[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"periapical-radiolucency\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:periapical-radiolucency":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,55,91],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100634677","evaluating-the-use-of-cgf-plugs-in-fresh-odontectomy-socket-100634677",false,"NCT07542795","Evaluating The Use of CGF Plugs in Fresh Odontectomy Socket.","Clinical and Radiographic Evaluation of the Use of CGF Plugs Packed in Fresh Odontectomy Socket (Case Series Study)","CGF","Inclusion Criteria:\n\n* Systemically healthy patients (ASA I or II)\n* Age between 20 and 50 years\n* Require simple, non-surgical extraction of a single tooth\n* Presence of periapical radiolucency at the extraction site\n* Willingness to comply with follow-up and provide signed informed consent\n\nExclusion Criteria:\n\n* • Systemic diseases (e.g., uncontrolled diabetes, bone metabolic disorders)\n\n  * History of radiotherapy or chemotherapy\n  * Use of medications affecting bone metabolism (e.g., bisphosphonates, chronic steroids)\n  * Heavy smokers\n  * Pregnant or lactating women\n  * Poor oral hygiene or active acute infection\u002Fsuppuration at the site","ALL","20 Years","50 Years",{"count":21,"type":22},10,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study evaluates the use of Concentrated Growth Factor (CGF) plugs-a third-generation healing material made from the patient's own blood-to improve recovery after simple tooth extractions. CGF contains a dense matrix of growth factors and regenerative cells designed to enhance wound healing and tissue regeneration.\n\nParticipants requiring a single, non-surgical tooth extraction will have a CGF plug placed into the empty socket immediately following the procedure. The researchers will then monitor two main factors:\n\n* Post-operative Pain: Patients will record their pain levels on a scale of 0 to 10 at 1, 3, and 7 days after the extraction.\n* Bone Density: Using specialized imaging (CBCT), the researchers will measure how well the bone heals and fills the socket immediately after the procedure and again at 3 months.\n\nThe goal of this research is to determine if CGF plugs can effectively reduce patient discomfort and help preserve bone density, which is critical for future dental treatments like implants.",[28,29,30,31],"Odontectomy (Tooth Extraction)","Socket Preservation and Healing Following Simple, Non-surgical Extraction","Alveolar Bone Density and Postoperative Pain Management","Periapical Radiolucency",[33,34,35,36,37,38,39,40,41],"Concentrated Growth Factor (CGF)","CGF Plug","Odontectomy","Tooth Extraction","Socket Preservation","Bone Density","Postoperative Pain","Alveolar Bone","Platelet Concentrates","NOT_YET_RECRUITING","2026-04-15",{"date":45,"type":46},"2026-04-21","ACTUAL",{"date":48,"type":22},"2026-09-28",{"date":50,"type":22},"2026-12-30",{"name":52,"class":53},"Cairo University","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":17,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":4,"studyType":23,"phases":67,"briefSummary":69,"conditions":70,"keywords":72,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":4},"100615235","phase-3-comparative-evaluation-of-clinical-and-radiographic-treatment-outcomes-of-garlic-gel-and-calcium-hydroxide-as-an-intracanal-medicament-in-nonsurgical-root-canal-treatment-of-permanent-teeth-100615235","NCT07289971","Comparative Evaluation of Clinical and Radiographic Treatment Outcomes of Garlic Gel and Calcium Hydroxide as an Intracanal Medicament in Nonsurgical Root Canal Treatment of Permanent Teeth.","Comparative Evaluation of Clinical and Radiographic Treatment Outcomes of Garlic Gel and Calcium Hydroxide as an Intracanal Medicament in Nonsurgical Root Canal Treatment of Permanent Teeth: A Randomized Controlled Trial.","Inclusion Criteria:\n\n* Patients with the physical status of ASA I and ASA II according to ASA classification.\n* Patients aged from 15-45 years.\n* Mature permanent single-rooted teeth with closed apices.\n* Patients with clinical signs of symptomatic apical periodontitis (pain, tenderness to palpation, and percussion).\n* Patients having radiographic evidence of periapical radiolucency of endodontic origin.\n* Patients who have not taken antibiotics for the past 14 days.\n* Cooperative patients who show good compliance.\n\nExclusion Criteria:\n\n* Patients with physical status of ASA III, IV, and V according to ASA classification.