[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"periapical-periodontitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:periapical-periodontitis":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,49,71,94,122,145,173,196,222],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100644596","antibacterial-efficacy-of-bioceramic-and-calcium-hydroxide-intracanal-medicaments-100644596",false,"NCT07671326","Antibacterial Efficacy of Bioceramic and Calcium Hydroxide Intracanal Medicaments","Antibacterial Efficacy of Bioceramic and Calcium Hydroxide-Based Intracanal Medicaments in Endodontic Treatment","Inclusion Criteria:\n\n* Patients aged between 18 and 65 years\n* Being systemically healthy (ASA I or ASA II)\n* Mandibular molar teeth with a radiographically detectable radiolucent lesion in the periapical region\n* Willingness of the volunteer or their legal representative to participate in the study by signing the Informed Consent Form\n\nExclusion Criteria:\n\n* Patients who have received antibiotics or corticosteroids within the last 3 months\n* Patients with systemic diseases\n* Teeth that cannot be properly isolated with a rubber dam\n* Teeth with periodontal pockets \\>4 mm and teeth with crown\u002Froot fractures\n* Individuals who are undergoing or planning to start orthodontic treatment during the study period\n* Pregnant or breastfeeding individuals",true,"ALL","18 Years","65 Years",{"count":21,"type":22},24,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study evaluates the antibacterial effectiveness of two different intracanal medicaments, Bio-C Temp and UltraCal XS , in mandibular molar teeth with chronic apical periodontitis. Intracanal bacterial load is assessed before and after root canal preparation, after intracanal medicament removal, and after final irrigation using droplet digital PCR.",[28,29,30],"Periapical Periodontitis","Root Canal Infection","Intracanal Medicaments",[32,33,34,35],"intracanal medicament","bioceramic medicament","ultrasonic activation","ddPCR","RECRUITING","2026-06-25",{"date":39,"type":40},"2026-06-29","ACTUAL",{"date":42,"type":40},"2025-10-15",{"date":44,"type":22},"2026-12",{"name":46,"class":47},"Medipol University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":48},"100626744","comparison-of-root-canal-desinfection-protocols-100626744","NCT07439614","Comparison of Root Canal Desinfection Protocols","Comparison of Different Root Canal Disinfection Protocols for Bacterial Reduction in Teeth With Apical Periodontitis Using Two Analytical Microbiological Methods: a Randomized Clinical Study","Inclusion Criteria:\n\n* Adult patients able to give informed consent and willing\u002Fable to comply with study procedures and follow-up.\n* Molar teeth indicated for endodontic treatment.\n* Teeth with intact pulp-chamber walls (no extensive coronal destruction).\n* Necrotic pulp confirmed by pulp testing.\n* Clinical and radiographic evidence of asymptomatic apical periodontitis.\n\nExclusion Criteria:\n\n* Immature teeth\n* Teeth with calcified or obliterated canals\n* Teeth with extensive coronal destruction\n* Teeth with previous endodontic treatment\n* Symptomatic apical periodontitis\n* Teeth with periodontal pockets greater than 4 mm\n* Patients who have received systemic antibiotics in the last 3 months\n* Patients with a history of diabetes or immune impairment\n* Pregnant patients","70 Years",{"count":58,"type":22},50,[25],"Evaluate and compare the disinfecting efficacy of two supplementary antimicrobial protocols in teeth with apical periodontitis",[28],"2026-06-18",{"date":64,"type":40},"2026-06-23",{"date":66,"type":40},"2026-04-01",{"date":68,"type":22},"2027-06",{"name":70,"class":47},"State University of New York at Buffalo",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":78,"targetDuration":4,"studyType":23,"phases":80,"briefSummary":81,"conditions":82,"keywords":83,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":48},"100631507","hyaluronic-acid-in-endodontic-microsurgery-100631507","NCT07501585","Hyaluronic Acid in Endodontic Microsurgery","Effectiveness of Using Cross-linked Hyaluronic Acid in Endodontic Microsurgery. A RCT","Inclusion Criteria:\n\n* Written informed consent\n* ≥18 years of age\n* Apical peridontitis at maxillar or mandibular first molars ≥ 12 months after non-surgical endodontical