[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"periimplantitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:periimplantitis":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,49,84,109],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100638497","comparison-of-anesthetic-efficacy-and-safety-between-inferior-alveolar-nerve-block-and-the-infiltrative-technique-for-the-treatment-of-peri-implant-diseases-in-posterior-mandibular-implants-100638497",false,"NCT07590037","Comparison of Anesthetic Efficacy and Safety Between Inferior Alveolar Nerve Block and the Infiltrative Technique for the Treatment of Peri-implant Diseases in Posterior Mandibular Implants","Comparison of Anesthetic Efficacy and Safety Between Inferior Alveolar Nerve Block and the Infiltrative Technique for the Treatment of Peri-implant Diseases in Posterior Mandibular Implants: A Triple-blind Randomized Clinical Trial","Inclusion Criteria:\n\n* Adult patients (≥18 years) requiring surgical treatment of peri-implantitis in the posterior mandibular sector.\n* Patients without relevant systemic disease (ASA II or lower).\n* Sufficient intellectual capacity to understand the study and informed consent and to complete the questionnaires adequately.\n\nExclusion Criteria:\n\n* Pregnant patients.\n* Patients with allergy or hypersensitivity to articaine or epinephrine.\n* Patients with uncontrolled systemic diseases.\n* Patients with coagulation disorders or medication that alters coagulation.\n* Patients who may be able to recognize the anesthetic technique used, such as dentists.\n* Drugs or systemic diseases (ASA III or higher) that contraindicate surgical intervention or the use of anesthetics and\u002For vasoconstrictors.\n* Patients with relative or absolute contraindication to conventional analgesic or anti-inflammatory regimens.",true,"ALL","18 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","This triple-blind randomized clinical trial aims to compare the anesthetic efficacy and safety of two local anesthesia techniques for the surgical treatment of peri-implantitis in posterior mandibular implants: inferior alveolar nerve block (IANB) and infiltrative anesthesia with 4% articaine and epinephrine 1:100,000.\n\nPeri-implantitis is an inflammatory disease affecting the tissues around dental implants, characterized by progressive bone loss and clinical signs of inflammation. When non-surgical therapy is insufficient, surgical treatment is required, usually involving flap elevation, debridement of granulation tissue, implant surface decontamination, and, depending on the defect, resective, regenerative, or combined surgery.\n\nEffective local anesthesia is essential in these procedures, especially in the posterior mandible, where dense bone may limit anesthetic diffusion. IANB is the conventional technique for achieving profound mandibular anesthesia, but it may fail due to anatomical variations, accessory innervation, or technical difficulty. Infiltrative anesthesia has been proposed as an alternative, particularly with articaine because of its high diffusion capacity, although its predictability in complex mandibular surgery remains uncertain.\n\nThe main objective is to compare the efficacy of IANB and infiltrative anesthesia, measured by the need for re-anesthesia during surgery. Secondary objectives include assessing safety, intraoperative discomfort, postoperative pain, duration of anesthesia, patient satisfaction, and adverse events.\n\nAdult patients requiring surgical treatment for peri-implantitis in posterior mandibular implants at the Dental Hospital of the University of Barcelona will be included. Eligible participants must be ≥18 years old, medically fit for surgery, and able to understand the study and complete the questionnaires. Exclusion criteria include pregnancy, allergy to articaine or epinephrine, uncontrolled systemic disease, coagulation disorders or anticoagulant medication, ASA III or higher status, and contraindications to conventional analgesic or anti-inflammatory medication.\n\nParticipants will be randomly assigned to either the IANB group or the infiltrative anesthesia group. Randomization will be performed using a computer-generated sequence placed in opaque, sequentially numbered envelopes. The patient, surgeon, outcome assessor, and statistician will remain blinded to group allocation.\n\nThe study includes three visits. At the first visit, eligibility will be assessed and informed consent obtained. At the second visit, surgery will be performed after the assigned anesthetic technique. Patients will record pain using visual analogue scales at injection, during surgery, 2 h, 6 h, 12 h, 24 h, and daily until day 7, as well as rescue medication use and sick leave. At the third visit, 7-9 days after surgery, postoperative healing, complications, adverse events, pain diary, and patient satisfaction will be assessed.