\n* Teeth with a calcified pulp chamber in periapical radiography.\n* Patients who have undergone previous endodontic treatment failure and those with the presence of sinus tract on clinical examination.\n* Teeth having advanced periodontal disease, with the basic periodontal examination (BPE) of 3 and 4.\n* Presence of internal and external resorption of the root as viewed on the periapical radiograph.\n* Presence of vertical root fracture and perforation as viewed on the periapical radiograph",true,"15 Years","45 Years",{"count":66,"type":22},96,[68],"PHASE3","Researchers want to check how well garlic works inside permanent teeth as a medicament during root canal treatments. Garlic has shown to possess many helpful properties, like reducing inflammation, helping wounds heal, and antimicrobial characteristics. Because conventional medicaments can be expensive or have potential side effects, researchers are actively exploring natural options like garlic. Some lab studies have already shown that garlic gel can kill the microbes inside the teeth. However, no real-life clinical or X-ray studies have been done on using garlic in permanent teeth. This study may help scientists find a much safer and effective new material for dental treatments in the future.",[71,31],"Apical Periodontitis",[73,74,75,76,77,78,79,80,81],"Intracanal Medicament","Allium Sativum","Calcium hydroxide","Root canal treatment","Periapical Index","Resolution of Periapical Radiolucency","Visual Analogue Scale","Palpation","Percussion","2026-01-01",{"date":84,"type":46},"2026-01-06",{"date":86,"type":22},"2026-01-20",{"date":88,"type":22},"2026-05",{"name":90,"class":53},"University of Health Sciences Lahore",{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":4,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":98,"enrollmentInfo":99,"targetDuration":4,"studyType":23,"phases":101,"briefSummary":102,"conditions":103,"keywords":4,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":54},"100612667","antimicrobial-and-anti-inflammatory-effects-of-simvastatin-as-an-intracanal-medication-100612667","NCT07256561","Antimicrobial and Anti-inflammatory Effects of Simvastatin as an Intracanal Medication","Antimicrobial and Anti-inflammatory Effects of Simvastatin as an Intracanal Medication in Endodontically Retreated Teeth With Periapical Radiolucency, Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Patients had anon contributory medical history.\n* Patients of age categories between 20 to 40 years old, with no physical disability or psychological problems.\n* Single rooted teeth with type I root canal anatomy.\n* Symptomatic cases of failed endodontic treatment with radiographic evidence of periapical bone loss, and the lesion size ranging from 2mm up to 8mm.\n\nExclusion Criteria:\n\n* Patients with known sensitivity to the pharmaceutical used in this trial\n* Patients with former endodontic mishaps (as ledges, transportations, perforations or separated instruments)\n* Non restorable teeth\n* Presence of an associated sinus tract.\n* Advanced periodontal involvement\n* Teeth representing root fracture.\n* Pregnant women","40 Years",{"count":100,"type":22},54,[25],"Successful endodontic treatment and a predictable outcome can only be achieved by effective root canal debridement, irrigation, and elimination of microorganisms .\n\nThe outcome of endodontic treatment performed in controlled clinical environment has demonstrated success rate around 90%.\n\nIn certain cases, endodontic treatment may fail, one of the most common reasons is inability to eliminate microorganisms from the root canal. When non-surgical root canal therapy fails, the treatment options include orthograde re-treatment, periradicular surgery, or extraction.\n\nSimvastatin (SIM) is a drug used primarily to treat hyperlipidemia and protect against cardiovascular diseases. It has been shown to possess pleiotropic effects such as antimicrobial, anti-inflammatory, immunomodulatory, antioxidant, and bone-forming properties .\n\nThe side chain of this material has a single methyl group. It inhibits hydroxymethyl glutarylcoenzyme reductase that prevents endogenous cholesterol synthesis",[104,31],"Endodontically Retard Teeth","RECRUITING","2025-11-20",{"date":108,"type":46},"2025-12-01",{"date":110,"type":46},"2025-08-10",{"date":112,"type":22},"2026-08-10",{"name":114,"class":115},"Hadeer Maher Mostafa Mohamed","OTHER_GOV"]