[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"periapical-diseases\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:periapical-diseases":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,44,70,97,127,156],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100507557","detection-of-periapical-lesions-on-dental-panoramic-radiographs-based-on-artificial-intelligence-100507557",false,"NCT05888935","Detection of Periapical Lesions on Dental Panoramic Radiographs Based on Artificial Intelligence","Detection of Periapical Lesions on Dental Panoramic Images Based on Artificial Intelligence Using Cone Beam Computed Tomography","OPTITOMO","Inclusion Criteria:\n\n* Patients who have had CBCT and panoramic dental imaging with less than 3 months between the two examinations\n\nExclusion Criteria:\n\n* Patients who refused to participe in the study.","ALL","18 Years",{"count":20,"type":21},2000,"ESTIMATED","OBSERVATIONAL","Dental periapical damages can have various reasons and is reflected by a radiolucent lesion on complementary imaging: angulated retro-alveolar (RA) radiographs, dental panoramic radiographs, and three-dimensional imaging such as computed tomography (CT) or cone-beam computed tomography (CBCT).\n\nFor the radiographic detection of these deep periodontal lesions, the dental panoramic represents a first approach commonly performed with relatively low radiation. The investigation can be followed by retroalveolar radiology imaging that are more localized and more precise. However, using these techniques, the detection rates of these lesions are low (20% and 36% respectively), it is necessary to use three-dimensional tomographic investigation to be more discriminating (69%). The gold standard imaging for detection of these lesions is CBCT followed by retroalveolar radiography (\\~2x less sensitive than CBCT) and panoramic radiography (\\~2x less sensitive than RA). Although not a full-thickness radiograph, the dental panoramic has the advantage of being more commonly performed while being less radiating than CBCT and giving a global view of the dental arches on a single image.\n\nThe detection of periapical lesions is done after a clinical assessment and a visual appreciation of the complementary examinations.\n\nThe aim of this project is to improve the detection of periapical lesions, by developing an algorithm able to identify them on a panoramic dental radiograph. This algorithm is based on a deep learning system trained with reference data including panoramic dental imaging and CBCT with an acquisition interval of less than 3 months. The model is based on a previous work, will improve the quality of the initial data (using CBCT), using innovative artificial intelligence algorithms (transfer learning).",[25],"Periapical Diseases",[27,28,29,30],"tomography","dental injury","artificial intelligence","periapical lesions","RECRUITING","2026-06-20",{"date":34,"type":35},"2026-06-24","ACTUAL",{"date":37,"type":35},"2022-10-01",{"date":39,"type":21},"2027-12-01",{"name":41,"class":42},"Centre Hospitalier Régional Metz-Thionville","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":58,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":43},"100640843","evaluation-of-post-operative-pain-after-using-intracranial-cryotherapy-during-single-visit-rct-100640843","NCT07598188","Evaluation of Post Operative Pain After Using Intracranial Cryotherapy During Single Visit RCT","Evaluation of Post Operative Pain After Using Intracranial Cryotherapy During Single Visit Root Canal Treatment in Teeth With Symptomatic Apical Periodontitis","Inclusion Criteria:\n\nIndividual (male\u002Ffemale) with age \\>18 years with symptomatic apical periodontitis in permanent teeth\n\nExclusion Criteria:\n\n1. Teeth with calcified canals or aberrant root anatomy,\n2. Female Pregnant patients\n3. Patients using medications such as analgesics or anti-biotics drugs and\n4. Those who refuse to participate in the study",{"count":52,"type":21},60,"INTERVENTIONAL",[55],"NA","A total of 60 patients presenting with single-rooted teeth exhibiting symptomatic apical periodontitis were subjected to a randomized allocation into two groups of 30 each. Irrigation was done using 3% sodium hypochlorite for 5 seconds in all 60 teeth. Group 1 underwent final irrigation utilizing normal saline at room temperature. Group 2 received final irrigation using normal saline refrigerated between 2-5°C. Pain levels were assessed and recorded before the procedure and at 24 and 48-hour time intervals.",[25],[59],"Cold therapy, Saline solution, periapical diseases, sodium hypochlorite","NOT_YET_RECRUITING","2026-05-19",{"date":63,"type":35},"2026-05-20",{"date":65,"type":21},"2026-07-10",{"date":67,"type":21},"2027-03-31",{"name":69,"class":42},"Islamabad