treatment\n* Full mouth plaque score (FMPS) and bleeding score (BoP) \\\u003C or 20%\n* Periapical lesion \\\u003C or 10 mm\n* Four-wall bone defect morphology\n\nExclusion Criteria:\n\n* Smokers of more than 10 cigarettes a day\n* Allergy to hyaluronic acid\n* Pregnancy or lactation\n* Uncontrolled Diabetes\n* Untreated periodontal conditions\n* Any conditions associated with poor compliance or failure to maintain good oral hygiene\n* Acute infections lesions in areas intended for surgery\n* Chemotherapy and radiotherapy treatment",{"count":79,"type":22},46,[25],"This randomized clinical trial (RCT) will evaluate the effectiveness of cross-linked hyaluronic acid as an adjunct to endodontic microsurgery in adult patients with apical periodontitis affecting maxillary or mandibular first molars. Participants previously treated with non-surgical endodontic therapy will be allocated to either endodontic microsurgery with cross-linked hyaluronic acid application (test group) or the same surgical procedure without adjunctive material (control group), with 12 months of follow-up.\n\nThe study hypothesis is that cross-linked hyaluronic acid improves soft- and hard-tissue healing, reduces postoperative inflammation and pain, and supports more stable surgical outcomes. Primary outcomes include early soft tissue healing (Early Wound Healing Score, day 4) and postoperative pain (visual analogue scale). Secondary outcomes include periapical healing assessed by blinded evaluators on periapical radiographs (Molven criteria) at 3, 6, and 12 months, and on CBCT scans (PENN 3D criteria) at 6 and 12 months, as well as cortical plate healing (RAC\u002FB index). This study aims to provide clinical evidence on the potential regenerative and anti-inflammatory benefits of cross-linked hyaluronic acid in endodontic microsurgery.",[28],[84],"Endodontic microsurgery","2026-03-24",{"date":87,"type":40},"2026-03-30",{"date":89,"type":40},"2026-02-20",{"date":91,"type":22},"2028-12-31",{"name":93,"class":47},"University of Bern",{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":4,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":101,"targetDuration":4,"studyType":23,"phases":103,"briefSummary":104,"conditions":105,"keywords":107,"overallStatus":112,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":4},"100611373","comparing-two-medicines-for-healing-jaw-bone-infections-after-root-canal-treatment-100611373","NCT07239739","Comparing Two Medicines for Healing Jaw Bone Infections After Root Canal Treatment","Effect of Triple Antibiotic Paste and Calcium Hydroxide on the Rate of Healing of Periapical Lesions in Single-Rooted Teeth: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Systemically healthy adult patients between 18 and 65 years of age.\n\nPresence of a single-rooted tooth diagnosed with pulpal necrosis and asymptomatic apical periodontitis or chronic apical abscess.\n\nRadiographic evidence of a distinct periapical radiolucency with a minimum diameter of 2mm.\n\nThe involved tooth must be deemed restorable after endodontic treatment.\n\nPatient willingness and ability to provide informed consent and comply with the follow-up schedule\n\nExclusion Criteria:\n\nPatients under 18 or over 65 years of age.\n\nPresence of systemic diseases known to affect bone metabolism or immune response (e.g., uncontrolled diabetes).\n\nPregnancy or lactation.\n\nKnown allergies to any components of Triple Antibiotic Paste or calcium hydroxide.\n\nTeeth with previous root canal treatment, internal\u002Fexternal root resorption, root fractures, or non-endodontic periapical pathology.Exclusion Criteria:\n\n\\-",{"count":102,"type":22},62,[25],"This study compares two commonly used intracanal medicaments-Triple Antibiotic Paste and Calcium Hydroxide-in patients with infected single-rooted teeth. The purpose is to determine which medicament promotes faster healing of periapical lesions after root canal treatment by measuring reduction in lesion size and improvement in bone density over 3, 6, and 12 months.",[106,28],"Periapical Lesion",[108,109,110,111],"Triple Antibiotic Paste,","Calcium Hydroxide,","Periapical Healing","Intracanal Medicament","NOT_YET_RECRUITING","2026-03-16",{"date":115,"type":40},"2026-03-18",{"date":117,"type":22},"2026-06-15",{"date":119,"type":22},"2026-12-15",{"name":121,"class":47},"Faiz ur