[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"perinatal-stroke\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:perinatal-stroke":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,51],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100440318","baby-brain-recovery-study-100440318",false,"NCT05013736","Baby Brain Recovery Study","Perinatal Stroke: Longitudinal Assessment of Infant Brain Organization and Recovery Through Neuroexcitability, Neuroimaging and Motor Development","Main Inclusion Criteria:\n\n* Infants with corrected gestational age between term age and 24 months of age at study enrollment\n* Radiologically-confirmed acute unilateral or bilateral brain lesions, including perinatal stroke, neonatal hemorrhagic or thrombotic stroke, involving the motor cortex and\u002For subcortical structures, and intracranial hemorrhage, involving the motor cortex and\u002For subcortical white matter, periventricular leukomalacia, and hypoxic-ischemic encephalopathy (HIE)\n* English-speaking parent\u002Flegal guardian (able to provide consent)\n\nMain Exclusion Criteria:\n\n* Other neurologic disorders unrelated to perinatal stroke\u002Fbrain bleed\u002FHIE\n* Metabolic disorders\n* Disorders of Cellular Migration and Proliferation\n* Acquired Traumatic Brain Injury","ALL","0 Years","24 Months",{"count":20,"type":21},65,"ESTIMATED","OBSERVATIONAL","This study will be a longitudinal multiple-visit observational study, done to identify possible bioindicators of recovery and repair of motor corticospinal pathways which may be targeted by future interventions in infants with perinatal stroke.\n\n65 participants will be recruited and complete 1 visit at time point 1 (0-2 months), and 2 visits at each timepoints 2-5 with windows of +- 4 weeks (3-6 months, 12 months, 18 months and 24 months). Visits will consist of Magnetic Resonance Imaging (MRI) assessment during the child's natural sleep, Transcranial Magnetic Stimulation (TMS), and Motor Behavioral Assessments.",[25],"Perinatal Stroke",[27,28,29,30,31,32,33,34,35,36,37],"Magnetic Resonance Imaging (MRI)","Brain Reorganization","Brain Lesions","perinatal stroke","neonatal hemorrhagic stroke","neonatal thrombotic stroke","neonatal intracranial hemorrhage","neonatal periventricular leukomalacia","hypoxic ischemic encephalopathy","neonatal brain bleed","early brain injury","RECRUITING","2026-01-07",{"date":41,"type":42},"2026-01-08","ACTUAL",{"date":44,"type":42},"2022-07-26",{"date":46,"type":21},"2026-09",{"name":48,"class":49},"University of Wisconsin, Madison","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":16,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":64,"conditions":65,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":50},"100615351","behavioral-assessment-method-index-100615351","NCT07291479","Behavioral Assessment Method Index","Development of Upper Extremity Behavioral Assessment Methods for Reach-and-grasp and Physical Rehabilitation.","BAM","Inclusion Criteria:\n\n* Between 8 and 36 months old at baseline\n* Full Term Birth (37 to 41 weeks gestation)\n* Healthy development (meeting age-appropriate milestones)\n\nExclusion Criteria:\n\n* Diagnosed or suspected impairments (auditory, visual, cognitive or motor)",true,"4 Months","36 Months",{"count":63,"type":21},80,"The overall goal of this study is to develop and improve assessment methods for children with and without perinatal arterial ischemic stroke (PAS)\u002Fhemiparetic cerebral palsy (HCP). The focus is on behaviors of the arms and hands and includes other domains of child development like fine motor, gross motor, language, cognition, and social-emotional skills. This study involves 1) the use of data, including video recordings, from \"I-ACQUIRE - Perinatal Arterial Stroke: A Multi-site RCT of Intensive Infant Rehabilitation\" (NCT03910075) and 2) a prospective longitudinal observational data collection with a typically developing cohort using a comprehensive assessment battery (play, fine motor, gross motor, language, cognition, and social emotional skills). The current study is called the BAM Index. No intervention or treatment is provided as part of the BAM Index. The I-ACQUIRE study is an RCT that includes an intervention. The BAM index study is a use of data from the I-ACQUIRE cohorts and a prospective observational study of a typically developing cohort (children without stroke or cerebral palsy) over time. The results of this work will develop, test, refine, and validate a new methodology based on reach-and-grasp and other behaviors related to child development that will have profound and lasting impact on assessment and selection of treatment strategies for pediatric physical rehabilitation of children. The use and reuse of video technology is also well-suited to remote or virtual assessment. This proposal will add to our current knowledge by 1) yielding a psychometrically robust and alternative approach to measuring upper extremity function in children with stroke and\u002For hemiparetic cerebral palsy and 2) defining specific parameters about how to promote closer-to-normal upper extremity function in children with motor disability.",[66,25,67,68],"Infant Development","Hemiparesis","Cerebral Palsy","2025-12-05",{"date":71,"type":42},"2025-12-18",{"date":73,"type":42},"2023-07-07",{"date":75,"type":21},"2026-06",{"name":77,"class":49},"Ohio State University"]