianal-fistula-100645321",false,"NCT07681531","Laser Ablation Versus Conventional Fistulectomy for Uncomplicated Perianal Fistula","Comparison Between Conventional Surgery and Laser Ablation for Uncomplicated Perianal Fistula","Inclusion Criteria:\n\n* Age 18 to 55 years.\n* Male and female patients.\n* Scheduled for surgical treatment of uncomplicated perianal fistula.\n* Single fistula tract.\n* Less than 30% involvement of the external anal sphincter.\n* Penetration of tract limited to subcutaneous tissue.\n\nExclusion Criteria:\n\n* Recurrent fistula.\n* Complex fistula.\n* History of gut malignancy.\n* History of inflammatory bowel disease.\n* Patients unfit for anesthesia.","ALL","18 Years","55 Years",{"count":20,"type":21},72,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized controlled trial aims to compare conventional open fistulectomy and laser ablation in the treatment of uncomplicated perianal fistula. The study will evaluate postoperative recovery time and recurrence rates between the two procedures. A total of 72 patients with uncomplicated perianal fistula will be randomly assigned to either conventional open fistulectomy or laser ablation and followed for six months after surgery.",[27,28],"Perianal Fistula","Anal Fistula",[30,31,32,33,34,35,36,37],"Perianal fistula","Anal fistula","Laser ablation","Laser-assisted anal fistula surgery","FiLaC","Fistulectomy","Conventional surgery","Randomized controlled trial","NOT_YET_RECRUITING","2026-06-26",{"date":41,"type":42},"2026-07-02","ACTUAL",{"date":44,"type":21},"2026-07-01",{"date":46,"type":21},"2027-03-31",{"name":48,"class":49},"PNS Hafeez - Naval Hospital","OTHER_GOV",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":59,"targetDuration":61,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":70,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":50},"100632912","the-impact-of-perianal-disease-on-patients-sex-life-100632912","NCT07519850","The Impact of Perianal Disease on Patient's Sex Life","The \"Hidden Morbidity\" of Perianal Disease: A Prospective Evaluation of Psychosexual Health and Body Image.","SEXTON","Inclusion Criteria:\n\n* Diagnosis of chronic perianal disease (fistula-in-ano, pCD, pilonidal).\n* Age \\>18 years.\n* Ability to understand and complete the Greek versions of the IIEF-5\u002FFSFI-6 and the study PROM.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Active malignancy (colorectal or anal cancer).\n* Major pelvic surgery in the last 3 months (unrelated to perianal disease).\n* Cognitive impairment preventing survey completion.",{"count":60,"type":21},60,"3 Months","OBSERVATIONAL","Perianal diseases, such as perianal abcesses, anal fistulae and perianal Crohn's disease, are often associated with significant physical symptoms, including pain and chronic drainage. However, the impact of these conditions on a patient's personal life, intimacy, and body image-often referred to as \"hidden morbidity\"-is frequently overlooked in clinical practice.\n\nThe purpose of this prospective observational study is to evaluate the psychosexual burden in patients suffering from chronic perianal disease. Using validated tools (IIEF-5 for men, FSFI-6 for women) and a specialized Supplemental Patient-Reported Outcome Measure (PROM), researchers will investigate how the presence of surgical devices (such as setons), disease etiology, and clinical symptoms affect sexual function and self-esteem.\n\nThe study also aims to identify gaps in physician-patient communication regarding sexual health. By quantifying these impacts, the study seeks to promote a more holistic, patient-centered approach to the surgical management of perianal conditions.",[65,27,66,67,68,69],"Perianal Crohn Disease","Fistula in Ano","Perianal Abscess","Pilonidal Cyst\u002FFistula","Anal Fissure and Fistula",[71,72,73,74,75,76,77,78],"fistula in ano","perianal fistula","perianal Crohn's disease","anal fissure","psychosexual life","sex life","intimacy","fistula","RECRUITING","2026-04-02",{"date":82,"type":42},"2026-04-09",{"date":84,"type":21},"2026-03-31",{"date":86,"type":21},"2026-06-20",{"name":88,"class":89},"AHEPA University Hospital","OTHER",{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":98,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":100,"conditions":101,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":108,"locationsCount":50},"100632170","role-of-mri-in-perianal-fistula-100632170","NCT07510204","Role of MRI in Perianal Fistula","Role of Magnetic Resonance Imaging in Assessment of Perianal Fistula","MRI PA fistula","Inclusion Criteria:\n\n* Patients clinically diagnosed or suspected to have perianal fistula.\n* Both male and female patients of any age group\n* Patients referred for preoperative MRI assessment prior to surgical management.\n\nExclusion Criteria:\n\n* Patients with contraindications to MRI, such as pacemakers, metallic implants, or severe claustrophobia.