rahman",{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":128,"eligibilityCriteria":129,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":130,"targetDuration":4,"studyType":132,"phases":4,"briefSummary":133,"conditions":134,"keywords":4,"overallStatus":112,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":4},"100625146","clinical-and-radiographic-evaluation-of-primary-endodontic-treatment-and-non-surgical-endodontic-retreatments-100625146","NCT07418840","Clinical and Radiographic Evaluation of Primary Endodontic Treatment and Non-surgical Endodontic Retreatments","Clinical and Radiographic Evaluation of Primary Endodontic Treatments and Non-Surgical Endodontic Retreatments Performed in a Hospital Setting, a Prospective Study","CR-ET","Inclusion Criteria:\n\n* Patients requiring primary endodontic treatment or non-surgical endodontic retreatment due to symptomatic or asymptomatic irreversible pulpitis, symptomatic or asymptomatic apical periodontitis, or an acute or chronic abscess.\n* Patients aged over 18 years.\n* Signed written informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Inability to undergo consistent and continuous follow-up.\n* Patients with teeth affected by vertical root fractures.\n* Patients with teeth presenting periodontal compromise requiring extraction.\n* Pregnant or breastfeeding patients.\n* Inability to provide written informed consent.",{"count":131,"type":22},75,"OBSERVATIONAL","Background:\n\nPulpitis and apical periodontitis are inflammatory conditions of the dental pulp and periapical tissues, primarily caused by microbial invasion. The global prevalence of pulpitis is considered high but underestimated, as up to 40% of cases are asymptomatic. Similarly, the prevalence of apical periodontitis varies widely (16-86%) depending on population characteristics, systemic conditions, and socioeconomic status, and it is reported to be higher in hospital settings. Endodontic therapy aims to disinfect and seal the root canal system, promoting healing of apical periodontitis or maintaining periapical health. Reported success rates for primary and non-surgical retreatment procedures are comparable (75% and 77%, respectively), though outcomes tend to be more favorable in vital teeth compared to those with apical periodontitis (84% vs. 75%). Despite the widespread use of endodontic therapy, few studies have assessed treatment outcomes in a hospital setting.\n\nObjectives:\n\nThe primary aim of this prospective study is to evaluate the success of primary and non-surgical endodontic retreatments performed in a hospital environment.\n\nSecondary objectives include assessing (1) the survival of treated teeth, (2) patient-related outcomes (PROs), and (3) the influence of systemic diseases or ongoing therapies on treatment outcomes.\n\nMethods:\n\nThis is a monocentric, prospective, observational, study to be conducted at the Dental Clinic of the A. Gemelli University Hospital, Rome. Adult patients (\\>18 years) requiring primary or non-surgical endodontic retreatment due to symptomatic or asymptomatic irreversible pulpitis, apical periodontitis, or acute\u002Fchronic abscesses will be enrolled after providing written informed consent in accordance with the Declaration of Helsinki.\n\nExclusion criteria include inability to complete follow-up, vertical root fractures, advanced periodontal disease requiring extraction, pregnancy or breastfeeding, and inability to provide informed consent.\n\nPatients will undergo standard endodontic therapy according to the European Society of Endodontology (ESE) guidelines. Clinical and radiographic evaluations will be performed preoperatively, intraoperatively, and postoperatively. Radiographic assessments will be based on the Periapical Index (PAI), and follow-ups will occur at 6 months, 1 year, and annually for up to 4 years, with a final clinical follow-up at 5 years.\n\nPatient-related outcomes will be evaluated using the Numerical Rating Scale (NRS-12) for pain and the Oral Health Impact Profile (OHIP-14) questionnaire before treatment and at 1, 3, and 7 days post-treatment.\n\nOutcome Measures:\n\nThe primary endpoint is the rate of endodontic success, defined by the absence of clinical symptoms (pain, swelling, sinus tract, tenderness) and radiographic healing or maintenance of periapical health (Periapical Apex Index, PAI).