Medical and Dental College",{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":53,"phases":79,"briefSummary":80,"conditions":81,"keywords":84,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":43},"100629630","mineral-trioxide-aggregate-mta-vs-gutta-percha-for-non-surgical-endodontic-retreatment-in-teeth-with-apical-lesions-100629630","NCT07477171","Mineral Trioxide Aggregate (MTA) vs Gutta-Percha for Non-Surgical Endodontic Retreatment in Teeth With Apical Lesions","Comparison of Two Root Canal Filling Materials in Non-Surgical Endodontic Retreatment: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\nPatients ≥18 years old American Society of Anesthesiologists (ASA) physical status I and II Teeth requiring non-surgical endodontic retreatment Periapical lesion ≤10 mm in maximum diameter on periapical radiograph Apical canal diameter ≤ size 50 Teeth without periodontal defects or mobility\n\nExclusion Criteria:\n\nSmokers Teeth with insufficient remaining tooth structure Teeth requiring surgical retreatment Primary endodontic treatment complications (fractured instrument, perforation, ledge or apical transportation)",{"count":78,"type":21},58,[55],"The main objective of this study is to compare the healing rate of periapical lesions after non-surgical endodontic retreatment in teeth obturated with gutta-percha versus those obturated with mineral trioxide aggregate (MTA), with a 12-month follow-up. Secondary objectives include evaluating differences between groups in healing time, postoperative pain, and tooth discoloration.",[25,82,83],"Root Canal Therapy","Mineral Trioxide Aggregate (MTA)",[85,86,87],"non-surgical endodontic retreatment","bioceramic","gutta-percha","2026-03-18",{"date":90,"type":35},"2026-03-23",{"date":92,"type":21},"2026-03",{"date":94,"type":21},"2027-04",{"name":96,"class":42},"University of Santiago de Compostela",{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":104,"enrollmentInfo":105,"targetDuration":4,"studyType":53,"phases":107,"briefSummary":108,"conditions":109,"keywords":111,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":125,"locationsCount":43},"100627433","evaluation-of-revitalization-success-using-i-prf-in-non-surgical-root-canal-retreatment-100627433","NCT07448571","Evaluation of Revitalization Success Using i-PRF in Non-Surgical Root Canal Retreatment","Evaluation of Revitalization Success Using i-PRF in Non-Surgical Root Canal Retreatment: A Clinical Study","Inclusion Criteria:\n\n* Patients aged between 18 and 50 years.\n* Single-rooted maxillary anterior teeth with closed apices.\n* Presence of periapical lesion confirmed radiographically.\n* Previously treated root canal tooth requiring non-surgical retreatment.\n* Tooth has not previously undergone non-surgical root canal retreatment.\n* Tooth is considered restorable.\n* Patient is systemically healthy.\n* Patient is willing to participate and provides informed consent.\n\nExclusion Criteria:\n\n* Teeth without radiographic evidence of periapical lesion.\n* Teeth with developmental anomalies.\n* Patients with systemic diseases that may affect healing.\n* Pregnant patients.\n* Teeth presenting with internal or external root resorption.","50 Years",{"count":106,"type":21},140,[55],"The goal of this randomized controlled clinical trial is to determine whether regenerative endodontic treatment can improve healing outcomes in teeth with apical periodontitis following failed root canal treatment. The study includes adult patients who require non-surgical root canal retreatment due to persistent periapical lesions.\n\nThe main questions it aims to answer are:\n\nDoes regenerative endodontic treatment improve periapical healing compared with conventional non-surgical root canal retreatment? Does regenerative treatment increase long-term treatment success and tooth survival? Researchers will compare conventional non-surgical root canal retreatment with regenerative endodontic treatment using injectable platelet-rich fibrin (i-PRF) to see if the regenerative approach results in better clinical and radiographic outcomes.\n\nParticipants will:\n\nBe randomly assigned to receive either conventional retreatment or regenerative endodontic treatment.