\n* Patients refusing to participate in the study.",{"count":99,"type":21},30,"The aim of this study is to assess the diagnostic accuracy of MRI in detecting and assessment the primary fistulous tract, internal openings, secondary extensions, and associated abscesses. (and compare these findings with the surgical findings in patients who underwent surgery).",[27],"2026-03-29",{"date":104,"type":42},"2026-04-03",{"date":106,"type":21},"2026-03-15",{"date":44,"type":21},{"name":109,"class":89},"Sohag University",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":116,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":118,"targetDuration":120,"studyType":62,"phases":4,"briefSummary":121,"conditions":122,"keywords":124,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":50},"100629655","recurrence-and-anal-fistula-patient-reported-outcomes-trial-100629655","NCT07477496","Recurrence and Anal Fistula Patient Reported Outcomes Trial","Prospective Study of Functional Disorders and Quality of Life Following Surgical Management of Perianal Fistulas","RAPPORT","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Clinically and\u002For radiologically confirmed perianal fistula (primary or recurrent).\n* Planned definitive surgical treatment (any sphincter-dividing or sphincter-preserving technique).\n* Ability to understand and complete study questionnaires.\n* Commitment to attend follow-up visits at 1, 3, 6, and 12 months (or to complete remote assessments).\n* Signed written informed consent.\n\nExclusion Criteria:\n\n* Diagnosed inflammatory bowel disease (Crohn's disease or ulcerative colitis).\n* Active perianal sepsis requiring emergency drainage after enrolment and before definitive surgery.\n* Prior abdominoperineal resection or permanent colostomy.\n* Pregnancy or planned pregnancy during the 12-month follow-up.\n* Severe uncontrolled systemic disease (e.g., decompensated heart failure, end-stage renal disease, uncontrolled diabetes).\n* Cognitive impairment or psychiatric disorder precluding reliable consent or questionnaire completion.\n* Lack of reliable contact information or inability to attend at least one scheduled follow-up visit.",{"count":119,"type":21},100,"24 Months","Perianal fistulas are a chronic anorectal condition associated with significant morbidity, including pain, persistent discharge, infection, and impaired continence, all of which can substantially affect patients' quality of life. Surgical management aims to eradicate the fistulous tract while preserving anal sphincter function and continence.\n\nDespite numerous available surgical techniques, high-quality comparative evidence regarding optimal management remains limited. This prospective observational study aims to evaluate clinical outcomes, functional outcomes, and patient-reported quality of life following surgical treatment of perianal fistulas.\n\nThe study will collect both clinician-reported and patient-reported outcomes over a 12-month follow-up period. Outcomes of interest include fistula healing, recurrence, postoperative complications, continence status, symptom burden, and health-related quality of life. The findings are expected to provide real-world data that may inform clinical decision-making and contribute to improved patient-centered care.",[123,28,27],"Anal Fistula Surgery",[125,78,126,127,128,129],"perianal","anal","PROMs","patient-reported outcomes","quality of life","2026-03-17",{"date":132,"type":42},"2026-03-19",{"date":134,"type":42},"2026-01-01",{"date":136,"type":21},"2030-01-01",{"name":138,"class":89},"National and Kapodistrian University of Athens",{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":4,"eligibilityCriteria":145,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":146,"enrollmentInfo":147,"targetDuration":4,"studyType":22,"phases":149,"briefSummary":150,"conditions":151,"keywords":152,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":159,"leadSponsor":161,"locationsCount":4},"100611089","comparing-three-surgical-techniques-for-the-treatment-of-transsphincteric-perianal-fistula-1-traditional-fistulotomy-lay-open-2-ligation-of-the-intersphincteric-tract-lift-with-adjunctive-endo-fistula-laser-ablation-and-3-open-lift-procedure-followed-by-laser-100611089","NCT07236047","Comparing Three Surgical Techniques for the Treatment of Transsphincteric Perianal Fistula: (1) Traditional Fistulotomy (Lay Open), (2) Ligation of the Intersphincteric Tract (LIFT) With Adjunctive Endo Fistula Laser Ablation, and (3) Open LIFT Procedure Followed by LASER","Randomized Controlled Trial Comparing Fistulotomy vs LIFT Plus Laser Ablation vs Open LIFT Plus Laser in the Treatment of Trans-sphincteric Perianal Fistula","Inclusion Criteria:\n\n* Adults aged 18-65\n* Confirmed diagnosis of transsphincteric cryptoglandular perianal fistula\n* Primary (first-time) surgery\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Crohn's disease or other inflammatory bowel disease\n* Suprasphincteric, extrasphincteric, or horseshoe fistulas\n* Previous fistula surgery\n* Active perianal abscess\n* Current immunosuppression\n* Pregnant or breastfeeding women","65 Years",{"count":148,"type":21},90,[24],"\\>This randomized clinical trial compares three different surgical techniques for the treatment of transsphincteric perianal fistula: (1) traditional fistulotomy (lay open), (2) ligation of the intersphincteric tract (LIFT) with adjunctive endofistula laser ablation, and (3) open LIFT procedure followed by direct laser ablation of the tract under vision. The aim is to determine which approach offers the highest healing rate, lowest recurrence, and best postoperative outcomes with minimal impact on continence.",[27],[153,72,154],"LIFT","LASER","2025-11-20",{"date":157,"type":42},"2025-11-21",{"date":155,"type":21},{"date":160,"type":21},"2027-09-01",{"name":162,"class":89},"Alexandria University"]