\n\nSecondary endpoints include the incidence of postoperative complications, survival rate of treated teeth, associations between systemic conditions and endodontic outcomes, and patient-reported outcome measures.\n\nStatistical Analysis:\n\nThe sample size was calculated according to Lachin et al., assuming an expected success rate of 85%, a 5% margin of error, and 90% power, resulting in a minimum of 74 patients.\n\nQualitative variables will be expressed as frequencies and percentages, while quantitative variables will be summarized as mean ± SD or median, depending on distribution. Normality will be tested with the Kolmogorov-Smirnov test.\n\nAssociations between categorical variables will be evaluated using Pearson's χ² or Fisher's exact test, and continuous variables with Student's t-test, Mann-Whitney U, ANOVA, or Kruskal-Wallis tests as appropriate. Repeated measures ANOVA or Friedman tests will be applied to detect longitudinal changes.\n\nMixed-effects models ((G)LMM) will be used to analyze changes in PAI, NRS-12, and OHIP-14 over time while adjusting for confounders. Logistic regression will identify independent predictors of success, and Kaplan-Meier survival curves (log-rank test) will estimate tooth survival over follow-up. Significance will be set at p \\\u003C 0.05. Statistical analyses will be performed using IBM SPSS Statistics v25.0 (IBM Corp., Armonk, NY, USA).\n\nExpected Results and Conclusions:\n\nThis study is expected to provide data on the clinical and radiographic success rates of primary and non-surgical endodontic treatments performed in a hospital setting. It will also clarify the impact of systemic diseases and patient-related factors on treatment outcomes. The findings may help optimize clinical protocols and patient management strategies in hospital-based endodontic care, contributing to evidence-based improvement of dental services and patient quality of life.",[28,135],"Pulpitis","2026-02-11",{"date":138,"type":40},"2026-02-18",{"date":140,"type":22},"2026-03-15",{"date":142,"type":22},"2032-10-15",{"name":144,"class":47},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":4,"eligibilityCriteria":151,"healthyVolunteers":11,"sex":17,"minAge":152,"maxAge":4,"enrollmentInfo":153,"targetDuration":4,"studyType":23,"phases":155,"briefSummary":156,"conditions":157,"keywords":159,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":48},"100619375","the-effect-of-endodontic-treatment-on-cardiovascular-risk-biomarkers-in-patients-with-stable-coronary-artery-disease-100619375","NCT07343804","THE EFFECT OF ENDODONTIC TREATMENT ON CARDIOVASCULAR RISK BIOMARKERS IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE","THE EFFECT OF ENDODONTIC TREATMENT ON CARDIOVASCULAR RISK BIOMARKERS IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE : A RANDOMIZED CONTROLLED TRIAL","Inclusion Criteria:\n\n1. Individuals 30 years of age and older, with a diagnosis of stable coronary artery disease (CAD) and chronic apical periodontitis.\n2. All patients had to present with CAD defined by the Brazilian Society of Cardiology (Xavier et al., 2013) as the documented occurrence of one or more of the following events 6 months before entering the study: history of myocardial infarction, stable angina or ischaemia in non-invasive tests; surgical or percutaneous myocardial revascularization and lesion size of greater than 50% in at least one major coronary artery, as assessed by angiography; presence of angina and positive results of non-invasive testing of ischaemia.\n3. Presence of apical periodontitis defined by the presence of at least 1 radiographic radiolucency ( ≥ 3mm) in teeth as assessed both clinically and radiographically ,with periapical index (PAI) scores ≥3 in a single permanent tooth and pulp necrosis verified by cold and electric pulp test.\n\n   \\-\n\nExclusion Criteria:\n\n1. Chronic conditions associated with periodontitis or with changes in systemic inflammation (e.g. diabetes mellitus, rheumatoid arthritis, rheumatic fever, malignancy, respiratory diseases, renal diseases).\n2. Presence of localized or diffuse periodontal disease.