\n\nThe primary outcome is anesthetic efficacy, defined as absence of need for re-anesthesia. Secondary variables include demographic factors, systemic disease, medication, smoking, dental anxiety, type and duration of surgery, surgeon experience, number and position of implants, intraoperative and postoperative pain, duration of anesthesia, adverse events, complications, and patient-reported experience measures.\n\nData will be analyzed using Stata\u002FIC 15.1. Quantitative variables will be described using means and standard deviations or medians and interquartile ranges, depending on normality. Qualitative variables will be presented as frequencies and percentages. Group comparisons will use appropriate statistical tests, with significance set at p \\\u003C 0.05.\n\nAs a pilot exploratory trial, the study will include 30 patients, 15 per group. Its aim is to assess feasibility, estimate preliminary event rates, and generate data for future confirmatory trials. The study will follow the Declaration of Helsinki and applicable data protection regulations. Participation will be voluntary, anonymous, and based on written informed consent.",[27,28,29],"Local Anesthesia","Dental Implants","Periimplantitis",[31,32,33,34,35],"dental implants","articaine","periimplantitis","block nerve","local anesthesia","NOT_YET_RECRUITING","2026-05-19",{"date":39,"type":40},"2026-05-22","ACTUAL",{"date":42,"type":21},"2026-09",{"date":44,"type":21},"2027-12",{"name":46,"class":47},"University of Barcelona","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":48},"100624812","micro-surg-subgingival-microbiome-in-peri-implantitis-regenerative-and-resective-periodontal-surgery-100624812","NCT07414498","MICRO-SURG: Subgingival Microbiome in Peri-Implantitis, Regenerative, and Resective Periodontal Surgery","MICRO-SURG: Investigation of Subgingival Microbiome Changes Following Surgical Peri-Implantitis Therapy, Regenerative Periodontal Surgery, and Resective Periodontal Surgery Using Next-Generation Sequencing","MICROSURG","Inclusion Criteria:\n\n* Age 18 years or older\n* Confirmed diagnosis of Peri-implantitis (for the peri-implantitis surgery arm), or Stage III\u002FIV periodontitis (for the periodontal surgery arms)\n* Indication for surgical therapy corresponding to the assigned study arm\n* Ability to understand the study procedures and provide written informed consent\n* Adequate oral hygiene (API\u002FSBI according to the clinician's judgment)\n* Willingness and ability to attend all follow-up visits\n* Willingness to provide salivary and subgingival plaque samples for microbiome analyses (NGS, SMDI)\n\nExclusion Criteria:\n\n* Systemic conditions contraindicating oral surgical procedures\n* Severe systemic diseases (e.g., uncontrolled diabetes mellitus, immunosuppressive disorders)\n* Use of systemic antibiotics within the previous 3 months\n* Active COVID-19 infection at the time of surgery\n* Pregnancy or breastfeeding\n* Drug or alcohol abuse\n* Smoking more than 10 cigarettes per day\n* Known allergies to materials used in the assigned intervention (e.g., local anesthetics, sutures, membranes, bone grafting materials)\n* Participation in another clinical study within the previous 30 days\n* Acute oral infections that contraindicate participation\n* Inability or unwillingness to comply with all follow-up appointments Lack of capacity to provide informed consent","80 Years",{"count":59,"type":21},84,[24],"This clinical study investigates how the subgingival microbiome changes after three different periodontal and peri-implant surgical procedures: (1) resective periodontal surgery, (2) regenerative periodontal surgery, and (3) peri-implantitis surgery. The aim is to characterize microbial shifts associated with these commonly used surgical treatments and to determine whether the type of surgery influences the recovery or disruption of the subgingival ecosystem. Adult patients with periodontitis or peri-implantitis will receive the procedure indicated for their condition. Subgingival plaque samples will be collected at baseline and at defined postoperative follow-up intervals. Microbiome analysis will be performed using next-generation sequencing (NGS), and microbial changes will be evaluated with the Subgingival Microbial Dysbiosis Index (SMDI). Insights from this study may help improve prevention, diagnostics, and treatment strategies for periodontal and peri-implant diseases.",[63,29],"Periodontitis",[65,66,67,68,69,70,71,72,73],"Subgingival