[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"perinatal-mental-health\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:perinatal-mental-health":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,54,85,114,138,165,190],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100635380","womens-reproductive-choices-and-mental-health-during-pregnancy-and-after-birth-in-wartime-ukraine-100635380",false,"NCT07551934","Women's Reproductive Choices and Mental Health During Pregnancy and After Birth in Wartime Ukraine","Integrative Model of Factors Influencing Reproductive Behavior and Perinatal Mental Health of Women Amidst War","Inclusion Criteria:\n\n* able and willing to provide informed consent;\n* aged 18 years or older.\n\nExclusion Criteria:\n\n* younger than 18 years;\n* unable to provide informed consent;\n* do not have sufficient language proficiency to complete the study procedures;\n* at the time of recruitment, they have an acute medical or psychological condition that would make participation unsafe, inappropriate, or unduly burdensome (e.g., obstetric emergencies, immediate postoperative or critical care status, or severe acute distress requiring urgent clinical care);\n* participation or the handling of personal data could reasonably pose a risk to the safety of the participant or their family.",true,"ALL","18 Years",{"count":20,"type":21},328,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn how war affects reproductive decisions and perinatal mental health in Ukrainian women.\n\nThe main questions it aims to answer are: (1) how are wartime stress and trauma related to women's decisions about pregnancy and childbirth?; (2) what mental health symptoms and psychological difficulties are experienced during the perinatal period under wartime conditions? (3) which demographic, obstetric, and psychological factors are linked to poorer mental health and childbirth experiences?\n\nResearchers will survey at least 300 women.\n\nParticipants will: (1) complete questionnaires about their mental health and psychological well-being; (2) answer questions about their reproductive choices, pregnancy, and\u002For childbirth experiences; (3) report on the impact of war, social support, maternal care, and postpartum trauma; (4) provide demographic and obstetric information.\n\nThe findings will be used to develop an evidence-based model of the factors influencing reproductive behavior and perinatal mental health during war.",[25,26,27,28],"Perinatal Mental Health","Reproductive Behavior","Women","Cohort Studies",[30,31,32,33,34,35,36,37,38,39,40],"perinatal psychology","mental health","reproductive behavior","psychological trauma","PTSD","CB-PTSD","postpartum depression","pregnancy","sexual health","Ukraine","war-affected population","NOT_YET_RECRUITING","2026-05-04",{"date":44,"type":45},"2026-05-08","ACTUAL",{"date":47,"type":21},"2026-06",{"date":49,"type":21},"2028-11",{"name":51,"class":52},"Taras Shevchenko National University of Kyiv","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":62,"minAge":18,"maxAge":4,"enrollmentInfo":63,"targetDuration":4,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":70,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":53},"100581404","collaborative-care-model-for-perinatal-wellness-support-services---population-level-equity-centered-systems-change-100581404","NCT06849869","Collaborative Care Model for Perinatal Wellness Support Services - Population-Level Equity-Centered Systems Change","Collaborative Care Model for Perinatal Depression Support Services -- Population-Level Equity-Centered Systems Change (COMPASS-PLUS): A Hybrid Type 2 Cluster Randomized Trial","COMPASS+","Inclusion Criteria:\n\n* all pregnant and postpartum people receiving care at participating sites, who reach a gestational age of 20 or more weeks\n* age \\> 17 years\n\nExclusion Criteria:\n\n* age \\\u003C 18 years\n* all pregnant and postpartum people receiving care at participating sites, who do not reach a gestational age of 20 or more weeks","FEMALE",{"count":64,"type":21},14820,"INTERVENTIONAL",[67],"NA","The collaborative care model (CCM) is a health services intervention that integrates mental health care in primary care settings. The goal of this study is to adapt the CCM to the perinatal care context, including community co-designed adaptations to enhance health equity (COMPASS+). The main objectives of the