[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"periimplant-diseases\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:periimplant-diseases":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,78],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100633650","microbiological-evaluation-of-the-effectiveness-of-different-surface-decontamination-protocols-for-dental-implants-100633650",false,"NCT07529444","Microbiological Evaluation of the Effectiveness of Different Surface Decontamination Protocols for Dental Implants","Microbiological Evaluation of the Effectiveness of Different Surface Decontamination Protocols for Dental Implants Using the Polymerase Chain Reaction Method","Inclusion Criteria:\n\nPatients presenting with at least one bone-level dental implant affected by peri-implantitis.\n\nThe affected implant must be deemed viable with a perspective for preservation\u002Fretention in the dental arch.\n\nPatients must be non-smokers.\n\nPatients in good general health, classified as ASA I (a normal healthy patient) or ASA II (a patient with mild systemic disease) according to the American Society of Anesthesiologists physical status classification system.\n\nExclusion Criteria:\n\nPresence of vertical bone loss around the affected implant.\n\nImplants that are not bone-level (e.g., tissue-level implants).\n\nPatients with any systemic comorbidities.\n\nPatients who are currently smokers.\n\nImplants with a poor prognosis that cannot be preserved in the dental arch.","ALL",{"count":18,"type":19},90,"ESTIMATED","INTERVENTIONAL",[22],"NA","The purpose of this prospective clinical study is to evaluate and compare the effectiveness of different cleaning (decontamination) methods for dental implants affected by peri-implantitis. Peri-implantitis is an inflammatory condition caused by a bacterial biofilm on the implant surface, which can lead to bone loss and implant failure if left untreated. Because the rough surface and threads of implants make them difficult to clean, finding the most effective decontamination method is critical for saving the implant.\n\nThis study will include 90 healthy, non-smoking participants who have a bone-level dental implant affected by peri-implantitis without vertical bone loss. Participants will be randomly assigned to one of three treatment groups (30 implants per group) to undergo a specific decontamination procedure during their surgical treatment:\n\nGroup 1 (Laser PDT): Decontamination using photodynamic therapy with a blue laser and riboflavin, followed by a sterile saline rinse.\n\nGroup 2 (GalvoSurge): Decontamination using an electrolytic cleaning device, followed by a sterile saline rinse.\n\nGroup 3 (Active Control): Decontamination using a 0.2% chlorhexidine gluconate rinse, which is the current standard of care.\n\nTo measure the effectiveness of these treatments, researchers will take sterile swabs from the implant surface immediately before and after the decontamination process. These swabs will be analyzed using PCR to detect changes in the microbiological load of five specific bacteria known to cause gum and implant disease (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Treponema denticola, and Tannerella forsythia).\n\nFollowing the decontamination and swabbing, all participants will receive a standard Guided Bone Regeneration (GBR) procedure using autogenous bone, a xenograft, and a collagen membrane to help rebuild the bone around the implant.\n\nBy comparing the microbiological results before and after treatment, the study aims to determine whether the newer methods (Laser PDT or electrolytic cleaning) are more effective at removing harmful bacteria than the traditional chlorhexidine rinse prior to bone regeneration.",[25,26,27],"Periimplant Diseases","Dental Implant Failure","Dental Implant Complications",[29,30,31,32,33,34],"peri-implantitis","implant decontamination","PDT","electrolytic cleaning","GalvoSurge","Chlorhexidine Gluconate","RECRUITING","2026-04-07",{"date":38,"type":39},"2026-04-14","ACTUAL",{"date":41,"type":39},"2026-03-01",{"date":43,"type":19},"2027-06-01",{"name":45,"class":46},"University of Zagreb","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":16,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":4},"100623534","markers-of-bone-destruction-and-oxidative-stress-in-peri-implantitis-100623534","NCT07397884","Markers of Bone Destruction and Oxidative Stress in Peri-implantitis","Evaluation of Bone Destruction and Oxidative Stress Markers in Saliva and Peri-implant Sulcus Fluid in Peri-implantitis","Inclusion Criteria:\n\nSystemically healthy volunteers aged 18-65. For Peri-implantitis group: Implants in function for ≥1 year, radiographic bone loss ≥ 2 mm, probing depth (PD) ≥ 5 mm, and presence of bleeding on probing (BOP) or suppuration.\n\nFor Periodontitis group: At least one tooth with PD ≥ 4 mm, presence of BOP, and radiographic bone loss.For Healthy groups: PD ≤ 3 mm, no clinical inflammation (BOP-), and no radiographic bone loss.\n\n(According to the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases) -\n\nExclusion Criteria:Presence of systemic diseases (e.g., diabetes, rheumatoid arthritis, osteoporosis).\n\nUse of antibiotics, anti-inflammatory, or immunosuppressive drugs within the last 3 months.\n\nPregnancy or breastfeeding.\n\nSmoking (current smokers).\n\nHistory of periodontal or peri-implant surgical treatment within the last 6 months.\n\nImplant failure (mobility).\n\nSigns of acute infection (fever, systemic symptoms).\n\n\\-",true,"18 Years","65 Years",{"count":59,"type":19},80,"OBSERVATIONAL","The aim of this study is to evaluate and compare the levels of bone resorption (RANKL, OPG) and oxidative stress (Nitrotyrosine, NQO1) markers, along with pro-inflammatory cytokines (IL-1β), in the saliva and peri-implant sulcular fluid (PISF) of patients with peri-implantitis, periodontitis, and healthy individuals. The study seeks to determine the diagnostic value of these biomarkers in the early detection and progression of peri-implant diseases.",[63,25],"Periodontal Diseases",[63,65,66,67],"periimplant diseases","Oxidative Stress","Alveolar Bone Loss","NOT_YET_RECRUITING","2026-02-02",{"date":71,"type":39},"2026-02-09",{"date":73,"type":19},"2026-02-15",{"date":75,"type":19},"2026-09-15",{"name":77,"class":46},"Saglik Bilimleri Universitesi",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":4,"enrollmentInfo":86,"targetDuration":88,"studyType":60,"phases":4,"briefSummary":89,"conditions":90,"keywords":95,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":4},"100508232","salivary-minerals-in-patients-with-peri-implantitis-100508232","NCT05897736","Salivary Minerals in Patients With Peri-implantitis","Analysis of Salivary Minerals Level Variations in Patients With Peri-implantitis","mineral-perio","Inclusion Criteria:\n\n* diagnosed peri-implantitis\n\nExclusion Criteria:\n\n* uncooperative patient\n* younger then 18 years old",{"count":87,"type":19},25,"3 Weeks","Patients included in the study will be recruited after arriving at the Faculty of Dentistry of the University of Zagreb. During the clinical examination, the patient's periodontal status (bleeding during probing, and the depth of the pockets around the implant) and a control x-ray will be taken to check bone loss. Saliva sampling will occur at 3-time points, when establishing the diagnosis of periimplantitis, before the start of therapy, and at the first control after treatment.",[91,92,93,25,94],"Peri-Implantitis and Peri-implant Mucositis","Peri-implant Mucositis","Periimplant Bone Loss","Peri-implant Health",[96,29,97,98],"salivary minerals","peri-implant health","salivary biomarkers","2023-06-01",{"date":101,"type":39},"2023-06-09",{"date":103,"type":19},"2023-10",{"date":105,"type":19},"2026-09",{"name":45,"class":46}]