\n\nUndergo clinical and radiographic evaluations over a two-year follow-up period. Be assessed for pain, sensitivity, pulp vitality, hard tissue formation, and periapical healing.",[110,25],"Apical Periodontitis",[112,113,114,115,116,117,118],"apical periodontitis","root canal retreatment","regenerative endodontic treatment","Injectable Platelet-Rich Fibrin","Non-Surgical Endodontic Retreatment","Periapical Healing","Randomized Controlled Trial","2026-02-26",{"date":121,"type":35},"2026-03-04",{"date":123,"type":35},"2025-05-01",{"date":39,"type":21},{"name":126,"class":42},"Marmara University",{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":4,"eligibilityCriteria":133,"healthyVolunteers":134,"sex":17,"minAge":135,"maxAge":4,"enrollmentInfo":136,"targetDuration":4,"studyType":53,"phases":138,"briefSummary":139,"conditions":140,"keywords":142,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":43},"100565552","role-of-gtr-on-healing-outcome--quality-of-life-in-combined-endo-perio-lesions-with-communication-100565552","NCT06643663","Role of GTR on Healing Outcome & Quality of Life in Combined Endo Perio Lesions With Communication","\"Role of Guided Tissue Regeneration on Healing Outcome & Quality of Life in Combined Endo Perio Lesions With Communication: A Randomized Controlled Trial\"","Inclusion Criteria:\n\n1. Patients of age 16yrs and above.\n2. Patients with apico-marginal defects and deep pocket upto apex of tooth.\n3. Failed primary root canal treatment.\n4. Presence of interproximal bone loss.\n5. Negative response to vitality test.\n6. ASA-1 or ASA- 2 according to the classification of the American Society of Anesthesiologists)\n\nExclusion criteria:\n\n1. Presence of vertical root fracture\n2. Presence of root perforations\n3. ASA-3 or ASA-4 according to the classification of the American Society of Anesthesiologists)\n4. Presence of root resorption\n5. Combined endodontic-periodontic lesions.\n6. Pregnancy",true,"16 Years",{"count":137,"type":21},30,[55],"The recovery of periapical defects linked to periodontal communication frequently yields less satisfactory results. Numerous studies and case reports have highlighted the notable success achieved through the application of guided tissue regeneration techniques. More recently, autologous platelet concentrate plug \\& placental membrane have emerged as a treatment option for addressing such lesions. Nevertheless, there has been no study using PRF-Medium with ACM membrane on the healing of aforesaid lesion \\& quality of life assessment.",[25,141],"Endodontic Disease",[143,144,145,146],"Guided tissue regeneration","healing","endo-perio lesions","endodontic surgery","2025-01-06",{"date":149,"type":35},"2025-01-08",{"date":151,"type":35},"2024-05-23",{"date":153,"type":21},"2025-12-23",{"name":155,"class":42},"Postgraduate Institute of Dental Sciences Rohtak",{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":4,"eligibilityCriteria":162,"healthyVolunteers":134,"sex":17,"minAge":18,"maxAge":163,"enrollmentInfo":164,"targetDuration":4,"studyType":53,"phases":166,"briefSummary":167,"conditions":168,"keywords":172,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":43},"100573928","postoperative-pain-in-photodynamic-therapy-using-curcumin-as-a-photosensitizer-100573928","NCT06752655","Postoperative Pain in Photodynamic Therapy Using Curcumin As a Photosensitizer","The Effect of Photodynamic Therapy Using Curcumin As a Photosensitizer on Postoperative Pain After Non-Surgical Root Canal Retreatment: a Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* healthy patients with aged between 18-60.\n* Incisor, canine, and premolar teeth that had previously undergone root canal treatment\n* Incisor, canine, and premolar teeth with a diagnosis of chronic apical abscess or asymptomatic apical periodontitis\n* teeth with only 1 root canal\n* the patients had not used any antibiotics for 3 months before treatment\n\nExclusion Criteria:\n\n* the presence of a root fracture\n* teeth with any swelling\n* ankyloses,\n* periodontal pockets deeper than 4 mm.\n* teeth which a rubber dam could not be performed\n* patients with allergy to ibuprofen or ciprofloxacin were also excluded.","60 Years",{"count":165,"type":21},50,[55],"In endodontics, various irrigation solutions are used to achieve antibacterial efficacy within the root canal. The antibacterial effect of curcumin-containing root canal solutions, when combined with photodynamic therapy, has been demonstrated in several studies. However, no research has specifically examined their effect on postoperative pain. The aim of this study is to investigate the impact of using a curcumin solution in combination with photodynamic therapy as the final irrigation solution on postoperative pain.",[25,169,170,171],"Postoperative Dental Pain","Irrigation Solution","Photodynamic Therapy (PDT)",[173,174,175,176,177],"postoperative pain","endodontics","root canal irrigation","curcumin","photodynamic therapy","2024-12-28",{"date":180,"type":35},"2024-12-31",{"date":182,"type":21},"2025-01",{"date":184,"type":21},"2025-06",{"name":186,"class":42},"Ataturk University"]