study are to:\n\n1. Evaluate the effect of COMPASS+ on depression symptom outcomes. Specifically we will evaluate population-level depression symptom trajectories and the prevalence of suicidal ideation among. We will also measure rates of depression response and remission for those who have elevated screen scores (i.e., PHQ9 ≥ 10)\n2. Adapt, optimize, and evaluate COMPASS+ implementation strategies to the unique context of perinatal care and evaluate implementation outcomes. The RE-AIM framework will be used to evaluate implementation outcomes (acceptability, appropriateness, feasibility, and fidelity). We hypothesize that variability in effectiveness outcomes will be attributable to variability in fidelity to the implementation strategies or in implementation outcomes.\n3. Identify the effect of COMPASS+ on perinatal depression and implementation outcomes across racial and ethnic subgroups.",[25],[71,31,72,73,74],"health services interventions","collaborative care model","compass+","perinatal care","RECRUITING","2026-04-14",{"date":78,"type":45},"2026-04-20",{"date":80,"type":45},"2024-06-03",{"date":82,"type":21},"2028-06-30",{"name":84,"class":52},"Women and Infants Hospital of Rhode Island",{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":92,"targetDuration":4,"studyType":65,"phases":94,"briefSummary":95,"conditions":96,"keywords":100,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":53},"100566756","prevention-of-mother-to-child-transmission-pmtct-among-women-experiencing-depression-in-malawi-100566756","NCT06659315","Prevention of Mother-to-child Transmission (PMTCT) Among Women Experiencing Depression in Malawi","Addressing Perinatal Depression and PMTCT Adherence in Malawi: A Couple-Based Approach","Inclusion Criteria:\n\n* In a marriage or cohabitating union for at least 6 months.\n* One member of the couple is a woman in the second or third trimester of pregnancy who is living with HIV and screens positive for depression (\\>10 on the PHQ9).\n* Have revealed their HIV status to their partner if living with HIV\\>\n\nExclusion Criteria:\n\n* Fear their safety would be at risk.\n* Report incidents of severe intimate partner violence (IPV) in the past three months using the WHO IPV measure.",{"count":93,"type":21},180,[67],"Prevention of mother-to-child transmission (PMTCT) of HIV virtually eliminates transmission of HIV from mothers to their infants. Adherence to PMTCT (i.e., to antiretroviral therapy, infant prophylaxis, and exclusive breastfeeding) during pregnancy and the postpartum period is challenging, with evidence from sub-Saharan Africa (SSA) showing suboptimal adherence and persistent viremia among perinatal women. Perinatal depression (PD) is a major driver of women's poor adherence to PMTCT. Interventions that involve male partners to provide social and food\u002Feconomic support could be a promising approach for addressing PD and PMTCT, yet few interventions have intervened with couples to improve systems of support, communication, and other dyadic processes. The investigators propose to develop and test a couple-based approach to intervene on the mother's perinatal depressive symptoms and to strengthen the relationship and support system for partners to work together around depression to improve PMTCT adherence. The study will take place in antenatal and HIV care settings in Zomba, Malawi. The specific aims are: (1) to develop a couple-based intervention to target perinatal depression (PD) based on an evidence-based approach using problem-solving therapy (PST), augmented with content on couple communication and problem-solving skills; and (2) to assess the feasibility and acceptability (F\\&A) of the intervention via a pilot randomized controlled trial (RCT). Our short-term goal is the produce a couple-focused PST intervention that can be added to the global health toolkit for treating depression in perinatal women. Our long-term goal is to produce a high-impact and sustainable intervention leveraging the couple relationship that can be scaled-up to address depression, PMTCT adherence, and family health.",[97,25,98,99],"HIV Antiretroviral Therapy (ART) Adherence","Depression During Pregnancy","PMTCT",[101,102,103,99,104],"Perinatal depression","Couples","Problem-solving","ART adherence","2026-03-26",{"date":107,"type":45},"2026-03-30",{"date":109,"type":45},"2025-11-11",{"date":111,"type":21},"2027-07-01",{"name":113,"class":52},"University