\n3. Acute symptomatic patients\n4. Presence of CV risk factor - history of smoking\n5. Acute conditions known to affect systemic inflammatory markers (orthopaedic trauma, surgery ,viral infections)\n6. Medications (during last 3 months) known to affect systemic inflammatory markers (systemic steroids,immunosuppressants, hormone replacement therapy, contraceptives and systemic antibiotics\n7. Obesity (body mass index \\[BMI\\]≥30 kg\u002Fm2\n8. Pregnancy \\& Lactation.37","30 Years",{"count":154,"type":22},80,[25],"Study subjects were obtained from the pool of OPD patients in the Department of Conservative Dentistry and Endodontics, PGIDS, Rohtak, and the Department of Cardiology, PGIMS, Rohtak. Baseline clinical, radiographic, and laboratory parameters (hsCRP and IL-6) were recorded. Patients were then randomly allocated to one of the two groups. In the test group, single-sitting root canal treatment was performed immediately, while in the control group, delayed endodontic intervention (after 3 months) was performed after three months. Clinical and laboratory parameters were again assessed at the end of 3 months in both groups. hsCRP and IL-6 indices were again done in the delayed treatment group after 3 months of root canal treatment.",[158,28],"Cardiovascular Disease Risk Factor",[160,161,162,163],"cardiovascular disease","endodontic therapy","hs-CRP","IL-6","2026-01-07",{"date":166,"type":40},"2026-01-15",{"date":168,"type":40},"2025-11-01",{"date":170,"type":22},"2026-03",{"name":172,"class":47},"Postgraduate Institute of Dental Sciences Rohtak",{"id":174,"slug":175,"hasResults":11,"nctId":176,"briefTitle":177,"officialTitle":178,"acronym":179,"eligibilityCriteria":180,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":181,"targetDuration":4,"studyType":23,"phases":183,"briefSummary":184,"conditions":185,"keywords":4,"overallStatus":112,"whyStopped":4,"lastUpdateSubmitDate":187,"lastUpdatePostDateStruct":188,"startDateStruct":190,"completionDateStruct":192,"leadSponsor":194,"locationsCount":4},"100611374","influence-of-maintaining-apical-patency-on-post-endodontic-pain-in-molars-100611374","NCT07239752","Influence of Maintaining Apical Patency on Post-Endodontic Pain in Molars","Influence of Maintaining Apical Patency in Post-Endodontic Pain in Molars With Necrotic Pulp and Apical Periodontitis: A Randomized Controlled Trial","IMAP-Pain","Inclusion Criteria:Adult patients aged 18-65 years.\n\nMedically healthy, classified as American Society of Anesthesiologists (ASA) Physical Status I or II.\n\nPresence of a single permanent molar tooth diagnosed with necrotic pulp and symptomatic apical periodontitis, and indicated for primary root canal treatment.\n\nPatients who provide informed written consent to participate in the study. -\n\nExclusion Criteria:\n\nTeeth with prior endodontic treatment or complex anatomy (e.g., calcified canals, severe curvature).\n\nPatients with significant systemic illness (e.g., uncontrolled diabetes, immunocompromised status) or pregnancy.\n\nHistory of analgesic intake within 72 hours prior to the root canal procedure.\n\nNon-restorable teeth, teeth with severe periodontal disease (pocket depth \\>5mm), or teeth with root fractures.\n\nExclusion Criteria:\n\n\\-",{"count":182,"type":22},48,[25],"This randomized controlled trial will investigate if maintaining apical patency-a technique where a small file is gently moved past the root's end during cleaning-affects pain after a root canal. The study will include 48 adult patients needing root canal treatment on a back molar tooth with a dead nerve and infection at the root tip. Participants will be randomly assigned to one of two groups: one where the apical patency technique is used, and one where it is not. All other treatment steps will be identical. Patients will record their pain levels on a standard scale (0-100 mm Visual Analog Scale) at 6, 12, 24, 48, and 72 hours after the procedure. The goal is to determine if this specific technique influences the intensity and duration of post-treatment pain",[28,186],"Dental Pulp Necrosis","2025-11-16",{"date":189,"type":40},"2025-11-20",{"date":191,"type":22},"2026-02-10",{"date":193,"type":22},"2026-10-10",{"name":195,"class":47},"College of Physicians and Surgeons Pakistan",{"id":197,"slug":198,"hasResults":11,"nctId":199,"briefTitle":200,"officialTitle":201,"acronym":4,"eligibilityCriteria":202,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":203,"targetDuration":4,"studyType":23,"phases":205,"briefSummary":206,"conditions":207,"keywords":209,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":213,"lastUpdatePostDateStruct":214,"startDateStruct":216,"completionDateStruct":218,"leadSponsor":220,"locationsCount":48},"100594349","postoperative-pain-evaluation-after-obturation-with-different-sealers-100594349","NCT07018284","Postoperative Pain Evaluation After Obturation With Different Sealers","Assessment of Postoperative Pain Incidence in Teeth Affected by Pulpitis, Necrosis, or Previously Treated, Following Obturation With Bioceramic or Resin-based Sealers","Inclusion Criteria:\n\nPatients aged 18 years and older. Teeth with a diagnosis of pulpal necrosis or irreversible pulpitis. Informed consent provided for data usage.