[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"periapical-lesion\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:periapical-lesion":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,77],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100611373","comparing-two-medicines-for-healing-jaw-bone-infections-after-root-canal-treatment-100611373",false,"NCT07239739","Comparing Two Medicines for Healing Jaw Bone Infections After Root Canal Treatment","Effect of Triple Antibiotic Paste and Calcium Hydroxide on the Rate of Healing of Periapical Lesions in Single-Rooted Teeth: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Systemically healthy adult patients between 18 and 65 years of age.\n\nPresence of a single-rooted tooth diagnosed with pulpal necrosis and asymptomatic apical periodontitis or chronic apical abscess.\n\nRadiographic evidence of a distinct periapical radiolucency with a minimum diameter of 2mm.\n\nThe involved tooth must be deemed restorable after endodontic treatment.\n\nPatient willingness and ability to provide informed consent and comply with the follow-up schedule\n\nExclusion Criteria:\n\nPatients under 18 or over 65 years of age.\n\nPresence of systemic diseases known to affect bone metabolism or immune response (e.g., uncontrolled diabetes).\n\nPregnancy or lactation.\n\nKnown allergies to any components of Triple Antibiotic Paste or calcium hydroxide.\n\nTeeth with previous root canal treatment, internal\u002Fexternal root resorption, root fractures, or non-endodontic periapical pathology.Exclusion Criteria:\n\n\\-","ALL","18 Years","65 Years",{"count":20,"type":21},62,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study compares two commonly used intracanal medicaments-Triple Antibiotic Paste and Calcium Hydroxide-in patients with infected single-rooted teeth. The purpose is to determine which medicament promotes faster healing of periapical lesions after root canal treatment by measuring reduction in lesion size and improvement in bone density over 3, 6, and 12 months.",[27,28],"Periapical Lesion","Periapical Periodontitis",[30,31,32,33],"Triple Antibiotic Paste,","Calcium Hydroxide,","Periapical Healing","Intracanal Medicament","NOT_YET_RECRUITING","2026-03-16",{"date":37,"type":38},"2026-03-18","ACTUAL",{"date":40,"type":21},"2026-06-15",{"date":42,"type":21},"2026-12-15",{"name":44,"class":45},"Faiz ur rahman","OTHER",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100600709","effect-of-local-use-of-non-steroidal-anti-inflammatory-agent-diclofenac-sodium-with-and-without-hyaluronidase-on-post-surgical-pain-and-swelling-100600709","NCT07101016","Effect of Local Use of Non-steroidal Anti-inflammatory Agent (Diclofenac Sodium) With and Without Hyaluronidase on Post-surgical Pain and Swelling","Effect of Local Use of Non-steroidal Anti-inflammatory Agent (Diclofenac Sodium) With and Without Hyaluronidase on Post-surgical Pain and Swelling: A Randomized Clinical Trial","Inclusion Criteria:\n\n1. Patients in good physical health; American Society of Anesthesiologists (ASA) class I or II, with no known allergic manifestations to the drugs used in the study and no involvement with other medication during the study (Appendix 2).\n2. Patients who are 18 years of age or older, without underlying chronic systemic conditions.\n3. Male and female patients.\n4. Patients having asymptomatic single rooted teeth with periapical lesions 5-10mm in diameter (Appendix 3).\n5. Patients who can understand the visual analogue scale (Appendix 4).\n6. Patients who accept to participate in the trial and can sign the informed consent (Appendix 1).\n\nExclusion Criteria:\n\n* 1\\. Teeth with pathosis associated with vertical root fractures, teeth with coronal perforations, and periodontal pockets (7 mm).\n\n  2\\. Miller class III\u002FIV mobility, compromised crown-to-root ratio, combined endodontic-periodontic lesions 3. Systemic medical diseases and autoimmune diseases 4. Pregnant females 5. Patients allergic to Diclofenac or Hyaluronidase 6. Teeth with previous root canal therapy",{"count":54,"type":21},44,[24],"The goal of this clinical trial is to evaluate whether locally applied diclofenac sodium, with or without hyaluronidase, can reduce post-surgical pain and swelling in adult male and female patients (18 years or older) with asymptomatic single-rooted teeth and periapical lesions (5-10 mm in diameter). The main questions it aims to answer are:\n\nDoes local application of diclofenac sodium reduce postoperative pain and swelling compared to no medication?\n\nDoes the combination of diclofenac sodium and hyaluronidase offer greater reduction in postoperative pain and swelling than diclofenac sodium alone?\n\nResearchers will compare four groups (diclofenac only, hyaluronidase only, diclofenac + hyaluronidase, and no medicament) to see if the medicated groups experience significantly less pain and swelling after periapical surgery compared to the control group.\n\nParticipants will:\n\nUndergo root canal treatment followed by periapical surgery in a single visit.\n\nReceive a randomly assigned intra-osseous gel (diclofenac, hyaluronidase, both, or none) placed into the surgical cavity.\n\nRecord their postoperative pain using a visual analogue scale at specified intervals (6, 12, 24, 48 hours, and 7 days).\n\nReturn for clinical assessments of swelling at 24, 72 hours, and 5 days post-surgery",[58,27,59],"Root End Resection","Single Rooted Teeth",[61,62,63,64,65,66,67],"Periapical lesion","Single rooted teeth","Post operative pain","Post operative swelling","Root end resection","Hyaluronidase","Diclofenac Sodium","2025-07-28",{"date":70,"type":38},"2025-08-03",{"date":72,"type":21},"2025-08-01",{"date":74,"type":21},"2025-08-08",{"name":76,"class":45},"Mariam Hesham Mahmoud Abdelfattah Eissa",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":83,"sex":16,"minAge":17,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":22,"phases":87,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":100},"100565456","effect-of-high-magnification-on-quality-of-life-and-success-after-endodontic-microsurgery-a-randomized-controlled-trial-100565456","NCT06642415","Effect Of High Magnification On Quality Of Life And Success After Endodontic Microsurgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients between age of 18-55 with the diagnosis of persistent symptomatic apical periodontitis in previously treated teeth with radiographic evidence of periapical radiolucency (≥ 5 mm). (Bharathi et al 2021) Tooth with a peri radicular lesion of strictly endodontic origin and unrestorable by nonsurgical retreatment. ASA-1 patients according to the classification of the American Society of Anesthesiologists).\n\nExclusion Criteria:\n\nPatients with systemic diseases (diabetes mellitus, uncontrolled hypertension grade III, hepatic\u002Frenal disease, or systemic bleeding disorders) Combined endodontic-periodontic lesions Pregnancy\n\n\\-",true,"55 Years",{"count":86,"type":21},40,[24],"Effect of high magnification on quality of life and success after endodontic surgery: a randomized controlled trial\"",[27],"RECRUITING","2024-10-14",{"date":93,"type":38},"2024-10-15",{"date":95,"type":38},"2023-11-01",{"date":97,"type":21},"2025-05-01",{"name":99,"class":45},"Postgraduate Institute of Dental Sciences Rohtak",1]