of California, San Francisco",{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":62,"minAge":18,"maxAge":4,"enrollmentInfo":121,"targetDuration":4,"studyType":65,"phases":123,"briefSummary":124,"conditions":125,"keywords":4,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":137},"100582352","effectiveness-of-digital-intervention-hm4mh-app-on-perinatal-psychological-wellbeing-100582352","NCT06862193","Effectiveness of Digital Intervention (HM4MH-app) on Perinatal Psychological Wellbeing","The Effectiveneness of a Digital Intervention (the HM4MH-app) on Perinatal Psychological Wellbeing: Randomized Controlled Trial","Inclusion Criteria:\n\n(i) pregnant women attending a participating maternity health care centre who (ii) have access to their own mobile phone and BankID and is (iii) currently in gestational week 8-15 and (iv) is 18 years or older.\n\nExclusion Criteria:\n\n* Previous psychotic disorder",{"count":122,"type":21},440,[67],"As many as 25% of pregnant women report mental health problems such as depressiveness and anxiety. This is a major concern as mental illness during pregnancy can have severe and long-lasting consequences for the pregnant woman, the baby, as well as the partner. Digital interventions (e.g., apps) have shown to be promising in promoting mental wellbeing, at scale, however, the majority of tools have been developed and evaluated in a general population rather than tailored for pregnancy. The objective of this trial is to investigate the effectiveness of a new digital tool (HealthyMoms4MentalHealth-app) on mental health outcomes during the perinatal period.",[126,127,25],"Mobile Application","Behavior","2025-12-15",{"date":130,"type":45},"2025-12-22",{"date":132,"type":45},"2025-03-10",{"date":134,"type":21},"2027-12-31",{"name":136,"class":52},"Karolinska Institutet",4,{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":11,"sex":62,"minAge":18,"maxAge":4,"enrollmentInfo":146,"targetDuration":4,"studyType":65,"phases":148,"briefSummary":149,"conditions":150,"keywords":151,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":53},"100593572","perinatal-thymic-dysregulation-characterization-of-perinatal-mood-episodes-100593572","NCT07008183","Perinatal Thymic DYsregulation: Characterization of Perinatal Mood Episodes","Perinatal Thymic Dysregulation: Characterization of Perinatal Mood Episodes","DYP","Inclusion Criteria:\n\n* Women over 18 years old\n* Pregnant or having given birth less than a year ago\n* First psychiatric consultation for the pregnancy concerned.\n* Good command of the French language.\n* Participant affiliated to the social security system\n* Participant who has given her consent to take part in the study.\n\nExclusion Criteria:\n\n* Women who gave birth more than a year ago.\n* Participant under psychiatric care\n* Participant under court protection",{"count":147,"type":21},200,[67],"The perinatal period is recognized as a time of heightened psychological vulnerability. This research aims to improve the diagnosis and therapeutic management of mood episodes occurring during this time. It is integrated into routine clinical care and seeks to standardize the evaluation of criteria used to characterize mood episodes, while also exploring relevant contextual factors.\n\nTraditionally, clinical attention has focused on postnatal depression; however, increasing evidence highlights the presence of hypomanic symptoms-such as distractibility, reduced need for sleep, tachypsychia, and irritability-during the postpartum period. These symptoms may coexist with depressive features, resulting in complex clinical presentations that are often difficult to recognize and manage. Consequently, many cases go undiagnosed and untreated.