Microbiome","Periodontal Surgery","Regenerative Surgery","Resective Surgery","Peri-Implantitis Surgery","Next-Generation Sequencing","16S rRNA Sequencing","Microbiome Analysis","SMDI","RECRUITING","2026-04-28",{"date":77,"type":40},"2026-05-05",{"date":79,"type":40},"2026-02-23",{"date":81,"type":21},"2026-06-01",{"name":83,"class":47},"University Hospital Muenster",{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":92,"enrollmentInfo":93,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":96,"conditions":97,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":4},"100608246","occlusal-load-distribution-and-periodontal-status-100608246","NCT07199062","Occlusal Load Distribution and Periodontal Status","Correlation Between Occlusal Load Distribution and Periodontal Status: A Cohort Study","Perio-Occlusio","Inclusion Criteria:\n\n* Adults (≥18 years).\n* Presence of natural dentition, fixed prostheses, or implant-supported fixed prostheses.\n* Ability to undergo radiological (OPT) and periodontal examinations.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Patients wearing removable prostheses.\n* Severe systemic conditions contraindicating dental treatment.\n* Inability to provide informed consent.","75 Years",{"count":94,"type":21},50,"OBSERVATIONAL","Occlusal forces are unevenly distributed among teeth during mastication, potentially predisposing certain teeth to higher functional loads. Teeth subjected to increased occlusal loading may be at greater risk of periodontal breakdown, especially in patients with pre-existing periodontal disease.\n\nTechnological advances, such as mandibular movement recording systems, allow for precise assessment of occlusal contacts and load distribution. However, the relationship between occlusal loading patterns and periodontal status remains insufficiently investigated.\n\nThis study aims to evaluate whether teeth exposed to higher masticatory loads show an association with periodontal disease severity.",[98,99,63,29],"Periodontal Diseases","Periodontal Pocket","2025-09-21",{"date":102,"type":40},"2025-09-30",{"date":104,"type":21},"2025-10-01",{"date":106,"type":21},"2026-04-01",{"name":108,"class":47},"University of Bari Aldo Moro",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":22,"phases":118,"briefSummary":119,"conditions":120,"keywords":121,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":48},"100602793","evaluation-of-the-effects-of-the-low-level-laser-therapy-as-an-adjunct-to-nonsurgical-treatment-in-patients-with-periimplantitis-100602793","NCT07128134","Evaluation of the Effects of the Low-level Laser Therapy as an Adjunct to Nonsurgical Treatment in Patients With Periimplantitis","Inclusion Criteria:\n\n* The patient must be willing to participate in the study.\n* At least one implant with a pocket depth ≥ 6 mm and radiographic bone loss ≥ 3 mm diagnosed with peri-implantitis.\n* Individuals aged 18-65.\n* Patients who can understand and maintain oral hygiene education.\n\nExclusion Criteria:\n\n* Individuals with any systemic disease that affects periodontal healing (diabetes, cancer, HIV\u002FAIDS, acute infections, liver or kidney dysfunction\u002Finsufficiency, autoimmune disorders: rheumatoid arthritis, systemic lupus erythematosus, Hashimoto's thyroiditis)\n* Female patients who are pregnant or breastfeeding\n* Patients who have undergone periodontal treatment within the last six months\n* Patients who have used antibiotics and regular anti-inflammatory medications within the last six months\n* Use of medications that affect periodontal tissues (cyclosporine, phenytoin, sodium valproate, etc.).","65 Years",{"count":117,"type":21},72,[24],"The main objective of this study is to evaluate the clinical efficacy of low-level laser therapy (LLLT) in addition to non-surgical periodontal treatment in patients with peri-implantitis. The study aims to investigate the anti-inflammatory and regenerative effects of low-level laser therapy on peri-implant soft and hard tissues and to reveal its contribution to treatment success.\n\nIn this context, the specific objectives of the study are as follows:\n\n1. To evaluate the effects of LLLT added to non-surgical mechanical treatment on clinical parameters such as plaque index, probing depth, bleeding index, and clinical attachment level.\n2. To examine the contributions of laser therapy to tissue healing by analyzing biochemical markers in peri-implant sulcular fluid over time.",[29],[122,123,124],"Peri-implantitis","Laser therapy","Non-surgical treatment","2025-08-15",{"date":127,"type":40},"2025-08-17",{"date":129,"type":21},"2025-08-20",{"date":131,"type":21},"2026-06-30",{"name":133,"class":47},"Mustafa Kemal University"]