[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"periapical-abscess\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:periapical-abscess":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,53],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":34,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100642888","phase-1-biological-radiographic-and-clinical-evaluation-of-various-inter-visit-root-canal-dressings-in-retreatment-cases-100642888",false,"NCT07641933","Biological, Radiographic and Clinical Evaluation of Various Inter-Visit Root Canal Dressings in Retreatment Cases","Biological, Radiographic and Clinical Evaluation of Various Inter-Visit Root Canal Dressings in Retreatment Cases: A Randomized Controlled Clinical Trial","RCT","Inclusion Criteria:\n\n1. Age: 21-45 years.\n2. Medically free patients. (ASA Class 1)\n3. Gender: males and females\n4. Patients who are cooperative at operation and in attendance at scheduled follow-up visits.\n5. Restorable root canal treated permanent lower first molars with periapical lesions.\n6. Small (\\\u003C5 mm) or medium periapical lesion size (5-10 mm)\n\nExclusion Criteria:\n\n1. Patients with a history of allergic reactions to any of the study materials.\n2. Teeth that become non-restorable after complete caries excavation.\n3. Teeth that have mobility or deep periodontal pockets.\n4. Teeth with internal or external resorption.",true,"ALL","21 Years","45 Years",{"count":22,"type":23},60,"ESTIMATED","INTERVENTIONAL",[26],"PHASE1","The aim of this clinical trial is to evaluate anti-inflammatory effect of various intracanal medications:\n\n1. Calcium Hydroxide Slurry mixed with 3% Sodium Hypochlorite\n2. Calcium Silicate\n3. Calcium Hydroxide\n\nIn retreatment cases in terms of:\n\n1. Biological Evaluation: Biomarker (IL 1B)\n2. Radiographic Evaluation: CBCT\n3. Clinical Evaluation: Pain Score (VAS)",[29,30,31,32,33],"Intervention Studies","ASA Physical Status I","Intracanal Medication","Periapical Abscess","Retreatment",[35,36,37,38,39],"intracanal medication","retreatment","inflammatory marker","radiographic","pain score","RECRUITING","2026-06-10",{"date":43,"type":44},"2026-06-12","ACTUAL",{"date":46,"type":44},"2026-06-01",{"date":48,"type":23},"2027-08",{"name":50,"class":51},"Ain Shams University","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":17,"sex":18,"minAge":59,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":24,"phases":62,"briefSummary":64,"conditions":65,"keywords":69,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":52},"100607725","using-platelet-rich-fibrin-in-regenerative-endodontic-treatment-in-mature-permanent-teeth-100607725","NCT07192289","Using Platelet-rich Fibrin in Regenerative Endodontic Treatment in Mature Permanent Teeth","Inclusion Criteria:\n\nParticipants had a single-rooted tooth with necrotic pulp (negative response to electric pulp testing), with or without periapical pathology (acute apical periodontitis of pulpal origin, chronic periapical periodontitis, periapical abscess with sinus, periapical abscess without sinus), and gave their consent to participate in the study.\n\nExclusion Criteria: Study samples will be excluded if any of the following criteria are met:\n\n* The tooth has had previous endodontic treatment.\n* The root apex is not fully developed, or there is root resorption\u002Fcracking\u002Ffracture.\n* The tooth has severe tooth loss and is indicated for extraction, or is indicated for restoration with a post or cast core after endodontic treatment.\n* The root canal is calcified.\n* The root canal curvature is greater than 25º.\n* The tooth has a periapical cyst or is associated with a jawbone cyst.\n* The tooth has a periodontal pocket deeper than 4 mm.\n* The tooth has no occlusal contact.\n* The patient is pregnant.\n* The patient has diabetes or HIV or other immunocompromised conditions.","18 Years",{"count":61,"type":23},57,[63],"NA","This study aims to evaluate the antibacterial effects of injectable platelet-rich fibrin (i-PRF) in vitro, and to assess the clinical and radiographic outcomes of using advanced platelet-rich fibrin (A-PRF+) and i-PRF in regenerative endodontic treatment of mature permanent teeth with necrotic pulp. The study will compare the effectiveness of PRF-based treatment with conventional blood clot-based regenerative endodontics.",[66,67,68,32],"Chronic Apical Periodontitis","Necrosis of Pulp","Acute Apical Periodontitis of Pulpal Origin",[70,71,72],"PRF","regenerative endodontic treatment","mature permanent treatment","NOT_YET_RECRUITING","2025-09-21",{"date":76,"type":44},"2025-09-25",{"date":78,"type":23},"2025-09-15",{"date":80,"type":23},"2027-08-31",{"name":82,"class":51},"University of Medicine and Pharmacy at Ho Chi Minh City"]