\n\nCurrent research has largely concentrated on depressive episodes (perinatal depression), with less emphasis on manic, hypomanic, or mixed episodes indicative of bipolar disorder. A systematic evaluation of hypomanic symptoms occurring alongside depressive symptoms in the postpartum period could refine clinical diagnosis and support more targeted and effective therapeutic interventions.",[25],[152,153,154],"perinatal mental health","perinatal depression","perinatal bipolar troubles","2025-11-24",{"date":157,"type":45},"2025-12-01",{"date":159,"type":45},"2025-10-13",{"date":161,"type":21},"2026-12-31",{"name":163,"class":164},"Centre Hospitalier Charles Perrens, Bordeaux","OTHER_GOV",{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":169,"acronym":4,"eligibilityCriteria":170,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":171,"targetDuration":4,"studyType":65,"phases":173,"briefSummary":174,"conditions":175,"keywords":176,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":180,"lastUpdatePostDateStruct":181,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":189},"100552040","the-development-of-path-a-program-to-support-nicu-parent-mental-health-through-the-transition-from-hospital-to-home-100552040","NCT06467916","The Development of PATH, a Program to Support NICU Parent Mental Health Through the Transition From Hospital to Home","Inclusion Criteria:\n\n* NICU parents: Participants will be parents of currently hospitalized preterm infants from either the OHSU NICU or the UCH NICU. We will include parents of live preterm infants who have been admitted in the NICU for at least 2 weeks. Parents must speak English or Spanish. Parents can be of any age.\n* NICU stakeholders: Participants will be stakeholders from either the OHSU NICU or the UCH NICU. Stakeholders will be social workers, mental health providers responsible for providing more intensive mental health support for NICU parents, nurses, neonatologists, and hospital administrators.",{"count":172,"type":21},72,[67],"The objective of this study is to develop and pilot test a telehealth-based mental health screening and engagement program that supports parents as their infants transition home from the NICU. The program will use a stepped-care approach to screen parents for depression, anxiety, and PTSD; provide a brief behavioral intervention to those who screen as having at least a low risk of these conditions; and provide a warm hand-off to community mental health services for those at medium to high risk.",[25],[177,152,153,178,179],"neonatal intensive care unit","perinatal anxiety","posttraumatic stress disorder","2025-04-21",{"date":182,"type":45},"2025-04-24",{"date":184,"type":21},"2025-04-22",{"date":186,"type":21},"2026-04-30",{"name":188,"class":52},"University of Colorado, Denver",2,{"id":191,"slug":192,"hasResults":11,"nctId":193,"briefTitle":194,"officialTitle":195,"acronym":4,"eligibilityCriteria":196,"healthyVolunteers":11,"sex":62,"minAge":4,"maxAge":4,"enrollmentInfo":197,"targetDuration":4,"studyType":65,"phases":199,"briefSummary":200,"conditions":201,"keywords":205,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":4},"100566222","perinatal-bereavement-counseling-training-for-midwives-100566222","NCT06652373","Perinatal Bereavement Counseling Training for Midwives","Evaluation of The Effectiveness of Perinatal Bereavement Counseling Training for Midwives","Inclusion Criteria:\n\n* Midwives who have been active midwives in one of the obstetrics, postnatal, perinatology, septic and aseptic services for at least one year\n\nExclusion Criteria:\n\n* Academic and freelance midwives\n* Midwives who have previously received specialised training in bereavement care",{"count":198,"type":21},126,[67],"Perinatal bereavement is a condition that can lead to serious psychological problems for parents and their families. Bereaved women are at high risk of mental health problems (e.g. anxiety, post-traumatic stress disorder and depression). They may also blame themselves and their bodies for the loss and feel inadequate. Inadequate support from their environment in this process may lead them to experience social isolation. Research highlights the impact of caring for bereaved parents on health professionals, and that inadequate training can have a negative impact. In this context, there is a need for well-structured and tailored training programmes that focus on the specific needs and skills required to provide appropriate bereavement care to parents experiencing pregnancy loss and perinatal death. In this context, this study was planned both to prepare a training programme with evidence of effectiveness and to investigate the effectiveness of perinatal bereavement counselling training for midwives.",[202,203,204,25],"Still Births","Bereavement","Perinatal Care",[203,206,207,208,209],"Hospice Care","Research Design","Midwifery","Pregnancy","2024-10-19",{"date":212,"type":45},"2024-10-22",{"date":214,"type":21},"2024-12-01",{"date":216,"type":21},"2025-12-30",{"name":218,"class":52},"Istanbul University - Cerrahpasa"]