\n\nExclusion Criteria:\n\n* Patients with systemic conditions that may impair healing (e.g., uncontrolled diabetes, immunosuppression).\n* Asymptomatic presentation\n* Teeth with root fractures, resorption, or open apices.\n* Incomplete clinical or radiographic records.\n* Cases with poor-quality radiographs or lack of standardization for evaluation",{"count":204,"type":22},270,[25],"This study aims to evaluate the incidence and intensity of postoperative pain in patients undergoing root canal treatment on teeth diagnosed with pulpitis, pulp necrosis, or with previous endodontic treatment. Teeth will be obturated using either bioceramic or resin-based sealers. The primary objective is to determine whether the type of sealer significantly influences the level of postoperative pain as reported by patients. Pain intensity will be assessed using the Visual Analogue Scale (VAS) at three time points: immediately after treatment, 24 hours, and 72 hours postoperatively. The findings are expected to provide clinical insight into which obturation material may be more effective in minimizing postoperative discomfort.",[28,135,208],"Necorsis",[210,211,212],"Bioceramic sealers","Resin-based sealers","Endodontics","2025-06-04",{"date":215,"type":40},"2025-06-12",{"date":217,"type":40},"2025-06-01",{"date":219,"type":22},"2026-01-30",{"name":221,"class":47},"University of Siena",{"id":223,"slug":224,"hasResults":11,"nctId":225,"briefTitle":226,"officialTitle":227,"acronym":4,"eligibilityCriteria":228,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":229,"targetDuration":4,"studyType":23,"phases":230,"briefSummary":231,"conditions":232,"keywords":235,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":213,"lastUpdatePostDateStruct":239,"startDateStruct":241,"completionDateStruct":242,"leadSponsor":244,"locationsCount":48},"100594427","success-of-endodontic-treatment-with-different-obturation-techniques-and-sealer-cements-100594427","NCT07019298","Success of Endodontic Treatment With Different Obturation Techniques and Sealer Cements","Evaluation of the Success Rate of Endodontic Treatment Using Different Obturation Techniques and Root Canal Sealer Cements: A Randomized Controlled Trial","Inclusion Criteria:\n\nPatients aged 18 years and older. Teeth with a diagnosis of pulpal necrosis or irreversible pulpitis. Informed consent provided for data usage.\n\nExclusion Criteria:\n\n* Patients with systemic conditions that may impair healing (e.g., uncontrolled diabetes, immunosuppression).\n* Teeth with root fractures, resorption, or open apices.\n* Incomplete clinical or radiographic records.\n* Cases with poor-quality radiographs or lack of standardization for evaluation",{"count":204,"type":22},[25],"The present study aims to compare the radiographic success of endodontic treatment using Orstavik's criteria between two sealers: AH Plus (Dentsply DeTrey, Konstanz, Germany) and Neosealer Flo (Avalon Biomed, Bradenton, Florida, USA), as well as between two obturation techniques: continuous wave and single cone. The study includes 270 patients, with a minimum follow-up period of 6 months. Clinical and radiographic variables will be assessed, including quality of obturation, lesion healing, and restoration. The study seeks to determine if the use of bioceramic sealer is effective regardless of the obturation technique used, highlighting the importance of clinical follow-up to evaluate endodontic treatment success.",[135,233,28,234],"Periapical Lesions","Periapical Pathology",[212,236,237,238],"Endodontic Sealer","Calcium Silicate-Based Sealer","Ah Plus",{"date":240,"type":40},"2025-06-13",{"date":217,"type":40},{"date":243,"type":22},"2029-06-01",{"name":221,"class":47}]